metoclopramide and methotrexate

metoclopramide has been researched along with methotrexate in 28 studies

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199010 (35.71)18.7374
1990's4 (14.29)18.2507
2000's7 (25.00)29.6817
2010's7 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Andricopulo, AD; Moda, TL; Montanari, CA1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Akkemik, E; Budak, H; Ciftci, M1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Busnardo, B; Casara, D; De Besi, P; Fiorentino, MV; Girelli, ME; Nacamulli, D; Simioni, N; Toso, S; Zorat, P1
Giannarelli, D; Marolla, P; Nardi, M; Pinnaró, P; Pollera, CF; Terzoli, E1
Biran, S; Cass, Y; Gera, C; Gez, E; Nathan, S; Ochayon, L; Rubello, E; Sulkes, A1
Ballatori, E; Basurto, C; del Favero, A; Minotti, V; Roila, F; Tonato, M2
Ben-Baruch, N; Ben-Yosef, R; Biran, S; Brufman, G; Gez, E; Uziely, B; Warner-Efraty, E; Yitzhaki, N1
Gerra, C; Gez, E; Goodman, S; Isacson, R; Sulkes, A1
Aonuma, K; Hanaoka, Y; Katoh, M; Kawai, H; Kobayashi, T; Morohashi, F; Nakahata, T; Norose, N; Tsuji, K; Tsukada, M1
Ballatori, E; Basurto, C; Minotti, V; Roila, F; Tonato, M1
Bruzzi, P; Campora, E; Chiara, S; Rosso, R; Scarsi, P1
Bui, BN; Chauvergne, J; David, M; Durand, M; Hoerni, B; Mauriac, L1
Latreille, J; Levitt, M; Lofters, WS; Perrault, DJ; Potvin, M; Rayner, HL; Warner, E; Warr, D; Wilson, KS; Yelle, L1
Barrenetxea, G; Centeno, MM; de la Rica, M; Rodríguez-Escudero, FJ; Romero, H; Schneider, J1
Brown, RS; Brown, TK; Gaze, MN; Hoare, D1
Eksborg, S; Lönnqvist, PA; Öbrink, E; Oddby-Muhrbeck, E; Rotstein, S1

Reviews

1 review(s) available for metoclopramide and methotrexate

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

8 trial(s) available for metoclopramide and methotrexate

ArticleYear
Effective control of CMF-related emesis with high-dose dexamethasone: results of a double-blind crossover trial with metoclopramide and placebo.
    American journal of clinical oncology, 1989, Volume: 12, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dexamethasone; Double-Blind Method; Drug Therapy, Combination; Female; Fluorouracil; Humans; Methotrexate; Metoclopramide; Middle Aged; Random Allocation; Vomiting

1989
Methylprednisolone versus metoclopramide as antiemetic treatment in patients receiving adjuvant cyclophosphamide, methotrexate, 5-fluorouracil (CMF) chemotherapy: a randomized crossover blind study.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Fluorouracil; Humans; Methotrexate; Methylprednisolone; Metoclopramide; Middle Aged; Randomized Controlled Trials as Topic; Vomiting

1989
Double-blind controlled trial of the antiemetic efficacy and toxicity of methylprednisolone (MP), metoclopramide (MTC) and domperidone (DMP) in breast cancer patients treated with i.v. CMF.
    European journal of cancer & clinical oncology, 1987, Volume: 23, Issue:6

    Topics: Age Factors; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Cyclophosphamide; Domperidone; Double-Blind Method; Female; Fluorouracil; Humans; Methotrexate; Methylprednisolone; Metoclopramide; Middle Aged; Nausea; Vomiting

1987
Methylprednisolone versus metoclopramide for prevention of nausea and vomiting in breast cancer patients treated with intravenous cyclophosphamide methotrexate 5-fluorouracil: a double-blind randomized study.
    Oncology, 1988, Volume: 45, Issue:5

    Topics: Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Double-Blind Method; Female; Fluorouracil; Humans; Methotrexate; Methylprednisolone; Metoclopramide; Middle Aged; Nausea; Random Allocation; Vomiting

1988
Evaluation of the antiemetic activity of bromopride in cancer patients treated with i.v. CMF.
    Tumori, 1985, Oct-31, Volume: 71, Issue:5

    Topics: Adult; Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Drug Evaluation; Female; Fluorouracil; Humans; Methotrexate; Metoclopramide; Middle Aged

1985
The antiemetic efficacy of methylprednisolone compared with metoclopramide in outpatients receiving adjuvant CMF chemotherapy for breast cancer: a randomized trial.
    Tumori, 1985, Oct-31, Volume: 71, Issue:5

    Topics: Adult; Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials as Topic; Cyclophosphamide; Female; Fluorouracil; Humans; Methotrexate; Methylprednisolone; Metoclopramide; Middle Aged; Random Allocation

1985
Ondansetron compared with dexamethasone and metoclopramide as antiemetics in the chemotherapy of breast cancer with cyclophosphamide, methotrexate, and fluorouracil.
    The New England journal of medicine, 1993, Apr-15, Volume: 328, Issue:15

    Topics: Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dexamethasone; Drug Therapy, Combination; Female; Fluorouracil; Humans; Methotrexate; Metoclopramide; Middle Aged; Nausea; Ondansetron; Regression Analysis; Vomiting

1993
Chemotherapy-induced emesis: management of early and delayed emesis in milder emetogenic regimens.
    Cancer chemotherapy and pharmacology, 1996, Volume: 38, Issue:5

    Topics: Administration, Oral; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Epirubicin; Female; Fluorouracil; Humans; Infusions, Intravenous; Methotrexate; Metoclopramide; Ondansetron; Patient Satisfaction; Quality of Life; Surveys and Questionnaires; Vomiting

1996

Other Studies

19 other study(ies) available for metoclopramide and methotrexate

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study.
    Journal of enzyme inhibition and medicinal chemistry, 2010, Volume: 25, Issue:4

    Topics: Enzyme Inhibitors; Erythrocytes; Humans; Inhibitory Concentration 50; Kinetics; Pharmaceutical Preparations; Phosphogluconate Dehydrogenase; Spectrum Analysis

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Combined chemotherapy with bleomycin, adriamycin, and platinum in advanced thyroid cancer.
    Journal of endocrinological investigation, 1991, Volume: 14, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Betamethasone; Bleomycin; Carcinoma; Carmustine; Cisplatin; Doxorubicin; Female; Fluorouracil; Humans; Male; Methotrexate; Metoclopramide; Middle Aged; Nausea; Thyroid Neoplasms; Vincristine

1991
High-dose metoclopramide and dexamethasone as an antiemetic in outpatients receiving chemotherapy for breast cancer. Second study.
    Oncology, 1987, Volume: 44, Issue:4

    Topics: Adult; Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Dexamethasone; Drug Therapy, Combination; Female; Fluorouracil; Humans; Methotrexate; Metoclopramide; Middle Aged; Nausea; Vomiting

1987
High-dose metoclopramide and dexamethasone as an antiemetic in chemotherapy of breast cancer.
    Oncology, 1986, Volume: 43, Issue:3

    Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dexamethasone; Double-Blind Method; Drug Therapy, Combination; Female; Fluorouracil; Humans; Methotrexate; Metoclopramide

1986
[Modified VAPA therapy in children with acute nonlymphocytic leukemia].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1986, Volume: 27, Issue:11

    Topics: Acute Disease; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cytarabine; Doxorubicin; Female; Humans; Infant; Leukemia; Male; Methotrexate; Methylprednisolone; Metoclopramide; Prognosis; Remission Induction; Vincristine

1986
Cyclophosphamide, methotrexate, and 5-FU (CMF)-induced nausea and vomiting: a controlled study with high-dose metoclopramide.
    Cancer treatment reports, 1984, Volume: 68, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Drug Administration Schedule; Drug Evaluation; Female; Fluorouracil; Humans; Methotrexate; Metoclopramide; Middle Aged; Nausea; Random Allocation; Time Factors

1984
An audit of antiemetic use with CMF chemotherapy.
    Clinical oncology (Royal College of Radiologists (Great Britain)), 1998, Volume: 10, Issue:5

    Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dexamethasone; Drug Therapy, Combination; Female; Fluorouracil; Granisetron; Humans; Medical Records; Methotrexate; Metoclopramide; Retrospective Studies; Serotonin Antagonists; Treatment Outcome; Vomiting

1998
Is there an association between PONV and chemotherapy-induced nausea and vomiting?
    Acta anaesthesiologica Scandinavica, 2013, Volume: 57, Issue:6

    Topics: Adult; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Betamethasone; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Disease Resistance; Droperidol; Epirubicin; Female; Fluorouracil; Granisetron; Humans; Mastectomy; Methotrexate; Metoclopramide; Middle Aged; Models, Biological; Narcotics; Nausea; Ondansetron; Postoperative Nausea and Vomiting; Prospective Studies; Risk Factors; Vomiting

2013