Compounds > methylthio-adp
Page last updated: 2024-09-03

methylthio-adp and adenosine

methylthio-adp has been researched along with adenosine in 15 studies

Compound Research Comparison

Studies
(methylthio-adp)		Trials
(methylthio-adp)		Recent Studies (post-2010)
(methylthio-adp)		Studies
(adenosine)		Trials
(adenosine)		Recent Studies (post-2010) (adenosine)
14624332,5361,0758,930

Protein Interaction Comparison

ProteinTaxonomymethylthio-adp (IC50)adenosine (IC50)
high affinity choline transporter 1 isoform aHomo sapiens (human)0.3851
Sodium/nucleoside cotransporter 1Homo sapiens (human)5.5
Sodium/nucleoside cotransporter 2Homo sapiens (human)5.5
Adenosine receptor A3Homo sapiens (human)0.0011
Adenosine receptor A1Homo sapiens (human)0.0023
Equilibrative nucleoside transporter 1Homo sapiens (human)63
Solute carrier family 28 member 3Homo sapiens (human)3.3

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19902 (13.33)18.7374
1990's4 (26.67)18.2507
2000's5 (33.33)29.6817
2010's3 (20.00)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Boyer, JL; Brizzolara, AL; Burnstock, G; Fischer, B; Harden, TK; Hoyle, CH; Jacobson, KA; Knight, GE; Ziganshin, AU; Zimmet, J1
Azran, S; Danino, O; Dixit, M; Fischer, B; Förster, D; Kenigsberg, S; Major, DT; Reiser, G; Singh, V1
Colman, RF; Colman, RW; Freedman, MD; Grana, G; Hu, CJ; Mills, DC; Minniti, C; Puri, R1
Colman, RF; Colman, RW; Figures, WR; Mills, DC; Scearce, LM; Stewart, GJ1
Colman, RF; Colman, RW; Figures, WR; Mills, DC; Morinelli, TA; Niewiarowski, S1
Barnard, EA; Burnstock, G; King, BF; Simon, J; Webb, TE1
Duchêne, AD; Takeda, K1
Enkvist, E; Järv, J; Kelve, M; Raidaru, G; Sak, K; Subbi, J; Uri, A1
Claes, P; Grobben, B; Roymans, D; Slegers, H; Van Kolen, K1
Bagorda, A; Casavola, V; Di Sole, F; Favia, M; Guerra, L; Helmle-Kolb, C; Jacobson, KA; Reshkin, SJ1
Burnstock, G; Chiaravalli, AM; Frigo, G; Giaroni, C; Knight, GE; Lecchini, S; Zanetti, E1
Losavio, A; Muchnik, S; Veggetti, M1
Inoue, K; Kohsaka, S; Nakamura, Y; Ohsawa, K; Sanagi, T; Suzuki, E1
Baqi, Y; Hoffmann, K; Lutz, DA; Müller, CE; Straßburger, J; von Kügelgen, I1
Amaradasa, K; Bancroft, S; Dimofte, T; Hindle, MS; Hutchinson, JL; Johnson, T; Keith, M; Khalil, J; Mundell, SJ; Naseem, K; Roberts, T1

Trials

1 trial(s) available for methylthio-adp and adenosine

ArticleYear
Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclase.
    Arteriosclerosis and thrombosis : a journal of vascular biology, 1992, Volume: 12, Issue:4

    Topics: Adenosine; Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adult; Binding Sites; Blood Platelets; Clopidogrel; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Purinergic; Thionucleotides; Thrombin; Ticlopidine

1992

Other Studies

14 other study(ies) available for methylthio-adp and adenosine

ArticleYear
Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate.
    Journal of medicinal chemistry, 1993, Nov-26, Volume: 36, Issue:24

    Topics: Adenine Nucleotides; Animals; Aorta; Colon; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth; Rabbits; Receptors, Purinergic P2; Structure-Activity Relationship; Sulfides; Turkeys; Type C Phospholipases; Vas Deferens

1993
Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action.
    Journal of medicinal chemistry, 2015, Nov-12, Volume: 58, Issue:21

    Topics: Animals; Antioxidants; Cells, Cultured; Drug Discovery; Humans; Hydrogen Peroxide; Hydrolysis; Iron; Models, Molecular; Neurons; Neuroprotective Agents; Nucleosides; Nucleotides; PC12 Cells; Phosphorothioate Oligonucleotides; Purinergic P2Y Receptor Agonists; Rats; Reactive Oxygen Species; Receptors, Purinergic P2Y1

2015
Two mechanisms for inhibition of ADP-induced platelet shape change by 5'-p-fluorosulfonylbenzoyladenosine. Conversion to adenosine, and covalent modification at an ADP binding site distinct from that which inhibits adenylate cyclase.
    The Journal of biological chemistry, 1985, Jul-05, Volume: 260, Issue:13

    Topics: Adenosine; Adenosine Deaminase; Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Binding Sites; Blood Platelets; Cyclic AMP; Drug Synergism; Humans; Microscopy, Electron, Scanning; Thionucleotides

1985
Identification of two distinct adenosine diphosphate receptors in human platelets.
    Transactions of the Association of American Physicians, 1980, Volume: 93

    Topics: Adenosine; Adenosine Diphosphate; Blood Platelets; Chymotrypsin; Cyclic AMP; Fibrinogen; Humans; In Vitro Techniques; Platelet Aggregation; Receptors, Cell Surface; Receptors, Purinergic; Thionucleotides

1980
Characterisation of a recombinant P2Y purinoceptor.
    European journal of pharmacology, 1995, Nov-30, Volume: 291, Issue:3

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Affinity Labels; Animals; Brain; Cell Line; Electrophysiology; Inositol Phosphates; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Recombinant Proteins; Suramin; Thionucleotides; Triazines; Uridine Triphosphate; Xenopus

1995
P2Y- and P2U-mediated increases in internal calcium in single bovine aortic endothelial cells in primary culture.
    Endothelium : journal of endothelial cell research, 1997, Volume: 5, Issue:4

    Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Cattle; Cells, Cultured; Ion Transport; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Thionucleotides; Uridine Triphosphate

1997
Adenosine-derived non-phosphate antagonists for P2Y(1) purinoceptors.
    Biochemical and biophysical research communications, 2000, Jun-07, Volume: 272, Issue:2

    Topics: Adenosine; Adenosine Diphosphate; Aspartic Acid; Astrocytoma; Dose-Response Relationship, Drug; Humans; Phosphates; Phosphatidylinositols; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thionucleotides; Tumor Cells, Cultured

2000
P2Y(AC)(-)-receptor agonists enhance the proliferation of rat C6 glioma cells through activation of the p42/44 mitogen-activated protein kinase.
    British journal of pharmacology, 2001, Volume: 134, Issue:2

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cell Division; Dinucleoside Phosphates; Enzyme Activation; Glioma; Hydrolysis; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Purinergic P2 Receptor Agonists; Pyridoxal Phosphate; Rats; Receptors, Purinergic P2; Thionucleotides; Time Factors; Triazines; Tumor Cells, Cultured

2001
Extracellular adenine nucleotides regulate Na+/H+ exchanger NHE3 activity in A6-NHE3 transfectants by a cAMP/PKA-dependent mechanism.
    The Journal of membrane biology, 2002, Aug-01, Volume: 188, Issue:3

    Topics: Adenosine; Adenosine Diphosphate; Animals; Calcium; Cell Line; Cell Membrane; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Hydrogen-Ion Concentration; Rats; Signal Transduction; Sodium-Hydrogen Exchangers; Thionucleotides; Transfection; Xenopus laevis

2002
Postnatal development of P2 receptors in the murine gastrointestinal tract.
    Neuropharmacology, 2006, Volume: 50, Issue:6

    Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Dose-Response Relationship, Drug; Female; Gastrointestinal Tract; Gene Expression Regulation, Developmental; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Thionucleotides; Uridine Triphosphate

2006
Effect of purines on calcium-independent acetylcholine release at the mouse neuromuscular junction.
    Neuroscience, 2008, Jul-17, Volume: 154, Issue:4

    Topics: Acetylcholine; Adenosine; Adenosine A1 Receptor Agonists; Adenosine Diphosphate; Animals; Calcium; Electrophysiology; Exocytosis; Mice; Neuromuscular Junction; Purinergic P2 Receptor Agonists; Purines; Synaptic Transmission; Thionucleotides

2008
Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration.
    Journal of neurochemistry, 2012, Volume: 121, Issue:2

    Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Animals; Animals, Newborn; Cell Movement; Cells, Cultured; Cerebral Cortex; Chemotaxis; Collagen; Flow Cytometry; Indicators and Reagents; JNK Mitogen-Activated Protein Kinases; Microglia; Purinergic P2Y Receptor Agonists; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptor, Adenosine A1; Receptor, Adenosine A3; Receptors, Purinergic P2Y12; Thionucleotides

2012
Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12 -receptor.
    Journal of thrombosis and haemostasis : JTH, 2014, Volume: 12, Issue:11

    Topics: Adenosine; Adenosine Diphosphate; Animals; Binding Sites; Binding, Competitive; CHO Cells; Colforsin; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, Reporter; Humans; Luciferases; Mutation; Platelet Aggregation Inhibitors; Protein Binding; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Response Elements; Thionucleotides; Ticagrelor; Transfection

2014
Ticagrelor inverse agonist activity at the P2Y
    British journal of pharmacology, 2024, Volume: 181, Issue:1

    Topics: Acute Coronary Syndrome; Adenosine; Adenosine Diphosphate; Blood Platelets; Diphosphates; Drug Inverse Agonism; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticagrelor

2024