methylthio-adp has been researched along with adenosine diphosphate in 131 studies
| Studies (methylthio-adp) | Trials (methylthio-adp) | Recent Studies (post-2010) (methylthio-adp) | Studies (adenosine diphosphate) | Trials (adenosine diphosphate) | Recent Studies (post-2010) (adenosine diphosphate) |
|---|---|---|---|---|---|
| 146 | 2 | 43 | 23,989 | 498 | 3,114 |
| Protein | Taxonomy | methylthio-adp (IC50) | adenosine diphosphate (IC50) |
|---|---|---|---|
| Chain A, Kinesin-like protein KIF11 | Homo sapiens (human) | 0.45 | |
| Heat shock 70 kDa protein 1A | Homo sapiens (human) | 0.5 | |
| Sensor protein kinase WalK | Staphylococcus aureus | 7.189 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (4.58) | 18.7374 |
| 1990's | 22 (16.79) | 18.2507 |
| 2000's | 55 (41.98) | 29.6817 |
| 2010's | 42 (32.06) | 24.3611 |
| 2020's | 6 (4.58) | 2.80 |
| Authors | Studies |
|---|---|
| Abo, M; Hai, TT; Hampton, A | 1 |
| Boyer, JL; Brizzolara, AL; Burnstock, G; Fischer, B; Harden, TK; Hoyle, CH; Jacobson, KA; Knight, GE; Ziganshin, AU; Zimmet, J | 1 |
| Harden, TK; Schachter, JB | 1 |
| Jacobson, KA; Jarvis, MF; Williams, M | 1 |
| Boyer, JL; Corbitt, J; Harden, TK; Jacobson, KA; Ji, XD; Kim, HS; Lacy, J; Ravi, G; Waldo, GL | 1 |
| Boeynaems, JM; Communi, D; Gonzalez, NS; Labouret, C; Le Poul, E; Marteau, F; Savi, P | 1 |
| Herbert, JM; Savi, P | 2 |
| Camden, J; Eliahu, SE; Fischer, B; Gélinas, S; Lecka, J; Sévigny, J; Weisman, GA | 1 |
| Barr, HM; Camden, J; Eliahu, S; Fischer, B; Weisman, GA | 1 |
| Barr, HM; Camden, J; Fischer, B; Shai, E; Varon, D; Weisman, GA; Yelovitch, S | 1 |
| Azran, S; Danino, O; Fischer, B; Förster, D; Nadel, Y; Reiser, G | 1 |
| Azran, S; Danino, O; Dixit, M; Fischer, B; Förster, D; Kenigsberg, S; Major, DT; Reiser, G; Singh, V | 1 |
| Cazenave, JP; Gachet, C; Hilf, G; Jakobs, KH; Ohlmann, P; Wieland, T | 1 |
| Macfarlane, DE | 1 |
| Colman, RF; Colman, RW; Freedman, MD; Grana, G; Hu, CJ; Mills, DC; Minniti, C; Puri, R | 1 |
| Colman, RF; Colman, RW; Figures, WR; Mills, DC; Scearce, LM; Stewart, GJ | 1 |
| Colman, RF; Colman, RW; Figures, WR; Mills, DC; Morinelli, TA; Niewiarowski, S | 1 |
| Macfarlane, DE; Mills, DC; Srivastava, PC | 1 |
| Brammer, JP; Maguire, MH | 1 |
| Cusack, NJ; Hourani, SM | 1 |
| Balcar, VJ; Bennett, MR; Killinger, S; Li, Y | 1 |
| Bihour, C; Heilmann, E; Herbert, JM; Maffrand, JP; Nurden, A; Nurden, P; Savi, P | 1 |
| Herbert, JM; Savi, P; Troussard, A | 1 |
| Aït-Chek, L; Bernat, A; Dumas, A; Herbert, JM; Savi, P | 1 |
| Herbert, JM; Laplace, MC; Maffrand, JP; Savi, P | 1 |
| Cassel, D; Cattaneo, M; Cazenave, JP; Chevalier, J; Gachet, C; Hechler, B; Lecchi, A; Mannucci, PM; Ohlmann, P | 1 |
| Barnard, EA; Burnstock, G; King, BF; Simon, J; Webb, TE | 1 |
| Artçanuthurry, V; Bornia, J; Grelac, F; Herbert, JM; Levy-Toledano, S; Maclouf, J; Savi, P | 1 |
| Cattaneo, M; Cazenave, JP; Gachet, C; Lombardi, R; Mannucci, PM; Ohlmann, P; Zighetti, ML | 1 |
| Harden, TK; Nicholas, RA; Schachter, JB; Sromek, SM | 1 |
| Ashby, B; Dangelmaier, C; Daniel, JL; Jin, J; Kunapuli, SP; Smith, JB | 1 |
| Duchêne, AD; Takeda, K | 1 |
| Boyer, JL; Harden, TK; Nicholas, RA; Palmer, RK; Schachter, JB | 1 |
| Martinson, EA; Marx-Grunwitz, A; Presek, P; Scheible, S | 1 |
| Breittmayer, JP; Frelin, C; Gachet, C; Hechler, B; Vigne, P | 1 |
| Hourani, SM; Park, HS | 1 |
| Ias'ko, MV; Skoblov, IuS; Skoblov, MIu | 1 |
| Asai, F; Inoue, T; Koike, H; Ogawa, T; Sugidachi, A | 1 |
| Fam, SR; Gallagher, CJ; Salter, MW | 1 |
| Järv, J; Sak, K | 1 |
| Dixon, CJ | 1 |
| Enkvist, E; Järv, J; Kelve, M; Raidaru, G; Sak, K; Subbi, J; Uri, A | 1 |
| Järv, J; Raidaru, G; Sak, K; Webb, TE | 1 |
| Asai, F; Iwamura, R; Koike, H; Ogawa, T; Otsuguro, K; Sugidachi, A; Yoneda, K | 1 |
| Barnard, EA; Järv, J; Sak, K | 1 |
| Barnard, EA; Cousens, DJ; Humphrey, PP; Lundahl, TS; Sellers, LA; Simon, J | 1 |
| Maayani, S; Martinelli, G; Martinez, R; Schwarz, T; Shore-Lesserson, L; Tagliente, TM | 1 |
| Arnett, TR; Burnstock, G; Hoebertz, A; Meghji, S | 1 |
| Claes, P; Grobben, B; Roymans, D; Slegers, H; Van Kolen, K | 1 |
| Bagorda, A; Casavola, V; Di Sole, F; Favia, M; Guerra, L; Helmle-Kolb, C; Jacobson, KA; Reshkin, SJ | 1 |
| Chambers, JK; Emson, PC; Moore, DJ; Murdock, PR | 1 |
| Edvinsson, L; Erlinge, D; Hou, M; Malmsjö, M; Pendergast, W | 1 |
| Bryckaert, M; Contreres, JO; Dupuy, E; Habib, A; Herbert, JM; Job, B; Levy-Toledano, S; Rosa, JP; Savi, P; Simoneau, G | 1 |
| Fam, SR; Gallagher, CJ; Kalia, LV; Salter, MW | 1 |
| Barnard, EA; Cheng, AW; Choi, RC; Ling, KK; Simon, J; Siow, NL; Tsim, KW; Tung, EK | 1 |
| Allen, DG; Barden, JA; Huang, W; Jiang, L; Ju, YK | 1 |
| Herbert, JM; Pacaud, P; Payrastre, B; Plantavid, M; Sauzeau, V; Savi, P; Soulet, C | 1 |
| Slegers, H; Van Kolen, K | 1 |
| Choi, RC; Jiang, JX; Lee, HH; Massoulié, J; Siow, NL; Ting, AK; Tsim, KW | 1 |
| Ding, Z; Jin, J; Kim, S; Kunapuli, SP; Murugappan, S; Shankar, H; Wickman, K | 1 |
| Bagorda, A; Calamita, G; Casavola, V; Fanelli, T; Favia, M; Guerra, L; Jacobson, KA; Reshkin, SJ; Svetlo, M | 1 |
| Bandivadekar, KR; Ding, Z; Jin, J; Kunapuli, SP; Tuluc, F; Zhang, L | 1 |
| Erlinge, D; Götberg, M; Olivecrona, G; Olsson, ML; Wang, L; Winzell, MS | 1 |
| Kucher, BM; Neary, JT | 1 |
| Konishi, S; Murakoshi, T; Saitow, F; Suzuki, H | 1 |
| Giron, R; Mizumura, K; Nakamura, R; Sato, J; Yajima, H | 1 |
| Gerevich, Z; Illes, P; Müller, C | 1 |
| Burnstock, G; Cowen, T; Knight, GE; Wallace, A | 1 |
| Baker, OJ; Camden, JM; Erb, L; Ratchford, AM; Seye, CI; Weisman, GA | 1 |
| Burnstock, G; Chiaravalli, AM; Frigo, G; Giaroni, C; Knight, GE; Lecchini, S; Zanetti, E | 1 |
| Inoue, K; Koizumi, S; Nagao, T; Ohno, Y; Shinozaki, Y | 1 |
| Erlinge, D; Götberg, M; Harnek, J; Jacobson, KA; Jern, S; Olivecrona, GK | 1 |
| Vadakkan, KI; Wu, LJ; Zhuo, M | 1 |
| Boarder, MR; Dixon, CJ; Hall, JF; Luo, Y; White, PJ | 1 |
| Calleri, E; Frazier, CR; Massolini, G; Moaddel, R; Wainer, IW | 1 |
| Miras-Portugal, MT; Ortega, F; Pérez-Sen, R | 1 |
| DiCorleto, PE; Shen, J | 1 |
| Besada, P; Gachet, C; Gao, ZG; Hechler, B; Jacobson, KA | 1 |
| Losavio, A; Muchnik, S; Veggetti, M | 1 |
| Audinat, E; Avignone, E; Levavasseur, F; Rassendren, F; Ulmann, L | 1 |
| Di Pasquale, F; Hoffmann, K; Sixel, U; von Kügelgen, I | 1 |
| Daniel, JL; Jin, J; Kim, S; Kunapuli, SP; Mao, Y; Thomas, D | 1 |
| Crain, EJ; Hua, J; Rehfuss, R; Schumacher, WA; Watson, CA; Wong, PC | 1 |
| Fraga, S; Gonçalves, J; Queiroz, G; Quintas, C | 2 |
| Gomes, DA; Song, Z; Stevens, W | 1 |
| Baqi, Y; Glänzel, M; Hoffmann, K; Morena, MS; Müller, CE; von Kügelgen, I | 1 |
| Carneiro, FS; Giachini, FR; Inscho, EW; Lima, VV; Osmond, DA; Tostes, RC; Webb, RC; Zhang, S | 1 |
| Beckerman, J; Myers, A; Vicini, S; Young, JP | 1 |
| Antel, JP; Ase, AR; Lambert, C; Séguéla, P | 1 |
| Cuadrado, A; Espada, S; Miras-Portugal, MT; Molina-Jijón, E; Ortega, F; Pedraza-Chaverri, J; Pérez-Sen, R; Rojo, AI | 1 |
| Amisten, S; Erlinge, D; Lundquist, I; Meidute-Abaraviciene, S; Olde, B; Salehi, A; Tan, C | 1 |
| Bal Dit Sollier, C; Berge, N; Boval, B; Drouet, L; Dubar, M | 1 |
| Ajmone-Cat, MA; De Nuccio, C; De Simone, R; Minghetti, L; Niturad, CE; Visentin, S | 1 |
| Geddawy, A; Imamura, T; Okamura, T; Shimosato, T; Tawa, M | 1 |
| Böhm, A; Driessen, J; Ermler, S; Fischer, JW; Jakubowski, JA; Rauch, BH; Rosenkranz, AC; Schrör, K; Sugidachi, A | 1 |
| Grass, EH; Holstein, DM; Keller, C; Lechleiter, JD; Prajapati, SI; Walter, CA; Watts, LT; Zheng, W | 1 |
| Brasseur, D; Bremond, N; Delesque Touchard, N; Hurbin, F; Lavisse, M; Rouchon, MC; Roy, S; Savi, P; Schofield, J; Sultan, E; Tuffal, G | 1 |
| Jantaratnotai, N; McLarnon, JG | 1 |
| Boehm, S; Chandaka, GK; Drobny, H; Salzer, I; Schicker, KW | 1 |
| Kim, S; Kunapuli, SP | 1 |
| Harada, K; Matsumoto, Y; Umemura, K | 1 |
| Delicado, EG; Ortega, F; Pérez-Sen, R; Teresa Miras-Portugal, M | 1 |
| Bender, SB; Berwick, ZC; Laughlin, MH; Tune, JD | 1 |
| Coppi, E; Gibb, AJ; Pedata, F | 1 |
| Inoue, K; Kohsaka, S; Nakamura, Y; Ohsawa, K; Sanagi, T; Suzuki, E | 1 |
| Ishida, K; Kamata, K; Kobayashi, T; Matsumoto, T; Taguchi, K | 1 |
| Cousins, DJ; Foster, HR; Fuerst, E; Lee, TH; Woszczek, G | 1 |
| Cipolla, L; Guidetti, G; Jin, J; Kim, S; Kunapuli, SP; Okigaki, M; Torti, M | 1 |
| Bhavanasi, D; Dangelmaier, C; Goldfinger, LE; Kim, S; Kunapuli, SP; Meng, S; Wang, H | 1 |
| Haas, M; Reiser, G; Shaaban, A | 1 |
| Giachini, FR; Inscho, EW; Leite, R; Lima, VV; Osmond, DA; Tostes, RC; Webb, RC | 1 |
| Cherezov, V; Gao, ZG; Han, GW; Jacobson, KA; Jiang, H; Katritch, V; Li, T; Ma, L; Müller, CE; Paoletta, S; Stevens, RC; Wu, B; Yang, H; Zhang, D; Zhang, J; Zhang, K; Zhang, W; Zhao, Q | 1 |
| Delicado, EG; Huerta-Cepas, J; Miras-Portugal, MT; Morente, V; Ortega, F; Pérez-Sen, R | 1 |
| Boldron, C; Bonnet-Lignon, S; Bono, F; Delesque-Touchard, N; Herbert, JM; Lassalle, G; Millet, L; Pflieger, AM; Salel, V; Savi, P | 1 |
| Kobayashi, K; Noguchi, K; Sakagami, M; Tatsumi, E; Yagi, H; Yamanaka, H | 1 |
| Baqi, Y; Hoffmann, K; Lutz, DA; Müller, CE; Straßburger, J; von Kügelgen, I | 1 |
| Hu, J; Jiang, M; Liao, L; Liu, X; Luo, J; Wang, W; Xiang, F | 1 |
| Eilers, J; Kraft, R; Michaelis, M; Nieswandt, B; Stegner, D | 1 |
| Almo, SC; Burgos, ES; Cameron, SA; Gulab, SA; Schramm, VL; Thomas, K | 1 |
| Cherezov, V; Crane, S; Gao, ZG; Han, GW; Jacobson, KA; Jiang, H; Katritch, V; Kiselev, E; Liu, H; Ma, L; Paoletta, S; Stevens, RC; Wang, J; Wu, B; Yi, C; Zhang, D; Zhang, K; Zhang, W; Zhao, Q | 1 |
| Förster, D; Reiser, G | 1 |
| Cinalli, AR; Fernández, V; Guarracino, JF; Losavio, AS; Roquel, LI | 1 |
| Chaudhary, PK; Kim, S | 1 |
| Chen, Q; Hu, X; Shao, Q; Wu, Z; Zhao, Z | 1 |
| Chaudhary, PK; Jee, Y; Kim, S; Lee, SH; Park, KM | 1 |
| Delicado, EG; Gil-Redondo, JC; Iturri, J; Miras-Portugal, MT; Ortega, F; Pérez-Sen, R; Toca-Herrera, JL; Weber, A | 1 |
| Dangelmaier, C; Kunapuli, SP | 1 |
| Chee, XW; Gunasinghe, KKJ; Harper, MT; Rahman, T; Vadlamani, VMK | 1 |
| Amaradasa, K; Bancroft, S; Dimofte, T; Hindle, MS; Hutchinson, JL; Johnson, T; Keith, M; Khalil, J; Mundell, SJ; Naseem, K; Roberts, T | 1 |
2 review(s) available for methylthio-adp and adenosine diphosphate
| Article | Year |
|---|---|
Purine and pyrimidine (P2) receptors as drug targets.
Topics: Adenosine Triphosphate; Animals; Drug Design; Humans; Ligands; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyrimidines; Receptors, Purinergic P2; Uridine Triphosphate | 2002 |
P2Y12, a new platelet ADP receptor, target of clopidogrel.
Topics: Adenosine Diphosphate; Angina, Unstable; Animals; Blood Platelets; Clopidogrel; Down-Regulation; Humans; Membrane Proteins; Myocardial Infarction; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Stroke; Ticlopidine | 2003 |
2 trial(s) available for methylthio-adp and adenosine diphosphate
| Article | Year |
|---|---|
Clopidogrel inhibits the binding of ADP analogues to the receptor mediating inhibition of platelet adenylate cyclase.
Topics: Adenosine; Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Adult; Binding Sites; Blood Platelets; Clopidogrel; Humans; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Receptors, Purinergic; Thionucleotides; Thrombin; Ticlopidine | 1992 |
Differential sensitivity and kinetics of response of different ex vivo tests monitoring functional variability of platelet response to clopidogrel.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Flow Cytometry; Humans; Kinetics; Male; Microfilament Proteins; Nephelometry and Turbidimetry; P-Selectin; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Predictive Value of Tests; Receptors, Purinergic P2Y12; Sensitivity and Specificity; Thionucleotides; Thrombelastography; Ticlopidine; Young Adult | 2010 |
127 other study(ies) available for methylthio-adp and adenosine diphosphate
| Article | Year |
|---|---|
Species- or isozyme-specific enzyme inhibitors. 9. Selective effects in inhibitions of rat pyruvate kinase isozymes by adenosine 5'-diphosphate derivatives.
Topics: Adenosine Diphosphate; Animals; Catalysis; Chemical Phenomena; Chemistry; In Vitro Techniques; Isoenzymes; Kidney; Liver; Pyruvate Kinase; Rats; Species Specificity | 1982 |
Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate.
Topics: Adenine Nucleotides; Animals; Aorta; Colon; Enzyme Activation; Erythrocyte Membrane; Guinea Pigs; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth; Rabbits; Receptors, Purinergic P2; Structure-Activity Relationship; Sulfides; Turkeys; Type C Phospholipases; Vas Deferens | 1993 |
An examination of deoxyadenosine 5'(alpha-thio)triphosphate as a ligand to define P2Y receptors and its selectivity as a low potency partial agonist of the P2Y1 receptor.
Topics: Adenosine Triphosphate; Dose-Response Relationship, Drug; Humans; Radioligand Assay; Receptors, Purinergic P2; Receptors, Purinergic P2Y1 | 1997 |
Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist.
Topics: Adenosine Diphosphate; Animals; Cells, Cultured; Female; Humans; Insecta; Purinergic P2 Receptor Antagonists; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Tritium | 2002 |
Pharmacological characterization of the human P2Y13 receptor.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Membrane; CHO Cells; Cricetinae; Cyclic AMP; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Inositol Phosphates; Kinetics; Receptors, Purinergic P2; Thionucleotides | 2003 |
Identification of hydrolytically stable and selective P2Y(1) receptor agonists.
Topics: Adenosine Triphosphatases; Animals; Biomimetics; Cell Line, Tumor; Drug Design; Gastric Juice; Humans; Hydrogen-Ion Concentration; Hydrolysis; Nucleotides; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2Y1; Substrate Specificity; Temperature | 2009 |
A novel insulin secretagogue based on a dinucleoside polyphosphate scaffold.
Topics: Alkaline Phosphatase; Animals; Blood Glucose; Cell Line, Tumor; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Fasting; Humans; Insulin; Insulin Secretion; Male; Molecular Structure; Purinergic P2 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Serum; Structure-Activity Relationship | 2010 |
Identification of a promising drug candidate for the treatment of type 2 diabetes based on a P2Y(1) receptor agonist.
Topics: Animals; Blood Glucose; Cell Line, Tumor; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Molecular Structure; Purinergic P2Y Receptor Agonists; Rats; Rats, Wistar | 2012 |
Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists.
Topics: Animals; Antioxidants; Biocompatible Materials; Drug Design; Drug Stability; Humans; Hydrolysis; Models, Molecular; Neuroprotective Agents; Nucleotides; PC12 Cells; Protein Conformation; Purinergic P2Y Receptor Agonists; Rats; Reactive Oxygen Species; Receptors, Purinergic P2Y | 2013 |
Identification of Highly Promising Antioxidants/Neuroprotectants Based on Nucleoside 5'-Phosphorothioate Scaffold. Synthesis, Activity, and Mechanisms of Action.
Topics: Animals; Antioxidants; Cells, Cultured; Drug Discovery; Humans; Hydrogen Peroxide; Hydrolysis; Iron; Models, Molecular; Neurons; Neuroprotective Agents; Nucleosides; Nucleotides; PC12 Cells; Phosphorothioate Oligonucleotides; Purinergic P2Y Receptor Agonists; Rats; Reactive Oxygen Species; Receptors, Purinergic P2Y1 | 2015 |
ADP receptor-induced activation of guanine-nucleotide-binding proteins in human platelet membranes.
Topics: 6-Phytase; Adenosine Diphosphate; Blood Platelets; Cell Membrane; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; In Vitro Techniques; Kinetics; Platelet Aggregation; Receptors, Purinergic; Thionucleotides | 1992 |
2-Methylthioadenosine [beta-32P]diphosphate: synthesis and use as probe of platelet ADP receptors.
Topics: Adenosine Diphosphate; Blood Platelets; Humans; Indicators and Reagents; Kinetics; Phosphorus Radioisotopes; Radioligand Assay; Receptors, Purinergic; Thionucleotides | 1992 |
Two mechanisms for inhibition of ADP-induced platelet shape change by 5'-p-fluorosulfonylbenzoyladenosine. Conversion to adenosine, and covalent modification at an ADP binding site distinct from that which inhibits adenylate cyclase.
Topics: Adenosine; Adenosine Deaminase; Adenosine Diphosphate; Adenylyl Cyclase Inhibitors; Binding Sites; Blood Platelets; Cyclic AMP; Drug Synergism; Humans; Microscopy, Electron, Scanning; Thionucleotides | 1985 |
Identification of two distinct adenosine diphosphate receptors in human platelets.
Topics: Adenosine; Adenosine Diphosphate; Blood Platelets; Chymotrypsin; Cyclic AMP; Fibrinogen; Humans; In Vitro Techniques; Platelet Aggregation; Receptors, Cell Surface; Receptors, Purinergic; Thionucleotides | 1980 |
2-Methylthioadenosine[beta-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets.
Topics: Adenosine Diphosphate; Blood Platelets; Cyclic AMP; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Receptors, Cell Surface; Receptors, Purinergic; Temperature; Thionucleotides | 1983 |
Arachidonate metabolism, 5-hydroxytryptamine release and aggregation in human platelets activated by palmitaldehyde acetal phosphatidic acid.
Topics: Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Chlorpromazine; Humans; In Vitro Techniques; Indomethacin; Lipids; Malondialdehyde; Platelet Aggregation; Platelet Count; Quinacrine; Serotonin; Thionucleotides; Thrombin | 1984 |
Competitive inhibition by adenosine 5'-triphosphate of the actions on human platelets of 2-chloroadenosine 5'-diphosphate, 2-azidoadenosine 5'-diphosphate and 2-methylthioadenosine 5'-diphosphate.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclases; Azides; Binding, Competitive; Humans; In Vitro Techniques; Platelet Aggregation; Thionucleotides | 1982 |
Autoradiography of P2x ATP receptors in the rat brain.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Autoradiography; Binding, Competitive; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Dilazep; Female; Hippocampus; Ligands; Male; Ouabain; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Structure-Activity Relationship; Suramin; Thalamus; Thionucleotides | 1995 |
An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function.
Topics: Adenosine Diphosphate; Alprostadil; Blood Coagulation Disorders; Blood Platelets; Cyclic AMP; Cytoplasmic Granules; Epinephrine; Fibrinogen; Flow Cytometry; Humans; Male; Middle Aged; Platelet Aggregation; Platelet Membrane Glycoproteins; Receptors, Purinergic P2; Thionucleotides; White People | 1995 |
Characterization of specific binding sites for [3H]2-MeS-ADP on megakaryocytoblastic cell lines in culture.
Topics: Adenosine Diphosphate; Binding Sites; Cells, Cultured; Megakaryocytes; Thionucleotides; Tritium | 1994 |
Effect of aspirin and clopidogrel on platelet-dependent tissue factor expression in endothelial cells.
Topics: Adenosine Diphosphate; Animals; Aorta; Aspirin; Blood Platelets; Cattle; Clopidogrel; Endothelium, Vascular; Female; Ligation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Thionucleotides; Thrombin; Thromboplastin; Thrombosis; Ticlopidine; Vena Cava, Inferior | 1994 |
Binding of [3H]-2-methylthio ADP to rat platelets--effect of clopidogrel and ticlopidine.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Animals; Binding Sites; Blood Platelets; Clopidogrel; Female; In Vitro Techniques; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Ticlopidine | 1994 |
Purinoceptors on blood platelets: further pharmacological and clinical evidence to suggest the presence of two ADP receptors.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Clopidogrel; Female; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Receptors, Purinergic P2; Thionucleotides; Ticlopidine | 1995 |
Characterisation of a recombinant P2Y purinoceptor.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Affinity Labels; Animals; Brain; Cell Line; Electrophysiology; Inositol Phosphates; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Recombinant Proteins; Suramin; Thionucleotides; Triazines; Uridine Triphosphate; Xenopus | 1995 |
Effect of clopidogrel treatment on ADP-induced phosphorylations in rat platelets.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Clopidogrel; Female; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thionucleotides; Ticlopidine | 1997 |
Deficiency of (33P)2MeS-ADP binding sites on platelets with secretion defect, normal granule stores and normal thromboxane A2 production. Evidence that ADP potentiates platelet secretion independently of the formation of large platelet aggregates and thro
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Binding Sites; Blood Platelet Disorders; Blood Platelets; Cytoplasmic Granules; Female; Fibrinogen; Humans; In Vitro Techniques; Kinetics; Male; Middle Aged; Phosphorus Radioisotopes; Platelet Aggregation; Reference Values; Serotonin; Thionucleotides; Thromboxane A2 | 1997 |
HEK293 human embryonic kidney cells endogenously express the P2Y1 and P2Y2 receptors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Line; Cricetinae; Humans; In Vitro Techniques; Inositol Phosphates; Kidney; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Stimulation, Chemical; Thionucleotides | 1997 |
Molecular basis for ADP-induced platelet activation. I. Evidence for three distinct ADP receptors on human platelets.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Calcium; Humans; Inositol Phosphates; Membrane Proteins; Models, Chemical; Platelet Activation; Platelet Aggregation Inhibitors; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides | 1998 |
P2Y- and P2U-mediated increases in internal calcium in single bovine aortic endothelial cells in primary culture.
Topics: Adenine Nucleotides; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Cattle; Cells, Cultured; Ion Transport; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Thionucleotides; Uridine Triphosphate | 1997 |
Agonist action of adenosine triphosphates at the human P2Y1 receptor.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Calcium; Cell Line; Dose-Response Relationship, Drug; Humans; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2Y1; Thionucleotides; Tumor Cells, Cultured | 1998 |
Secreted ADP plays a central role in thrombin-induced phospholipase D activation in human platelets.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Apyrase; Blood Platelets; Blood Proteins; Enzyme Activation; Fibrinogen; Humans; Phospholipase D; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Purinergic Antagonists; Receptors, Thromboxane; Signal Transduction; Thionucleotides; Thrombin | 1998 |
Benzoyl ATP is an antagonist of rat and human P2Y1 receptors and of platelet aggregation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Animals; Blood Platelets; Brain; Calcium; Cholera Toxin; Cyclic AMP; Endothelium, Vascular; Humans; Inhibitory Concentration 50; Jurkat Cells; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thionucleotides; Transfection | 1999 |
Differential effects of adenine nucleotide analogues on shape change and aggregation induced by adnosine 5-diphosphate (ADP) in human platelets.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Triphosphate; Blood Platelets; Cell Size; Dose-Response Relationship, Drug; Humans; Platelet Aggregation; Suramin; Thionucleotides; Trypanocidal Agents; Uridine Triphosphate | 1999 |
[Preparation of 32P-labelled 2-methylthioadenosine di- and triphosphates].
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Chromatography, High Pressure Liquid; Phosphorus Radioisotopes; Phosphorylation; Radiochemistry; Thionucleotides | 1999 |
The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Arteriovenous Shunt, Surgical; Binding, Competitive; Bleeding Time; Blood Platelets; Clopidogrel; Collagen; Cyclic AMP; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Thionucleotides; Thiophenes; Thrombin; Thrombosis; Ticlopidine; Time Factors; Tritium | 2000 |
P2Y(1) purinoceptor-mediated Ca(2+) signaling and Ca(2+) wave propagation in dorsal spinal cord astrocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Astrocytes; Calcium; Calcium Signaling; Cells, Cultured; Embryo, Mammalian; Female; Posterior Horn Cells; Pregnancy; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; RNA, Messenger; Thionucleotides; Uridine Triphosphate | 2000 |
Adenosine triphosphate is full antagonist at human P2Y(1) purinoceptors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Cell Line; Creatine Kinase; Dose-Response Relationship, Drug; Half-Life; Humans; Inositol Phosphates; Phosphocreatine; Phosphorylation; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thionucleotides | 2000 |
Evidence that 2-methylthioATP and 2-methylthioADP are both agonists at the rat hepatocyte P2Y(1) receptor.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium Signaling; Liver; Male; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P2Y1; Thionucleotides; Uridine Triphosphate | 2000 |
Adenosine-derived non-phosphate antagonists for P2Y(1) purinoceptors.
Topics: Adenosine; Adenosine Diphosphate; Aspartic Acid; Astrocytoma; Dose-Response Relationship, Drug; Humans; Phosphates; Phosphatidylinositols; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thionucleotides; Tumor Cells, Cultured | 2000 |
Phosphate-substituted ATP analogs are antagonists at human P2Y1 purinoceptors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Cell Line; Humans; In Vitro Techniques; Inositol Phosphates; Kinetics; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2Y1; Thionucleotides | 2000 |
Antiplatelet action of R-99224, an active metabolite of a novel thienopyridine-type G(i)-linked P2T antagonist, CS-747.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cyclic AMP; Cyclopropanes; Fibrinogen; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; In Vitro Techniques; Male; Membrane Proteins; Piperazines; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Thiophenes | 2001 |
Dual effect of nucleotides on P2Y receptors.
Topics: Adenosine Diphosphate; Binding Sites; Calcium; Cell Line; Dose-Response Relationship, Drug; Humans; Hydrolysis; Inhibitory Concentration 50; Ions; Kinetics; Ligands; Magnesium; Nucleotides; Phosphatidylinositols; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thionucleotides; Tumor Cells, Cultured; Uridine Diphosphate | 2000 |
Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Annexin A5; Apoptosis; Astrocytoma; Carbachol; Carbazoles; Chromones; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; GTP-Binding Proteins; Humans; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Recombinant Proteins; Thionucleotides; Transcription Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
The balance of concurrent aggregation and deaggregation processes in platelets is linked to differential occupancy of ADP receptor subtypes.
Topics: Adenosine Diphosphate; Adult; Calcium Signaling; Cell Compartmentation; Female; Fibrinolytic Agents; Humans; Kinetics; Male; Membrane Proteins; Middle Aged; Models, Biological; Platelet Aggregation; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides | 2001 |
Extracellular ADP is a powerful osteolytic agent: evidence for signaling through the P2Y(1) receptor on bone cells.
Topics: Adenosine Diphosphate; Animals; Bone and Bones; Bone Resorption; Calcium; Cells, Cultured; Chondrocytes; Immunohistochemistry; In Situ Hybridization; Mice; Osteoblasts; Osteoclasts; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thionucleotides | 2001 |
P2Y(AC)(-)-receptor agonists enhance the proliferation of rat C6 glioma cells through activation of the p42/44 mitogen-activated protein kinase.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Cell Division; Dinucleoside Phosphates; Enzyme Activation; Glioma; Hydrolysis; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Purinergic P2 Receptor Agonists; Pyridoxal Phosphate; Rats; Receptors, Purinergic P2; Thionucleotides; Time Factors; Triazines; Tumor Cells, Cultured | 2001 |
Extracellular adenine nucleotides regulate Na+/H+ exchanger NHE3 activity in A6-NHE3 transfectants by a cAMP/PKA-dependent mechanism.
Topics: Adenosine; Adenosine Diphosphate; Animals; Calcium; Cell Line; Cell Membrane; Cyclic AMP; Enzyme Inhibitors; Epithelial Cells; Hydrogen-Ion Concentration; Rats; Signal Transduction; Sodium-Hydrogen Exchangers; Thionucleotides; Transfection; Xenopus laevis | 2002 |
Human Ntera-2/D1 neuronal progenitor cells endogenously express a functional P2Y1 receptor.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Antineoplastic Agents; Blotting, Western; Calcium; Cell Membrane; Cells, Cultured; Cyclic AMP; Fluorescence; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Humans; Membrane Proteins; Mitogen-Activated Protein Kinases; Neurons; Platelet Aggregation Inhibitors; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Receptors, Purinergic P2Y2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Suramin; Thionucleotides; Uridine Triphosphate | 2002 |
The stable pyrimidines UDPbetaS and UTPgammaS discriminate between contractile cerebrovascular P2 receptors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Basilar Artery; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; In Vitro Techniques; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thionucleotides; Uridine Diphosphate; Uridine Triphosphate; Vasoconstriction | 2003 |
Effect of clopidogrel administration to healthy volunteers on platelet phosphorylation events triggered by ADP.
Topics: Adenosine Diphosphate; Adolescent; Adult; Benzylamines; Blood Platelets; Clopidogrel; Electrophoresis, Polyacrylamide Gel; Humans; Male; Membrane Proteins; Phosphorylation; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Serine; Signal Transduction; Thiazoles; Thionucleotides; Threonine; Ticlopidine; Tyrosine | 2003 |
Differential frequency dependence of P2Y1- and P2Y2- mediated Ca 2+ signaling in astrocytes.
Topics: Adenosine Diphosphate; Animals; Astrocytes; Astrocytoma; Biological Clocks; Calcium; Calcium Signaling; Cells, Cultured; Feedback, Physiological; Fluorescent Dyes; Humans; Mutagenesis, Site-Directed; Protein Kinase C; Purinergic P2 Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y2; Spectrometry, Fluorescence; Structure-Activity Relationship; Thionucleotides; Uridine Triphosphate | 2003 |
ATP acts via P2Y1 receptors to stimulate acetylcholinesterase and acetylcholine receptor expression: transduction and transcription control.
Topics: Acetylcholinesterase; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Chick Embryo; Cytosol; DNA-Binding Proteins; ets-Domain Protein Elk-1; Gene Expression Regulation; Genes, Reporter; Mice; Mitogen-Activated Protein Kinases; Muscle Fibers, Skeletal; Myoblasts; Neuromuscular Junction; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins; Receptors, Cholinergic; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thionucleotides; Transcription Factors; Transcription, Genetic; Transduction, Genetic | 2003 |
ATP modulates intracellular Ca2+ and firing rate through a P2Y1 purinoceptor in cane toad pacemaker cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Biological Clocks; Blotting, Western; Bufo marinus; Calcium; Electrophysiology; Heart; Immunohistochemistry; Intracellular Membranes; Myocardium; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Sarcoplasmic Reticulum; Suramin; Thionucleotides; Type C Phospholipases | 2003 |
Gi-dependent and -independent mechanisms downstream of the P2Y12 ADP-receptor.
Topics: Actins; Adenosine Diphosphate; Animals; Cell Division; CHO Cells; Cricetinae; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; MAP Kinase Signaling System; Membrane Proteins; Models, Biological; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Platelet-Derived Growth Factor; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Recombinant Proteins; rhoA GTP-Binding Protein; Signal Transduction; Thionucleotides | 2004 |
P2Y12 receptor stimulation inhibits beta-adrenergic receptor-induced differentiation by reversing the cyclic AMP-dependent inhibition of protein kinase B.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Adrenergic beta-Agonists; Animals; Cell Differentiation; Cell Division; Cell Line, Tumor; Cyclic AMP; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Glioma; GTP-Binding Protein alpha Subunits, Gi-Go; Membrane Proteins; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Receptors, Adrenergic, beta; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides | 2004 |
Transcriptional regulation of acetylcholinesterase-associated collagen ColQ: differential expression in fast and slow twitch muscle fibers is driven by distinct promoters.
Topics: Acetylcholinesterase; Adenosine Diphosphate; Amino Acid Sequence; Animals; Cell Differentiation; Cell Line; Chickens; Collagen; DNA-Binding Proteins; Exons; Gene Expression Regulation, Enzymologic; Genes, Reporter; Humans; Mice; Molecular Sequence Data; Muscle Fibers, Fast-Twitch; Muscle Fibers, Skeletal; Muscle Fibers, Slow-Twitch; Muscle Proteins; Muscle, Skeletal; Neuregulins; NFATC Transcription Factors; Nuclear Proteins; Promoter Regions, Genetic; Rats; Regulatory Sequences, Nucleic Acid; Synaptic Transmission; Thionucleotides; Transcription Factors; Transcription, Genetic; Transfection | 2004 |
Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Diphosphate; Animals; Antihypertensive Agents; Benzazepines; Blood Platelets; Blotting, Western; Cytoplasmic Granules; Dopamine Antagonists; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Membrane Proteins; Mice; Peptide Fragments; Phosphorylation; Platelet Aggregation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Thionucleotides | 2004 |
Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells.
Topics: Adenosine Diphosphate; Animals; Calcium; Cell Line; Chlorides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Glyburide; Indomethacin; Isoquinolines; Kidney Tubules; Phosphoproteins; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Sodium-Hydrogen Exchangers; Sulfonamides; Thionucleotides; Xenopus laevis | 2004 |
Use of radiolabeled 2-methylthio-ADP to study P2Y receptors on platelets and cell lines.
Topics: Adenosine Diphosphate; Blood Platelets; Cell Line; Humans; Phosphorus Isotopes; Platelet Function Tests; Receptors, Purinergic P2; Thionucleotides | 2004 |
Arg333 and Arg334 in the COOH terminus of the human P2Y1 receptor are crucial for Gq coupling.
Topics: Adenosine Diphosphate; Alanine; Amino Acid Sequence; Animals; Arginine; CHO Cells; Cricetinae; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Molecular Sequence Data; Protein Structure, Tertiary; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Thionucleotides | 2005 |
ADP acting on P2Y13 receptors is a negative feedback pathway for ATP release from human red blood cells.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Apyrase; Cyclic AMP; Epinephrine; Erythrocyte Membrane; Erythrocytes; Feedback, Physiological; Female; Humans; Male; Microdialysis; Phentolamine; Propranolol; Receptors, Purinergic P2; Reticulocytes; RNA, Messenger; Sus scrofa; Thionucleotides | 2005 |
Bi-functional effects of ATP/P2 receptor activation on tumor necrosis factor-alpha release in lipopolysaccharide-stimulated astrocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Astrocytes; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Lipopolysaccharides; Purinergic P2 Receptor Agonists; Rats; Rats, Inbred F344; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2X7; Stimulation, Chemical; Thionucleotides; Tumor Necrosis Factor-alpha | 2005 |
Metabotropic P2Y purinoceptor-mediated presynaptic and postsynaptic enhancement of cerebellar GABAergic transmission.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenosine Diphosphate; Animals; Calcium; Cerebellar Cortex; Chelating Agents; Egtazic Acid; Female; gamma-Aminobutyric Acid; Interneurons; Long-Term Potentiation; Male; Neuroglia; Neuronal Plasticity; Patch-Clamp Techniques; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Presynaptic; Receptors, Purinergic P2; Synaptic Transmission; Tetrodotoxin; Thionucleotides; Xanthines | 2005 |
Inhibitory, facilitatory, and excitatory effects of ATP and purinergic receptor agonists on the activity of rat cutaneous nociceptors in vitro.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antineoplastic Agents; Electric Stimulation; Female; Hot Temperature; Nerve Fibers, Unmyelinated; Nociceptors; Organ Culture Techniques; Purinergic Agonists; Rats; Rats, Inbred Lew; Skin; Stimulation, Chemical; Thionucleotides; Uridine Triphosphate | 2005 |
Metabotropic P2Y1 receptors inhibit P2X3 receptor-channels in rat dorsal root ganglion neurons.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Ganglia, Spinal; Guanosine 5'-O-(3-Thiotriphosphate); Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Pertussis Toxin; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Receptors, Purinergic P2Y1; Thionucleotides | 2005 |
Changes in purinergic signalling in developing and ageing rat tail artery: importance for temperature control.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Arteries; Dose-Response Relationship, Drug; Electric Stimulation; Immunohistochemistry; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Regional Blood Flow; Signal Transduction; Suramin; Tail; Thionucleotides; Uridine Triphosphate | 2006 |
Differential coupling of the P2Y1 receptor to Galpha14 and Galphaq/11 proteins during the development of the rat salivary gland.
Topics: Adenosine Diphosphate; Animals; Blotting, Northern; Blotting, Western; Calcium; Calcium Signaling; Carbachol; Edetic Acid; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits; Guanosine 5'-O-(3-Thiotriphosphate); Muscarinic Agonists; Phosphorylation; Protein Binding; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Reverse Transcriptase Polymerase Chain Reaction; Salivary Glands; Thionucleotides | 2006 |
Postnatal development of P2 receptors in the murine gastrointestinal tract.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Triphosphate; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Dose-Response Relationship, Drug; Female; Gastrointestinal Tract; Gene Expression Regulation, Developmental; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Thionucleotides; Uridine Triphosphate | 2006 |
Extracellular ATP counteracts the ERK1/2-mediated death-promoting signaling cascades in astrocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Brain; Cell Death; Cell Nucleus; Cells, Cultured; Enzyme Activation; Extracellular Fluid; Hydrogen Peroxide; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Phosphorylation; Protein Tyrosine Phosphatases; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; src-Family Kinases; Thionucleotides; Thioredoxin-Disulfide Reductase | 2006 |
The ADP receptor P2Y(1) mediates t-PA release in pigs during cardiac ischemia.
Topics: Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Animals; Hyperemia; Myocardial Ischemia; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Swine; Thionucleotides; Tissue Plasminogen Activator | 2007 |
ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Chemotaxis; Green Fluorescent Proteins; Male; Membrane Potentials; Mice; Mice, Transgenic; Microglia; Organ Culture Techniques; Patch-Clamp Techniques; Potassium; Receptors, Purinergic P2; Thionucleotides | 2007 |
A role for Akt in epidermal growth factor-stimulated cell cycle progression in cultured hepatocytes: generation of a hyperproliferative window after adenoviral expression of constitutively active Akt.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adenoviridae; Animals; Cell Cycle; Cell Proliferation; Cell Survival; Epidermal Growth Factor; Glycogen Phosphorylase; Hepatocytes; Inositol Phosphates; Insulin; Male; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; S Phase; Thionucleotides; TOR Serine-Threonine Kinases; Transfection; Uridine Diphosphate; Uridine Triphosphate | 2007 |
The synthesis and initial characterization of an immobilized purinergic receptor (P2Y1) liquid chromatography stationary phase for online screening.
Topics: Adenosine Diphosphate; Astrocytoma; Binding Sites; Binding, Competitive; Chromatography, Affinity; Deoxyadenine Nucleotides; Humans; Membranes, Artificial; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Sensitivity and Specificity; Thionucleotides; Transfection; Tumor Cells, Cultured | 2007 |
Gi-coupled P2Y-ADP receptor mediates GSK-3 phosphorylation and beta-catenin nuclear translocation in granule neurons.
Topics: Adenosine Diphosphate; Animals; Animals, Newborn; beta Catenin; Cell Nucleus; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycogen Synthase Kinase 3; GTP-Binding Protein alpha Subunits, Gi-Go; Neurons; Phosphorylation; Rats; Rats, Wistar; Receptors, Purinergic P2; Signal Transduction; Thionucleotides; Time Factors | 2008 |
ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways.
Topics: Adenosine Diphosphate; Cell Movement; Cells, Cultured; Chemotaxis; Endothelial Cells; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thionucleotides; Umbilical Veins | 2008 |
Caged agonist of P2Y1 and P2Y12 receptors for light-directed facilitation of platelet aggregation.
Topics: Adenosine Diphosphate; Calcium; Cell Line, Tumor; Cells, Cultured; Humans; Platelet Aggregation; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thionucleotides; Transfection; Ultraviolet Rays | 2008 |
Effect of purines on calcium-independent acetylcholine release at the mouse neuromuscular junction.
Topics: Acetylcholine; Adenosine; Adenosine A1 Receptor Agonists; Adenosine Diphosphate; Animals; Calcium; Electrophysiology; Exocytosis; Mice; Neuromuscular Junction; Purinergic P2 Receptor Agonists; Purines; Synaptic Transmission; Thionucleotides | 2008 |
Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Movement; Cell Proliferation; CX3C Chemokine Receptor 1; Cytokines; Disease Models, Animal; Electroencephalography; Fluoresceins; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Organic Chemicals; Patch-Clamp Techniques; Purines; Receptors, Chemokine; Receptors, Purinergic; RNA, Messenger; Signal Transduction; Status Epilepticus; Thionucleotides; Time Factors; Up-Regulation | 2008 |
Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y(12)-receptor.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Amino Acid Motifs; Animals; Binding Sites; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; Humans; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides | 2008 |
RhoA downstream of G(q) and G(12/13) pathways regulates protease-activated receptor-mediated dense granule release in platelets.
Topics: Adenosine Diphosphate; Aspirin; Blood Platelets; Blotting, Western; Cytoplasmic Granules; Enzyme Activation; GTP-Binding Proteins; Humans; In Vitro Techniques; Oligopeptides; Peptides, Cyclic; Protein Kinase C-delta; Receptor, PAR-1; Receptors, Thrombin; rhoA GTP-Binding Protein; Thionucleotides; Type C Phospholipases | 2009 |
Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability.
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Binding, Competitive; Bleeding Time; Clopidogrel; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hemorrhage; Hemostasis; Male; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2 Receptor Antagonists; Rabbits; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Thiophenes; Thrombosis; Ticlopidine | 2009 |
The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antidepressive Agents, Tricyclic; Arteries; Blotting, Western; Desipramine; Epididymis; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Wistar; Receptor Cross-Talk; Receptor, Adenosine A1; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Signal Transduction; Sympathetic Nervous System; Thionucleotides; Vas Deferens | 2009 |
Role of purinergic P2Y1 receptors in regulation of vasopressin and oxytocin secretion.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium Signaling; Hypothalamo-Hypophyseal System; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Oxytocin; Paraventricular Hypothalamic Nucleus; Perfusion; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Supraoptic Nucleus; Thapsigargin; Thionucleotides; Vasopressins | 2009 |
Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor.
Topics: Adenosine Diphosphate; Animals; Arginine; Binding, Competitive; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclic AMP Response Element Modulator; Humans; Isomerism; Luciferases; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Sulfonic Acids; Suramin; Thionucleotides; Triazines | 2009 |
Clopidogrel, independent of the vascular P2Y12 receptor, improves arterial function in small mesenteric arteries from AngII-hypertensive rats.
Topics: Acetylcholine; Adenosine Diphosphate; Angiotensin II; Animals; Blotting, Western; Clopidogrel; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Purinergic P2Y Receptor Antagonists; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Ticlopidine; Vasodilation; Vasodilator Agents | 2010 |
Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytes.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Aspirin; Calcium; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Resistance; Fibrinolytic Agents; Ionophores; Kinetics; Male; Megakaryocytes; Membrane Potentials; Nystatin; Patch-Clamp Techniques; Platelet Aggregation Inhibitors; Potassium; Potassium Channels, Calcium-Activated; Rats; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Purinergic; Receptors, Thromboxane; Signal Transduction; Thionucleotides | 2010 |
Distinct migratory and cytokine responses of human microglia and macrophages to ATP.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Brain; Cell Movement; Chemokine CCL2; Cytokines; Female; Fetus; Flow Cytometry; Humans; In Vitro Techniques; Indicators and Reagents; Interleukin-10; Interleukin-6; Lipopolysaccharides; Macrophages; Microglia; Pregnancy; Purinergic P2Y Receptor Agonists; Receptors, Purinergic P2Y1; Thionucleotides; Tumor Necrosis Factor-alpha | 2010 |
The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death.
Topics: Adenosine Diphosphate; Animals; Cell Death; Cells, Cultured; Heme Oxygenase-1; Mice; Neurons; NF-E2-Related Factor 2; Oxidative Stress; Rats; Receptors, Purinergic P2; Thionucleotides | 2010 |
ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Apyrase; Cell Line; Cells, Cultured; Cyclic AMP; Female; Glucagon; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Polymerase Chain Reaction; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Thionucleotides | 2010 |
TGF-β and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression.
Topics: Adenosine Diphosphate; Animals; Animals, Newborn; Calcium; Cell Movement; Cells, Cultured; Cerebral Cortex; Gene Expression Regulation; Interferon-gamma; Lipopolysaccharides; Microglia; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; RNA, Small Interfering; Thionucleotides; Transforming Growth Factor beta | 2010 |
Mechanism underlying endothelium-dependent relaxation by 2-methylthio-ADP in monkey cerebral artery.
Topics: Adenosine Diphosphate; Animals; Apamin; Arachidonic Acids; Arginine; Biological Factors; Cerebral Arteries; Charybdotoxin; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Female; Glycyrrhetinic Acid; Macaca; Male; Nitric Oxide; Nitroprusside; Thionucleotides; Vasodilation | 2010 |
Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions.
Topics: Adenosine Diphosphate; Carotid Artery Diseases; Cell Proliferation; Cells, Cultured; Cyclic AMP; Humans; Interleukin-6; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Piperazines; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; RNA Interference; RNA, Messenger; Thionucleotides; Thrombin; Time Factors; Transcriptional Activation; Up-Regulation | 2010 |
Purinergic receptor stimulation reduces cytotoxic edema and brain infarcts in mouse induced by photothrombosis by energizing glial mitochondria.
Topics: Adenosine Diphosphate; Animals; Astrocytes; Brain Infarction; Cerebral Infarction; Edema; Inositol 1,4,5-Trisphosphate; Light; Male; Mice; Mitochondria; Neuroglia; Receptors, Purinergic; Receptors, Purinergic P2Y1; Thionucleotides; Thrombosis | 2010 |
An improved method for specific and quantitative determination of the clopidogrel active metabolite isomers in human plasma.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; CHO Cells; Chromatography, High Pressure Liquid; Clopidogrel; Cricetinae; Cricetulus; Humans; Mass Spectrometry; Phosphorus Isotopes; Plasma; Product Surveillance, Postmarketing; Protein Binding; Receptors, Purinergic P2Y12; Sensitivity and Specificity; Stereoisomerism; Thionucleotides; Ticlopidine; Transgenes | 2011 |
Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate and 2-methylthioadenosine-5'-diphosphate: mechanisms involved.
Topics: Adenosine Diphosphate; Animals; Animals, Newborn; Astrocytes; Cell Proliferation; Cells, Cultured; Purinergic P2Y Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thionucleotides | 2011 |
Calcium dependence of purinergic subtype P2Y₁ receptor modulation of C6 glioma cell migration.
Topics: Adenosine Diphosphate; Animals; Brain Neoplasms; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Line, Tumor; Cell Movement; Glioma; Intracellular Fluid; Ion Channel Gating; Neoplasm Invasiveness; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Rats; Receptors, Purinergic P2Y1; Thionucleotides; Time Factors | 2011 |
Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y(1) receptors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Cell Culture Techniques; Cloning, Molecular; Electric Stimulation; Green Fluorescent Proteins; KCNQ Potassium Channels; Maximum Tolerated Dose; Neurons; Neurotransmitter Agents; Norepinephrine; Patch-Clamp Techniques; PC12 Cells; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Presynaptic; Receptors, Purinergic P2Y1; Superior Cervical Ganglion; Synaptic Transmission; Thionucleotides | 2011 |
Negative regulation of Gq-mediated pathways in platelets by G(12/13) pathways through Fyn kinase.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Calcium; Enzyme Activation; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Mice; Mice, Mutant Strains; Oligopeptides; Peptide Fragments; Platelet Aggregation; Protein Kinase C; Proto-Oncogene Proteins c-fyn; Thionucleotides | 2011 |
Adenosine diphosphate receptor P2Y12-mediated migration of host smooth muscle-like cells and leukocytes in the development of transplant arteriosclerosis.
Topics: Adenosine Diphosphate; Animals; Arteriosclerosis; Bone Marrow; Carotid Arteries; Cell Movement; Chemokine CCL2; Leukocyte Common Antigens; Leukocytes; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Models, Animal; Muscle, Smooth, Vascular; Receptors, Purinergic P2Y12; Signal Transduction; Thionucleotides | 2011 |
ERK1/2 activation is involved in the neuroprotective action of P2Y13 and P2X7 receptors against glutamate excitotoxicity in cerebellar granule neurons.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cerebellum; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Gene Expression Regulation; Glutamic Acid; MAP Kinase Signaling System; Neurons; Phosphorylation; Purinergic P2X Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Thionucleotides; Time Factors | 2011 |
Functional contribution of P2Y1 receptors to the control of coronary blood flow.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arterioles; Blood Flow Velocity; Coronary Circulation; Dogs; Hyperemia; In Vitro Techniques; Male; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y1; Thionucleotides; Vasodilation | 2011 |
P2Y1 receptor modulation of Ca2+-activated K+ currents in medium-sized neurons from neonatal rat striatal slices.
Topics: Action Potentials; Adenosine Diphosphate; Animals; Animals, Newborn; Apamin; Calcium; Corpus Striatum; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Neurons; Peptides; Potassium; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2Y1; Small-Conductance Calcium-Activated Potassium Channels; Tetraethylammonium; Thionucleotides | 2012 |
Adenosine A3 receptor is involved in ADP-induced microglial process extension and migration.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Animals; Animals, Newborn; Cell Movement; Cells, Cultured; Cerebral Cortex; Chemotaxis; Collagen; Flow Cytometry; Indicators and Reagents; JNK Mitogen-Activated Protein Kinases; Microglia; Purinergic P2Y Receptor Agonists; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptor, Adenosine A1; Receptor, Adenosine A3; Receptors, Purinergic P2Y12; Thionucleotides | 2012 |
Mechanisms underlying reduced P2Y(1) -receptor-mediated relaxation in superior mesenteric arteries from long-term streptozotocin-induced diabetic rats.
Topics: Adenosine Diphosphate; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Angiopathies; Disease Models, Animal; Male; Mesenteric Artery, Superior; Nitric Oxide; Nitric Oxide Synthase Type III; Purinergic P2Y Receptor Agonists; Rats; Rats, Wistar; Receptors, Purinergic P2Y1; Signal Transduction; Thionucleotides; Time; Vasodilation | 2013 |
Characterisation of P2Y(12) receptor responsiveness to cysteinyl leukotrienes.
Topics: Adenosine Diphosphate; Animals; Arrestins; beta-Arrestins; Blood Platelets; Calcium; CHO Cells; Cricetulus; Cyclic AMP; Cysteine; HEK293 Cells; Humans; Inflammation; Leukotriene E4; Leukotrienes; Mice; Platelet Activation; Purinergic P2Y Receptor Agonists; Receptors, Leukotriene; Receptors, Purinergic P2Y12; Signal Transduction; Thionucleotides | 2013 |
Distinct role of Pyk2 in mediating thromboxane generation downstream of both G12/13 and integrin αIIbβ3 in platelets.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Focal Adhesion Kinase 2; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Mice; Mice, Knockout; Oligopeptides; Phosphorylation; Platelet Aggregation; Platelet Glycoprotein GPIIb-IIIa Complex; Signal Transduction; Thionucleotides; Thromboxane A2; Time Factors; Tyrphostins | 2013 |
RhoG protein regulates glycoprotein VI-Fc receptor γ-chain complex-mediated platelet activation and thrombus formation.
Topics: Adenosine Diphosphate; Animals; Anticoagulants; Carrier Proteins; Crotalid Venoms; Female; GTP Phosphohydrolases; Humans; Lectins, C-Type; Male; Membrane Glycoproteins; Mice; Mice, Knockout; Oligopeptides; Peptides; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Polysaccharides; Protein Kinases; Receptors, Fc; rho GTP-Binding Proteins; Thionucleotides; Thrombosis | 2013 |
Alanine-(87)-threonine polymorphism impairs signaling and internalization of the human P2Y11 receptor, when co-expressed with the P2Y1 receptor.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Substitution; Astrocytoma; Autoimmunity; Brain; Calcium Signaling; Cell Line, Tumor; Cyclic AMP; HEK293 Cells; Humans; Mutagenesis, Site-Directed; Polymorphism, Single Nucleotide; Protein Interaction Mapping; Purinergic Agonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Structure-Activity Relationship; Thionucleotides; Transfection | 2014 |
Anti-platelet therapy with clopidogrel prevents endothelial dysfunction and vascular remodeling in aortas from hypertensive rats.
Topics: Adenosine Diphosphate; Animals; Aorta; Blood Pressure; Clopidogrel; Disease Models, Animal; Endothelium, Vascular; Gene Expression; Hypertension; Male; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Rats; Receptors, Purinergic P2Y; Thionucleotides; Ticlopidine; Vascular Remodeling; Vasoconstriction; Vasodilation | 2014 |
Agonist-bound structure of the human P2Y12 receptor.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Binding Sites; Crystallography, X-Ray; Humans; Ligands; Models, Molecular; Niacin; Protein Conformation; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Substrate Specificity; Sulfonamides; Thionucleotides | 2014 |
Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery.
Topics: Adenosine Diphosphate; Animals; Caspase 3; Cell Death; Cell Nucleus; Cerebellum; Cisplatin; Cytoprotection; DNA Damage; Dual Specificity Phosphatase 2; Enzyme Activation; MAP Kinase Signaling System; Models, Biological; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Wistar; Receptors, Purinergic P2; Thionucleotides; Ultraviolet Rays | 2014 |
SAR216471, an alternative to the use of currently available P2Y₁₂ receptor inhibitors?
Topics: Adenosine Diphosphate; Administration, Oral; Animals; Binding, Competitive; Biological Availability; Blood Platelets; CHO Cells; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Hemorrhage; Humans; Indoles; Male; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Binding; Purinergic P2Y Receptor Antagonists; Pyridazines; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Signal Transduction; Thionucleotides; Thrombosis; Transfection | 2014 |
RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain.
Topics: Adenosine Diphosphate; Animals; Calcium-Binding Proteins; Disease Models, Animal; Enzyme Inhibitors; Hyperalgesia; Male; Microfilament Proteins; Microglia; Neuralgia; p38 Mitogen-Activated Protein Kinases; Pain Threshold; Phosphorylation; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2Y; rhoA GTP-Binding Protein; Signal Transduction; Spinal Cord; Spinal Cord Injuries; Thionucleotides | 2015 |
Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12 -receptor.
Topics: Adenosine; Adenosine Diphosphate; Animals; Binding Sites; Binding, Competitive; CHO Cells; Colforsin; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, Reporter; Humans; Luciferases; Mutation; Platelet Aggregation Inhibitors; Protein Binding; Purinergic P2Y Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Response Elements; Thionucleotides; Ticagrelor; Transfection | 2014 |
Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells.
Topics: Adenosine Diphosphate; Antineoplastic Agents; Aorta; Apoptosis; Azo Compounds; Cell Line; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Endothelial Cells; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Monocytes; Nucleolin; Phosphoproteins; Primary Cell Culture; Proto-Oncogene Proteins c-bcl-2; Purinergic Agonists; Purinergic Antagonists; Pyridoxal Phosphate; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; RNA-Binding Proteins; RNA, Messenger; S Phase Cell Cycle Checkpoints; Signal Transduction; Thionucleotides | 2014 |
STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Calcium Signaling; Cell Culture Techniques; Indoles; Lipopolysaccharides; Membrane Glycoproteins; Mice; Mice, Knockout; Mice, Transgenic; Microglia; ORAI1 Protein; Phagocytosis; Stromal Interaction Molecule 1; Stromal Interaction Molecule 2; Thionucleotides; Uridine Diphosphate | 2015 |
Active site and remote contributions to catalysis in methylthioadenosine nucleosidases.
Topics: Adenosine Diphosphate; Alanine; Amino Acid Substitution; Catalysis; Catalytic Domain; Crystallography, X-Ray; Escherichia coli; Escherichia coli Proteins; Mutation, Missense; N-Glycosyl Hydrolases; Thionucleotides; Valine; Vibrio cholerae | 2015 |
Two disparate ligand-binding sites in the human P2Y1 receptor.
Topics: Adenosine Diphosphate; Binding Sites; Crystallography, X-Ray; Deoxyadenine Nucleotides; Humans; Ligands; Models, Molecular; Molecular Conformation; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y1; Thionucleotides; Uracil | 2015 |
Nucleotides protect rat brain astrocytes against hydrogen peroxide toxicity and induce antioxidant defense via P2Y receptors.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Animals, Newborn; Antioxidants; Cell Survival; Cells, Cultured; Cytoprotection; Hydrogen Peroxide; Neuroprotective Agents; Nucleotides; Rats; Receptors, Purinergic P2Y; Thionucleotides | 2016 |
P2Y13 receptors mediate presynaptic inhibition of acetylcholine release induced by adenine nucleotides at the mouse neuromuscular junction.
Topics: Acetylcholine; Adenosine Diphosphate; Adenosine Monophosphate; Animals; Female; Male; Mice; Miniature Postsynaptic Potentials; Neuromuscular Junction; Purinergic P2 Receptor Agonists; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides | 2016 |
Characterization of the distinct mechanism of agonist-induced canine platelet activation.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Dogs; Female; Hemostatics; Male; Oligopeptides; Platelet Aggregation; Receptors, Purinergic P2Y; Thionucleotides; Thrombin | 2019 |
A Selective P2Y Purinergic Receptor Agonist 2-MesADP Enhances Locomotor Recovery after Acute Spinal Cord Injury.
Topics: Adenosine Diphosphate; Animals; Doublecortin Protein; Gene Expression Regulation; Humans; Locomotion; Mice; Nerve Regeneration; Purinergic Agonists; Recovery of Function; Remyelination; Spinal Cord Injuries; Thionucleotides | 2020 |
Role of GRK6 in the Regulation of Platelet Activation through Selective G Protein-Coupled Receptor (GPCR) Desensitization.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Blood Platelets; Female; G-Protein-Coupled Receptor Kinases; Gene Expression Regulation; Hemostatics; Male; Mice; Mice, Knockout; Oligopeptides; Phosphorylation; Platelet Activation; Platelet Aggregation; Receptors, G-Protein-Coupled; Thionucleotides; Thrombin; Thromboxane A2 | 2020 |
Nucleotides-Induced Changes in the Mechanical Properties of Living Endothelial Cells and Astrocytes, Analyzed by Atomic Force Microscopy.
Topics: Adenosine Diphosphate; Astrocytes; Human Umbilical Vein Endothelial Cells; Humans; Microscopy, Atomic Force; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Signal Transduction; Thionucleotides; Uridine Triphosphate | 2021 |
Evidence for a PI3-kinase independent pathway in the regulation of Rap1b activation downstream of the P2Y12 receptor in platelets.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Blood Platelets; Calcium; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Purinergic P2Y Receptor Antagonists; rap GTP-Binding Proteins; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; Thionucleotides; Type C Phospholipases | 2022 |
Human soluble CD39 displays substrate inhibition in a substrate-specific manner.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Apyrase; Humans; Uridine Diphosphate | 2023 |
Ticagrelor inverse agonist activity at the P2Y
Topics: Acute Coronary Syndrome; Adenosine; Adenosine Diphosphate; Blood Platelets; Diphosphates; Drug Inverse Agonism; Humans; Platelet Aggregation Inhibitors; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Ticagrelor | 2024 |