methylthioinosine has been researched along with mercaptopurine in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (19.23) | 18.7374 |
| 1990's | 9 (34.62) | 18.2507 |
| 2000's | 5 (19.23) | 29.6817 |
| 2010's | 5 (19.23) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Chao, EY; Elion, GB; Inmon, RB; Koszalka, GW; Krenitsky, TA; Latter, VS; Rideout, JL; Williams, RB | 1 |
| Basso, LA; de Azevedo, WF; Ducati, RG; Santos, DS | 1 |
| Abel-Santos, E; Alvarez, Z; Lee, K | 1 |
| Bodey, GP; Hewlett, JS; Stuckey, WJ; Wilson, HE | 1 |
| Adamson, DJ; Carpenter, JW; Nelson, JA; Rose, LM | 1 |
| Lennard, L; Singleton, HJ | 1 |
| Holcenberg, JS; Lavi, LE | 1 |
| Blechman, WJ; Kim, K; Pardee, AB; Riddle, VG | 1 |
| Bökkerink, JP; De Abreu, RA; Lambooy, LH; Stet, EH; Trijbels, FJ; Vogt, MH | 1 |
| Bökkerink, JP; De Abreu, RA; Keizer-Garritsen, JJ; Lambooy, LH; Stet, EH; Trijbels, FJ; Vogels-Mentink, TM | 1 |
| Bökkerink, JP; De Abreu, RA; Lambooy, LH; Stet, EH; Trijbels, FJ; Trueworthy, RC; Vogels-Mentink, TM | 1 |
| Bökkerink, JP; DeAbreu, RA; Keuzenkamp-Jansen, CW; Lambooy, MA; Trijbels, JM | 1 |
| Aarbakke, J; Fuskevaag, OM; Giverhaug, T | 1 |
| Sandborn, WJ | 1 |
| Aarbakke, J; Bergan, S; Giverhaug, T; Loennechen, T; Rugstad, HE | 1 |
| Belleri, M; Morbidelli, L; Presta, M; Ribatti, D; Rusnati, M; Ziche, M | 1 |
| Beijnen, JH; Borst, P; Brouwer, C; Challa, EE; De Abreu, RA; de Haas, M; Groeneveld, E; Kuil, AJ; Mol, C; Reid, G; Schuetz, JD; van Deemter, L; van der Heijden, I; Wielinga, PR; Wijnholds, J | 1 |
| Dubinsky, MC | 1 |
| Griffiths, AM | 1 |
| Dejaco, C; Harrer, M; Mantl, M; Miehsler, W; Reinisch, W; Schaeffeler, E; Schneider, B; Schwab, M; Teml, A; Vogelsang, H | 1 |
| Gisbert, JP; González-Lama, Y; Maté, J | 1 |
| Greenley, RN; Hommel, KA; Kunz, JH | 1 |
| Angelberger, S; Heinkele, G; Hofmann, U; Jaeger, S; Lichtenberger, C; Reinisch, W; Schaeffeler, E; Schwab, M | 1 |
| Almer, S; Andersson, D; Hindorf, U; Peterson, C; Vikingsson, S | 1 |
| Han, J; Jin, S; Mei, D; Sun, N; Wang, X; Xu, J; Zhao, L | 1 |
| Andrews, JM; Bampton, P; Barnes, A; Bishara, M; Connor, S; Gounder, M; Grafton, R; Leach, P; Lynch, KD; Mountifield, R; Ng, W; Ooi, SJ; Parthasarathy, N; Sechi, A; van Langenberg, D | 1 |
1 review(s) available for methylthioinosine and mercaptopurine
| Article | Year |
|---|---|
[Monitoring of thiopurine methyltransferase and thiopurine metabolites to optimize azathioprine therapy in inflammatory bowel disease].
Topics: Antimetabolites; Azathioprine; Drug Monitoring; Genotype; Humans; Immunosuppressive Agents; Mercaptopurine; Methylthioinosine; Methyltransferases; Phenotype; Thioguanine | 2006 |
3 trial(s) available for methylthioinosine and mercaptopurine
| Article | Year |
|---|---|
Combination 6-mercaptopurine and 6-methylmercaptopurine riboside in the treatment of adult acute leukemia: a Southwest Oncology Group study.
Topics: Acute Disease; Adolescent; Adult; Aged; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Inosine; Leukemia; Male; Mercaptopurine; Methylthioinosine; Middle Aged; Time Factors | 1979 |
Metabolism of intravenously administered high-dose 6-mercaptopurine with and without allopurinol treatment in patients with non-Hodgkin lymphoma.
Topics: Allopurinol; Antimetabolites, Antineoplastic; Antineoplastic Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Female; Humans; Hypoxanthine; Hypoxanthines; Individuality; Infusions, Intravenous; Lymphoma, Non-Hodgkin; Male; Mercaptopurine; Methylthioinosine; Nucleotides; Xanthine; Xanthine Oxidase; Xanthines | 1996 |
A prospective, open-label trial of 6-thioguanine in patients with ulcerative or indeterminate colitis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Biomarkers; C-Reactive Protein; Colitis, Ulcerative; Dose-Response Relationship, Drug; Endoscopy, Gastrointestinal; Female; Genotype; Guanine Nucleotides; Humans; Male; Mercaptopurine; Methylthioinosine; Methyltransferases; Middle Aged; Orosomucoid; Patient Compliance; Prospective Studies; Quality of Life; Thioguanine; Thionucleotides; Treatment Outcome | 2005 |
22 other study(ies) available for methylthioinosine and mercaptopurine
| Article | Year |
|---|---|
Pyrazolo[3,4-d]pyrimidine ribonucleosides as anticoccidials. 1. Synthesis and activity of some nucleosides of purines and 4-(alkylthio)pyrazolo[3,4-d]pyrimidines.
Topics: Animals; Chickens; Coccidiostats; Eimeria; Pyrimidine Nucleosides; Structure-Activity Relationship | 1982 |
Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis.
Topics: Binding Sites; Catalytic Domain; Computer Simulation; Crystallography, X-Ray; Deoxyguanosine; Enzyme Inhibitors; Mycobacterium tuberculosis; Purine-Nucleoside Phosphorylase; Small Molecule Libraries; Sulfates | 2010 |
Testing nucleoside analogues as inhibitors of Bacillus anthracis spore germination in vitro and in macrophage cell culture.
Topics: Alanine; Animals; Bacillus anthracis; Cell Line; Guanosine; Macrophages; Mice; Spores, Bacterial; Structure-Activity Relationship; Thionucleosides | 2010 |
Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine.
Topics: Azaguanine; Azauridine; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Cytarabine; Deoxycytidine; DNA, Neoplasm; Guanine; Hypoxanthines; Imidazoles; Mercaptopurine; Methylthioinosine; Purines; RNA, Neoplasm; Thioguanine; Thymidine | 1975 |
High-performance liquid chromatographic assay of the methyl and nucleotide metabolites of 6-mercaptopurine: quantitation of red blood cell 6-thioguanine nucleotide, 6-thioinosinic acid and 6-methylmercaptopurine metabolites in a single sample.
Topics: Chromatography, High Pressure Liquid; Erythrocytes; Humans; Hydrolysis; Inosine Monophosphate; Mercaptopurine; Methylthioinosine; Thionucleotides | 1992 |
A rapid and sensitive high-performance liquid chromatographic assay for 6-mercaptopurine metabolites in red blood cells.
Topics: Biotransformation; Cellulose; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Leukemia; Mercaptoethanol; Mercaptopurine; Methylthioinosine; Organomercury Compounds; Thioguanine | 1985 |
Basis of observed resistance of L1210 leukemia in mice: methotrexate, 6-thioguanine, 6-methylmercaptopurine riboside, 6-mercaptopurine, 5-fluorouracil, and 1-beta-D-arabinofuranosylcytosine administered in different combinations.
Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Line; Cytarabine; Drug Evaluation, Preclinical; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Fluorouracil; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Methylthioinosine; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Thioguanine | 1981 |
The importance of methylthio-IMP for methylmercaptopurine ribonucleoside (Me-MPR) cytotoxicity in Molt F4 human malignant T-lymphoblasts.
Topics: Cell Division; Cell Survival; Humans; Inosine Monophosphate; Mercaptopurine; Methylthioinosine; Phosphoribosyl Pyrophosphate; Purine Nucleotides; T-Lymphocytes; Thioinosine; Thionucleosides; Thionucleotides; Tumor Cells, Cultured | 1993 |
Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine.
Topics: Adenine; Adenosine; Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Guanosine; Humans; Inosine; Mercaptopurine; Methylthioinosine; Nucleosides; Nucleotides; Purine Nucleosides; Ribonucleosides; T-Lymphocytes; Thioinosine; Thionucleotides | 1995 |
Reversal of 6-mercaptopurine and 6-methylmercaptopurine ribonucleoside cytotoxicity by amidoimidazole carboxamide ribonucleoside in Molt F4 human malignant T-lymphoblasts.
Topics: Adenine Nucleotides; Aminoimidazole Carboxamide; Cell Count; Cell Death; Drug Interactions; Guanine Nucleotides; Humans; Mercaptopurine; Methylthioinosine; Ribonucleosides; Thioinosine; Thionucleosides; Thionucleotides; Time Factors; Tumor Cells, Cultured | 1993 |
Methotrexate increases red blood cell concentrations of 6-methylmercaptopurine ribonucleotide in rats in vivo.
Topics: Animals; Erythrocytes; Guanine Nucleotides; Male; Mercaptopurine; Methotrexate; Methylthioinosine; Methyltransferases; Nucleic Acid Synthesis Inhibitors; Rats; Rats, Wistar; Thionucleotides | 1997 |
6-MP metabolite levels: a potential guide to Crohn's disease therapy.
Topics: Antimetabolites; Antimetabolites, Antineoplastic; Azathioprine; Chromatography, High Pressure Liquid; Crohn Disease; Humans; Mercaptopurine; Methylthioinosine; Thioguanine | 1997 |
Analysis of methylated 6-mercaptopurine metabolites in human red blood cells: comparison of two methods.
Topics: Azathioprine; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Hydrolysis; Kidney Transplantation; Mercaptopurine; Methylation; Methylthioinosine | 1997 |
Purine analogue 6-methylmercaptopurine riboside inhibits early and late phases of the angiogenesis process.
Topics: 2-Aminopurine; Adenocarcinoma; Adenosine; Allantois; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aorta; Brain; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chick Embryo; Chorion; Cornea; Depression, Chemical; Endometrial Neoplasms; Endothelium, Vascular; Female; Fibroblast Growth Factor 2; Humans; Mercaptopurine; Methylthioinosine; Mice; Mitogen-Activated Protein Kinase 1; Neoplasm Transplantation; Neovascularization, Physiologic; Phosphorylation; Protein Processing, Post-Translational; Rabbits; Recombinant Fusion Proteins; Signal Transduction; Transfection | 1999 |
Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.
Topics: Biological Transport; Cells, Cultured; Chromatography, High Pressure Liquid; Drug Interactions; Humans; Kidney; Kinetics; Mercaptopurine; Methylthioinosine; Multidrug Resistance-Associated Proteins; Ribosomal Proteins; Thioguanine; Transfection | 2002 |
Monitoring of AZA/6-MP treatment in children with IBD is necessary.
Topics: Azathioprine; Child; Drug Monitoring; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercaptopurine; Methylthioinosine; Methyltransferases; Polymorphism, Genetic; Thionucleotides | 2003 |
Monitoring of azathioprine/6-mercaptopurine treatment in children with IBD is not necessary.
Topics: Azathioprine; Child; Drug Monitoring; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercaptopurine; Methylthioinosine; Methyltransferases; Polymorphism, Genetic; Thionucleotides | 2003 |
Health-related quality of life of youth with inflammatory bowel disease: a comparison with published data using the PedsQL 4.0 generic core scales.
Topics: Adolescent; Adult; Child; Female; Humans; Inflammatory Bowel Diseases; Interpersonal Relations; Male; Mercaptopurine; Mesalamine; Methylthioinosine; Middle Aged; Parents; Quality of Life; Self Concept; Severity of Illness Index; Sickness Impact Profile; Social Adjustment; Thioguanine | 2010 |
Simultaneous quantification of eleven thiopurine nucleotides by liquid chromatography-tandem mass spectrometry.
Topics: Azathioprine; Chromatography, High Pressure Liquid; Crohn Disease; Erythrocytes; Guanine Nucleotides; Humans; Immunosuppressive Agents; Isotope Labeling; Mercaptopurine; Methylthioinosine; Tandem Mass Spectrometry; Thionucleotides | 2012 |
Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.
Topics: Adolescent; Adult; Aged; Azathioprine; Cross-Sectional Studies; Drug Monitoring; Erythrocytes; Female; GTP Phosphohydrolases; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methylthioinosine; Middle Aged; Thioguanine; Thioinosine; Thionucleotides; Young Adult | 2014 |
Analysis of mono-, di-, and triphosphates of thioguanosine and methylthioinosine in children with acute lymphoblastic leukemia by LC-MS/MS.
Topics: Child; Chromatography, Liquid; Humans; Mercaptopurine; Methylthioinosine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tandem Mass Spectrometry | 2022 |
Proactive Metabolite Testing in Patients on Thiopurine May Yield Long-Term Clinical Benefits in Inflammatory Bowel Disease.
Topics: Azathioprine; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercaptopurine; Methylthioinosine; Retrospective Studies | 2023 |