metolazone and chlorothiazide

metolazone has been researched along with chlorothiazide in 20 studies

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (25.00)	18.7374
1990's	2 (10.00)	18.2507
2000's	1 (5.00)	29.6817
2010's	8 (40.00)	24.3611
2020's	4 (20.00)	2.80

Authors

Authors	Studies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Campillo, NE; Guerra, A; Páez, JA	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Hua, AS; Kincaid-Smith, P	1
Ellison, DH; Morsing, P; Velázquez, H; Wright, FS	1
Fanestil, DD; Lukeman, DS	1
Egel, J; Pfanstiel, J; Puschett, JB	1
Kempson, SA; Kowalski, JC; Puschett, JB	1
Anast, C; Puschett, JB; Teredesai, P; Winaver, J	1
Bartiss, A; Bernstein, P; Ellison, DH; Velázquez, H	1
Aliaga, S; Chantala, K; Clark, RH; Herring, AH; Hornik, CP; Hughes, R; Laughon, MM; Smith, PB	1
Anderson, AS; Choi, S; Hogg, J; Moranville, MP; Rich, JD	1
Altshuler, J; Cardinale, M; Testani, JM	1
Devabhakthuni, S; Ivaturi, V; Jiang, A; Liu, T; Reed, BN; Shulenberger, CE	1
Michaud, CJ; Mintus, KC	1
Cox, ZL; Hung, R; Lenihan, DJ; Testani, JM	1
Howard, ML; Janzen, KM; Steuber, TD	1
Ahlschwede, KM; Andey, T; Ofori, E; Osei, A; Somberg, JS	1
Biskupiak, J; Cisowska, T; Fang, JC; Jacobs, JA; Pan, IZ; Shah, KS	1

Reviews

2 review(s) available for metolazone and chlorothiazide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
A Systematic Review and Meta-Analysis of Metolazone Compared to Chlorothiazide for Treatment of Acute Decompensated Heart Failure. Pharmacotherapy, 2020, Volume: 40, Issue:9 Topics: Chlorothiazide; Diuretics; Heart Failure; Humans; Metolazone	2020

Trials

2 trial(s) available for metolazone and chlorothiazide

Article	Year
A comparison of the effects of chlorothiazide and of metolazone in the treatment of hypertension. Clinical science and molecular medicine. Supplement, 1976, Volume: 3 Topics: Adult; Aged; Chlorothiazide; Diuretics; Female; Humans; Hypertension; Male; Metolazone; Middle Aged; Potassium	1976
Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial. JACC. Heart failure, 2020, Volume: 8, Issue:3 Topics: Administration, Oral; Aged; Chlorothiazide; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Furosemide; Heart Failure; Humans; Infusions, Intravenous; Male; Metolazone; Middle Aged; Prospective Studies; Retrospective Studies; Tolvaptan; Treatment Outcome	2020

Article

Year

A comparison of the effects of chlorothiazide and of metolazone in the treatment of hypertension.

Clinical science and molecular medicine. Supplement, 1976, Volume: 3

Topics: Adult; Aged; Chlorothiazide; Diuretics; Female; Humans; Hypertension; Male; Metolazone; Middle Aged; Potassium

1976

Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial.

JACC. Heart failure, 2020, Volume: 8, Issue:3

Topics: Administration, Oral; Aged; Chlorothiazide; Diuretics; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Furosemide; Heart Failure; Humans; Infusions, Intravenous; Male; Metolazone; Middle Aged; Prospective Studies; Retrospective Studies; Tolvaptan; Treatment Outcome

2020

Other Studies

16 other study(ies) available for metolazone and chlorothiazide

Article	Year
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
Adaptation of distal convoluted tubule of rats. II. Effects of chronic thiazide infusion. The American journal of physiology, 1991, Volume: 261, Issue:1 Pt 2 Topics: Adaptation, Physiological; Animals; Binding Sites; Chlorothiazide; Hydrochlorothiazide; Kidney Tubules, Distal; Male; Metolazone; Rats; Time Factors	1991
Interactions of diuretics with the peripheral-type benzodiazepine receptor in rat kidney. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:3 Topics: Animals; Benzodiazepinones; Chlorothiazide; Diuretics; Dose-Response Relationship, Drug; Hydrochlorothiazide; Isoquinolines; Kidney; Metolazone; Rats; Rats, Inbred Strains; Receptors, GABA-A; Solubility	1987
Diuretic effects on renal brush border membrane transport and metabolism. Life sciences, 1985, Nov-04, Volume: 37, Issue:18 Topics: Acetazolamide; Animals; Biological Transport, Active; Chlorothiazide; Diuretics; Female; Gluconeogenesis; Inulin; Kidney; Metolazone; Microvilli; Natriuresis; Phosphates; Rats; Rats, Inbred Strains	1985
Direct effect of metolazone on sodium-dependent transport across the renal brush border membrane. The Journal of laboratory and clinical medicine, 1983, Volume: 101, Issue:2 Topics: Acetazolamide; Animals; Biological Transport; Chlorothiazide; Diuretics; In Vitro Techniques; Kidney Tubules, Proximal; Male; Metolazone; Microvilli; Phosphates; Rats; Rats, Inbred Strains; Sodium	1983
Investigations into the mechanism of the phosphaturia induced by chlorothiazide. The Journal of pharmacology and experimental therapeutics, 1981, Volume: 218, Issue:1 Topics: Acetazolamide; Animals; Bicarbonates; Calcium; Chlorothiazide; Dogs; Female; Glomerular Filtration Rate; Hydrogen-Ion Concentration; Kidney; Metolazone; Parathyroid Glands; Parathyroid Hormone; Phosphates; Regional Blood Flow; Thyroidectomy	1981
Adrenal steroids stimulate thiazide-sensitive NaCl transport by rat renal distal tubules. The American journal of physiology, 1996, Volume: 270, Issue:1 Pt 2 Topics: Adrenalectomy; Aldosterone; Animals; Binding Sites; Carrier Proteins; Chlorothiazide; Dexamethasone; Drug Combinations; Kidney Cortex; Kidney Tubules, Distal; Male; Metolazone; Rats; Rats, Sprague-Dawley; Sodium Chloride Symporters; Symporters	1996
Diuretic exposure in premature infants from 1997 to 2011. American journal of perinatology, 2015, Volume: 32, Issue:1 Topics: Acetazolamide; Amiloride; Bronchopulmonary Dysplasia; Chlorothiazide; Cohort Studies; Diazoxide; Diuretics; Drug Therapy, Combination; Ethacrynic Acid; Female; Furosemide; Humans; Hydrochlorothiazide; Infant, Extremely Premature; Infant, Newborn; Infant, Premature; Male; Mannitol; Metolazone; Off-Label Use; Respiration, Artificial; Retrospective Studies; Spironolactone; Thrombocytopenia	2015
Comparison of metolazone versus chlorothiazide in acute decompensated heart failure with diuretic resistance. Cardiovascular therapeutics, 2015, Volume: 33, Issue:2 Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Aged; Chicago; Chlorothiazide; Drug Resistance; Drug Therapy, Combination; Female; Heart Failure; Hospitalization; Humans; Length of Stay; Male; Metolazone; Middle Aged; Nephrons; Retrospective Studies; Sodium Chloride Symporter Inhibitors; Sodium Potassium Chloride Symporter Inhibitors; Time Factors; Treatment Outcome; Urination	2015
Efficacy of Intravenous Chlorothiazide for Refractory Acute Decompensated Heart Failure Unresponsive to Adjunct Metolazone. Pharmacotherapy, 2016, Volume: 36, Issue:8 Topics: Acute Disease; Administration, Intravenous; Adult; Aged; Chlorothiazide; Diuretics; Female; Heart Failure; Humans; Male; Metolazone; Middle Aged; Retrospective Studies	2016
Efficacy and Safety of Intravenous Chlorothiazide versus Oral Metolazone in Patients with Acute Decompensated Heart Failure and Loop Diuretic Resistance. Pharmacotherapy, 2016, Volume: 36, Issue:8 Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Adult; Aged; Chlorothiazide; Cohort Studies; Diuretics; Drug Resistance; Female; Heart Failure; Humans; Male; Metolazone; Middle Aged; Retrospective Studies	2016
Intravenous Chlorothiazide Versus Enteral Metolazone to Augment Loop Diuretic Therapy in the Intensive Care Unit. The Annals of pharmacotherapy, 2017, Volume: 51, Issue:4 Topics: Administration, Intravenous; Administration, Oral; Adult; Chlorothiazide; Critical Illness; Diuresis; Drug Therapy, Combination; Female; Furosemide; Humans; Intensive Care Units; Male; Metolazone; Retrospective Studies; Sodium Potassium Chloride Symporter Inhibitors	2017
Formulation, Characterization, and the Diuretic Effects of a New Intravenous Metolazone Emulsion. Drug research, 2022, Volume: 72, Issue:6 Topics: Administration, Intravenous; Animals; Chlorothiazide; Diuretics; Emulsions; Heart Failure; Metolazone; Polysorbates; Rats; Water	2022
Metolazone Versus Intravenous Chlorothiazide for Decompensated Heart Failure Sequential Nephron Blockade: A Retrospective Cohort Study. Journal of cardiac failure, 2022, Volume: 28, Issue:8 Topics: Chlorothiazide; Diuretics; Furosemide; Heart Failure; Humans; Metolazone; Nephrons; Retrospective Studies	2022