Page last updated: 2024-09-04

methylselenic acid and paclitaxel

methylselenic acid has been researched along with paclitaxel in 6 studies

Compound Research Comparison

Studies
(methylselenic acid)
Trials
(methylselenic acid)
Recent Studies (post-2010)
(methylselenic acid)
Studies
(paclitaxel)
Trials
(paclitaxel)
Recent Studies (post-2010) (paclitaxel)
14416831,8745,72915,395

Protein Interaction Comparison

ProteinTaxonomymethylselenic acid (IC50)paclitaxel (IC50)
Integrin beta-3Homo sapiens (human)0.034
Integrin alpha-V Homo sapiens (human)0.034
ATP-dependent translocase ABCB1Homo sapiens (human)2.598
Botulinum neurotoxin type A Clostridium botulinum5.2
UDP-glucuronosyltransferase 2B7Homo sapiens (human)4.9
UDP-glucuronosyltransferase 1-6Homo sapiens (human)4.9
Substance-K receptorHomo sapiens (human)6.125
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)4.9
UDP-glucuronosyltransferase 1A4Homo sapiens (human)4.9
UDP-glucuronosyltransferase 2B10 Homo sapiens (human)4.9
Delta-type opioid receptorHomo sapiens (human)4.202
Tyrosine-protein kinase MerHomo sapiens (human)4.9
Tubulin beta-3 chainHomo sapiens (human)0.0082
Beta-tubulin Leishmania donovani1
Nucleotide-binding oligomerization domain-containing protein 2Homo sapiens (human)7.9433
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)0.26
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)0.28

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hu, H; Ip, C; Jiang, C; Lü, J; Rustum, YM1
Combs, GF; Hu, H; Li, GX; Lü, J; Wang, L; Watts, J1
Azrak, RG; Frank, CL; Ghadersohi, A; Rustum, YM1
Fabritius, M; Ip, C; Wu, Y1
Azrak, RG; Rempinski, DR; Rustum, YM; Saifo, MS1
Dong, Y; Fu, X; Hill, SM; Qi, Y; Rowan, BG; Xiong, Z; Zhang, H1

Other Studies

6 other study(ies) available for methylselenic acid and paclitaxel

ArticleYear
Methylseleninic acid potentiates apoptosis induced by chemotherapeutic drugs in androgen-independent prostate cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Mar-15, Volume: 11, Issue:6

    Topics: Androgens; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Caspases; Drug Therapy, Combination; Enzyme Activation; Etoposide; Humans; JNK Mitogen-Activated Protein Kinases; Male; Organoselenium Compounds; p38 Mitogen-Activated Protein Kinases; Paclitaxel; Phosphorylation; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Tumor Cells, Cultured

2005
Methylseleninic acid enhances taxane drug efficacy against human prostate cancer and down-regulates antiapoptotic proteins Bcl-XL and survivin.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Feb-15, Volume: 14, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Cell Line, Tumor; Docetaxel; Down-Regulation; Drug Synergism; Humans; Immunoblotting; Inhibitor of Apoptosis Proteins; Male; Mice; Microtubule-Associated Proteins; Neoplasm Proteins; Organoselenium Compounds; Paclitaxel; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Survivin; Taxoids; Xenograft Model Antitumor Assays

2008
Silencing survivin results in synergy between methylseleninic acid and paclitaxel against skov3 ovarian cancer cells.
    Cancer biology & therapy, 2008, Volume: 7, Issue:12

    Topics: Cell Death; Cell Division; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Organoselenium Compounds; Ovarian Neoplasms; Paclitaxel; Survivin

2008
Chemotherapeutic sensitization by endoplasmic reticulum stress: increasing the efficacy of taxane against prostate cancer.
    Cancer biology & therapy, 2009, Volume: 8, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Death; Cell Line, Tumor; Docetaxel; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Enzyme-Linked Immunosorbent Assay; Formazans; Heat-Shock Proteins; Humans; Male; Molecular Chaperones; Organoselenium Compounds; Paclitaxel; Prostatic Neoplasms; RNA, Small Interfering; Taxoids; Tetrazolium Salts; Thapsigargin; Time Factors; Transcription Factor CHOP; Transfection

2009
Targeting the oncogenic protein beta-catenin to enhance chemotherapy outcome against solid human cancers.
    Molecular cancer, 2010, Dec-02, Volume: 9

    Topics: Antineoplastic Agents; beta Catenin; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Docetaxel; Humans; Neoplasms; Organoplatinum Compounds; Organoselenium Compounds; Oxaliplatin; Paclitaxel; RNA Interference; Taxoids; Topotecan

2010
Methylseleninic acid enhances paclitaxel efficacy for the treatment of triple-negative breast cancer.
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Proliferation; Drug Synergism; Female; G2 Phase Cell Cycle Checkpoints; Humans; Mice; Organoselenium Compounds; Paclitaxel; Xenograft Model Antitumor Assays

2012