methylnitrosourea has been researched along with methyl methanesulfonate in 126 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 73 (57.94) | 18.7374 |
| 1990's | 28 (22.22) | 18.2507 |
| 2000's | 18 (14.29) | 29.6817 |
| 2010's | 7 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Divo, AA; Patton, CL; Penketh, PG; Sartorelli, AC; Shyam, K | 1 |
| Craig, AW; Magin, MN; Margison, GP; O'Connor, PJ | 1 |
| Frie, JV; Maitra, SC | 1 |
| Fujiwara, Y | 1 |
| Reygers, U; Thielmann, HW; Vosberg, HP | 1 |
| Frei, JV; Venitt, S | 1 |
| Sridhar, R; Walker, IG | 1 |
| Merrifield, RK; Shooter, KV | 1 |
| Banerjee, MR; Bodell, WJ | 2 |
| Smith, BJ | 1 |
| Bases, R; Elequin, F; Kadish, A; Liebeskind, D; Mendez, F; Rubinstein, A; Wittner, D | 1 |
| Carver, JP; Krepinsky, J; Rajalakshmi, S; Rao, PM; Sarma, DS | 1 |
| Chang, C; Lee, CG | 1 |
| Chaudhuri, S; Sarma, DS | 1 |
| Ellenberger, J; McGregor, D; Merker, HJ; Mohn, G | 1 |
| Lawley, PD | 1 |
| Kleihues, P; Margison, GP | 1 |
| Kendall, F; Murphy, J; Nicolini, C; Parodi, S; Ramanathan, R; Sarma, DS | 1 |
| Masek, F; Sedliaková, M | 1 |
| Fairbairn, L; Klungland, A; Margison, GP; Seeberg, E; Watson, AJ | 1 |
| Bilbin, M; Czeczot, H; Tudek, B | 1 |
| Sakai, K; Uchida, R | 1 |
| Blonsky, KS; Lee, GS; Morgan, AR; Savage, EA; Van On, DL; von Borstel, RC | 1 |
| Barrera, I; Negro, L; Schneider, B; Suter, W | 1 |
| Link, A; Tempel, K | 1 |
| Ahnström, G; Eizirik, DL; Sandler, S; Welsh, M | 1 |
| Clark, JP; Cooper, CS; Gardner, E; Harris, G; Lawley, PD; Warren, W | 1 |
| Kroese, ED; Meerman, JH; Mohn, GR; Zeilmaker, MJ | 1 |
| Bastlová, T; Dusinská, M; Gábelová, A; Slamenová, D | 1 |
| Domshlak, MG; Sanotskiĭ, IV; Serebrianyĭ, AM | 1 |
| Faustman, EM; Gage, D; Kirby, Z; Varnum, M | 1 |
| Aquilina, G; Bignami, M; Dogliotti, E; Moscufo, N; Zijno, A | 1 |
| Hakura, A; Kawazoe, Y; Kohda, K | 1 |
| Dexter, TM; Jelinek, J; Kleibl, K; Margison, GP | 1 |
| Kawazoe, Y; Nakabeppu, Y; Sakumi, K; Sekiguchi, M; Takahashi, K | 1 |
| Brent, TP | 1 |
| Hofecker, G; Niedermüller, H; Skalicky, M | 1 |
| Sakagishi, Y; Sakamoto, Y; Sonoda, M; Uyemura, K; Yano, K | 1 |
| Berger, ML; Reitman, FA; Shertzer, HG | 1 |
| Brennand, J; Margison, GP; Ockey, CH; White, GR | 1 |
| Burkhardt, MR; Edler, L; Jung, EG; Thielmann, HW | 1 |
| Goth-Goldstein, R; Hughes, M | 1 |
| Kim, S; Paik, WK; Park, KS; Trézl, L | 1 |
| Kaina, B | 2 |
| Daniel, FB; Haas, DL; Lin, EL; Mattox, JK; Pereira, MA; Schenck, KM | 1 |
| D'Ambrosio, SM; Wani, AA | 1 |
| Herrera, RJ; Luckett, DC; Mukherjee, AB | 1 |
| Edler, L; Friemel, S; Thielmann, HW | 1 |
| Laval, F | 1 |
| Ireland, CM; Stewart, BW | 1 |
| Denman, AM; Doré, CJ; Palmer, RG; Smith-Burchnell, CA | 1 |
| Day, RS; DiPaolo, JA; Doniger, J | 1 |
| Abbondandolo, A; Frosina, G | 1 |
| Boffa, LC; Bolognesi, C | 1 |
| Rajalakshmi, S; Rao, RM; Sarma, DS | 1 |
| Jirakulsomchok, S; Yielding, KL | 1 |
| Fukamachi, H | 1 |
| Sidik, K; Smerdon, MJ | 1 |
| Cleaver, JE; Morgan, WF | 1 |
| DiMaria, P; Kim, S; Lotlikar, PD; Magee, PN; Paik, WK | 1 |
| Grisham, JW; Smith, GJ | 1 |
| Behlau, I; Rein, RP; Shanabruch, WG; Walker, GC | 1 |
| Dusenbery, RL; McCormick, SC; Smith, PD | 1 |
| Schrotel, KR; Skare, JA | 1 |
| Natarajan, AT; Simons, JW; van Zeeland, AA; Vogel, EW | 1 |
| Dornish, JM; Markussen, G; Smith-Kielland, I | 1 |
| Booth, JA; Ockey, CH; Saffhill, R | 1 |
| Laval, F; Laval, J | 1 |
| Beranek, DT; Heflich, RH; Morris, SM | 1 |
| Hicks, RM | 1 |
| Fujimura, S; Ohkubo, M; Sakiyama, S | 1 |
| Hicks, RM; Severs, NJ; Tudor, RJ | 1 |
| Boorstein, RJ; Pardee, AB | 1 |
| Asbery, LJ; Chandler, PM; Harris, G; Jones, MG; Lawley, PD | 1 |
| Lieberman, MW; Moranelli, F | 1 |
| Davnichenko, LS; Rapoport, IA; Vasil'eva, SV | 1 |
| Niedermüller, H | 1 |
| Becker, Y; Shiloh, Y | 1 |
| Balwierz, PS; Molinary, SV; Oshiro, Y | 1 |
| Owens, JG; Sega, GA; Wolfe, KW | 1 |
| Jenssen, D; Ramel, C | 1 |
| Bronzetti, G; Fiorio, R | 1 |
| Faustman, EM; Seeley, MR | 3 |
| Cowling, GJ; Dexter, TM; Fairbairn, LJ; Margison, GP; Rafferty, JA; Reipert, B | 1 |
| Hamilton, JW; McCaffrey, J | 1 |
| Itzhaki, RF; Neary, D; Tobi, SE | 1 |
| Calsou, P; Fournié, GJ; Gosset, I; Hennebelle, I; Provot, C; Salles, B | 1 |
| Cunningham, JM; Delaney, CA; Di Matteo, M; Dunger, A; Green, IC; Green, MH | 1 |
| Baan, RA; Bergmans, A; van Delft, JH | 1 |
| Brooks, T; Carr, GJ; Douglas, GR; Gorelick, NJ; Liegibel, UM; Lockhart, AC; Margolin, BH; Piegorsch, WW; Suzuki, T; Thybaud, V; van Delft, JH | 1 |
| Angelis, KJ; Babůrek, I; Levy, A; Stibůrková, B | 1 |
| Mine, Y; Miyamae, Y; Ohara, K; Sasaki, YF; Zaizen, K | 1 |
| Petras, ML; Vrzoc, M | 1 |
| Dobrzańska, M; Kraszewska, E; Tudek, B | 1 |
| Gichner, T; Plewa, MJ; Ptácek, O; Stavreva, DA | 1 |
| Horton, JK; Hou, E; Prasad, R; Wilson, SH | 1 |
| Kusuoka, O; Masutani, M; Nakagama, H; Nakamoto, K; Nozaki, T; Sugimura, T; Suzuki, H; Tsutsumi, M | 1 |
| Arceo, C; Olvera, O; Zimmering, S | 1 |
| Elsner, M; Guldbakke, B; Lenzen, S; Munday, R; Tiedge, M | 1 |
| Harbach, PR; Swenson, DH; Trzos, RJ | 1 |
| Brennand, J; Fox, M | 1 |
| Ayllón, F; Garcia-Vazquez, E | 1 |
| Angelis, KJ; Chen, I; Menke, M; Schubert, I | 1 |
| Dobrovolsky, VN; Heflich, RH; McGarrity, LJ; Morris, SM | 1 |
| Fatur, T; Filipic, M; Lah, TT | 1 |
| Caldwell, D; Kelley, MR; Rinne, M | 1 |
| Bartels, MJ; Gollapudi, BB; Pottenger, LH; Zhang, F | 1 |
| Dúhová, V; Farkassová, A; Kamasová, S; Kogan, G; Miadoková, E; Rauko, P; Svidová, S; Vlcek, D; Vlcková, V | 1 |
| Lutz, RW; Lutz, WK; Stopper, H; Tiedge, O | 1 |
| Kobayashi, H; Sato, I; Suzuki, T; Tsuda, S | 1 |
| Glaab, WE; Skopek, TR; Vlasakova, K | 1 |
| Doak, SH; Jenkins, GJ; Johnson, GE; Parry, EM; Parry, JM; Quick, E | 1 |
| Hidaka, M; Komori, K; Lim, TH; Nakatsu, Y; Sanada, M; Sekiguchi, M; Takagi, Y; Tsuzuki, T | 1 |
| Bronson, RT; Calvo, JA; Green, SL; Meira, LB; Moroski-Erkul, CA; Samson, LD; Shah, D | 1 |
| Bartels, MJ; Bhaskar Gollapudi, B; Fontaine, DD; McFadden, LG; Pottenger, LH; Schisler, MR; Zhang, F | 1 |
| Donovan, P; Smith, G | 1 |
| Guérard, M; Tang, L; Zeller, A | 1 |
| Bausinger, J; Duong, G; Linsenmeyer, R; Speit, G | 1 |
| Abraham, L; Bodger, OG; Dearfield, KL; Gollapudi, BB; Heflich, RH; Hixon, JG; Johnson, GE; Lovell, DP; MacGregor, JT; Pottenger, LH; Soeteman-Hernández, LG; Tanir, JY; Thompson, CM; Thybaud, V; van Benthem, J; White, PA; Zeiger, E | 1 |
| Chocian, K; Clatworthy, M; Doak, S; Doherty, AT; Jenkins, G; Molloy, J; O'Donovan, M; Wilson, A | 1 |
| Bartels, MJ; Gollapudi, BB; Ji, Z; LeBaron, MJ; Pottenger, LH; Schisler, MR; Zhang, F | 1 |
| Cruces, MP; Pimentel, E | 1 |
3 review(s) available for methylnitrosourea and methyl methanesulfonate
| Article | Year |
|---|---|
"Excision" of bases from DNA methylated by carcinogens in vivo and its possible significance in mutagenesis and carcinogenesis.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Carcinogens; Dimethylnitrosamine; DNA; Escherichia coli; Liver; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mutagens; Organ Specificity; Rats; Species Specificity | 1975 |
The current evidence for an adaptive response to alkylating agents in mammalian cells, with special reference to experiments with in vitro cell cultures.
Topics: Alkylating Agents; Animals; Bacterial Proteins; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Glycosylases; DNA Ligases; DNA Repair; Drug Resistance; Escherichia coli; Guanine; Haplorhini; Kidney; Liver; Mammals; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mice; Mutation; N-Glycosyl Hydrolases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Placenta; Rats | 1985 |
Predictive and mechanistic evaluation to toxic responses in mammalian cell culture systems.
Topics: Alkylating Agents; Animals; Cell Division; Cell Line; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; Culture Techniques; Cytological Techniques; Dimethylnitrosamine; Flow Cytometry; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Toxicology | 1984 |
123 other study(ies) available for methylnitrosourea and methyl methanesulfonate
| Article | Year |
|---|---|
Methylating agents as trypanocides.
Topics: Alkylating Agents; Animals; Methylation; Mice; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis | 1990 |
The effect of hormone induced stress upon the extent of alkylation of rat liver nucleic acids by N-methyl-N-nitrosourea.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA; Drug Synergism; Epinephrine; Hydrocortisone; Liver; Male; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Nitrosourea Compounds; Nucleic Acids; Rats; RNA, Ribosomal; Stress, Physiological | 1975 |
Organ-specific effects of DNA methylation by alkylating agents in the inbred Swiss mouse.
Topics: Alkylating Agents; Animals; Bone Marrow; DNA; Female; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds; Organ Specificity; Spleen; Thymus Gland; Time Factors | 1975 |
Postreplication repair of alkylation damage to DNA of mammalian cells in culture.
Topics: Alkylation; Bromodeoxyuridine; Caffeine; DNA; DNA Repair; DNA Replication; Dose-Response Relationship, Drug; Drug Synergism; L Cells; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Molecular Weight; Nitrosourea Compounds; Photolysis; Thymidine; Ultraviolet Rays | 1975 |
Carcinogen-induced DNA repair in nucleotide-permeable Escherichia coli cells. Induction of DNA repair by the carcinogens methyl and ethyl nitrosourea and methyl methanesulfonate.
Topics: Carcinogens; DNA Nucleotidyltransferases; DNA Repair; DNA Replication; Escherichia coli; Ethylnitrosourea; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mitomycins; Nitrosourea Compounds; Nucleotides; Permeability; Radiation Effects; Ultraviolet Rays | 1975 |
Chromosome damage in the bone marrow of mice treated with the methylating agents methyl methanesulphonate and N-methyl-N-nitrosourea in the presence or absence of caffeine, and its relationship with thymoma induction.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Caffeine; Chromosome Aberrations; Chromosome Deletion; Chromosomes; Drug Synergism; Female; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mutagens; Nitrosourea Compounds; Specific Pathogen-Free Organisms; Thymoma; Thymus Neoplasms | 1975 |
The formation and repair of single-strand breaks in DNA of cultured mammalian cells treated with UV-light, methylating agents or 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Cell Line; DNA Repair; DNA, Single-Stranded; HeLa Cells; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Molecular Weight; Nitroquinolines; Nitrosourea Compounds; Radiation Effects; Ultraviolet Rays | 1976 |
An assay for phosphotriester formation in the reaction of alkylating agents with deoxyribosenucleic acid in vitro and in vivo.
Topics: Animals; Coliphages; DNA, Viral; Ethyl Methanesulfonate; Ethylnitrosourea; Liver; Mathematics; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mice; Molecular Weight; Nitrosourea Compounds; Sulfuric Acids | 1976 |
Reduced DNA repair in mouse satellite DNA after treatment with methylmethanesulfonate, and N-methyl-N-nitrosourea.
Topics: Animals; DNA; DNA Repair; DNA Replication; DNA, Satellite; Female; Mammary Glands, Animal; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Inbred BALB C; Nitrosourea Compounds; Pregnancy | 1976 |
Alkylation of cytosine and 5-hydroxymethyl-cytosine by methyl methanesulphonate and N-methyl-N-nitrosourea: its relevance to mutagenesis.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Paper; Cytosine; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Nitrosourea Compounds | 1977 |
The influence of chromatin structure on the distribution of DNA repair synthesis studied by nuclease digestion.
Topics: Animals; Chromatin; DNA Repair; Female; In Vitro Techniques; Kinetics; Mammary Glands, Animal; Methyl Methanesulfonate; Methylnitrosourea; Mice; Micrococcal Nuclease; Pregnancy | 1979 |
Mutagen-induced disturbances in the DNA of human lymphocytes detected by antinucleoside antibodies.
Topics: Alkylating Agents; Antibodies; Cell Survival; DNA; DNA Repair; Dose-Response Relationship, Drug; HeLa Cells; Humans; In Vitro Techniques; Lymphocytes; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Nucleosides | 1979 |
Detection by nuclear magnetic resonance of methylation sites on rat liver DNA utilizing magnetically labelled N-methyl-N-nitrosourea and methyl methane sulfonate.
Topics: Animals; DNA; Liver; Magnetic Resonance Spectroscopy; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Nitrosourea Compounds; Rats | 1979 |
Direct study of alkylating agent--RNA interaction by 13C nuclear magnetic resonance spectroscopy.
Topics: Alkylating Agents; Binding Sites; Carcinogens; DNA; Magnetic Resonance Spectroscopy; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Structure-Activity Relationship; Sulfuric Acid Esters | 1978 |
Repair of DNA damage induced by methylating agents in human uterine cervical cells with or without cancer precursor lesions.
Topics: Alkylating Agents; Cell Line; Centrifugation, Density Gradient; Cervix Uteri; DNA; DNA Repair; DNA, Neoplasm; Female; Fibroblasts; Humans; Methyl Methanesulfonate; Methylnitrosourea; Precancerous Conditions; Uterine Cervical Neoplasms | 1977 |
Mutagenicity studies in microorganisms in vitro, with extracts of mammalian organs, and with the host-mediated-assay.
Topics: DNA Repair; Drug Interactions; Escherichia coli; Kupffer Cells; Liver; Methods; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Nitrosomethylurethane; Quinones | 1975 |
Exhaustion and recovery of repair excision of O6-methylguanine from rat liver DNA.
Topics: Animals; Carcinogens; DNA; DNA Repair; Female; Guanine; Liver; Methyl Methanesulfonate; Methylnitrosourea; Nitrosourea Compounds; Radiation Effects; Rats; Time Factors; X-Rays | 1976 |
Physicochemical alterations in the conformation of rat liver chromatin induced by carcinogens in vivo.
Topics: Animals; Carcinogens; Chromatin; Circular Dichroism; Dimethylnitrosamine; DNA; DNA Repair; Ethidium; Liver; Male; Methyl Methanesulfonate; Methylnitrosourea; Nucleic Acid Conformation; Proteins; Rats; RNA; Time Factors | 1976 |
Inducible stable DNA replication in Escherichia coli uvr+ and uvr- cells, treated with genotoxic chemicals.
Topics: 4-Nitroquinoline-1-oxide; 4-Quinolones; Acrylates; Anti-Infective Agents; Chloramphenicol; DNA Replication; Escherichia coli; Furans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mitomycin; Mutagens; Nalidixic Acid; Nitro Compounds; Nitrofurans | 1992 |
Expression of the E.coli 3-methyladenine DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents.
Topics: Alkylating Agents; Animals; Base Sequence; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA Glycosylases; DNA Repair; DNA, Single-Stranded; Drug Resistance; Escherichia coli; Genes, Bacterial; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Molecular Sequence Data; Mutagens; N-Glycosyl Hydrolases; Plasmids; Transfection | 1992 |
Induction of aberrant crypts in the colons of rats by alkylating agents.
Topics: 1,2-Dimethylhydrazine; Aging; Alkylating Agents; Animals; Carcinogens; Colonic Neoplasms; Dimethylhydrazines; Female; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Precancerous Conditions; Rats; Rats, Wistar | 1992 |
Comparative effects of potassium dichromate on the mutagenicity of some nitrohydrocarbons and methylating agents.
Topics: Drug Interactions; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Nitroparaffins; Potassium Dichromate; Propane; Pyrenes | 1992 |
Base alterations in yeast induced by alkylating agents with differing Swain-Scott substrate constants.
Topics: Alkylating Agents; Base Sequence; DNA Mutational Analysis; DNA, Fungal; Ethyl Methanesulfonate; Ethylnitrosourea; Gene Amplification; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Saccharomyces cerevisiae | 1992 |
Resistance to Pseudomonas toxin A: a sensitive marker to screen for mutagenic substances using V79 cells.
Topics: ADP Ribose Transferases; Aflatoxin B1; Animals; Bacterial Toxins; Biomarkers; Cell Line; Cricetinae; Drug Resistance; Exotoxins; Hypoxanthine Phosphoribosyltransferase; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutation; Pseudomonas aeruginosa Exotoxin A; Tetradecanoylphorbol Acetate; Ultraviolet Rays; Virulence Factors | 1992 |
Inhibition of O6-alkylguanine-DNA alkyltransferase and DNase I activities in vitro by some alkylating substances and antineoplastic agents.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Bisbenzimidazole; Bleomycin; Brain; Chick Embryo; Deoxyribonucleases; DNA Repair; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Doxorubicin; Ethidium; Ethyl Methanesulfonate; Ethylnitrosourea; Hot Temperature; In Vitro Techniques; Liver; Methyl Methanesulfonate; Methylnitrosourea; Methyltransferases; Novobiocin; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity; Suramin; X-Rays | 1991 |
Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells.
Topics: Adenine; Alkylating Agents; Animals; Cytochrome b Group; DNA; Dose-Response Relationship, Drug; Glucagon; Glucose; Guanine; Immunoblotting; Insulin; Islets of Langerhans; Male; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mitochondria; RNA, Messenger; Streptozocin | 1991 |
Chemical induction of thymomas in AKR mice: interaction of chemical carcinogens and endogenous murine leukemia viruses. Comparison of N-methyl-N-nitrosourea and methyl methanesulphonate.
Topics: Animals; DNA, Neoplasm; Gene Expression Regulation; Gene Rearrangement; Genes, ras; Leukemia Virus, Murine; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Inbred AKR; Mink Cell Focus-Inducing Viruses; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; Proviruses; Thymoma; Thymus Neoplasms; Transcription, Genetic | 1990 |
Preventive action of thioethers towards in vitro DNA binding and mutagenesis in E. coli K12 by alkylating agents.
Topics: Alkylating Agents; Benzoates; DNA; Escherichia coli; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Sulfides | 1990 |
Differences between survival, mutagenicity and DNA replication in MMS- and MNU-treated V79 hamster cells.
Topics: Animals; Cell Line; Cell Survival; Chromatography, Liquid; Cricetinae; Cricetulus; DNA; DNA Repair; DNA Replication; DNA, Single-Stranded; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutation | 1990 |
[Study of the possibilities of using a short-term test system in vitro for detection of potential mutagens (carcinogens)].
Topics: Animals; Aziridines; Carcinogenicity Tests; Carcinogens; Cattle; DNA; Ethyl Methanesulfonate; Luminescent Measurements; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutagens; Thiotepa; Time Factors | 1989 |
In vitro developmental toxicity of five direct-acting alkylating agents in rodent embryos: structure-activity patterns.
Topics: Alkylating Agents; Analysis of Variance; Animals; Brain; Dose-Response Relationship, Drug; Embryo, Mammalian; Ethyl Methanesulfonate; Ethylnitrosourea; Female; In Vitro Techniques; Maternal-Fetal Exchange; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Pregnancy; Rats; Rats, Inbred Strains | 1989 |
Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO cells.
Topics: Animals; Cell Line; Cell Survival; Clone Cells; Cricetinae; Cricetulus; DNA Damage; Drug Resistance; Female; Methyl Methanesulfonate; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Thioguanine | 1989 |
Inhibitory effect of heavy water on mutability of chemically injured Escherichia coli cells.
Topics: 4-Nitroquinoline-1-oxide; Deuterium; Deuterium Oxide; Escherichia coli; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutagens; Mutation; Nitroquinolines; Water | 1987 |
Transfection of murine multi-potent haemopoietic stem cells with an E. coli DNA alkyltransferase gene confers resistance to the toxic effects of alkylating agents.
Topics: Alkyl and Aryl Transferases; Alkylating Agents; Animals; Deoxyribonuclease BamHI; Deoxyribonuclease EcoRI; DNA Restriction Enzymes; Drug Resistance; Escherichia coli; Fluorometry; Hematopoietic Stem Cells; Mechlorethamine; Methyl Methanesulfonate; Methylnitrosourea; Mice; Nitrogen Mustard Compounds; Nitrosourea Compounds; Plasmids; Taurine; Transfection; Transferases | 1988 |
Activation of Ada protein as a transcriptional regulator by direct alkylation with methylating agents.
Topics: Alkylation; Animals; Bacterial Proteins; Cattle; DNA; Escherichia coli; Hydrocarbons, Iodinated; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Promoter Regions, Genetic; Transcription Factors; Transcription, Genetic | 1988 |
Inactivation of purified human O6-alkylguanine-DNA alkyltransferase by alkylating agents or alkylated DNA.
Topics: Alkylating Agents; DNA; Dose-Response Relationship, Drug; Ethylnitrosourea; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Sulfuric Acid Esters | 1986 |
Changes of DNA repair mechanisms during the aging of the rat.
Topics: 4-Nitroquinoline-1-oxide; Aging; Animals; Biomechanical Phenomena; DNA; DNA Repair; DNA, Single-Stranded; Drug Resistance; Endonucleases; Kinetics; Male; Methyl Methanesulfonate; Methylnitrosourea; Rats; Rats, Inbred Strains | 1985 |
Reactions of ultimate carcinogens with cell membranes: importance of carbamoylation of phosphatidylethanolamine by the carcinogens.
Topics: Animals; Cell Membrane; Cell Transformation, Neoplastic; Chickens; Erythrocyte Membrane; Kidney; Magnetic Resonance Spectroscopy; Mass Spectrometry; Membrane Lipids; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Phosphatidylethanolamines; Rats | 1988 |
Toxicity of methylating agents in isolated hepatocytes.
Topics: Animals; Cell Survival; Dimethylnitrosamine; Lipid Peroxides; Liver; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Promethazine; Rats; Rats, Inbred Strains | 1988 |
Chinese hamster cells harbouring the Escherichia coli O6-alkylguanine alkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents.
Topics: Alkylating Agents; Animals; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Escherichia coli; Guanine; Methyl Methanesulfonate; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange | 1986 |
DNA repair synthesis in fibroblast strains from patients with actinic keratosis, squamous cell carcinoma, basal cell carcinoma, or malignant melanoma after treatment with ultraviolet light, N-acetoxy-2-acetyl-aminofluorene, methyl methanesulfonate, and N-
Topics: Acetoxyacetylaminofluorene; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cells, Cultured; DNA Repair; DNA, Neoplasm; Fibroblasts; Humans; Keratosis; Melanoma; Methyl Methanesulfonate; Methylnitrosourea; Skin Neoplasms; Ultraviolet Rays | 1987 |
Cell killing by various monofunctional alkylating agents in Chinese hamster ovary cells.
Topics: Alkylating Agents; Animals; Caffeine; Cell Cycle; Cell Line; Cell Survival; Colony-Forming Units Assay; Cricetinae; Cricetulus; Ethylnitrosourea; Female; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Ovary | 1987 |
Studies on in vitro S-methylation of naturally occurring thiol compounds with N-methyl-N-nitrosourea and methyl methanesulfonate.
Topics: Amino Acids; Glutathione; Kinetics; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Oxidation-Reduction | 1987 |
Correction of alkylation hypersensitivity of CHO-W27-1 cells by transfection with human DNA.
Topics: Alkylation; Animals; Cricetinae; Cricetulus; DNA; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Transfection | 1987 |
Genotoxic properties of haloacetonitriles: drinking water by-products of chlorine disinfection.
Topics: Acetonitriles; Alkylation; Animals; Bromine; Cell Survival; Cells, Cultured; Chlorine; Disinfection; DNA; Humans; Lymphocytes; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mutagens; Pyridines; Skin Neoplasms; Sterilization; Sulfuric Acid Esters; Water Pollutants; Water Pollutants, Chemical; Water Supply | 1986 |
Specific DNA alkylation damage and its repair in carcinogen-treated rat liver and brain.
Topics: Adenine; Alkylating Agents; Animals; Brain; Carcinogens; DNA; DNA Repair; Guanine; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Methyl Methanesulfonate; Methylnitrosourea; Rats; Rats, Inbred Strains | 1986 |
Spontaneous and induced sister-chromatid exchanges in cultured mosquito cells.
Topics: Aedes; Animals; Bromodeoxyuridine; Cell Line; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Sister Chromatid Exchange; Species Specificity | 1986 |
Xeroderma pigmentosum patients from Germany: repair capacity of 45 XP fibroblast strains of the Mannheim XP Collection as measured by colony-forming ability and unscheduled DNA synthesis following treatment with methyl methanesulfonate and N-methyl-N-nitr
Topics: Alkylation; Carcinogens; Cell Cycle; Colony-Forming Units Assay; DNA; DNA Repair; Fibroblasts; Humans; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Xeroderma Pigmentosum | 1986 |
Adaptive response to alkylating agents in mammalian cells.
Topics: Adaptation, Physiological; Alkylating Agents; Animals; Cell Survival; Guanine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1986 |
DNA-mediated gene transfer as an indicator of DNA damage and its repair by recipient cells.
Topics: Animals; Cytarabine; Dideoxynucleosides; DNA Damage; DNA Repair; L Cells; Methyl Methanesulfonate; Methylnitrosourea; Mice; Thymidine; Thymidine Kinase; Transfection | 1987 |
Sensitivity of lymphocytes from patients with systemic lupus erythematosus to the induction of sister chromatid exchanges by alkylating agents and bromodeoxyuridine.
Topics: Alkylating Agents; Bromodeoxyuridine; Chlorambucil; Humans; In Vitro Techniques; Lupus Erythematosus, Systemic; Lymphocytes; Methyl Methanesulfonate; Methylnitrosourea; Sister Chromatid Exchange | 1987 |
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; DNA; Dose-Response Relationship, Drug; Female; Guanine; Mesocricetus; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Pregnancy | 1985 |
Nuclear proteins damage by alkylating agents with different degrees of carcinogenicity.
Topics: Alkylating Agents; Alkylation; Animals; Carcinogens; Cells, Cultured; Cricetinae; Cricetulus; DNA; Liver; Male; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Microsomes, Liver; Nucleoproteins; Rats; Rats, Inbred Strains | 1985 |
Carcinogen-DNA interaction: differential effects of distamycin-a and spermine on the formation of 7-methylguanine in DNA by N-methyl-N-nitrosourea, methylmethanesulfonate, and dimethylsulfate.
Topics: Animals; Carcinogens; Distamycins; DNA; Drug Interactions; Guanine; Liver; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Pyrroles; Rats; Spermine; Sulfuric Acid Esters | 1980 |
DNA damage and repair in mouse embryos following treatment transplacentally with methylnitrosourea and methylmethanesulfonate.
Topics: Animals; DNA; DNA Repair; Embryo, Mammalian; Female; Liver; Methyl Methanesulfonate; Methylnitrosourea; Mice; Nitrosourea Compounds; Pregnancy; Pregnancy, Animal; Teratogens; X-Rays | 1984 |
Acceleration of epithelial keratinization by carcinogens in fetal rat forestomach in organ culture.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Acetoxyacetylaminofluorene; Animals; Carcinogens; Epithelium; Gastric Mucosa; Keratins; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Organ Culture Techniques; Rats; Rats, Inbred F344; Stomach; Tretinoin | 1984 |
Nuclease sensitivity of repair-incorporated nucleotides in chromatin and nucleosome rearrangement in human cells damaged by methyl methanesulfonate and methylnitrosourea.
Topics: Cell Line; Chromatin; Deoxyribonuclease I; DNA Repair; DNA Replication; Endodeoxyribonucleases; Fibroblasts; Humans; Kinetics; Methyl Methanesulfonate; Methylnitrosourea; Micrococcal Nuclease; Nitrosourea Compounds; Nucleosomes | 1984 |
Effect of 3-aminobenzamide on the rate of ligation during repair of alkylated DNA in human fibroblasts.
Topics: Benzamides; Cells, Cultured; DNA Repair; DNA, Single-Stranded; Fibroblasts; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; NAD+ Nucleosidase; Poly(ADP-ribose) Polymerases; Time Factors; Ultraviolet Rays; X-Rays | 1983 |
Alkylation of protein by methyl methanesulfonate and 1-methyl-1-nitrosourea in vitro.
Topics: Alkylating Agents; Amino Acids; Chymotrypsin; Cytochrome c Group; Histone-Lysine N-Methyltransferase; Hydrogen-Ion Concentration; In Vitro Techniques; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Nitrosourea Compounds; Peptides; Protein Methyltransferases; Proteins | 1984 |
Mutagenesis, by methylating and ethylating agents, in mutH, mutL, mutS, and uvrD mutants of Salmonella typhimurium LT2.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; DNA Repair; Ethyl Methanesulfonate; Genes, Bacterial; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Models, Genetic; Mutagens; Mutation; Recombination, Genetic; Salmonella typhimurium; Ultraviolet Rays | 1983 |
Drosophila mutations at the mei-9 and mus(2)201 loci which block excision of thymine dimers also block induction of unscheduled DNA synthesis by methyl methanesulfonate, ethyl methanesulfonate, N-methyl-N-nitrosourea, UV light and X-rays.
Topics: Animals; DNA Replication; Drosophila melanogaster; Embryo, Nonmammalian; Ethyl Methanesulfonate; Methyl Methanesulfonate; Methylnitrosourea; Mutation; Nitrosourea Compounds; Ultraviolet Rays; X-Rays | 1983 |
Alkaline elution of rat testicular DNA: detection of DNA strand breaks after in vivo treatment with chemical mutagens.
Topics: Animals; Dimethyl Sulfoxide; DNA, Single-Stranded; Edetic Acid; Ethyl Methanesulfonate; Ethylnitrosourea; Hydrogen-Ion Concentration; Male; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Phenols; Polyethylene Glycols; Rats; Testis; Time Factors | 1984 |
Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells. A correlation with different ethylation products in DNA.
Topics: Alkylating Agents; Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Crossing Over, Genetic; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Methyl Methanesulfonate; Methylnitrosourea; Mutation; Sister Chromatid Exchange; Sulfuric Acid Esters | 1984 |
Inhibition of protein A24 lyase by nitrosoureas.
Topics: Animals; Carcinoma, Ehrlich Tumor; Carmustine; Cyanates; Ethyl Methanesulfonate; Ethylnitrosourea; Histones; Isocyanates; Lyases; Methyl Methanesulfonate; Methylnitrosourea; Nitrosourea Compounds; Ubiquitins | 1984 |
The effect of cell proliferation, bromodeoxyuridine concentration, and deoxynucleoside triphosphate pools on sister chromatid exchange induction.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cell Line; Cricetinae; Cricetulus; Deoxyribonucleotides; Female; Fibroblasts; Methyl Methanesulfonate; Methylnitrosourea; Ovary; Sister Chromatid Exchange | 1984 |
Adaptive response in mammalian cells: crossreactivity of different pretreatments on cytotoxicity as contrasted to mutagenicity.
Topics: Acclimatization; Alkylating Agents; Animals; Cell Line; Cell Survival; Drug Resistance; Kinetics; Liver Neoplasms, Experimental; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Rats | 1984 |
The relationship between sister-chromatid exchange induction and the formation of specific methylated DNA adducts in Chinese hamster ovary cells.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Crossing Over, Genetic; DNA; Female; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Ovary; Sister Chromatid Exchange | 1983 |
Multi-stage tumour development in the urinary bladder.
Topics: Adult; Age Factors; Animals; Cyclophosphamide; Humans; Methyl Methanesulfonate; Methylnitrosourea; Middle Aged; Ornithine Decarboxylase; Risk; Schistosomiasis; Urinary Bladder Calculi; Urinary Bladder Neoplasms | 1983 |
Cross-resistance studies with V79 Chinese hamster cells adapted to the mutagenic or clastogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Drug Resistance; Ethyl Methanesulfonate; Ethylnitrosourea; Lung; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Thioguanine; Ultraviolet Rays | 1983 |
Increase of nicotinamide methyltransferase and N1-methyl-nicotinamide oxidase activities in the livers of the rats administered alkylating agents.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Alkylating Agents; Animals; Chromatography, Thin Layer; Enzyme Induction; Humans; Liver; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Nicotinamide N-Methyltransferase; Rats; Rats, Inbred Strains | 1983 |
The "promoting" activity of methyl methanesulphonate in rat bladder carcinogenesis.
Topics: Animals; Carcinoma, Transitional Cell; Cocarcinogenesis; Drug Synergism; Female; Hyperplasia; Methyl Methanesulfonate; Methylnitrosourea; Rats; Rats, Inbred F344; Urinary Bladder; Urinary Bladder Neoplasms | 1984 |
Factors modifying 3-aminobenzamide cytotoxicity in normal and repair-deficient human fibroblasts.
Topics: Benzamides; Caffeine; Cell Cycle; Cell Division; Cell Survival; DNA Repair; Fibroblasts; Humans; Male; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Poly Adenosine Diphosphate Ribose; Time Factors | 1984 |
Autoimmune haemolytic disease in mice after exposure to a methylating carcinogen.
Topics: Anemia, Hemolytic, Autoimmune; Animals; DNA; Dose-Response Relationship, Drug; Guanine; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds; Species Specificity; Spleen; Thymoma; Thymus Neoplasms | 1983 |
Recognition of chemical carcinogen-modified DNA by a DNA-binding protein.
Topics: Acetoxyacetylaminofluorene; Carcinogens; Carrier Proteins; Chromatography, Affinity; Chromatography, DEAE-Cellulose; DNA; DNA Repair; DNA-Binding Proteins; DNA, Viral; Female; Genes, Viral; Humans; Methyl Methanesulfonate; Methylnitrosourea; Micropore Filters; Placenta; Pregnancy; Protein Binding; Substrate Specificity; T-Phages | 1980 |
[Para-aminobenzoic acid intensification of DNA repair processes in Escherichia coli K-12].
Topics: 4-Aminobenzoic Acid; Aminobenzoates; DNA Repair; DNA, Bacterial; Drug Interactions; Escherichia coli; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Stimulation, Chemical | 1982 |
Age dependency of DNA repair in rats after DNA damage by carcinogens.
Topics: Aging; Animals; Carcinogens; Dimethylnitrosamine; DNA; DNA Repair; Male; Methyl Methanesulfonate; Methylnitrosourea; Rats; Rats, Inbred Strains; Thymidine; Time Factors; Tritium | 1982 |
Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents.
Topics: Adolescent; Adult; Alkylating Agents; Ataxia Telangiectasia; Cell Division; Cells, Cultured; Child; DNA; DNA Repair; Female; Guanine; Humans; Infant, Newborn; Kinetics; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea | 1981 |
Morphological transformation of C3H/10T1/2 CL8 cells by alkylating agents.
Topics: Alkylating Agents; Animals; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Drug Evaluation, Preclinical; Hydrocarbons, Iodinated; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Propiolactone; Thiophenes | 1981 |
A comparison of the molecular action of an SN1-type methylating agent, methyl nitrosourea and an SN2-type methylating agent, methyl methanesulfonate, in the germ cells of male mice.
Topics: Alkylating Agents; Animals; DNA; Male; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Mice; Nitrosourea Compounds; Sperm Head; Spermatozoa; Time Factors | 1981 |
Relationship between chemical damage of DNA and mutations in mammalian cells. I. Dose-response curves for the induction of 6-thioguanine-resistant mutants by low doses of monofunctional alkylating agents, X-rays and UV radiation in V79 Chinese hamster cel
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Ethyl Methanesulfonate; Ethylnitrosourea; Lung; Methyl Methanesulfonate; Methylnitrosourea; Mutation; Ultraviolet Rays; X-Rays | 1980 |
Effects of cinnamaldehyde on survival and formation of HGPRT- mutants in V79 cells treated with methyl methanesulfonate, N-nitroso-N-methylurea, ethyl methanesulfonate and UV light.
Topics: Acrolein; Animals; Cell Survival; Cricetinae; Cricetulus; DNA Repair; Ethyl Methanesulfonate; Hypoxanthine Phosphoribosyltransferase; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests | 1994 |
Toxicity of four alkylating agents on in vitro rat embryo differentiation and development.
Topics: Abnormalities, Drug-Induced; Animals; Cell Differentiation; Cells, Cultured; Central Nervous System; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Forelimb; Methyl Methanesulfonate; Methylnitrosourea; Rats | 1995 |
bcl-2 delay of alkylating agent-induced apoptotic death in a murine hemopoietic stem cell line.
Topics: Animals; Apoptosis; DNA Repair; Hematopoiesis; Hematopoietic Stem Cells; In Vitro Techniques; Methyl Methanesulfonate; Methylnitrosourea; Mice; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2 | 1994 |
Comparison of effects of direct-acting DNA methylating and ethylating agents on inducible gene expression in vivo.
Topics: Alkylating Agents; Animals; Carcinogens; Chick Embryo; DNA; DNA Damage; Enzyme Induction; Ethyl Methanesulfonate; Ethylnitrosourea; Genes; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Mutagenesis, Site-Directed; Phosphoenolpyruvate Carboxykinase (GTP) | 1994 |
Alkylation damage and repair in Alzheimer's disease lymphocytes.
Topics: Adult; Aged; Alkylation; Alzheimer Disease; Cell Count; Cell Survival; DNA; DNA Damage; DNA Repair; Female; Humans; In Vitro Techniques; Lymphocytes; Male; Methyl Methanesulfonate; Methylnitrosourea; Middle Aged; Sister Chromatid Exchange; Thymidine | 1993 |
A chemiluminescent microplate assay to detect DNA damage induced by genotoxic treatments.
Topics: Cell Extracts; Deoxyribonucleotides; DNA; DNA Damage; DNA Repair; HeLa Cells; Humans; Kinetics; Luminescent Measurements; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Plasmids; Polylysine; Ultraviolet Rays | 1995 |
Comparison of inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans by streptozotocin and methyl and ethyl nitrosoureas and methanesulphonates. Lack of correlation with nitric oxide-releasing or O6-alkylating ability.
Topics: Alkylating Agents; Animals; Cyclic GMP; Ethyl Methanesulfonate; Ethylnitrosourea; Glucose; Guanine; Insulin; Islets of Langerhans; Methyl Methanesulfonate; Methylnitrosourea; Nitric Oxide; Rats; Rats, Sprague-Dawley; Streptozocin; Structure-Activity Relationship | 1995 |
Germ-cell mutagenesis in lambda lacZ transgenic mice treated with ethylating and methylating agents: comparison with specific-locus test.
Topics: Animals; Bacteriophage lambda; Epididymis; Ethyl Methanesulfonate; Ethylnitrosourea; Lac Operon; Male; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Transgenic; Mutagenesis; Mutagenicity Tests; Mutagens; Spermatozoa; Vas Deferens | 1997 |
Sources of variability in data from a positive selection lacZ transgenic mouse mutation assay: an interlaboratory study.
Topics: Animals; Data Interpretation, Statistical; Ethyl Methanesulfonate; Ethylnitrosourea; International Cooperation; Laboratories; Lac Operon; Male; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens; Spermatozoa | 1997 |
Tobacco cotyledons: a novel system for testing mutagenicity in plants.
Topics: Cotyledon; DNA Repair; Genes, Plant; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutagens; Nicotiana; Plants, Genetically Modified; Plants, Toxic; Sensitivity and Specificity | 1997 |
Detection of DNA lesions induced by chemical mutagens by the single cell gel electrophoresis (Comet) assay. 1. Relationship between the onset of DNA damage and the characteristics of mutagens.
Topics: Animals; Bleomycin; Cross-Linking Reagents; DNA Damage; Electrophoresis; Leukemia L5178; Mercaptopurine; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mitomycin; Mutagenicity Tests; Mutagens; Nucleic Acid Synthesis Inhibitors; Time Factors; Tumor Cells, Cultured; Ultraviolet Rays; X-Rays | 1997 |
Comparison of alkaline single cell gel (Comet) and peripheral blood micronucleus assays in detecting DNA damage caused by direct and indirect acting mutagens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Cyclophosphamide; DNA Damage; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Lymphocytes; Male; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Inbred Strains; Micronucleus Tests; Mitomycin; Mutagenicity Tests; Mutagens; Sensitivity and Specificity | 1997 |
Evaluation of P19 cells for studying mechanisms of developmental toxicity: application to four direct-acting alkylating agents.
Topics: Alkylating Agents; Aminobutyrates; Animals; Antineoplastic Agents, Alkylating; Carcinoma, Embryonal; Cell Differentiation; Cell Division; Dimethyl Sulfoxide; Ethyl Methanesulfonate; Ethylnitrosourea; gamma-Aminobutyric Acid; Male; Mesencephalon; Methyl Methanesulfonate; Methylnitrosourea; Mice; Neurons; Tretinoin; Tumor Cells, Cultured | 1998 |
Effects of O6-benzylguanine on growth and differentiation of P19 embryonic carcinoma cells treated with alkylating agents.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Embryonal; Cell Differentiation; Cell Division; Cell Survival; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Guanine; Mesencephalon; Methyl Methanesulfonate; Methylnitrosourea; Mice; Neurons; O(6)-Methylguanine-DNA Methyltransferase; Rats; Tretinoin; Tumor Cells, Cultured | 1998 |
Tobacco BY-2 cells excise both 3-methyladenine and 7-methylguanine from methylated DNA.
Topics: Adenine; Animals; Cattle; Cell Line; Chromatography, High Pressure Liquid; DNA; DNA Glycosylases; DNA Methylation; Guanine; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; N-Glycosyl Hydrolases; Nicotiana; Plants, Toxic | 1998 |
Comparison of DNA damage in plants as measured by single cell gel electrophoresis and somatic leaf mutations induced by monofunctional alkylating agents.
Topics: Alkylating Agents; DNA Damage; DNA, Plant; Electrophoresis; Environmental Monitoring; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Nicotiana; Nucleic Acid Conformation; Plant Leaves; Plant Roots; Plants, Toxic | 1999 |
Protection against methylation-induced cytotoxicity by DNA polymerase beta-dependent long patch base excision repair.
Topics: Alkylating Agents; Animals; Cell Division; Cell Extracts; DNA Adducts; DNA Methylation; DNA Polymerase beta; DNA Repair; Dose-Response Relationship, Drug; Drug Interactions; Fibroblasts; Gene Deletion; Hydroxylamines; Lyases; Methyl Methanesulfonate; Methylnitrosourea; Mice; Models, Genetic; Mutagens; Phenotype; Plasmids; Ribosemonophosphates; Time Factors; Ultraviolet Rays; Uracil | 2000 |
The response of Parp knockout mice against DNA damaging agents.
Topics: Alkylating Agents; Animals; Cell Death; DNA; DNA Damage; DNA Repair; Gastric Mucosa; Male; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Inbred Strains; Mice, Knockout; Mice, SCID; Mutation; NAD; Poly(ADP-ribose) Polymerases; Spleen; Stomach; Survival Analysis; Testis | 2000 |
Chlorophyllin [CHLN] and the mutagenicity of monofunctional alkylating agents in Drosophila: the action of CHLN need not include an influence on metabolic activation.
Topics: Alkylating Agents; Animals; Antimutagenic Agents; Chlorophyllides; Diethylnitrosamine; Dose-Response Relationship, Drug; Drosophila; Ethylnitrosourea; Female; Male; Methyl Methanesulfonate; Methylnitrosourea; Mutagenesis; Mutagenicity Tests; Wings, Animal | 2000 |
Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin.
Topics: 3-O-Methylglucose; Alkylating Agents; Alkylation; Animals; Biological Transport; Biotransformation; Cell Line; Cell Survival; Ethyl Methanesulfonate; Ethylnitrosourea; Glucose Transporter Type 2; Islets of Langerhans; Kinetics; Methyl Methanesulfonate; Methylnitrosourea; Monosaccharide Transport Proteins; Rats; Recombinant Proteins; Streptozocin; Transfection | 2000 |
The relationship between alkylation of specific DNA bases and induction of sister chromatid exchange.
Topics: Alkylating Agents; Alkylation; Animals; Cell Line; Cricetinae; Cricetulus; DNA; DNA Methylation; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Sister Chromatid Exchange | 1980 |
Evidence for the involvement of lesions other than O6-alkylguanine in mammalian cell mutagenesis.
Topics: Adenine; Alkylating Agents; Animals; Carcinogens; Cricetinae; DNA; DNA Damage; Drug Resistance; Guanine; Hypoxanthine Phosphoribosyltransferase; Methyl Methanesulfonate; Methylnitrosourea; Mutagenesis; Mutagens; Sulfuric Acid Esters; Thioguanine | 1980 |
Micronuclei and other nuclear lesions as genotoxicity indicators in rainbow trout Oncorhynchus mykiss.
Topics: Acrylamide; Animals; Cell Nucleus; Colchicine; Cyclophosphamide; Erythrocytes; Injections, Intraperitoneal; Methyl Methanesulfonate; Methylnitrosourea; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mitomycin; Mutagens; Oncorhynchus mykiss | 2001 |
DNA damage and repair in Arabidopsis thaliana as measured by the comet assay after treatment with different classes of genotoxins.
Topics: Alkylating Agents; Arabidopsis; Bleomycin; Comet Assay; DNA Damage; DNA Repair; Herbicides; Maleic Hydrazide; Methyl Methanesulfonate; Methylnitrosourea; Mitomycin; Mutagens; Radiation-Sensitizing Agents | 2001 |
Detection of mutation in transgenic CHO cells using green fluorescent protein as a reporter.
Topics: Animals; Base Sequence; CHO Cells; Cricetinae; DNA, Recombinant; Flow Cytometry; Gamma Rays; Genes, Reporter; Genetic Engineering; Green Fluorescent Proteins; Luminescent Proteins; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutation; Promoter Regions, Genetic; Repressor Proteins | 2002 |
Cadmium inhibits repair of UV-, methyl methanesulfonate- and N-methyl-N-nitrosourea-induced DNA damage in Chinese hamster ovary cells.
Topics: Animals; Cadmium Chloride; CHO Cells; Comet Assay; Cricetinae; DNA; DNA Damage; DNA Repair; DNA, Single-Stranded; Kinetics; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutagens; Ultraviolet Rays | 2003 |
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells.
Topics: Adenoviridae; Alkylating Agents; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Comet Assay; Dacarbazine; DNA Glycosylases; DNA Repair; Dose-Response Relationship, Drug; Genetic Therapy; Genetic Vectors; Humans; Hydroxylamines; Immunohistochemistry; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Oligonucleotides; Sensitivity and Specificity; Sulfuric Acid Esters; Temozolomide; Time Factors | 2004 |
Differential adduction of proteins vs. deoxynucleosides by methyl methanesulfonate and 1-methyl-1-nitrosourea in vitro.
Topics: Amino Acid Sequence; Apoproteins; Chromatography, High Pressure Liquid; Deoxyribonucleosides; Hemoglobins; Humans; Methyl Methanesulfonate; Methylnitrosourea; Molecular Sequence Data; Mutagens; Myoglobin; Proteins; Sequence Analysis, Protein; Spectrometry, Mass, Electrospray Ionization | 2005 |
Antigenotoxic potential of glucomannan on four model test systems.
Topics: 4-Nitroquinoline-1-oxide; Aminacrine; Animals; Antimutagenic Agents; Candida; Cell Division; Chlamydomonas reinhardtii; Chromosome Aberrations; Crossing Over, Genetic; DNA Damage; Mannans; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutagens; Saccharomyces cerevisiae; Salmonella typhimurium; Sodium Azide; Vicia sativa | 2004 |
Different types of combination effects for the induction of micronuclei in mouse lymphoma cells by binary mixtures of the genotoxic agents MMS, MNU, and genistein.
Topics: Alkylating Agents; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Genistein; Methyl Methanesulfonate; Methylnitrosourea; Mice; Micronuclei, Chromosome-Defective; Mutagens; Topoisomerase II Inhibitors | 2005 |
Antioxidative and antigenotoxic effects of Japanese horse chestnut (Aesculus turbinata) seeds.
Topics: Aesculus; Aflatoxin B1; Anthracenes; Antimutagenic Agents; Antioxidants; Dose-Response Relationship, Drug; Furylfuramide; Hydrogen Peroxide; Linoleic Acid; Methyl Methanesulfonate; Methylnitrosourea; Mitomycin; Phenols; Plant Extracts; Seeds | 2005 |
Induced mutation spectra at the upp locus in Salmonella typhimurium: response of the target gene in the FU assay to mechanistically different mutagens.
Topics: Aminacrine; Benzo(a)pyrene; Drug Resistance, Microbial; Fluorouracil; Frameshift Mutation; Genes, Bacterial; Hydrogen Peroxide; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutagens; Mutation; Nitrogen Mustard Compounds; Pentosyltransferases; Salmonella typhimurium | 2005 |
Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens.
Topics: Alkylating Agents; Cell Line; Chromosome Aberrations; DNA; DNA Adducts; DNA Damage; Ethyl Methanesulfonate; Ethylnitrosourea; Humans; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Point Mutation | 2007 |
A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Apoptosis; Base Pair Mismatch; Caspase 3; DNA; DNA Modification Methylases; DNA Repair Enzymes; Etoposide; Fibroblasts; Gene Expression Regulation; Guanine; Humans; Lung; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Knockout; Mutagenesis; Mutation; MutL Protein Homolog 1; Nuclear Proteins; RNA, Small Interfering; Tumor Suppressor Proteins; Ultraviolet Rays | 2009 |
Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice.
Topics: Alkylating Agents; Animals; Apoptosis; DNA Glycosylases; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Methyl Methanesulfonate; Methylnitrosourea; Mice; Photoreceptor Cells, Vertebrate; Retinal Degeneration; Tumor Suppressor Proteins | 2009 |
Dose-response and operational thresholds/NOAELs for in vitro mutagenic effects from DNA-reactive mutagens, MMS and MNU.
Topics: Animals; DNA Adducts; Dose-Response Relationship, Drug; Leukemia L5178; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mutagenicity Tests; Mutagens; No-Observed-Adverse-Effect Level; Threshold Limit Values | 2009 |
Mutagenicity of N-ethyl-N-nitrosourea, N-methyl-N-nitrosourea, methyl methanesulfonate and ethyl methanesulfonate in the developing Syrian hamster fetus.
Topics: Animals; Cricetinae; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Mesocricetus; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutagens; Pregnancy; Pregnancy, Animal | 2010 |
Quantitative assessment of the dose-response of alkylating agents in DNA repair proficient and deficient ames tester strains.
Topics: Alkylating Agents; Dacarbazine; DNA Helicases; DNA Repair; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Methyl Methanesulfonate; Methylnitrosourea; Methyltransferases; Mutagenicity Tests; Mutagens; Salmonella typhimurium; Species Specificity; Temozolomide | 2014 |
Investigations on potential co-mutagenic effects of formaldehyde.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Alkylating Agents; Chromosome Aberrations; Comet Assay; Disinfectants; Drug Combinations; Drug Synergism; Formaldehyde; Gamma Rays; Humans; Lung Neoplasms; Methyl Methanesulfonate; Methylnitrosourea; Micronucleus Tests; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2014 |
Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment.
Topics: Animals; Benchmarking; Databases, Factual; Dose-Response Relationship, Drug; Ecotoxicology; Ethyl Methanesulfonate; Ethylnitrosourea; Humans; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; No-Observed-Adverse-Effect Level; Risk Assessment | 2014 |
Genotoxins induce binucleation in L5178Y and TK6 cells.
Topics: Animals; Cell Line; Colchicine; Cytarabine; Cytokinesis; DNA Damage; Humans; Methyl Methanesulfonate; Methylnitrosourea; Mice; Micronucleus Tests; Mitomycin; Mutagens | 2014 |
Dose-Response for Multiple Biomarkers of Exposure and Genotoxic Effect Following Repeated Treatment of Rats with the Alkylating Agents, MMS and MNU.
Topics: Alkylating Agents; Animals; Biomarkers; DNA; DNA Adducts; Dose-Response Relationship, Drug; Hemoglobins; Liver; Male; Methyl Methanesulfonate; Methylnitrosourea; Models, Biological; Mutagens; Organ Specificity; Rats; Rats, Inbred F344; Reticulocytes | 2016 |
Antimutagenic action of the live yeast can be transmitted to the offspring of Drosophila melanogaster. A genetic study using the wing spot assay.
Topics: Animals; Biological Assay; Chromium Compounds; Drosophila melanogaster; Ethyl Methanesulfonate; Female; Fertility; Gamma Rays; Male; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Mutation; Saccharomyces cerevisiae; Wings, Animal | 2018 |