metoclopramide has been researched along with clozapine in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (32.65) | 18.7374 |
| 1990's | 6 (12.24) | 18.2507 |
| 2000's | 14 (28.57) | 29.6817 |
| 2010's | 12 (24.49) | 24.3611 |
| 2020's | 1 (2.04) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Fang, X; Hu, Z; Levant, B; Min, J; Varady, J; Wang, S; Wu, X | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bergström, F; Giordanetto, F; Rehngren, M; Tunek, A; Wan, H | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Hicks, TP; McLennan, H | 1 |
| Costall, B; Naylor, RJ | 1 |
| Roufogalis, BD; Thornton, M; Wade, DN | 1 |
| Marsden, CD; Pycock, C; Tarsy, D | 1 |
| Joshi, RS; Marco, LA | 1 |
| Budygin, EA; Gaĭnetdinov, RR; Kovalev, GI; Kudrin, VS; Raevskiĭ, KS | 1 |
| Bakhtiar, R; Bull, DR; Sheehan, MJ | 1 |
| Jenkins, M; Metzer, WS | 1 |
| Pfaus, JG; Phillips, AG | 1 |
| Davis, KL; Guerin, JJ; Halperin, R | 1 |
| Blackburn, JR; Phillips, AG | 1 |
| Ekker, M; Sourkes, TL | 1 |
| Blaha, CD; Lane, RF | 1 |
| Cools, AR; Ellenbroek, BA; Honig, WM; Peeters, BW | 1 |
| Pinnock, RD; Suppes, T | 1 |
| Hall, N; Liebman, JM; Prowse, J | 1 |
| Pi, EH; Simpson, GM | 1 |
| Borsini, F; Nowakowska, E; Samanin, R | 1 |
| Arushanian, EB; Smirnova, LE; Tolpyshev, BA | 1 |
| Kim, HS; Liebman, J; Welch, JJ | 1 |
| Lynch, AM; See, RE; Sorg, BA | 1 |
| Graybiel, AM; Hiroi, N | 1 |
| Emrich, HM; Grohmann, R; Hauser, U; Kropp, S | 1 |
| Abílio, VC; Calzavara, MB; Levin, R; Medrano, WA; Niigaki, ST; Santos, CM | 1 |
| Baker, TW; Beninger, RJ; Florczynski, MM | 1 |
| Bergman, J; Bersudsky, Y; Gaiduk, Y; Kreinin, A; Lerner, PP; Lerner, V; Miodownik, C; Mirkin, V; Yankovsky, Y | 1 |
| Hallahan, B | 1 |
| Bailey, L; Dzahini, O; Livermore, C; Oloyede, E; Osborne, I; Whiskey, E; White, H | 1 |
2 review(s) available for metoclopramide and clozapine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Atypical neuroleptics: clozapine and the benzamides in the prevention and treatment of tardive dyskinesia.
Topics: Antipsychotic Agents; Benzamides; Clinical Trials as Topic; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Haloperidol; Humans; Metoclopramide; Prospective Studies; Schizophrenia; Sulpiride; Tiapamil Hydrochloride | 1983 |
2 trial(s) available for metoclopramide and clozapine
| Article | Year |
|---|---|
Atypical neuroleptics: clozapine and the benzamides in the prevention and treatment of tardive dyskinesia.
Topics: Antipsychotic Agents; Benzamides; Clinical Trials as Topic; Clozapine; Dibenzazepines; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Haloperidol; Humans; Metoclopramide; Prospective Studies; Schizophrenia; Sulpiride; Tiapamil Hydrochloride | 1983 |
Double-Blind, Randomized, Placebo-Controlled Trial of Metoclopramide for Hypersalivation Associated With Clozapine.
Topics: Adult; Antipsychotic Agents; Clozapine; Dopamine D2 Receptor Antagonists; Double-Blind Method; Humans; Metoclopramide; Middle Aged; Schizophrenia; Sialorrhea; Young Adult | 2016 |
46 other study(ies) available for metoclopramide and clozapine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Molecular modeling of the three-dimensional structure of dopamine 3 (D3) subtype receptor: discovery of novel and potent D3 ligands through a hybrid pharmacophore- and structure-based database searching approach.
Topics: Algorithms; Binding Sites; Computational Biology; Crystallography, X-Ray; Databases, Protein; Humans; Kinetics; Ligands; Lipid Bilayers; Models, Molecular; Molecular Conformation; Mutation; Receptors, Dopamine D2; Receptors, Dopamine D3; Reproducibility of Results; Solvents; Structure-Activity Relationship; Tetrahydronaphthalenes; Water | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery.
Topics: Animals; Brain; Central Nervous System Agents; Dialysis; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Mice; Models, Statistical; Protein Binding; Quantitative Structure-Activity Relationship; Rats | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Actions of octopamine upon dorsal horn neurones of the spinal cord.
Topics: Animals; Clozapine; Dopamine; Electrophysiology; Glutamates; Interneurons; Metoclopramide; Norepinephrine; Octopamine; Propranolol; Rats; Receptors, Adrenergic; Spinal Cord | 1978 |
A comparison of the abilities of typical neuroleptic agents and of thioridazine, clozapine, sulpiride and metoclopramide to antagonise the hyperactivity induced by dopamine applied intracerebrally to areas of the extrapyramidal and mesolimbic systems.
Topics: Animals; Brain; Clozapine; Corpus Striatum; Dopamine Antagonists; Dose-Response Relationship, Drug; Extrapyramidal Tracts; Fluphenazine; Haloperidol; Limbic System; Male; Metoclopramide; Pimozide; Rats; Stereotaxic Techniques; Sulpiride; Thioridazine; Tranquilizing Agents | 1976 |
Specificity of the dopamine sensitive adenylate cyclase for antipsychotic antagonists.
Topics: Adenylyl Cyclases; Animals; Apomorphine; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Activation; Haloperidol; Male; Metoclopramide; Rats; Sulpiride | 1976 |
Inhibition of circling behavior by neuroleptic drugs in mice with unilateral 6-hydroxydopamine lesions of the striatum.
Topics: Animals; Apomorphine; Basal Ganglia Diseases; Behavior; Biogenic Amines; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Chlorpromazine; Clozapine; Corpus Striatum; Dextroamphetamine; Diazepam; Dopamine; Haloperidol; Humans; Hydroxydopamines; Levodopa; Male; Metoclopramide; Mice; Motor Activity; Pentobarbital; Phenoxybenzamine; Pimozide; Promethazine; Stereotyped Behavior; Tranquilizing Agents | 1975 |
A ketamine-induced rat model of tardive dyskinesia.
Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Dyskinesia, Drug-Induced; Haloperidol; Ketamine; Metoclopramide; Pharynx; Rats; Rats, Inbred Strains; Stereotyped Behavior; Tongue | 1992 |
[Different effects of typical and atypical neuroleptics on K+-stimulated dopamine release from isolated rat striatum].
Topics: Animals; Antipsychotic Agents; Carbolines; Clozapine; Corpus Striatum; Dopamine; Dopamine Antagonists; In Vitro Techniques; Male; Metoclopramide; Potassium; Raclopride; Rats; Rats, Wistar; Remoxipride; Salicylamides; Stimulation, Chemical; Sulpiride; Thioridazine; Tiapamil Hydrochloride; Trifluoperazine | 1992 |
Characterization of dopamine autoreceptors in the amygdala: a fast cyclic voltammetric study in vitro.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Amygdala; Animals; Antipsychotic Agents; Benzazepines; Clozapine; Dopamine; Electric Stimulation; Ergolines; Male; Metoclopramide; Neurotransmitter Uptake Inhibitors; Nialamide; Piperazines; Quinpirole; Rats; Rats, Inbred Strains; Receptors, Dopamine; Secretory Rate; Sulpiride | 1991 |
Avoidance of metoclopramide for the treatment of clozapine-induced nausea.
Topics: Clozapine; Dibenzazepines; Dyskinesia, Drug-Induced; Humans; Metoclopramide; Nausea; Parkinson Disease, Secondary | 1990 |
Differential effects of dopamine receptor antagonists on the sexual behavior of male rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Ejaculation; Female; Haloperidol; Male; Metoclopramide; Pimozide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Sexual Behavior, Animal; Sulpiride | 1989 |
Regional differences in the induction of behavioral supersensitivity by prolonged treatment with atypical neuroleptics.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Body Weight; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Humans; Injections; Metoclopramide; Motor Activity; Nucleus Accumbens; Rats; Rats, Inbred Strains; Stereotyped Behavior; Sulpiride | 1989 |
Blockade of acquisition of one-way conditioned avoidance responding by haloperidol and metoclopramide but not by thioridazine or clozapine: implications for screening new antipsychotic drugs.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Clozapine; Dibenzazepines; Drug Evaluation, Preclinical; Haloperidol; Male; Metoclopramide; Rats; Thioridazine | 1989 |
Differential effects of thioridazine, clozapine and metoclopramide on the induction of adrenomedullary enzymes by apomorphine.
Topics: Adrenal Medulla; Animals; Apomorphine; Clozapine; Corpus Striatum; Dibenzazepines; Enzyme Induction; Male; Metoclopramide; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Substantia Nigra; Thioridazine; Tyrosine 3-Monooxygenase | 1985 |
Chronic treatment with classical and atypical antipsychotic drugs differentially decreases dopamine release in striatum and nucleus accumbens in vivo.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Corpus Striatum; Dopamine; Haloperidol; Male; Metoclopramide; Nucleus Accumbens; Promethazine; Rats; Rats, Inbred Strains; Septal Nuclei; Thioridazine | 1987 |
The paw test: a behavioural paradigm for differentiating between classical and atypical neuroleptic drugs.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Clozapine; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Forelimb; Haloperidol; Hindlimb; Male; Metoclopramide; Morphine; Motor Activity; Rats; Rats, Inbred Strains; Thioridazine | 1987 |
Sensitivity of neuronal dopamine response in the substantia nigra and ventral tegmentum to clozapine, metoclopramide and SCH 23390.
Topics: Action Potentials; Animals; Benzazepines; Clozapine; Dibenzazepines; Dopamine; In Vitro Techniques; Male; Metoclopramide; Neurons; Rats; Substantia Nigra; Tegmentum Mesencephali | 1987 |
Effects of various catecholamine receptor antagonists, muscle relaxation and physical hindrance on shuttlebox self-stimulation.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Clozapine; Haloperidol; Male; Methocarbamol; Metoclopramide; Muscle Relaxants, Central; Prazosin; Rats; Rats, Inbred F344; Reaction Time; Receptors, Dopamine; Self Stimulation | 1982 |
Effect of repeated treatment with desipramine in the behavioral "despair" test in rats: antagonism by "atypical" but not "classical" neuroleptics or antiadrenergic drugs.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Butyrophenones; Chlorpromazine; Clonidine; Clozapine; Depressive Disorder; Desipramine; Dibenzazepines; Haloperidol; Humans; Male; Metoclopramide; Phentolamine; Prazosin; Propranolol; Rats; Sulpiride | 1984 |
[Possible discrepancy between behavioral adequacy and motor automatisms in cats with phenamine-induced stereotypy].
Topics: Amphetamine; Animals; Cats; Clozapine; Dibenzazepines; Female; Haloperidol; Humans; Male; Metoclopramide; Stereotyped Behavior | 1981 |
Amphetamine-induced increases in dopaminergic single cell firing rate after haloperidol pretreatment. Correlation with extrapyramidal side effects.
Topics: Animals; Apomorphine; Brain; Clozapine; Dextroamphetamine; Dopamine; Drug Interactions; Extrapyramidal Tracts; Haloperidol; Male; Metoclopramide; Neurons; Rats; Substantia Nigra; Thioridazine | 1980 |
Subchronic administration of clozapine, but not haloperidol or metoclopramide, decreases dopamine D2 receptor messenger RNA levels in the nucleus accumbens and caudate-putamen in rats.
Topics: Actins; Animals; Antipsychotic Agents; Blotting, Northern; Brain Chemistry; Caudate Nucleus; Clozapine; Dopamine Antagonists; Haloperidol; Male; Metoclopramide; Nucleus Accumbens; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; RNA, Messenger; Spiperone | 1996 |
Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatum.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Clozapine; Corpus Striatum; Haloperidol; Immunoblotting; Immunohistochemistry; Male; Metoclopramide; Neurons; Phenotype; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Transcription Factors | 1996 |
Metoclopramide-related pisa syndrome in clozapine treatment.
Topics: Clozapine; Dopamine Antagonists; Dyskinesia, Drug-Induced; Female; Humans; Metoclopramide; Middle Aged; Nausea; Schizophrenia; Syndrome | 2001 |
Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine.
Topics: Acoustic Stimulation; Amphetamine; Animals; Antimanic Agents; Antipsychotic Agents; Carbamazepine; Clozapine; Disease Models, Animal; Dopamine Antagonists; Dopamine Uptake Inhibitors; Male; Metoclopramide; Rats; Rats, Inbred SHR; Rats, Wistar; Reflex, Startle; Schizophrenia; Sensory Gating | 2011 |
Differential effects of clozapine, metoclopramide, haloperidol and risperidone on acquisition and performance of operant responding in rats.
Topics: Animals; Antipsychotic Agents; Clozapine; Conditioning, Operant; Dopamine D2 Receptor Antagonists; Haloperidol; Male; Metoclopramide; Prefrontal Cortex; Rats; Rats, Wistar; Risperidone | 2015 |
Metoclopramide may be effective for clozapine-induced hypersalivation.
Topics: Antipsychotic Agents; Clozapine; Humans; Metoclopramide; Schizophrenia; Sialorrhea | 2016 |
A retrospective case notes review of the effectiveness and tolerability of metoclopramide in the treatment of clozapine-induced hypersalivation (CIH).
Topics: Antipsychotic Agents; Clozapine; Humans; Metoclopramide; Retrospective Studies; Schizophrenia; Sialorrhea | 2022 |