metolazone has been researched along with hydrochlorothiazide in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (28.57) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 5 (23.81) | 29.6817 |
| 2010's | 7 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Faller, B; Wohnsland, F | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Cecchi, A; Scozzafava, A; Supuran, CT; Temperini, C | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bennett, WM; Hartnett, MN; Kuehnel, E; McDonald, WJ; Porter, GA | 1 |
| Fukuhara, A; Matsumura, Y; Morimoto, S | 1 |
| Ellison, DH; Morsing, P; Velázquez, H; Wright, FS | 1 |
| Beaumont, K; Chen, ZF; Fanestil, DD; Vaughn, DA | 1 |
| Fanestil, DD; Lukeman, DS | 1 |
| Greenberg, A | 1 |
| Cobb, SD; Miller, SA; Petrulis, AS; Vertes, V | 1 |
| Stokes, JB | 1 |
| Anderson, GM; Clark, JP; Gurwitz, JH; Lau, P; Rochon, PA; Shear, NH; Tu, JV | 1 |
| Gamba, G; Hebert, SC; Monroy, A; Plata, C | 1 |
| Aliaga, S; Chantala, K; Clark, RH; Herring, AH; Hornik, CP; Hughes, R; Laughon, MM; Smith, PB | 1 |
1 review(s) available for metolazone and hydrochlorothiazide
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
2 trial(s) available for metolazone and hydrochlorothiazide
| Article | Year |
|---|---|
Do diuretics have antihypertensive properties independent of natriuresis?
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Diuretics; Double-Blind Method; Humans; Hydrochlorothiazide; Kidney Failure, Chronic; Male; Metolazone; Middle Aged; Natriuresis; Placebos; Renal Dialysis | 1977 |
Step 1 1/2 therapy for the treatment of hypertension.
Topics: Antihypertensive Agents; Clinical Trials as Topic; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Metolazone; Middle Aged; Potassium; Spironolactone | 1985 |
18 other study(ies) available for metolazone and hydrochlorothiazide
| Article | Year |
|---|---|
High-throughput permeability pH profile and high-throughput alkane/water log P with artificial membranes.
Topics: Alkanes; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Octanols; Permeability; Pharmaceutical Preparations; Solubility; Water | 2001 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.
Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Computer Simulation; Crystallography, X-Ray; Humans; Indapamide; Isoenzymes; Mice; Models, Molecular; Molecular Structure | 2008 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Prediction of drug intestinal absorption by new linear and non-linear QSPR.
Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
[Pharmacological study on diuretic action of 2-methyl-3-(o-tolyl)-6-sulfamyl-7-chloro-1, 2, 3, 4-tetrahydro-4-quinazolinone (metolazone) (author's transl)].
Topics: Administration, Oral; Animals; Diuretics; Female; Hydrochlorothiazide; Injections, Intraperitoneal; Kidney; Male; Metolazone; Potassium; Rats; Sodium; Time Factors; Urodynamics | 1978 |
Adaptation of distal convoluted tubule of rats. II. Effects of chronic thiazide infusion.
Topics: Adaptation, Physiological; Animals; Binding Sites; Chlorothiazide; Hydrochlorothiazide; Kidney Tubules, Distal; Male; Metolazone; Rats; Time Factors | 1991 |
Effects of diuretic treatment and of dietary sodium on renal binding of 3H-metolazone.
Topics: Acetazolamide; Animals; Carrier Proteins; Diuretics; Furosemide; Hydrochlorothiazide; Kidney; Male; Metolazone; Rats; Rats, Inbred Strains; Receptors, Drug; Sodium Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Sodium, Dietary; Solute Carrier Family 12, Member 3; Symporters | 1990 |
Interactions of diuretics with the peripheral-type benzodiazepine receptor in rat kidney.
Topics: Animals; Benzodiazepinones; Chlorothiazide; Diuretics; Dose-Response Relationship, Drug; Hydrochlorothiazide; Isoquinolines; Kidney; Metolazone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Solubility | 1987 |
What's new in diuretic therapy.
Topics: Acetazolamide; Acid-Base Imbalance; Biological Transport; Diuretics; Drug Resistance; Ethacrynic Acid; Furosemide; Humans; Hydrochlorothiazide; Hyperkalemia; Hypernatremia; Hypokalemia; Hyponatremia; Indapamide; Kidney Tubules, Distal; Kidney Tubules, Proximal; Loop of Henle; Metolazone; Osmolar Concentration; Spironolactone; Triamterene; Vasopressins | 1986 |
Sodium chloride absorption by the urinary bladder of the winter flounder. A thiazide-sensitive, electrically neutral transport system.
Topics: Animals; Biological Transport, Active; Diuretics; Fishes; Hydrochlorothiazide; Kinetics; Metolazone; Mucous Membrane; Ouabain; Papaverine; Sodium Chloride; Sodium Chloride Symporter Inhibitors; Urinary Bladder | 1984 |
Age- and gender-related use of low-dose drug therapy: the need to manufacture low-dose therapy and evaluate the minimum effective dose.
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Aged, 80 and over; Atenolol; Chlorthalidone; Confidence Intervals; Databases as Topic; Diuretics; Drug Compounding; Evaluation Studies as Topic; Female; Humans; Hydrochlorothiazide; Logistic Models; Male; Metolazone; Metoprolol; Myocardial Infarction; Odds Ratio; Ontario; Propranolol; Retrospective Studies; Sex Factors; Sodium Chloride Symporter Inhibitors; Timolol | 1999 |
Characterization of the thiazide-sensitive Na(+)-Cl(-) cotransporter: a new model for ions and diuretics interaction.
Topics: Animals; Bendroflumethiazide; Binding Sites; Biological Transport; Carrier Proteins; Chlorides; Diuretics; Hydrochlorothiazide; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Kinetics; Metolazone; Microinjections; Models, Biological; Oocytes; Osmolar Concentration; Polythiazide; Rats; Receptors, Drug; Sodium; Sodium Chloride Symporter Inhibitors; Sodium Chloride Symporters; Solute Carrier Family 12, Member 3; Symporters; Xenopus | 2000 |
Diuretic exposure in premature infants from 1997 to 2011.
Topics: Acetazolamide; Amiloride; Bronchopulmonary Dysplasia; Chlorothiazide; Cohort Studies; Diazoxide; Diuretics; Drug Therapy, Combination; Ethacrynic Acid; Female; Furosemide; Humans; Hydrochlorothiazide; Infant, Extremely Premature; Infant, Newborn; Infant, Premature; Male; Mannitol; Metolazone; Off-Label Use; Respiration, Artificial; Retrospective Studies; Spironolactone; Thrombocytopenia | 2015 |