metoprine has been researched along with folic acid in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (83.33) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavallito, JC; Nichol, CA; Sigel, CW; Woolley, JL | 1 |
| Hansen, HH; Hansen, M; Lau, ME | 1 |
| Bunni, M; Dilwith, R; Galivan, J; Johnson, TB; Nair, MG; Priest, DG; Rhee, MS | 1 |
| Galivan, J; Nimec, Z; Rotundo, R | 1 |
| Mines, LS; Sirotnak, FM; Yang, CH | 1 |
| Galivan, J; Nimec, Z; Rhee, M | 1 |
| Boschelli, D; Galivan, J; Kerwar, SS; Nimec, Z; Oronsky, AL; Rhee, M | 1 |
| Goldie, JH; Hill, BT; Price, LA | 1 |
| Diddens, H; Jackson, RC; Niethammer, D | 2 |
| Bustamante, A; Henderson, GB; Patel, R; Rideout, DC | 1 |
| Cody, V; Queener, SF; Rosowsky, A | 1 |
12 other study(ies) available for metoprine and folic acid
| Article | Year |
|---|---|
Lipid-soluble diaminopyrimidine inhibitors of dihydrofolate reductase.
Topics: Administration, Oral; Animals; Brain; Brain Neoplasms; Dogs; Folic Acid; Folic Acid Antagonists; Half-Life; Humans; Leucovorin; Lipid Metabolism; Male; Models, Biological; Pyrimethamine; Pyrimidines; Rats; Solubility; Species Specificity | 1977 |
Unpredictable hematologic toxicity of weekly ddmp.
Topics: Antineoplastic Agents; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid; Hematologic Diseases; Humans; Leucovorin; Middle Aged; Pyrimethamine | 1978 |
The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Folic Acid; Folic Acid Antagonists; Kinetics; Liver Neoplasms, Experimental; Pyrimethamine; Quinazolines; Rats; Thymidylate Synthase; Trimetrexate | 1989 |
The characteristics and consequences of folate depletion in hepatoma cells in vitro by inhibition of dihydrofolate reductase.
Topics: Animals; Cell Division; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Pyrimethamine; Tumor Cells, Cultured | 1989 |
Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characterization
Topics: Affinity Labels; Aminopterin; Animals; Biological Transport; Carrier Proteins; Cell Division; Cell Membrane; Cholic Acids; Chromatography; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Folic Acid; Genetic Variation; Kinetics; Leukemia L1210; Methotrexate; Molecular Weight; Pyrimethamine; Receptors, Cell Surface; Succinimides | 1988 |
Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Liver Neoplasms, Experimental; Methotrexate; Pyrimethamine; Quinazolines; Rats; Thymidine; Thymidylate Synthase; Trimetrexate | 1987 |
Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate.
Topics: Acyltransferases; Animals; Drug Synergism; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Liver Neoplasms, Experimental; Phosphoribosylglycinamide Formyltransferase; Pyrimethamine; Quinazolines; Tetrahydrofolates; Thymidine Monophosphate; Trimetrexate; Tumor Cells, Cultured | 1988 |
Studies concerned with overcoming resistance to methotrexate: a comparison of the effects of methotrexate and 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (BW50197) on the colony forming ability of L5178Y cells.
Topics: Animals; Cell Line; Chlorobenzenes; Diamines; Folic Acid; Folic Acid Antagonists; Leukemia, Experimental; Methotrexate; Mice; Pyrimethamine; Pyrimidines | 1973 |
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Topics: Antineoplastic Agents; Biological Transport; Burkitt Lymphoma; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia, Lymphoid; Lymphoma; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; Structure-Activity Relationship; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1983 |
Resistance of human tumor cell lines to antifolates.
Topics: B-Lymphocytes; Biological Transport; Cell Line; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Karyotyping; Methotrexate; Osteosarcoma; Pyrimethamine; Quinazolines; T-Lymphocytes; Tetrahydrofolate Dehydrogenase; Trimetrexate | 1984 |
Suramin sodium: pronounced effects on methotrexate transport and anti-folate activity in cultured tumor cells.
Topics: Antineoplastic Agents; Biological Transport; Carrier Proteins; Cell Division; Drug Synergism; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Neoplasms; Pyrimethamine; Receptors, Cell Surface; Suramin; Tumor Cells, Cultured | 1995 |
Inhibition of dihydrofolate reductases from Toxoplasma gondii, Pneumocystis carinii, and rat liver by rotationally restricted analogues of pyrimethamine and metoprine.
Topics: Animals; Binding Sites; Computer Simulation; Folic Acid; Folic Acid Antagonists; Liver; Molecular Structure; Oxidoreductases; Pneumocystis; Pyrimethamine; Rats; Serine; Threonine; Toxoplasma | 1999 |