metoprine has been researched along with levoleucovorin in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (93.33) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goldie, JH; Hill, BT; Price, LA | 2 |
| Cavallito, JC; Nichol, CA; Sigel, CW; Woolley, JL | 1 |
| Hansen, HH; Hansen, M; Lau, ME | 1 |
| Brown, OE; Frazer, T; Kutler, M; Laszlo, J; Sedwick, WD | 1 |
| Alberto, P; Beretta-Piccoli, M; Medenica, R; Peytremann, R | 1 |
| Roos, DS; Schimke, RT | 1 |
| Browman, GP; Calvert, AH; Harrap, KR; Hart, LI; Taylor, GA | 1 |
| Alberto, P; Brugarolas, A; Cavalli, F; Hansen, HH; Klepp, O; Renard, J | 1 |
| de Jager, R; Dorlet, C; Dupont, D; Lagrange, G; Rodzynek, JJ | 1 |
| Brugarolas, A; de Jager, R; Hansen, M | 1 |
| Casper, ES; Golbey, RB; Gralla, RJ; Kelsen, DP; Lynch, GR; Stoopler, MB | 1 |
| Currie, V; Kemeny, N; Lynch, G | 1 |
| Hill, BT; Price, LA | 1 |
| Assaraf, YG; Slotky, JI | 1 |
1 trial(s) available for metoprine and levoleucovorin
| Article | Year |
|---|---|
Initial clinical experience with a simultaneous combination of 2,4-diamino-5(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP) with folinic acid.
Topics: Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Middle Aged; Neoplasms; Pyrimethamine | 1978 |
14 other study(ies) available for metoprine and levoleucovorin
| Article | Year |
|---|---|
Methodichlorophen as anti-tumor drug.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Bone Marrow Diseases; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Chlorobenzenes; Drug Therapy, Combination; Erythema; Headache; Humans; Kidney Neoplasms; Leucovorin; Leukemia, Myeloid, Acute; Lung Neoplasms; Male; Middle Aged; Neoplasms; Pyrimethamine; Pyrimidines; Teratoma; Testicular Neoplasms | 1975 |
Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase.
Topics: Administration, Oral; Animals; Brain; Brain Neoplasms; Dogs; Folic Acid; Folic Acid Antagonists; Half-Life; Humans; Leucovorin; Lipid Metabolism; Male; Models, Biological; Pyrimethamine; Pyrimidines; Rats; Solubility; Species Specificity | 1977 |
DDMP and selective folinic acid protection in the treatment of malignant disease: a further report.
Topics: Bone Marrow; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Neoplasms; Pyrimethamine; Remission, Spontaneous | 1977 |
Unpredictable hematologic toxicity of weekly ddmp.
Topics: Antineoplastic Agents; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid; Hematologic Diseases; Humans; Leucovorin; Middle Aged; Pyrimethamine | 1978 |
New dose-time relationships of folate antagonists to sustain inhibition of human lymphoblasts and leukemic cells in vitro.
Topics: Cell Line; Cell Survival; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid Antagonists; Humans; Leucovorin; Leukemia; Methotrexate; Pyrimethamine; Time Factors | 1979 |
Toxicity of folic acid analogs in cultured human cells: a microtiter assay for the analysis of drug competition.
Topics: Animals; Cell Division; Cell Line; Drug Interactions; Drug Resistance; Gene Amplification; Humans; Leucovorin; Methotrexate; Mice; Pyrimethamine; Pyrimidines; Tetrahydrofolate Dehydrogenase; Xeroderma Pigmentosum | 1987 |
The intracellular mechanism of action of metoprine (DDMP).
Topics: Animals; Cell Survival; Cells, Cultured; Deoxyuridine; Dose-Response Relationship, Drug; Drug Resistance; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimethamine; Pyrimidines; Thymidine | 1980 |
Phase II study of diamino-dichlorophenyl-methylpyrimidine (DDMP) with folinic acid (CF) protection and rescue.
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Child; Drug Evaluation; Drug Therapy, Combination; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Leucovorin; Leukocyte Count; Melanoma; Neoplasms; Platelet Count; Pyrimethamine; Sarcoma | 1980 |
Phase I clinical trial and pharmacology of 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (metoprine) (DDMP) and folinic acid (CF).
Topics: Antineoplastic Agents; Drug Evaluation; Humans; Kinetics; Leucovorin; Neoplasms; Protein Binding; Pyrimethamine | 1981 |
Phase II clinical trial of DDMP (2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine) and folinic acid (CF) in solid tumors.
Topics: Antineoplastic Agents; Bone Marrow Diseases; Drug Evaluation; Humans; Leucovorin; Neoplasms; Pyrimethamine | 1981 |
Phase II evaluation of metoprine in patients with non-small-cell lung carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Female; Humans; Leucovorin; Lung Neoplasms; Male; Middle Aged; Pyrimethamine | 1981 |
Phase II evaluation of metoprine with leucovorin rescue in patients with advanced colorectal carcinoma.
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Pyrimethamine; Rectal Neoplasms | 1981 |
An experimentally designed high dose simultaneous combination of a diaminopyrimidine and folinic acid for the treatment of human malignancies.
Topics: Antineoplastic Agents; Bone Marrow Diseases; Drug Administration Schedule; Drug Therapy, Combination; Humans; Leucovorin; Neoplasms; Pyrimethamine | 1981 |
Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine.
Topics: Animals; Cell Survival; CHO Cells; Cricetinae; Drug Resistance; Flow Cytometry; Folic Acid Antagonists; Leucovorin; Pyrimethamine; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimethoprim | 1993 |