methylthioinosine has been researched along with aspartic acid in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 12 (85.71) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Colofiore, JR; Koutcher, JA; Martin, DS; Nord, LD; Stolfi, RL | 1 |
| Colofiore, J; Comis, RL; Hoffman, J; Hudes, GR; LaCreta, FP; Martin, DS; O'Dwyer, PJ; Ozols, RF; Walczak, J | 1 |
| Martin, DS | 1 |
| O'Dwyer, PJ | 1 |
| Green, F; Hoffman, JP; O'Dwyer, PJ; Redei, I; Scher, R; Weiner, LM | 1 |
| Colofiore, JR; Martin, DS; Nord, LD; Sternberg, S; Stolfi, RL | 1 |
| Colofiore, JR; Martin, DS; Nord, LD; Stolfi, RL | 3 |
| Ballon, D; Koutcher, JA; Mahmood, U; Martin, DS; Matei, C; Street, JC | 1 |
| Alfieri, AA; Ballon, D; Koutcher, JA; Martin, DS; Matei, C; Stolfi, RL; Tsai, JC | 1 |
| Brennan, J; Greene, F; Hageboutros, A; Hudes, GR; LaCreta, FP; O'Dwyer, PJ | 1 |
| Alfieri, AA; Koutcher, JA; Martin, DS; Matei, C; Thaler, H | 1 |
| Gao, S; Hu, J; Liang, Z; Wu, X | 1 |
1 review(s) available for methylthioinosine and aspartic acid
| Article | Year |
|---|---|
Biochemical modulation as an approach to reversal of antimetabolite resistance.
Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Clinical Trials as Topic; Colorectal Neoplasms; Drug Design; Drug Resistance, Multiple; Fluorouracil; Humans; Interferons; Methylthioinosine; Multicenter Studies as Topic; Phosphonoacetic Acid; Purines; Pyrimidines; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
3 trial(s) available for methylthioinosine and aspartic acid
| Article | Year |
|---|---|
Phase I trial of fluorouracil modulation by N-phosphonacetyl-L-aspartate and 6-methylmercaptopurine riboside: optimization of 6-methylmercaptopurine riboside dose and schedule through biochemical analysis of sequential tumor biopsy specimens.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Biopsy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Female; Fluorouracil; Humans; Male; Methylthioinosine; Middle Aged; Neoplasms; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate | 1991 |
Phase II trial of PALA and 6-methylmercaptopurine riboside (MMPR) in combination with 5-fluorouracil in advanced pancreatic cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Aspartate Carbamoyltransferase; Aspartic Acid; Female; Fluorouracil; Humans; Male; Methylthioinosine; Middle Aged; Pancreatic Neoplasms; Phosphonoacetic Acid | 1994 |
Phase I trial of fluorouracil modulation by N-phosphonacetyl-L-aspartate and 6-methylmercaptopurine ribonucleoside (MMPR), and leucovorin in patients with advanced cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Aspartic Acid; Colorectal Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Leucovorin; Male; Methylthioinosine; Middle Aged; Phosphonoacetic Acid | 1997 |
10 other study(ies) available for methylthioinosine and aspartic acid
| Article | Year |
|---|---|
Biochemical modulation of tumor cell energy: regression of advanced spontaneous murine breast tumors with a 5-fluorouracil-containing drug combination.
Topics: 6-Aminonicotinamide; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Female; Fluorouracil; Mammary Neoplasms, Experimental; Methylthioinosine; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Orotic Acid; Phosphonoacetic Acid; Phosphoribosyl Pyrophosphate | 1992 |
Cancer chemotherapy: past is prologue.
Topics: 6-Aminonicotinamide; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Female; Fluorouracil; Humans; Male; Mammary Neoplasms, Experimental; Methotrexate; Methylthioinosine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Phosphonoacetic Acid | 1985 |
Biochemical modulation of tumor cell energy in vivo: II. A lower dose of adriamycin is required and a greater antitumor activity is induced when cellular energy is depressed.
Topics: 6-Aminonicotinamide; Animals; Apoptosis; Aspartic Acid; Dose-Response Relationship, Drug; Doxorubicin; Drug Therapy, Combination; Energy Metabolism; Mammary Neoplasms, Experimental; Methylthioinosine; Phosphonoacetic Acid | 1994 |
Biochemical modulation of tumor cell energy. IV. Evidence for the contribution of adenosine triphosphate (ATP) depletion to chemotherapeutically-induced tumor regression.
Topics: 6-Aminonicotinamide; Adenosine Triphosphate; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aspartic Acid; Doxorubicin; Mammary Neoplasms, Animal; Methylthioinosine; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Phosphonoacetic Acid; Time Factors | 1995 |
Correlation of retention of tumor methylmercaptopurine riboside-5'-phosphate with effectiveness in CD8F1 murine mammary tumor regression.
Topics: 6-Aminonicotinamide; Adenosine Kinase; Adenosine Triphosphate; Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Mammary Neoplasms, Experimental; Methylthioinosine; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Phosphonoacetic Acid | 1996 |
In vivo detection by 31P NMR of pentose phosphate pathway block secondary to biochemical modulation.
Topics: 6-Aminonicotinamide; Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Division; Magnetic Resonance Spectroscopy; Male; Mammary Neoplasms, Experimental; Methylthioinosine; Mice; Mice, Inbred C3H; Pentose Phosphate Pathway; Phosphonoacetic Acid; Phosphorus; Teratogens | 1996 |
Marked enhancement in vivo of paclitaxel's (taxol's) tumor-regressing activity by ATP-depleting modulation.
Topics: 6-Aminonicotinamide; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Female; Mammary Neoplasms, Experimental; Methylthioinosine; Mice; Paclitaxel; Phosphonoacetic Acid; Remission Induction | 1996 |
Evaluation of chemotherapy and radiation enhancement and 31P NMR spectral changes induced by biochemical modulation.
Topics: 6-Aminonicotinamide; Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Division; Disease Progression; Doxorubicin; Drug Synergism; Evaluation Studies as Topic; Magnetic Resonance Spectroscopy; Mammary Neoplasms, Experimental; Methylthioinosine; Mice; Phosphorus Isotopes; Radiation-Sensitizing Agents | 1997 |
Radiation enhancement by biochemical modulation and 5-fluorouracil.
Topics: 6-Aminonicotinamide; Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cell Division; Combined Modality Therapy; Fluorouracil; Mammary Neoplasms, Animal; Methylthioinosine; Mice; Radiation-Sensitizing Agents; Radiotherapy Dosage; Time Factors | 1997 |
PMA treated THP-1-derived-IL-6 promotes EMT of SW48 through STAT3/ERK-dependent activation of Wnt/β-catenin signaling pathway.
Topics: 6-Aminonicotinamide; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; beta Catenin; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Epithelial-Mesenchymal Transition; Humans; Interleukin-6; Macrophages; MAP Kinase Signaling System; Methylthioinosine; STAT3 Transcription Factor; THP-1 Cells; Wnt Signaling Pathway | 2018 |