Page last updated: 2024-08-21

methylthioinosine and inosine

methylthioinosine has been researched along with inosine in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199025 (86.21)18.7374
1990's1 (3.45)18.2507
2000's2 (6.90)29.6817
2010's1 (3.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cheng, JC; Ishiguro, K; Lin, TS; Sartorelli, AC1
Abel-Santos, E; Alvarez, Z; Lee, K1
Billiau, A; De Clercq, E; Hattori, M; Ikehara, M1
Chang, IM; Epps, D; Kimball, AP; Sherwood, E1
Koontz, JW; Wicks, WD2
Becker, MA; Yen, RC1
Bodey, GP; Hewlett, JS; Stuckey, WJ; Wilson, HE1
Henderson, JF; Henderson, RM; Woods, RA1
Divekar, AY; Grindey, GB; Hakala, MT; Lowe, JK1
Breen, TS; Fujitaki, JM; Matsumoto, SS; Nord, LD; Willis, RC1
Tomkins, DJ; Wong, YW1
Calabresi, P; Crabtree, GW; Cummings, FJ; Murray, C; Spremulli, EN; Weitberg, AB; Wiemann, MC1
Ferioli, ME; Scalabrino, G1
Sartorelli, AC; Sokoloski, JA2
Bowditch, J; Brown, AK; Dow, JW1
Kufe, DW; Peters, WP; Weiss, G1
Becker, MA; Raivio, KO; Yen, RC1
Kamatani, N; Mikanagi, K; Nishida, Y; Nishioka, K; Yamanaka, H1
Dexter, DL; Ghoda, LY; Parks, RE; Savarese, TM1
Carson, DA; Kamatani, N; Willis, EH1
Haight, TH; Leduc, EH; Melvin, JB1
Gupta, R; Ihara, M; Kuchino, Y; Nishimura, S; Woese, CR; Yamaizumi, Z1
Thacker, J1
Akiyama, SI; Komiyama, S; Kuwano, M; Saneyoshi, M1
Bökkerink, JP; De Abreu, RA; Keizer-Garritsen, JJ; Lambooy, LH; Stet, EH; Trijbels, FJ; Vogels-Mentink, TM1
Bench, G; Birck, MR; Evans, GB; Furneaux, RH; Kim, K; Lewandowicz, A; Madrid, DC; Mwakingwe, A; Ringia, EA; Schramm, VL; Shi, W; Singh, V; Ting, LM; Tyler, PC1
Kierzek, E; Kierzek, R1

Reviews

1 review(s) available for methylthioinosine and inosine

ArticleYear
Synthesis of oligoribonucleotides containing N6-alkyladenosine and 2-methylthio-N6-alkyladenosine.
    Current protocols in nucleic acid chemistry, 2004, Volume: Chapter 4

    Topics: Adenosine; Alkylation; Inosine; Methylthioinosine; Models, Biological; Oligoribonucleotides; Organophosphorus Compounds

2004

Trials

1 trial(s) available for methylthioinosine and inosine

ArticleYear
Combination 6-mercaptopurine and 6-methylmercaptopurine riboside in the treatment of adult acute leukemia: a Southwest Oncology Group study.
    Cancer treatment reports, 1979, Volume: 63, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Aged; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Inosine; Leukemia; Male; Mercaptopurine; Methylthioinosine; Middle Aged; Time Factors

1979

Other Studies

27 other study(ies) available for methylthioinosine and inosine

ArticleYear
Purine and 8-substituted purine arabinofuranosyl and ribofuranosyl nucleoside derivatives as potential inducers of the differentiation of the Friend erythroleukemia.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:10

    Topics: Animals; Antimetabolites; Arabinonucleosides; Cell Differentiation; Cell Division; Cell Line; Chemical Phenomena; Chemistry; Friend murine leukemia virus; Hematopoiesis; Leukemia, Erythroblastic, Acute; Mice; Purine Nucleosides; Ribonucleosides; Structure-Activity Relationship

1985
Testing nucleoside analogues as inhibitors of Bacillus anthracis spore germination in vitro and in macrophage cell culture.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:12

    Topics: Alanine; Animals; Bacillus anthracis; Cell Line; Guanosine; Macrophages; Mice; Spores, Bacterial; Structure-Activity Relationship; Thionucleosides

2010
Inhibition of oncornavirus functions by poly (2-methylthioinosinic acid).
    Nucleic acids research, 1975, Volume: 2, Issue:12

    Topics: Cell Transformation, Neoplastic; Cell Transformation, Viral; Gammaretrovirus; Inosine; Methylthioinosine; Moloney murine leukemia virus; Poly I; Polyribonucleotides; Rauscher Virus; Reverse Transcriptase Inhibitors; Sarcoma Viruses, Murine

1975
Feedback inhibition by 6-methylthioinosine 3',5'-cyclic monophosphate in tumor cells resistant to the nucleoside.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1975, Volume: 150, Issue:3

    Topics: Adenosine; Adenosine Kinase; Animals; Binding, Competitive; Carcinoma, Ehrlich Tumor; Drug Resistance; Female; Inosine; Methylthioinosine; Mice; Neoplasms, Experimental; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purines

1975
Comparison of the effects of 6- thio- and 6-methylthiopurine ribonucleoside cyclic monophosphates withtheir corresponding nucleosides on the growth of rat hepatoma cells.
    Cancer research, 1977, Volume: 37, Issue:3

    Topics: Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; Cyclic IMP; Dose-Response Relationship, Drug; Inosine; Inosine Nucleotides; Liver Neoplasms; Methylthioinosine; Neoplasms, Experimental; Phosphodiesterase Inhibitors; Purine Nucleosides; Thioinosine

1977
Methylmercaptopurine ribonucleoside toxicity in human fibroblasts: inhibition of phosphoribosylpyrophosphate synthetase as well as amidophosphoribosyltransferase.
    Advances in experimental medicine and biology, 1979, Volume: 122B

    Topics: Amidophosphoribosyltransferase; Cell Division; Cell Survival; Cells, Cultured; Fibroblasts; Humans; Inosine; Kinetics; Methylthioinosine; Pentosyltransferases; Phosphotransferases; Ribose-Phosphate Pyrophosphokinase; Skin

1979
Consequences of inhibition of purine biosynthesis de novo by 6-methylmercaptopurine ribonucleoside in cultured lymphoma L5178Y cells.
    European journal of cancer, 1978, Volume: 14, Issue:7

    Topics: Cell Count; Cells, Cultured; Inosine; Lymphoma; Methylthioinosine; Neoplasms, Experimental; Purine Nucleotides; Pyrimidine Nucleotides; Time Factors

1978
Potentiation by guanine nucleosides of the growth-inhibitory effects of adenosine analogs on L1210 and sarcoma 180 cells in culture.
    Cancer research, 1976, Volume: 36, Issue:2 Pt 1

    Topics: Animals; Cell Division; Cells, Cultured; Deoxyribonucleosides; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Guanosine; Hypoxanthines; Inosine; Isopentenyladenosine; Leukemia L1210; Methylthioinosine; Purines; Sarcoma 180

1976
Potent and specific inhibitors of mammalian phosphoribosylpyrophosphate (PRPP) synthetase.
    Advances in experimental medicine and biology, 1989, Volume: 253B

    Topics: B-Lymphocytes; Cell Line; Dose-Response Relationship, Drug; Erythrocytes; Humans; Inosine; Methylthioinosine; Phosphotransferases; Purine Nucleotides; Pyrimidine Nucleosides; Pyrimidine Nucleotides; Ribose-Phosphate Pyrophosphokinase

1989
6-Methylmercaptopurine riboside resistance in human lymphocytes in the in vivo somatic cell mutation test.
    Environmental mutagenesis, 1986, Volume: 8, Issue:3

    Topics: Adenosine Kinase; Cell Nucleus; Cells, Cultured; DNA Replication; Dose-Response Relationship, Drug; Drug Resistance; Fibroblasts; Genetic Variation; Humans; Inosine; Lymphocytes; Methylthioinosine; Mutagenicity Tests; Mutation; Phosphotransferases; Probability; Selection, Genetic

1986
Phase I trial of the combination of 6-methylmercaptopurine riboside and 5-fluorouracil.
    Medical oncology and tumor pharmacotherapy, 1988, Volume: 5, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Drug Therapy, Combination; Female; Fluorouracil; Humans; Inosine; Male; Methylthioinosine; Middle Aged

1988
Persistently decreased hepatic levels of 5'-deoxy-5'-methylthioadenosine during regeneration of and chemical carcinogenesis in rat liver.
    Journal of the National Cancer Institute, 1986, Volume: 76, Issue:6

    Topics: Animals; Hepatectomy; Inosine; Liver; Liver Neoplasms, Experimental; Liver Regeneration; Male; Methyldimethylaminoazobenzene; Methylthioinosine; Polyamines; Rats; Rats, Inbred Strains

1986
Inhibition of the synthesis of glycoproteins and induction of the differentiation of HL-60 promyelocytic leukemia cells by 6-methylmercaptopurine ribonucleoside.
    Cancer research, 1987, Dec-01, Volume: 47, Issue:23

    Topics: Antimetabolites, Antineoplastic; Cell Differentiation; Cell Line; Glycoproteins; Humans; Inosine; Leukemia, Myeloid, Acute; Mannose; Methylthioinosine

1987
Inhibition of mannose incorporation into glycoproteins and dolichol-linked intermediates of Sarcoma 180 cells by 6-methylmercaptopurine ribonucleoside.
    International journal of cancer, 1987, Jun-15, Volume: 39, Issue:6

    Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Diterpenes; Dolichols; Glycoproteins; Guanosine; Guanosine Triphosphate; Inosine; Mannose; Methylthioinosine; Oligosaccharides; Sarcoma 180; Thioguanine

1987
Accumulation and salvage of adenosine and inosine by isolated mature cardiac myocytes.
    Biochimica et biophysica acta, 1985, Feb-21, Volume: 844, Issue:2

    Topics: Adenosine; Adenosine Triphosphate; Animals; Biological Transport, Active; Chromatography, High Pressure Liquid; Hypoxanthine; Hypoxanthines; Inosine; Kinetics; Methylthioinosine; Myocardium; Phosphorylation; Rats

1985
Stimulation of tyrosine aminotransferase degradation by methylthioinosine.
    The Journal of biological chemistry, 1984, Jan-25, Volume: 259, Issue:2

    Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Hot Temperature; Inosine; Liver Neoplasms, Experimental; Methylthioinosine; Rats; Tyrosine Transaminase

1984
Phase-I trial of combination therapy with continuous-infusion MMPR and continuous-infusion 5-FU.
    Cancer chemotherapy and pharmacology, 1984, Volume: 13, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Female; Fluorouracil; Humans; Inosine; Male; Methylthioinosine; Middle Aged; Neoplasms; Phosphoribosyl Pyrophosphate; RNA, Neoplasm

1984
Inhibition of phosphoribosylpyrophosphate synthesis in human fibroblasts by 6-methylthioinosinate.
    The Journal of biological chemistry, 1981, Feb-25, Volume: 256, Issue:4

    Topics: Adenine; Cell Division; Feedback; Fibroblasts; Humans; Hypoxanthines; Inosine; Kinetics; Methylthioinosine; Phosphotransferases; Ribose-Phosphate Pyrophosphokinase; Skin

1981
Relationship between phosphorylation and cytotoxicity of 2-chloroadenosine and 6-methylmercaptopurine riboside in human cells.
    Biochimica et biophysica acta, 1984, Apr-10, Volume: 798, Issue:2

    Topics: 2-Chloroadenosine; Adenosine; Adenosine Kinase; B-Lymphocytes; Cell Line; Genetic Variation; Humans; Inosine; Methylthioinosine; Phosphorylation; Phosphotransferases

1984
Conversion of 5'-deoxy-5'-methylthioadenosine and 5'-deoxy-5'-methylthioinosine to methionine in cultured human leukemic cells.
    Cancer research, 1983, Volume: 43, Issue:10

    Topics: Adenosine; Cells, Cultured; Deoxyadenosines; Humans; Inosine; Leukemia; Leukemia, Myeloid, Acute; Methionine; Methylthioinosine; Purine-Nucleoside Phosphorylase; T-Lymphocytes; Thionucleosides

1983
Metabolism to methionine and growth stimulation by 5'-methylthioadenosine and 5'-methylthioinosine in mammalian cells.
    Biochemical and biophysical research communications, 1983, Apr-29, Volume: 112, Issue:2

    Topics: Adenosine; Animals; B-Lymphocytes; Cell Division; Cell Line; Deoxyadenosines; Humans; Inosine; Leukemia L1210; Methionine; Methylthioinosine; Mice; Thionucleosides

1983
Cytological effects of sulfur and selenium purine analogues on two transplantable hepatomas and on normal renewing cells in mice.
    Cancer research, 1984, Volume: 44, Issue:7

    Topics: Adenoma; Animals; Antineoplastic Agents; Duodenum; Epithelium; Female; Guanosine; Inosine; Liver; Liver Neoplasms, Experimental; Male; Methylthioinosine; Mice; Mice, Inbred Strains; Mitosis; Mitotic Index; Organoselenium Compounds; Selenium; Thionucleosides

1984
Archaebacterial tRNA contains 1-methylinosine at residue 57 in T psi C-loop.
    Nucleic acids symposium series, 1982, Issue:11

    Topics: Bacteria; Halobacterium; Inosine; Mass Spectrometry; Methylthioinosine; RNA, Transfer; Species Specificity; Spectrophotometry, Ultraviolet

1982
Resistance to methyl mercaptopurine riboside in cultured hamster cells. Preliminary characterization of resistant cells and conditions affecting their selection in quantitative mutation studies.
    Mutation research, 1980, Volume: 74, Issue:1

    Topics: Adenosine Kinase; Animals; Cell Fusion; Cell Line; Cells, Cultured; Cricetinae; Drug Evaluation, Preclinical; Drug Resistance; Ethyl Methanesulfonate; Inosine; Methylthioinosine; Mutagens; Radiation, Ionizing

1980
Antitumor effect of a combination of 6-methylthioinosine and amphotericin B on mouse leukemia L1210.
    Cancer letters, 1980, Volume: 9, Issue:4

    Topics: Adjuvants, Immunologic; Amphotericin B; Animals; Drug Synergism; Inosine; Leukemia L1210; Male; Methylthioinosine; Mice; Purine Nucleosides; Thymidine

1980
Reversal of methylmercaptopurine ribonucleoside cytotoxicity by purine ribonucleosides and adenine.
    Biochemical pharmacology, 1995, Jan-06, Volume: 49, Issue:1

    Topics: Adenine; Adenosine; Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Guanosine; Humans; Inosine; Mercaptopurine; Methylthioinosine; Nucleosides; Nucleotides; Purine Nucleosides; Ribonucleosides; T-Lymphocytes; Thioinosine; Thionucleotides

1995
Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins.
    The Journal of biological chemistry, 2005, Mar-11, Volume: 280, Issue:10

    Topics: Adenine; Adenosine Deaminase; Amino Acid Sequence; Animals; Conserved Sequence; Escherichia coli; Humans; Hypoxanthine; Inosine; Methylthioinosine; Molecular Sequence Data; Plasmodium falciparum; Purine-Nucleoside Phosphorylase; Purines; Sequence Alignment; Sequence Homology, Amino Acid

2005