metkephamid and bremazocine

metkephamid has been researched along with bremazocine* in 1 studies

Other Studies

1 other study(ies) available for metkephamid and bremazocine

ArticleYear
Diuresis and suppression of vasopressin by kappa opioids: comparison with mu and delta opioids and clonidine.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:2

    The effects of agonists at kappa, mu and delta opioid receptors were determined on vasopressin levels in water-deprived rats. Bremazocine and U-50, 488 (kappa agonists) markedly suppressed vasopressin levels, whereas morphine and methadone (mu agonists) and metkephamid (a mixed mu and delta agonist) did not suppress vasopressin levels. Likewise, clonidine, a potent diuretic in normally hydrated rats, did not clearly suppress vasopressin levels. Metkephamid was shown to have a modest diuretic effect in normally hydrated rats but not in water-deprived rats. The diuretic effects of bremazocine were blocked completely by simultaneous treatment with desmopressin, a synthetic vasopressin-like analog. Desmopressin also blocked the diuretic effect of a waterload, but only partially attenuated the diuretic effect of clonidine. These results support the hypothesis that kappa opioid agonists produce a diuretic effect by suppressing plasma levels of vasopressin, and at higher doses produce a pattern of urination similar to animals lacking vasopressin. By comparison, mu and delta opioid agonists have little effect on vasopressin levels in water-deprived rats.

    Topics: Animals; Benzomorphans; Clonidine; Deamino Arginine Vasopressin; Diuresis; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Male; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasopressins

1985