methylnitrosourea has been researched along with methylnitronitrosoguanidine in 150 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 101 (67.33) | 18.7374 |
| 1990's | 36 (24.00) | 18.2507 |
| 2000's | 9 (6.00) | 29.6817 |
| 2010's | 4 (2.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kawabe, Y; Kuriyama, K; Miki, N | 1 |
| Elespuru, RK | 2 |
| Neale, S | 1 |
| Gunther, GR; Jamieson, JD | 1 |
| Deluca, JG; Hoppe, H; Penman, BW; Thilly, WG | 1 |
| Guttenplan, JB | 1 |
| Endo, H; Hidaka, K; Ishizawa, M; Otsuji, N | 1 |
| Awerbuch, TE; Stark, AA | 1 |
| Pinsky, SD; Smulson, ME; Tew, KD; Woolley, PV | 1 |
| Bases, R; Elequin, F; Kadish, A; Liebeskind, D; Mendez, F; Rubinstein, A; Wittner, D | 1 |
| Couch, DB; Hsie, AW | 1 |
| Chang, C; Lee, CG | 1 |
| Krepinsky, J; Rajalakshmi, S; Rao, PM; Sarma, DS | 1 |
| Schepartz, SA | 1 |
| Schabel, FM | 1 |
| Bartsch, H; Montesano, R | 1 |
| Pozharisskiĭ, KM | 1 |
| Balish, E; Bryan, GT; Croft, WA; Lower, G; Pamukcu, AM; Shih, CN; Yale, CE | 1 |
| Lawley, PD; Warren, W | 1 |
| Ellenberger, J; McGregor, D; Merker, HJ; Mohn, G | 1 |
| Lawley, PD | 1 |
| Corbett, TH; Griswold, DP; Peckham, JC; Roberts, BJ; Schabel, FM | 1 |
| Mitsuno, T; Sugiyama, T; Tabuchi, Y | 1 |
| Corbett, TH; Griswold, DP | 1 |
| Masek, F; Sedliaková, M | 1 |
| Hall, A; Lohrer, H; Robson, T | 1 |
| Balansky, R | 1 |
| Bilbin, M; Czeczot, H; Tudek, B | 1 |
| Fountoulakis, JM; Hallada, TC; Kaplan, L; Masurekar, PS; Sosa, MS | 1 |
| Deorukhakar, VV; Murthy, MS | 1 |
| Balansky, RM | 1 |
| Gannon, J; Hall, J; Lindahl, T; Sedgwick, B; Vaughan, P | 1 |
| Sedgwick, B; Vaughan, P | 1 |
| Hutchinson, F; Romac, S; Sockett, H | 1 |
| Baburek, I; Gichner, T; Kappas, A; Velemínský, J | 1 |
| Balmain, A; Brown, K; Buchmann, A | 1 |
| Kalinovskiĭ, VP; Pliss, GB; Vol'fson, NI | 1 |
| Brucker, A; Loeb, LA; Thielmann, HW | 1 |
| Waldstein, EA | 1 |
| Jensen, DE; Mackay, RL | 1 |
| Herrlich, P; Kaina, B; Karin, M; Lohrer, H | 1 |
| Haggerty, HG; Holsapple, MP; Kim, BS | 1 |
| Faustman, EM; Gage, D; Kirby, Z; Varnum, M | 1 |
| Clyde, C; Dolan, ME; Erickson, LC; Hora, NK; Norbeck, L; Pegg, AE | 1 |
| Brent, TP | 1 |
| Fram, RJ; Marinus, MG; Volkert, MR | 1 |
| An, J; Chen, QG; Gao, FZ; Gu, M; Hu, GG; Ke, Y; Liu, J; Liu, X; Luo, XM | 1 |
| Campbell, PI; Kempson, SA | 1 |
| Nakabeppu, Y; Otsuka, M; Sekiguchi, M | 1 |
| Kuo, ML; Lin, JK | 1 |
| Gichner, T; Velemínský, J | 2 |
| Broitman, SA | 1 |
| Morohoshi, F; Munakata, N | 1 |
| Abbondandolo, A; Bignami, M; Calcagnile, A; Dogliotti, E; Frosina, G; Terlizzese, M; Zijno, A | 1 |
| Chen, QG; Gao, FZ; Hu, GG; Ke, Y; Liu, J; Liu, X; Luo, XM | 1 |
| Kalinovskiĭ, VP; Petrov, AS; Pliss, GB; Vol'fson, NI; Zaozerskaia, LA | 1 |
| Sakagishi, Y; Sakamoto, Y; Sonoda, M; Uyemura, K; Yano, K | 1 |
| Bertini, R; Citti, L; Fiorio, R; Gervasi, P; Mariani, L | 1 |
| Berger, ML; Reitman, FA; Shertzer, HG | 1 |
| Anderson, D; Fisher, P; Jenkinson, PC; Phillips, BJ | 1 |
| Reddy, B; Reiss, B; Tanaka, T; Weiss, CJ; Williams, GM | 1 |
| Gichner, T; Pospísil, F; Velemínský, J; Volke, J; Volkeová, V | 1 |
| Mitchel, RE; Morrison, DP | 1 |
| Goth-Goldstein, R; Hughes, M | 1 |
| Kaina, B | 5 |
| Amberger, H | 1 |
| Birt, DF; Bresnick, E; Tibbels, MG; Walker, B | 1 |
| Cuzick, RA; Goldmacher, VS; Thilly, WG | 1 |
| Becker, FF; Chan, JY; Stout, DL | 1 |
| Laval, F | 1 |
| Hard, GC; Jensen, DE; Magee, PN; Ogiu, T | 1 |
| Day, RS; DiPaolo, JA; Doniger, J | 1 |
| Balansky, RM; Bryson, L | 1 |
| Abbondandolo, A; Frosina, G | 1 |
| Kuenzig, WA; Norkus, EP | 1 |
| Cottrell, JR; Hudson, EA; Jones, RT; Resau, JH; Trump, BF | 1 |
| Hu, GG | 1 |
| Sakagishi, Y; Sonoda, M; Yano, K | 1 |
| Okulov, VB; Petrov, AS; Pliss, GB; Zabezhinski, MA | 1 |
| Kawasaki, H; Ninomiya, S; Yuki, H | 1 |
| Chinault, DN; Miller, MR | 2 |
| Fukamachi, H | 1 |
| Barton, RA; Jacobson, EL; Jacobson, MK; Juarez-Salinas, H; Levi, V | 1 |
| Johnson, FB | 1 |
| Cleaver, JE; Morgan, WF | 1 |
| Grisham, JW; Smith, GJ | 1 |
| Mandel, R; Ryser, HJ | 1 |
| Behlau, I; Rein, RP; Shanabruch, WG; Walker, GC | 1 |
| Okulov, VB; Petrov, AS; Pliss, GB; Zabezhinskiĭ, MA | 1 |
| Furihata, C; Ito, N; Katsuyama, T; Tatematsu, M; Tsuda, H | 1 |
| Laval, F; Laval, J | 1 |
| Chang, HW; Lin, JK; Lin-Shiau, SY; Yen, JY | 1 |
| Fujimura, S; Ohkubo, M; Sakiyama, S | 1 |
| Ahmed, Z; Ather, A; Riazuddin, S | 1 |
| Boorstein, RJ; Pardee, AB | 1 |
| Hudson, EA; Jones, RT; Resau, JH | 1 |
| Becker, FF; Chan, JY; Lapeyre, JN; Ruchirawat, M | 1 |
| Robins, P; Sedgwick, B | 1 |
| Matsushima, T; Shirai, A; Sugimura, T; Umezawa, K | 1 |
| Chung, KC; Hiratsuka, A; Shimodaira, T; Tanaka, A | 1 |
| Pinsky, SD; Woolley, PV | 1 |
| Arlett, CF; Teo, IA | 1 |
| Lijinsky, W | 1 |
| Pinsky, SD; Woolley, PV; Yerino, P | 1 |
| Amberger, H; Bachmann, U; Habs, M; Merz, R; Schmähl, D; Wagner, I | 1 |
| Becker, FF; Chan, JY | 1 |
| Becker, Y; Shiloh, Y | 1 |
| Balwierz, PS; Molinary, SV; Oshiro, Y | 1 |
| Eliseev, VV; Vlasov, NN | 1 |
| Andon, BM; Slapikoff, SA; Thilly, WG | 1 |
| Samson, L; Schwartz, JL | 1 |
| Olsen, RG; Tarr, MJ | 1 |
| Sledziewska-Gójska, E | 1 |
| O'Connor, PJ; Zaidi, NH | 1 |
| Bean, CL; Bradt, CI; Galloway, SM; Greenwood, SK; Hill, RB | 1 |
| Kusmierz, JJ; Mandel, HG; Straw, JA; Wenger, LJ | 1 |
| Laval, F; Lefebvre, P | 1 |
| Dosch, J; Fritz, G; Kaina, B; Thielmann, HW | 1 |
| Anderson, MW; Glickman, BW; Shoukry, S | 1 |
| Nivard, MJ; Pastink, A; Vogel, EW | 1 |
| Fukuda, T; Hayashi, Y; Hioki, K; Kodama, Y; Manabe, S; Matsunuma, N; Mitsumori, K; Nomura, G; Nomura, T; Okamiya, H; Sakamaki, Y; Sunaga, M; Suzuki, H; Wakana, S; Yamamoto, S | 1 |
| Armstrong, MJ; Galloway, SM | 1 |
| Kawate, H; Sekiguchi, M; Shiraishi, A; Tominaga, Y; Tsuzuki, T | 1 |
| Mironov, N; Yamasaki, H; Zhu, W | 1 |
| Foltínová, P; Grones, J | 1 |
| Fukami, H; Ikeno, T; Kaminishi, M; Oohara, T; Shimizu, N; Sugiyama, A; Tatematsu, M; Yamamoto, M; Yoshikawa, A | 1 |
| Aquilina, G; Bignami, M; Branch, P; Fiumicino, S; Humbert, O; Karran, P; Oda, S; Zijno, A | 1 |
| Aquilina, G; Bignami, M; Crompton, NE; Jiricny, J; Lettieri, T; Marra, G; Palombo, F | 1 |
| Aoufouchi, S; Milstein, C; Yélamos, J | 1 |
| Aquilina, G; Bignami, M; Karran, P; O'Driscoll, M | 1 |
| Christmann, M; Kaina, B | 1 |
| Nozaki, K; Shimizu, N; Tatematsu, M | 2 |
| Lee, KE; Pinsky, SD; Woolley, PV | 1 |
| Ishimura, Y; Kashiwabara, S; Katoh, O; Lu, H; Shiraki, K; Uesaka, T; Watanabe, H | 1 |
| Caldwell, D; Kelley, MR; Rinne, M | 1 |
| Mizoshita, T; Tatematsu, M; Tsukamoto, T | 1 |
| Janion, C | 1 |
| Fujiishi, Y; Ohyama, W; Okada, E; Yasutake, N | 1 |
| Brauers, KJ; de Kok, TM; Georgiadis, PA; Hebels, DG; Kleinjans, JC; Kyrtopoulos, SA; van Herwijnen, MH | 1 |
| Ferrero, RL; Sutton, P; Wilson, JE | 1 |
| Fujiishi, Y; Narumi, K; Ohyama, W; Okada, E; Yasutake, N | 1 |
| Chen, K; Ke, X; Qi, H; Shao, J; Shen, J; Zhang, S | 1 |
15 review(s) available for methylnitrosourea and methylnitronitrosoguanidine
| Article | Year |
|---|---|
Mutagenicity of nitrosamides and nitrosamidines in micro-organisms and plants.
Topics: Alkylating Agents; Bacteria; Bacteriophages; Carcinogens; Coliphages; DNA Repair; DNA Replication; Ethylnitrosourea; Fungi; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Neurospora crassa; Nitroso Compounds; Plants | 1976 |
Nitrosoureas: a review of experimental antitumor activity.
Topics: Animals; Carmustine; Colonic Neoplasms; Drug Evaluation, Preclinical; Drug Resistance; Drug Therapy, Combination; Leukemia L1210; Lomustine; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosourea Compounds; Semustine | 1976 |
Mutagenic and carcinogenic N-nitroso compounds: possible environmental hazards.
Topics: Abnormalities, Drug-Induced; Animals; Biotransformation; Carcinogens; Cricetinae; Dimethylnitrosamine; Environmental Exposure; Female; Humans; Liver; Maternal-Fetal Exchange; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mutagens; Nitrosamines; Nitroso Compounds; Pregnancy; Rats; Teratogens | 1976 |
[Successes of experimental oncology and problems of the study of the morphogenesis of tumors].
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Animals; Azoxymethane; Benzopyrenes; Brain Neoplasms; Carcinogens; Cricetinae; Dimethylhydrazines; Dogs; Esophageal Neoplasms; Ethionine; Ethylnitrosourea; Female; Hematopoietic System; Intestinal Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosamines; Nitroso Compounds; Nitrosoguanidines; o-Aminoazotoluene; p-Dimethylaminoazobenzene; Precancerous Conditions; Rats; Skin Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms | 1975 |
"Excision" of bases from DNA methylated by carcinogens in vivo and its possible significance in mutagenesis and carcinogenesis.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Carcinogens; Dimethylnitrosamine; DNA; Escherichia coli; Liver; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mutagens; Organ Specificity; Rats; Species Specificity | 1975 |
[Dynamics of morphological and biochemical changes in the gastric mucosa in rats during tumor induction].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Gastric Mucosa; Methylcholanthrene; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Rats; Sarcoma, Experimental; Stomach; Stomach Neoplasms | 1990 |
Cholesterol conundrums: the relationship between dietary and serum cholesterol in colon cancer.
Topics: 1,2-Dimethylhydrazine; Adult; Animals; Azoxymethane; Cholesterol; Cholesterol, Dietary; Cholestyramine Resin; Cocarcinogenesis; Colonic Neoplasms; Diagnosis-Related Groups; Dietary Fats; Dimethylhydrazines; Disease Models, Animal; Epidemiologic Methods; Humans; Methylnitronitrosoguanidine; Methylnitrosourea | 1986 |
The current evidence for an adaptive response to alkylating agents in mammalian cells, with special reference to experiments with in vitro cell cultures.
Topics: Alkylating Agents; Animals; Bacterial Proteins; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Glycosylases; DNA Ligases; DNA Repair; Drug Resistance; Escherichia coli; Guanine; Haplorhini; Kidney; Liver; Mammals; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mice; Mutation; N-Glycosyl Hydrolases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Placenta; Rats | 1985 |
Predictive and mechanistic evaluation to toxic responses in mammalian cell culture systems.
Topics: Alkylating Agents; Animals; Cell Division; Cell Line; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; Culture Techniques; Cytological Techniques; Dimethylnitrosamine; Flow Cytometry; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Toxicology | 1984 |
A review of in vitro and in vivo culture techniques for the study of pancreatic carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cattle; Cells, Cultured; Cricetinae; Culture Media; Gelatin Sponge, Absorbable; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosamines; Organ Culture Techniques; Pancreatic Ducts; Pancreatic Neoplasms | 1981 |
Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents.
Topics: Alkylating Agents; Animals; Cell Survival; DNA; DNA Damage; DNA Repair; Guanine; Humans; Mesylates; Methylnitronitrosoguanidine; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 2000 |
[Eradication model employing Mongolian gerbils treated with chemical carcinogen and infected with Helicobacter pylori--implications for human cancer prevention].
Topics: Adenocarcinoma; Animals; Carcinogens; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Stomach Neoplasms | 2000 |
[The role of Helicobacter pylori infection and effect of eradication in experimental animal models of gastric carcinogenesis].
Topics: Animals; Disease Models, Animal; Gastric Mucosa; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Humans; Metaplasia; Methylnitronitrosoguanidine; Methylnitrosourea; Stomach Neoplasms | 2001 |
Role of Helicobacter pylori in gastric carcinogenesis: the origin of gastric cancers and heterotopic proliferative glands in Mongolian gerbils.
Topics: Adenocarcinoma; Animals; Cocarcinogenesis; Disease Models, Animal; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Precancerous Conditions; Sodium Chloride, Dietary; Stem Cells; Stomach Neoplasms | 2005 |
[Chemically methylated DNA repair in Escherichia coli--the role of alkB protein].
Topics: Alkylating Agents; DNA Damage; DNA Glycosylases; DNA Methylation; DNA Repair; DNA Repair Enzymes; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Methylnitronitrosoguanidine; Methylnitrosourea; Mixed Function Oxygenases; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; SOS Response, Genetics; Transcription Factors | 2006 |
135 other study(ies) available for methylnitrosourea and methylnitronitrosoguanidine
| Article | Year |
|---|---|
Activation of cerebral guanylate cyclase by nitric oxide.
Topics: Animals; Azides; Blood Proteins; Catalase; Cerebral Cortex; Enzyme Activation; Guanylate Cyclase; Hemeproteins; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Nitric Oxide; Swine | 1977 |
Mutagenicity of nitrosocarbaryl and other methylating nitrosamides as related to uptake in Haemophilus influenzae.
Topics: Carbaryl; Dose-Response Relationship, Drug; Haemophilus influenzae; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenicity Tests; Mutagens; Nitrosamines; Nitroso Compounds; Nitrosourea Compounds | 1979 |
Increased intracellular cyclic GMP does not correlate with protein discharge from pancreatic acinar cells.
Topics: Animals; Ascorbic Acid; Cyclic GMP; Dehydroascorbic Acid; Guinea Pigs; Hydroxylamines; Methylnitronitrosoguanidine; Methylnitrosourea; Nitroprusside; Pancreas; Proteins; Sodium Nitrite; Tetradecanoylphorbol Acetate | 1979 |
Phenotypic lag and mutation to 6-thioguanine resistance in diploid human lymphoblasts.
Topics: Bromodeoxyuridine; Cells, Cultured; Cytological Techniques; Drug Resistance; Humans; Lymphocyte Activation; Lymphocytes; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Nitrogen Mustard Compounds; Phenotype; Thioguanine; Time Factors | 1978 |
Mechanisms of inhibition by ascorbate of microbial mutagenesis induced by N-nitroso compounds.
Topics: Animals; Ascorbic Acid; Copper; Dimethylnitrosamine; In Vitro Techniques; Iron; Methylnitronitrosoguanidine; Methylnitrosourea; Microsomes, Liver; Mutation; Nitrosamines; Rats; Salmonella typhimurium | 1978 |
Mode of mutagenic action of methylnitrosocyanamide, a potent carcinogen.
Topics: Codon; Cyanamide; Escherichia coli; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Nitrosamines; Suppression, Genetic | 1978 |
Deuterium isotope effects in mutagenesis by nitroso compounds.
Topics: Deuterium; Dose-Response Relationship, Drug; Escherichia coli; Genetic Techniques; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Nitrosamines; Nitroso Compounds | 1978 |
Plate diffusion assay as a rapid method for dosimetry of mutagens.
Topics: Biological Assay; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Mycotoxins; N-Nitrosopyrrolidine; Nitrosamines; Salmonella typhimurium | 1979 |
Modification of L1210 cell nuclear proteins by 1-methyl-1-nitrosourea and 1-methyl-3-nitro-1-nitrosoguanidine.
Topics: Animals; Cells, Cultured; Histones; Leukemia L1210; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasm Proteins; Nitrosourea Compounds; Nucleoproteins; Protein Binding | 1979 |
Mutagen-induced disturbances in the DNA of human lymphocytes detected by antinucleoside antibodies.
Topics: Alkylating Agents; Antibodies; Cell Survival; DNA; DNA Repair; Dose-Response Relationship, Drug; HeLa Cells; Humans; In Vitro Techniques; Lymphocytes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Nucleosides | 1979 |
Mutagenicity and cytotoxicity of congeners of two classes of nitroso compounds in Chinese hamster ovary cells.
Topics: Cell Line; Cell Survival; Dose-Response Relationship, Drug; Ethylnitrosourea; Hypoxanthine Phosphoribosyltransferase; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Nitroso Compounds; Nitrosourea Compounds | 1978 |
Direct study of alkylating agent--RNA interaction by 13C nuclear magnetic resonance spectroscopy.
Topics: Alkylating Agents; Binding Sites; Carcinogens; DNA; Magnetic Resonance Spectroscopy; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Structure-Activity Relationship; Sulfuric Acid Esters | 1978 |
N-Methyl-N-nitrosourea mediated conversion of O6-methylguanine to xanthine.
Topics: Animals; Dealkylation; Deamination; Guanine; In Vitro Techniques; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Rats; Xanthines | 1978 |
Early history and development of the nitrosoureas.
Topics: Animals; Carmustine; History, 20th Century; Leukemia L1210; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Nitrosourea Compounds; United States | 1976 |
Effect of age, sex, and intestinal flora on the induction of colon tumors in rats.
Topics: Adenocarcinoma; Age Factors; Animals; Colonic Neoplasms; Drug Administration Schedule; Female; Germ-Free Life; Intestines; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Sex Factors; Time Factors; Transplantation, Homologous | 1977 |
Specific excision of ethylated purines from DNA of Escherichia coli treated with N-ethyl-N-nitrosourea.
Topics: Adenine; DNA Replication; DNA, Bacterial; Escherichia coli; Ethanol; Ethylnitrosourea; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds | 1975 |
Mutagenicity studies in microorganisms in vitro, with extracts of mammalian organs, and with the host-mediated-assay.
Topics: DNA Repair; Drug Interactions; Escherichia coli; Kupffer Cells; Liver; Methods; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Nitrosomethylurethane; Quinones | 1975 |
Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure.
Topics: Adenocarcinoma; Animals; Carcinogens; Carcinoma; Chemical Phenomena; Chemistry; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosomethylurethane; Transplantation, Homologous | 1975 |
Mucosal damage induced by various gastric carcinogens in the glandular stomach of the rat.
Topics: 2-Acetylaminofluorene; Animals; Endoplasmic Reticulum; Female; Gastric Mucosa; Iodoacetamide; Lipid Metabolism; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Mucins; Nitroquinolines; Nitrosamines; Nitroso Compounds; Nitrosoguanidines; Rats | 1975 |
A colon tumor model for anticancer agent evaluation.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Dimethylhydrazines; Disease Models, Animal; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Nitrosomethylurethane; Transplantation, Homologous | 1975 |
Inducible stable DNA replication in Escherichia coli uvr+ and uvr- cells, treated with genotoxic chemicals.
Topics: 4-Nitroquinoline-1-oxide; 4-Quinolones; Acrylates; Anti-Infective Agents; Chloramphenicol; DNA Replication; Escherichia coli; Furans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mitomycin; Mutagens; Nalidixic Acid; Nitro Compounds; Nitrofurans | 1992 |
Increased sensitivity of a Chinese hamster ovary cell line to alkylating agents after overexpression of the human metallothionein II-A gene.
Topics: Alkylating Agents; Animals; Cadmium; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA; DNA Repair; Female; Gene Expression; Metallothionein; Methylnitronitrosoguanidine; Methylnitrosourea; Ovary; X-Rays | 1992 |
Effects of sodium selenite and caffeine on mutagenesis induced by N-methyl-N-nitrosourea, N-methyl-N'-nitro-N-nitrosoguanidine and aflatoxin B1 in S. typhimurium.
Topics: Aflatoxin B1; Caffeine; Dose-Response Relationship, Drug; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenesis; Mutagenicity Tests; Salmonella typhimurium; Selenium; Sodium Selenite | 1992 |
Induction of aberrant crypts in the colons of rats by alkylating agents.
Topics: 1,2-Dimethylhydrazine; Aging; Alkylating Agents; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Precancerous Conditions; Rats; Rats, Wistar | 1992 |
Pneumocandins from Zalerion arboricola. II. Modification of product spectrum by mutation and medium manipulation.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antiviral Agents; Candida albicans; Chromatography, High Pressure Liquid; Echinocandins; Fermentation; Methylnitronitrosoguanidine; Methylnitrosourea; Microbiological Techniques; Mitosporic Fungi; Mutation; Peptides; Peptides, Cyclic; Pneumocystis | 1992 |
Influence of anoxia and respiratory deficiency on the genotoxicity of some direct-acting alkylating agents in yeast.
Topics: Alkylating Agents; Cell Hypoxia; Cell Survival; Ethyl Methanesulfonate; Ethylnitrosourea; Mesylates; Methylnitronitrosoguanidine; Methylnitrosourea; Oxygen; Saccharomyces cerevisiae | 1991 |
Comutagenic and coclastogenic effects of selenium in vitro and in vivo.
Topics: Animals; Cell Line; Chromosome Aberrations; Erythrocytes; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Micronucleus Tests; Microsomes; Mitomycin; Mitomycins; Mutagenesis; Mutagens; Salmonella typhimurium; Selenium; Urethane | 1991 |
Environmental mutagens that induce the adaptive response to alkylating agents in Escherichia coli.
Topics: Adaptation, Physiological; Alkylating Agents; Anti-Bacterial Agents; Antibodies, Monoclonal; Bacterial Proteins; Carcinogens, Environmental; Creatinine; DNA Repair; Escherichia coli; Escherichia coli Proteins; Hydrogen-Ion Concentration; Immunoblotting; Intracellular Fluid; Methyl Chloride; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Methylurea Compounds; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Transcription Factors | 1991 |
A weak adaptive response to alkylation damage in Salmonella typhimurium.
Topics: Alkylation; Bacterial Proteins; DNA Repair; DNA, Bacterial; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genes, Bacterial; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Salmonella typhimurium; Transcription Factors | 1991 |
Mutagenic specificity of N-methyl-N'-nitro-N-nitrosoguanidine in the gpt gene on a chromosome of Chinese hamster ovary cells and of Escherichia coli cells.
Topics: Animals; Cell Line; DNA Repair; Escherichia coli; Genes, Bacterial; Guanine; Kinetics; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenesis; Plasmids; Polymerase Chain Reaction | 1991 |
UV-irradiation potentiates the antimutagenicity of p-aminobenzoic and p-aminosalicylic acids in Salmonella typhimurium.
Topics: 4-Aminobenzoic Acid; Aminosalicylic Acid; Azides; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Propylene Glycols; Salmonella typhimurium; Sodium Azide; Stimulation, Chemical; Ultraviolet Rays | 1991 |
Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Base Sequence; Carcinogens; Codon; DNA, Neoplasm; Female; Genes, ras; Immunoblotting; Methylcholanthrene; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred Strains; Molecular Sequence Data; Mutation; Nucleic Acid Hybridization; Oligonucleotide Probes; Polymerase Chain Reaction; Skin Neoplasms | 1990 |
DNA polymerase alpha-primase complexes from carcinogen-treated Chinese hamster ovary cells.
Topics: Animals; Bacterial Proteins; Cricetinae; Cricetulus; Diffusion; DNA; DNA Polymerase II; DNA Primase; DNA Replication; DNA, Single-Stranded; DNA, Superhelical; Female; Kinetics; Methylnitronitrosoguanidine; Methylnitrosourea; Molecular Weight; Ovary; RNA Nucleotidyltransferases; Templates, Genetic | 1990 |
Effect of O6-methylguanine-DNA methyltransferase gene activity on repair in human cells transformed by a regulatable ada gene.
Topics: Cell Line; Dexamethasone; DNA Repair; Gene Expression Regulation, Enzymologic; Genes; HeLa Cells; Humans; Kinetics; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Plasmids; Tetradecanoylphorbol Acetate; Transfection | 1990 |
Rat, mouse and hamster isozyme specificity in the glutathione transferase-mediated denitrosation of nitrosoguanidinium compounds.
Topics: Animals; Carmustine; Cimetidine; Cricetinae; Dimethylnitrosamine; Dinitrochlorobenzene; Glutathione Transferase; Guanidines; Isoenzymes; Liver; Mesocricetus; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Nitrosation; Nitrosoguanidines; Rats; Rats, Inbred Strains; Species Specificity | 1990 |
Overexpressed human metallothionein IIA gene protects Chinese hamster ovary cells from killing by alkylating agents.
Topics: Alkylating Agents; Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Drug Resistance; Female; Gamma Rays; Gene Expression; Genes; Kinetics; Metallothionein; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Nucleic Acid Hybridization; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Transfection | 1990 |
Characterization of the effects of direct alkylators on in vitro immune responses.
Topics: Alkylating Agents; Animals; Antibody Formation; Antigens, Differentiation, T-Lymphocyte; Dimethylnitrosamine; DNA Damage; DNA, Single-Stranded; Female; Immunosuppression Therapy; In Vitro Techniques; Lymphocyte Activation; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; T-Lymphocytes | 1990 |
In vitro developmental toxicity of five direct-acting alkylating agents in rodent embryos: structure-activity patterns.
Topics: Alkylating Agents; Analysis of Variance; Animals; Brain; Dose-Response Relationship, Drug; Embryo, Mammalian; Ethyl Methanesulfonate; Ethylnitrosourea; Female; In Vitro Techniques; Maternal-Fetal Exchange; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Pregnancy; Rats; Rats, Inbred Strains | 1989 |
Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
Topics: Alkylating Agents; Animals; Carmustine; Cell Division; Cell Line; Cricetinae; Cricetulus; Female; Guanine; Kinetics; Lomustine; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mitoguazone; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Transfection | 1989 |
Inactivation of purified human O6-alkylguanine-DNA alkyltransferase by alkylating agents or alkylated DNA.
Topics: Alkylating Agents; DNA; Dose-Response Relationship, Drug; Ethylnitrosourea; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Sulfuric Acid Esters | 1986 |
Gene expression in E. coli after treatment with streptozotocin.
Topics: Alkylating Agents; Anaerobiosis; Bacterial Proteins; Escherichia coli; Gene Expression Regulation; Genes, Bacterial; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Recombinant Fusion Proteins; Streptozocin; Transcriptional Activation | 1988 |
[Effects of sodium molybdate on sister chromatid exchange in V79 cells induced by MNU and MNNG].
Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; Fibroblasts; Methylnitronitrosoguanidine; Methylnitrosourea; Molybdenum; Sister Chromatid Exchange | 1987 |
Effect of carcinogenic nitroso compounds on rat kidney proximal tubule NAD levels.
Topics: Animals; Kidney Tubules, Proximal; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Microvilli; NAD; Nitroso Compounds; Phosphates; Rats; Rats, Inbred Strains; Sodium; Streptozocin | 1988 |
Ability of various alkylating agents to induce adaptive and SOS responses: a study with lacZ fusion.
Topics: Alkylating Agents; Bacterial Proteins; beta-Galactosidase; DNA Glycosylases; DNA Ligases; DNA Repair; Dose-Response Relationship, Drug; Enzyme Induction; Escherichia coli; Ethylnitrosourea; Genes, Bacterial; Genes, Synthetic; Guanine; Lac Operon; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; N-Glycosyl Hydrolases; Polynucleotide Ligases | 1985 |
N-nitroso-N-2-fluorenylacetamide: a new direct-acting mutagen and teratogen.
Topics: 2-Acetylaminofluorene; Abnormalities, Drug-Induced; Adenosine; Amino Acids; Animals; Chemical Phenomena; Chemistry; Chick Embryo; Chromatography, High Pressure Liquid; Cytidine; DNA Damage; Glutathione; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Nitroso Compounds; Nucleosides; Salmonella typhimurium; Spectrophotometry, Infrared | 1988 |
Inhibitory effects of para-aminobenzoic acid on the formation and mutagenicity of N-nitroso compounds.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Ascorbic Acid; Biotransformation; Dimethylnitrosamine; Methylnitronitrosoguanidine; Methylnitrosourea; Methylurea Compounds; Mutagenicity Tests; Mutation; Nitrites; Nitroso Compounds; Plants | 1988 |
Multiple species of Bacillus subtilis DNA alkyltransferase involved in the adaptive response to simple alkylating agents.
Topics: Bacillus subtilis; Enzyme Induction; Kinetics; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Molecular Weight; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity | 1987 |
Cytotoxicity, mutations and SCEs induced by methylating agents are reduced in CHO cells expressing an active mammalian O6-methylguanine-DNA methyltransferase gene.
Topics: 4-Nitroquinoline-1-oxide; Alkylation; Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Guanine; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Ouabain; Sister Chromatid Exchange | 1987 |
[Effect of sodium selenite on the chromosomal aberration of V 79 cells induced in vitro by MNNG and MNU].
Topics: Animals; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Fibroblasts; Lung; Methylnitronitrosoguanidine; Methylnitrosourea; Selenic Acid; Selenium; Selenium Compounds | 1987 |
[Stomach tumors in rats induced by a single administration of N-methyl-N-nitro-N-nitrosoguanidine and N-methyl-N-nitrosourea].
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cocarcinogenesis; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Papilloma; Precancerous Conditions; Rats; Sarcoma, Experimental; Stomach Neoplasms | 1988 |
Reactions of ultimate carcinogens with cell membranes: importance of carbamoylation of phosphatidylethanolamine by the carcinogens.
Topics: Animals; Cell Membrane; Cell Transformation, Neoplastic; Chickens; Erythrocyte Membrane; Kidney; Magnetic Resonance Spectroscopy; Mass Spectrometry; Membrane Lipids; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Phosphatidylethanolamines; Rats | 1988 |
The influence of chronic N-methyl-N'-nitro-N-nitrosoguanidine pre-treatments on mutagenic response and O6-methylguanine-DNA methyltransferase activity in V79 Chinese hamster cells.
Topics: Animals; Cricetinae; Cricetulus; DNA Damage; DNA Repair; Drug Resistance; Fibroblasts; Lung; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 1988 |
Toxicity of methylating agents in isolated hepatocytes.
Topics: Animals; Cell Survival; Dimethylnitrosamine; Lipid Peroxides; Liver; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Promethazine; Rats; Rats, Inbred Strains | 1988 |
Studies of the 'adaptive' repair response in human lymphocytes and V79 cells after treatment with MNNG and MNU.
Topics: Animals; Cell Line; DNA Damage; DNA Repair; Humans; Lymphocytes; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Sister Chromatid Exchange | 1988 |
Effects of bile acids on carcinogen-exposed rat colon in organ culture and as subsequent long-term transplants.
Topics: Animals; Bile Acids and Salts; Colon; Deoxycholic Acid; Dietary Fats; DNA Replication; Feces; Female; Intestinal Mucosa; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Organ Culture Techniques; Rats; Rats, Inbred F344 | 1987 |
Two types of antimutagenic effects of gallic and tannic acids towards N-nitroso-compounds-induced mutagenicity in the Ames Salmonella assay.
Topics: Gallic Acid; Hydrogen-Ion Concentration; Hydrolyzable Tannins; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenicity Tests; Mutation; Salmonella typhimurium; Tannins | 1987 |
Inducible DNA-repair systems in yeast: competition for lesions.
Topics: DNA Damage; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Gamma Rays; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Saccharomyces cerevisiae; Ultraviolet Rays | 1987 |
Cell killing by various monofunctional alkylating agents in Chinese hamster ovary cells.
Topics: Alkylating Agents; Animals; Caffeine; Cell Cycle; Cell Line; Cell Survival; Colony-Forming Units Assay; Cricetinae; Cricetulus; Ethylnitrosourea; Female; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Ovary | 1987 |
The organic solvents acetone, ethanol and dimethylformamide potentiate the mutagenic activity of N-methyl-N'-nitro-N-nitrosoguanidine, but have no effect on the mutagenic potential of N-methyl-N-nitrosourea.
Topics: Acetone; Dimethylformamide; Drug Synergism; Ethanol; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Plants; Solvents | 1987 |
Correction of alkylation hypersensitivity of CHO-W27-1 cells by transfection with human DNA.
Topics: Alkylation; Animals; Cricetinae; Cricetulus; DNA; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Transfection | 1987 |
Different autochthonous models of colorectal cancer in the rat.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylhydrazines; Dimethylnitrosamine; Disease Models, Animal; Methylnitronitrosoguanidine; Methylnitrosourea; Rats; Rectal Neoplasms | 1986 |
Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol.
Topics: 2-Acetylaminofluorene; Animals; Benzo(a)pyrene; Chamomile; Female; Flavonoids; Indoles; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred Strains; Mutagens; Mutation; Neoplasms, Experimental; Oils, Volatile; Ornithine Decarboxylase; Plant Extracts; Plants, Medicinal; Skin; Tetradecanoylphorbol Acetate | 1986 |
Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Alkylation; Cell Cycle; Cell Line; Cell Survival; DNA; Drug Resistance; Guanine; Humans; Lymphocytes; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation | 1986 |
Protective role of thiols in carcinogen-induced DNA damage in rat liver.
Topics: Acetylcysteine; Animals; Carcinogens; Diethylnitrosamine; DNA; DNA Damage; Female; Glutathione; Liver; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Tiopronin | 1986 |
Adaptive response to alkylating agents in mammalian cells.
Topics: Adaptation, Physiological; Alkylating Agents; Animals; Cell Survival; Guanine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1986 |
Comparison of the acute toxicity of N-nitrosocimetidine with three structurally related carcinogens in the rat.
Topics: Administration, Oral; Animals; Body Weight; Cimetidine; Female; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosomethylurethane; Rats; Rats, Inbred F344; Urethane | 1986 |
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; DNA; Dose-Response Relationship, Drug; Female; Guanine; Mesocricetus; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Pregnancy | 1985 |
Stimulatory effect of potassium ions on MNU- and MNNG-induced mutagenesis in Salmonella typhimurium TA1535 and TA100.
Topics: Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenicity Tests; Potassium; Salmonella typhimurium; Sodium | 1985 |
Studies on the antimutagenic activity of ascorbic acid in vitro and in vivo.
Topics: Animals; Ascorbic Acid; Copper; Dimethylnitrosamine; Edetic Acid; Guinea Pigs; Hydrogen Peroxide; In Vitro Techniques; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation | 1985 |
Studies on the mechanisms of altered exocrine acinar cell differentiation and ductal metaplasia following nitrosamine exposure using hamster pancreatic explant organ culture.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; Mesocricetus; Metaplasia; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Organ Culture Techniques; Pancreas; Pancreatic Neoplasms; Phenotype | 1985 |
[Influence of sodium selenite on the number of sister chromatid exchanges in V 79 cells induced by N-methyl-N-nitronitrosoguanidine (MNNG) and N-methyl-N-nitrosourea (MNU)].
Topics: Animals; Cell Line; Cricetinae; In Vitro Techniques; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Selenious Acid; Selenium; Sister Chromatid Exchange | 1985 |
Dynamic changes of the chicken erythrocyte membranes induced by N-methyl-N-aryl-N-nitrosoureas and their tumorigenicity.
Topics: Animals; Carcinogens; Chickens; Erythrocyte Membrane; In Vitro Techniques; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Nitrosourea Compounds; Skin Neoplasms; Solubility | 1985 |
Skin tumours induced by local and systemic action of N-nitroso-compounds in rats.
Topics: Administration, Topical; Animals; Carcinoma, Basal Cell; Diazonium Compounds; Female; Guanidines; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Lung Neoplasms; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Nitroso Compounds; Rats; Sarcoma, Experimental; Skin Neoplasms | 1985 |
High-performance liquid chromatographic determination of 3-methylcytosine in deoxyribonucleic acid treated with carcinogenic methylating agents in vitro and in vivo.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Cytosine; Dimethylnitrosamine; DNA; Liver; Male; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Thymus Gland | 1985 |
Evidence that DNA polymerases alpha and beta participate differentially in DNA repair synthesis induced by different agents.
Topics: Animals; Bleomycin; Cell Line; Cell Membrane Permeability; Cricetinae; Cricetulus; DNA Polymerase I; DNA Polymerase II; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Female; Kinetics; Methylnitronitrosoguanidine; Methylnitrosourea; Ovary; Zinostatin | 1982 |
The roles of DNA polymerases alpha, beta, and gamma in DNA repair synthesis induced in hamster and human cells by different DNA damaging agents.
Topics: Animals; Antibiotics, Antineoplastic; Bleomycin; Cell Line; Cricetinae; Cricetulus; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; Female; Fibroblasts; Humans; Kinetics; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Ovary; Ultraviolet Rays; Zinostatin | 1982 |
Acceleration of epithelial keratinization by carcinogens in fetal rat forestomach in organ culture.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Acetoxyacetylaminofluorene; Animals; Carcinogens; Epithelium; Gastric Mucosa; Keratins; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Organ Culture Techniques; Rats; Rats, Inbred F344; Stomach; Tretinoin | 1984 |
Effect of carcinogenic N-alkyl-N-nitroso compounds on nicotinamide adenine dinucleotide metabolism.
Topics: Animals; Carcinogens; DNA; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; NAD; NAD+ Nucleosidase; Nitrosourea Compounds; Poly(ADP-ribose) Polymerases; Streptozocin; Time Factors | 1980 |
Chemical interactions with herpes simplex type 2 virus: enhancement of transformation by selected chemical carcinogens and pro-carcinogens.
Topics: Animals; Benzene; Carcinogens; Cell Transformation, Viral; Cells, Cultured; Dose-Response Relationship, Drug; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Quinacrine Mustard; Simplexvirus; Urethane | 1982 |
Effect of 3-aminobenzamide on the rate of ligation during repair of alkylated DNA in human fibroblasts.
Topics: Benzamides; Cells, Cultured; DNA Repair; DNA, Single-Stranded; Fibroblasts; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; NAD+ Nucleosidase; Poly(ADP-ribose) Polymerases; Time Factors; Ultraviolet Rays; X-Rays | 1983 |
Mutagenicity of cadmium in Salmonella typhimurium and its synergism with two nitrosamines.
Topics: Cadmium; Drug Synergism; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Nitrosamines; Salmonella typhimurium | 1984 |
Mutagenesis, by methylating and ethylating agents, in mutH, mutL, mutS, and uvrD mutants of Salmonella typhimurium LT2.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; DNA Repair; Ethyl Methanesulfonate; Genes, Bacterial; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Models, Genetic; Mutagens; Mutation; Recombination, Genetic; Salmonella typhimurium; Ultraviolet Rays | 1983 |
[Comparison of the effect of different carcinogens on the skin of rats].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Diazonium Compounds; Female; Keratoacanthoma; Male; Methylnitronitrosoguanidine; Methylnitrosourea; o-Aminoazotoluene; p-Dimethylaminoazobenzene; Papilloma; Rats; Skin Neoplasms | 1984 |
Stable intestinal phenotypic expression of gastric and small intestinal tumor cells induced by N-methyl-N'-nitro-N-nitrosoguanidine or methylnitrosourea in rats.
Topics: Adenocarcinoma; Animals; Gastric Mucosa; Hyperplasia; Intestinal Neoplasms; Intestines; Male; Metaplasia; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Phenotype; Rats; Rats, Inbred Strains; Stomach Neoplasms | 1984 |
Adaptive response in mammalian cells: crossreactivity of different pretreatments on cytotoxicity as contrasted to mutagenicity.
Topics: Acclimatization; Alkylating Agents; Animals; Cell Line; Cell Survival; Drug Resistance; Kinetics; Liver Neoplasms, Experimental; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Rats | 1984 |
N-nitrosophenacetin: its synthesis, characterization, mutagenicity, and teratogenicity.
Topics: Abnormalities, Drug-Induced; Animals; Chemical Phenomena; Chemistry; Chick Embryo; Diethylnitrosamine; Dimethylnitrosamine; Lethal Dose 50; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenicity Tests; Mutagens; Nitrosamines; Rats; Rats, Inbred Strains; Spectrophotometry; Teratogens | 1984 |
Studies on adaptation of V79 Chinese hamster cells to low doses of methylating agents.
Topics: Animals; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Replication; Kinetics; Lung; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Nitrosourea Compounds; Sister Chromatid Exchange | 1983 |
Cross-resistance studies with V79 Chinese hamster cells adapted to the mutagenic or clastogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Drug Resistance; Ethyl Methanesulfonate; Ethylnitrosourea; Lung; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Thioguanine; Ultraviolet Rays | 1983 |
Increase of nicotinamide methyltransferase and N1-methyl-nicotinamide oxidase activities in the livers of the rats administered alkylating agents.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Alkylating Agents; Animals; Chromatography, Thin Layer; Enzyme Induction; Humans; Liver; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Nicotinamide N-Methyltransferase; Rats; Rats, Inbred Strains | 1983 |
Adaptive response of Micrococcus luteus to alkylating chemicals.
Topics: Alkylating Agents; DNA Repair; DNA, Bacterial; Drug Resistance; Kinetics; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Micrococcus; Structure-Activity Relationship | 1984 |
Factors modifying 3-aminobenzamide cytotoxicity in normal and repair-deficient human fibroblasts.
Topics: Benzamides; Caffeine; Cell Cycle; Cell Division; Cell Survival; DNA Repair; Fibroblasts; Humans; Male; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Poly Adenosine Diphosphate Ribose; Time Factors | 1984 |
The protective role of thiol reducing agents in the in vitro inhibition of rat liver DNA methylase by direct acting carcinogens.
Topics: Acetoxyacetylaminofluorene; Animals; Carcinogens; Cell Nucleus; DNA (Cytosine-5-)-Methyltransferases; Kinetics; Liver; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Rats; Structure-Activity Relationship; Sulfhydryl Compounds | 1983 |
Isolation of mutants of Escherichia coli with increased resistance to alkylating agents: mutants deficient in thiols and mutants constitutive for the adaptive response.
Topics: Alkylating Agents; DNA Repair; Drug Resistance, Microbial; Escherichia coli; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Phenotype; Sulfhydryl Compounds | 1980 |
Enhancement of the mutagenicities of N-methyl-N'-nitro-N-nitrosoguanidine and N-methyl-N-nitrosourea by glucose.
Topics: Biotransformation; Dose-Response Relationship, Drug; Glucose; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Nitrosourea Compounds; Salmonella typhimurium | 1980 |
Comparison of inactivating effects of blood upon the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine and N-methyl-N-nitrosourea in Escherichia coli.
Topics: Animals; Blood; Erythrocyte Membrane; Erythrocytes; Escherichia coli; Humans; Inactivation, Metabolic; Liver; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Nitrosourea Compounds; Plasma; Rats | 1980 |
Binding of N-nitroso carcinogens in pancreatic tissue.
Topics: Animals; Binding Sites; Chromatin; DNA; Guinea Pigs; Islets of Langerhans; Methylnitronitrosoguanidine; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Organoids; Pancreatic Neoplasms; Tissue Distribution | 1981 |
Enhanced survival and reduced mutation and aberration frequencies induced in V79 chinese hamster cells pre-exposed to low levels of methylating agents.
Topics: Animals; Cell Line; Cell Survival; Chromosome Aberrations; Cricetinae; Cricetulus; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenicity Tests; Mutation; Nitrosourea Compounds | 1982 |
The response of a variety of human fibroblast cell strains to the lethal effects of alkylating agents.
Topics: Alkylating Agents; Cell Survival; DNA; Ethylnitrosourea; Fibroblasts; Humans; Methylnitronitrosoguanidine; Methylnitrosourea | 1982 |
Comparison of the carcinogenic effectiveness in mouse skin of methyl- and ethylnitrosourea, nitrosourethane and nitrosonitro-guanidine and the effect of deuterium labeling.
Topics: Administration, Topical; Alkylating Agents; Animals; Deuterium; Ethylnitrosourea; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitroso Compounds; Nitrosoguanidines; Nitrosomethylurethane; Skin Neoplasms | 1982 |
Distribution and binding of the carcinogens 1-methyl-1-nitrosourea and 1-methyl-3-nitro-1-nitrosoguanidine in the guinea pig after oral administration.
Topics: Administration, Oral; Animals; Biotransformation; Guinea Pigs; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Protein Binding; Tissue Distribution | 1982 |
Endoscopic diagnosis of chemically induced autochthonous colonic tumors in rats.
Topics: Adenocarcinoma; Animals; Carcinogens; Colon; Colonic Neoplasms; Colonoscopy; Dimethylnitrosamine; Evaluation Studies as Topic; Hyperplasia; Intestinal Polyps; Male; Methylamines; Methylnitronitrosoguanidine; Methylnitrosourea; Rats | 1981 |
Differential inhibition of rat liver DNA polymerases in vitro by direct-acting carcinogens and the protective effect of a thiol reducing agent.
Topics: Acetoxyacetylaminofluorene; Animals; Carcinogens; Dithiothreitol; In Vitro Techniques; Iodoacetamide; Liver; Methylnitronitrosoguanidine; Methylnitrosourea; Nucleic Acid Synthesis Inhibitors; Protein Binding; Rats | 1981 |
Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents.
Topics: Adolescent; Adult; Alkylating Agents; Ataxia Telangiectasia; Cell Division; Cells, Cultured; Child; DNA; DNA Repair; Female; Guanine; Humans; Infant, Newborn; Kinetics; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea | 1981 |
Morphological transformation of C3H/10T1/2 CL8 cells by alkylating agents.
Topics: Alkylating Agents; Animals; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Drug Evaluation, Preclinical; Hydrocarbons, Iodinated; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Propiolactone; Thiophenes | 1981 |
[Mammary gland tumor induction in rats by N-nitroso-N-methylurea and N-methyl-N1-nitro-N-nitrosoguanidine].
Topics: Animals; Female; Mammary Neoplasms, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Rats; Time Factors | 1980 |
Comparison of toxicity and mutagenicity of methylnitrosourea, methylnitronitrosoguanidine and ICR-191 among human lymphoblast lines.
Topics: Aminacrine; Aminoacridines; Cell Line; Dose-Response Relationship, Drug; Humans; Lymphocytes; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Nitrogen Mustard Compounds; Nitrosourea Compounds | 1980 |
Evidence for an adaptive DNA repair pathway in CHO and human skin fibroblast cell lines.
Topics: Alkylation; Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA Repair; Dose-Response Relationship, Drug; Female; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Ovary; Sister Chromatid Exchange; Skin; Ultraviolet Rays | 1980 |
Suppression of mitogen-induced blastogenesis of feline lymphocytes by in vitro incubation with carcinogenic nitrosamides.
Topics: Animals; Cats; Immunosuppressive Agents; Lymphocyte Activation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds | 1980 |
Inactivation of O6-methylguanine-DNA methyltransferase in vivo by SN2 alkylating agents.
Topics: DNA Repair; Escherichia coli; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase | 1995 |
Identification in rat stomach mucosae of a cell population characterized by a deficiency for the repair of O6-methyldeoxyguanosine from DNA.
Topics: Animals; Carcinogens; Deoxyguanosine; DNA; DNA Repair; Duodenum; Gastric Mucosa; Immunohistochemistry; Male; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Rats; Rats, Wistar | 1995 |
A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells.
Topics: Alkylating Agents; B-Lymphocytes; Cell Line; Chromosome Aberrations; Dimethylnitrosamine; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Erythroid Precursor Cells; Guanine; Humans; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea | 1995 |
The excretion of 7-methyladenine in the urine of rats exposed to carcinogenic methylating agents.
Topics: Adenine; Aflatoxin B1; Alkylating Agents; Animals; Dimethylnitrosamine; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Rats; Rats, Inbred F344 | 1994 |
A human cell line proficient in O6-methylguanine-DNA-methyltransferase and hypersensitive to alkylating agents.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Death; Cell Division; CHO Cells; Cricetinae; DNA Damage; DNA Repair; Drug Hypersensitivity; Drug Resistance; Guanine; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Rats; Tumor Cells, Cultured | 1993 |
Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.
Topics: Amino Acid Sequence; Animals; Blood; CHO Cells; Cloning, Molecular; Cricetinae; DNA; DNA Repair; Drug Resistance; HeLa Cells; Humans; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Molecular Sequence Data; Mutagens; Neoplasms; Nucleic Acid Hybridization; Phenotype; Sequence Homology, Amino Acid; Transfection | 1993 |
Use of fluorescently tagged DNA and an automated DNA sequencer for the comparison of the sequence selectivity of SN1 and SN2 alkylating agents.
Topics: Alkylating Agents; Base Sequence; Binding Sites; Dimethyl Sulfoxide; DNA; Methylnitronitrosoguanidine; Methylnitrosourea; Molecular Sequence Data; Polymerase Chain Reaction; Sequence Analysis, DNA | 1993 |
Mutational spectra induced under distinct excision repair conditions by the 3 methylating agents N-methyl-N-nitrosourea, N-methyl-N'-nitro-N-nitrosoguanidine and N-nitrosodimethylamine in postmeiotic male germ cells of Drosophila.
Topics: Alkylating Agents; Animals; Base Sequence; Dimethylnitrosamine; DNA Repair; Drosophila melanogaster; Female; Genes, Insect; Genes, Lethal; Infertility, Female; Male; Meiosis; Methylnitronitrosoguanidine; Methylnitrosourea; Molecular Sequence Data; Mutagenesis; Mutagens; Spermatozoa; Zygote | 1996 |
Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Cyclophosphamide; Diethylnitrosamine; Female; Genes, ras; Humans; Male; Methylazoxymethanol Acetate; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental | 1996 |
Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents.
Topics: Alkylating Agents; Animals; Cell Division; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Enzyme Inhibitors; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Thioguanine | 1997 |
Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting.
Topics: Alkylation; Animals; Apoptosis; DNA Repair; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mice; Mice, Knockout; O(6)-Methylguanine-DNA Methyltransferase; Stem Cells; Time Factors | 1997 |
Increased genetic stability of HeLa cells after connexin 43 gene transfection.
Topics: Antimetabolites, Antineoplastic; beta-Galactosidase; Cell Communication; Cell Survival; Cells, Cultured; Connexin 43; Glycyrrhetinic Acid; HeLa Cells; Humans; Hypoxanthine Phosphoribosyltransferase; Methylnitronitrosoguanidine; Methylnitrosourea; Microsatellite Repeats; Mutagenesis, Insertional; Mutagens; Mutation; Sequence Deletion; Thioguanine; Transfection | 1997 |
Euglena gracilis as an eukaryotic test organism for detecting mutagens and antimutagens.
Topics: 4-Aminobenzoic Acid; Aminosalicylic Acid; Animals; Antimutagenic Agents; Aspirin; Chloroplasts; Euglena gracilis; Eukaryotic Cells; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenicity Tests; Mutagens; Mutation; ortho-Aminobenzoates; Pigmentation; Salicylates; Salicylic Acid; Sodium Salicylate | 1997 |
Induction of glandular stomach cancers in Helicobacter pylori-sensitive Mongolian gerbils treated with N-methyl-N-nitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine in drinking water.
Topics: Adenocarcinoma; Administration, Oral; Animals; Carcinogens; Cocarcinogenesis; Disease Models, Animal; Disease Susceptibility; Drinking; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Stomach Neoplasms; Water | 1998 |
Critical steps in alkylation-induced aberration formation.
Topics: Alkylating Agents; Animals; Cell Cycle; Chromosome Aberrations; DNA Damage; DNA Repair; DNA Replication; Fibroblasts; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mutagens; Nucleic Acid Synthesis Inhibitors; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Sister Chromatid Exchange | 1998 |
Mismatch repair and differential sensitivity of mouse and human cells to methylating agents.
Topics: 3T3 Cells; Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Base Pair Mismatch; Chromosomes, Human, Pair 2; DNA Methylation; DNA Repair; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Transfer Techniques; Genotype; Guanine; HeLa Cells; Humans; Melanoma, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Species Specificity; Tumor Cells, Cultured | 1999 |
Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15.
Topics: Base Pair Mismatch; Base Sequence; Colonic Neoplasms; DNA Primers; DNA Repair; DNA-Binding Proteins; DNA, Complementary; G2 Phase; Guanine; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Microsatellite Repeats; Mutation; Phenotype; Transfection; Tumor Cells, Cultured | 1999 |
Inhibition of apoptosis of a PARP(-)/(-)cell line transfected with PARP DNA-binding domain mutants.
Topics: Alkylation; Annexin A5; Apoptosis; Caspase 3; Caspases; Catalytic Domain; Cell Line; Cell Survival; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Activation; Fibroblasts; Gene Deletion; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Nuclear Proteins; Peptide Fragments; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Staurosporine; Time Factors; Transfection | 1999 |
Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Alkylating Agents; Base Pair Mismatch; Carrier Proteins; Cell Line; Cell Nucleus; Cytoplasm; DNA; DNA Damage; DNA Methylation; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Gene Expression Regulation; Guanine; HeLa Cells; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Mismatch Repair Endonuclease PMS2; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Protein Binding; Proto-Oncogene Proteins; RNA Stability; RNA, Messenger | 2000 |
Uptake and binding of 1-methyl-1-nitrosourea (MNU) and 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) by the isolated guinea pig pancreas.
Topics: Animals; Carbon Radioisotopes; Carcinogens; Chemical Precipitation; Culture Techniques; DNA; DNA Methylation; Female; Guinea Pigs; Histones; Methylnitronitrosoguanidine; Methylnitrosourea; Nuclear Proteins; Pancreas; Protein Binding; Subcellular Fractions | 1980 |
Effects of weaning by surrogate mothers (ACI) on tumor development in SD rats treated with methylnitrosourea (MNU) and/or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Topics: Animals; Animals, Suckling; Carcinogens; Female; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Milk; Neoplasms, Experimental; Rats; Rats, Inbred ACI; Rats, Sprague-Dawley; Species Specificity | 2002 |
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
Topics: Adenoviridae; Alkylating Agents; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Comet Assay; Dacarbazine; DNA Glycosylases; DNA Repair; Dose-Response Relationship, Drug; Genetic Therapy; Genetic Vectors; Humans; Hydroxylamines; Immunohistochemistry; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Oligonucleotides; Sensitivity and Specificity; Sulfuric Acid Esters; Temozolomide; Time Factors | 2004 |
Detection of micronucleated cells and gene expression changes in glandular stomach of mice treated with stomach-targeted carcinogens.
Topics: Animals; Carcinogens; Cyclin-Dependent Kinase Inhibitor p21; Gastric Mucosa; Gene Expression; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Micronucleus Tests; Protein Kinases; Protein Serine-Threonine Kinases; Stomach | 2008 |
Time-series analysis of gene expression profiles induced by nitrosamides and nitrosamines elucidates modes of action underlying their genotoxicity in human colon cells.
Topics: Apoptosis; Caco-2 Cells; Carcinogens; Cell Cycle; Colon; Diethylnitrosamine; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; N-Nitrosopyrrolidine; Nitrosamines; Nitroso Compounds; Oligonucleotide Array Sequence Analysis; Time Factors | 2011 |
Mouse models of Helicobacter-induced gastric cancer: use of cocarcinogens.
Topics: Animals; Carcinogens; Cell Proliferation; Culture Media; Culture Techniques; Cytokines; Disease Models, Animal; Drug Interactions; Epithelial Cells; Female; Helicobacter pylori; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Microbial Viability; Polymerase Chain Reaction; Specimen Handling; Stomach Neoplasms; Urease | 2012 |
In vivo rat glandular stomach and colon micronucleus tests: Kinetics of micronucleated cells, apoptosis, and cell proliferation in the target tissues after a single oral administration of stomach- or colon-carcinogens.
Topics: 1,2-Dimethylhydrazine; Administration, Oral; Animals; Apoptosis; Bone Marrow; Carcinogens; Cell Division; Cell Separation; Colon; Deoxyuridine; Gastric Mucosa; Intestinal Mucosa; Ki-67 Antigen; Male; Methylnitronitrosoguanidine; Methylnitrosourea; Micronucleus Tests; Organ Specificity; Random Allocation; Rats; Time Factors | 2013 |
Biphasic reduction of histone H3 phosphorylation in response to N-nitroso compounds induced DNA damage.
Topics: Acetylation; Cell Line; Cell Line, Tumor; Chromatin; DNA Damage; Down-Regulation; HeLa Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; Methylnitronitrosoguanidine; Methylnitrosourea; Nitroso Compounds; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Transcription, Genetic; Tumor Suppressor Protein p53 | 2016 |