methylnitrosourea has been researched along with guanine in 142 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 66 (46.48) | 18.7374 |
| 1990's | 59 (41.55) | 18.2507 |
| 2000's | 13 (9.15) | 29.6817 |
| 2010's | 4 (2.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abbott, PJ; Saffhill, R | 1 |
| Chang, MJ; Koestner, A; Webb, TE | 1 |
| Cox, R; Irving, CC | 1 |
| Thielmann, HW | 1 |
| Roberts, JJ; Shackleton, J; Warren, W | 1 |
| Buecheler, J; Cooper, HK; Diessner, H; Kleihues, P; Kolar, GF | 1 |
| Crathorn, AR; Shooter, KV; Warren, W | 1 |
| Krepinsky, J; Rajalakshmi, S; Rao, PM; Sarma, DS | 1 |
| Pegg, AE | 2 |
| Buecheler, J; Kleihues, P | 1 |
| Cooper, HK; Kleihues, P | 1 |
| Bresil, H; Margison, GP; Margison, JM; Montensano, R | 1 |
| Lawley, PD; Warren, W | 2 |
| Frei, JV; Lawley, PD | 1 |
| Kleihues, P; Margison, GP | 2 |
| Basic-Zaninovic, T; Bignami, M; Dogliotti, E; Palombo, F | 1 |
| Ludlum, DB; Matijasevic, Z; Sekiguchi, M | 1 |
| Mikheev, AM | 1 |
| Graves, R; Laval, J; Pegg, AE | 1 |
| Archer, MC; Chaulk, EJ; Lu, SJ | 1 |
| Archer, MC; Lu, SJ; Milligan, JR | 1 |
| Asai, A; Handa, H; Huh, NH; Kuroki, T; Moriyama, C; Rajewsky, MF; Satoh, MS | 1 |
| Ahnström, G; Eizirik, DL; Sandler, S; Welsh, M | 1 |
| Said, B; Shank, RC | 1 |
| Bochert, G; Neubert, D; Platzek, T; Rahm, U | 1 |
| Elksne, SJ; Gorbacheva, LB; Kukushkina, GV; Miniker, TD; Preobrazhenskaya, MN | 1 |
| Arce, C; Dumenco, LL; Gerson, SL; Norton, K; Wagner, T; Yun, J | 1 |
| Hutchinson, F; Romac, S; Sockett, H | 1 |
| Kawazoe, Y; Kohda, K; Sawada, N | 1 |
| Kawazoe, Y; Sekiguchi, M; Takahashi, K | 1 |
| Aquilina, G; Bignami, M; Di Muccio, A; Dogliotti, E; Giammarioli, AM; Zijno, A | 1 |
| Archer, MC; Catz-Biro, L; Hirani-Hojatti, S; Milligan, JR | 1 |
| Greene, PS; Mandel, HG; Richardson, DC; Straw, JA | 1 |
| Conrad, M; Rossi, SC; Topal, MD; Voigt, JM | 1 |
| Chaudhuri, I; Couto, LB; Demple, B; Donahue, BA; Essigmann, JM | 1 |
| Clyde, C; Dolan, ME; Erickson, LC; Hora, NK; Norbeck, L; Pegg, AE | 1 |
| Archer, MC; Gunhouse, BW; Milligan, JR | 1 |
| Nakabeppu, Y; Otsuka, M; Sekiguchi, M | 1 |
| Rajewsky, MF; Samson, L; Thomale, J | 1 |
| Abbondandolo, A; Bignami, M; Calcagnile, A; Dogliotti, E; Frosina, G; Terlizzese, M; Zijno, A | 1 |
| Dolan, ME; Oplinger, M; Pegg, AE | 1 |
| Denman, AM; Harris, G; Hill, ID; Hylton, W; Lawley, PD; Topper, R | 1 |
| Dixit, R; Gold, B | 1 |
| Brennand, J; Margison, GP; Ockey, CH; White, GR | 1 |
| Benjamin, E; Gerson, SL; Miller, K; Trey, JE | 1 |
| Beattie, CW; Braun, RJ; Pezzuto, JM; Ratko, TA | 1 |
| D'Ambrosio, SM; Wani, AA | 1 |
| Aida, T; Berger, MS; Bodell, WJ; Rosenblum, ML | 1 |
| Cuzick, RA; Goldmacher, VS; Thilly, WG | 1 |
| Boyle, JM; Fox, M; Margison, GP; Saffhill, R | 1 |
| Laval, F | 1 |
| Devor, D; Kaufman, DG; Kaufmann, WK; Rice, JM; Wenk, ML | 1 |
| Day, RS; DiPaolo, JA; Doniger, J | 1 |
| Boiteux, S; Costa de Oliveira, R; Laval, J | 1 |
| Abbondandolo, A; Frosina, G | 1 |
| Curren, RD; Grafstrom, RC; Harris, CC; Yang, LL | 1 |
| Boiteux, S; Laval, F | 1 |
| Pezzuto, JM; Ratko, TA | 1 |
| Sakai, K; Umeda, T; Yamane, Y | 1 |
| Bücher, T; Kerler, R; Legner, M; Müller, L; Rabes, HM; Rode, G; Schuster, C | 1 |
| Briscoe, WT; Cotter, LE | 2 |
| Rajalakshmi, S; Rao, RM; Sarma, DS | 1 |
| Bresil, H; Cooper, DP; Margison, GP; Montesano, R; O'Connor, PJ; Planche-Martel, G; Smith, RA | 1 |
| Craddock, VM | 1 |
| Brent, TP | 1 |
| Singer, B | 1 |
| Kerler, R; Rabes, HM; Rode, G; Schuster, C; Wilhelm, R | 1 |
| Asbery, LJ; Chandler, PM; Harris, G; Jones, MG; Lawley, PD | 1 |
| Alekandrov, VA; Anisimov, VN; Bespalov, VG; Korsakov, MV; Likhachev, AJ; Napalkov, NP; Ovsyannikov, AI; Popovich, IG; Tomatis, L | 1 |
| Harris, G; Lawley, PD; Olsen, I | 1 |
| Margison, GP | 1 |
| Bogden, JM; Bresnick, E; Eastman, A | 1 |
| Becker, Y; Shiloh, Y | 1 |
| Goth-Goldstein, R | 1 |
| Balls, M; Clothier, R; Hodgson, R; Swann, P | 1 |
| Pegg, AE; Umbenhauer, DR | 1 |
| Kyrtopoulos, SA; Souliotis, VL; Valavanis, C | 1 |
| Faustman, EM; Kidney, JK | 1 |
| Capucci, MS; De Groot, A; Hoffmann, ME; Natarajan, AT | 1 |
| Gaubatz, JW; Tan, BH | 3 |
| Bleicher, F; Martel-Planche, G; Mironov, NM; Montesano, R | 1 |
| Bean, CL; Bradt, CI; Galloway, SM; Greenwood, SK; Hill, RB | 1 |
| Aquilina, G; Bignami, M; Ceccotti, S; Fiumicino, S; Hess, P | 1 |
| Harris, G; Lawley, PD | 1 |
| Allay, E; Dumenco, LL; Gerson, SL; Liu, L | 1 |
| Bochert, G; Meister, R; Neubert, D; Platzek, T | 1 |
| Billett, MA; Cooper, DP; Gordon, AT; Manning, FC; Margison, GP; O'Connor, PJ | 1 |
| Douskey, MC; Gold, B; Wurdeman, RL | 1 |
| Anver, MR; Lijinsky, W; Moschel, RC; Pegg, AE | 1 |
| Arai, M; Ishikawa, T; Nakatsuru, Y; Oda, H; Qin, X; Zarkovic, M | 1 |
| Aquilina, G; Bignami, M; Biondo, R; Dogliotti, E | 1 |
| Bignami, M; Ceccotti, S; Dogliotti, E; Gannon, J; Karran, P | 1 |
| Collier, JM; Forsyth, CS; Frank, AA; Stoner, GD; Zeng, W | 1 |
| Ledoux, SP; Nelson, JW; Wilson, GL | 1 |
| Laval, F; Lefebvre, P | 1 |
| Mathison, BH; Said, B; Shank, RC | 1 |
| Avery, LJ; LeDoux, SP; Patton, NJ; Wilson, GL | 1 |
| Katayama, H; Niimi, S; Skagishi, Y; Sonoda, M; Yano, K | 1 |
| Cunningham, JM; Delaney, CA; Di Matteo, M; Dunger, A; Green, IC; Green, MH | 1 |
| Chen, FX; Church, K; Encell, L; Gold, B; Mehta, P; Shuker, DE; Williams, J | 1 |
| Brent, TP; Hollensworth, BS; LeDoux, SP; Rajewsky, MF; Shen, C; Thomale, J; Williams, BA; Wilson, GL | 1 |
| Schleifer, S; Tempel, K | 1 |
| Anisimov, VN; Buzard, GS; Calvert, RJ; Rice, JM | 1 |
| Armstrong, MJ; Galloway, SM | 1 |
| Baranczewski, P; Nehls, P; Pich, U; Rajewsky, MF; Rieger, R; Schubert, I | 1 |
| Baranczewski, P; Nehls, P; Rajewsky, MF; Rieger, R; Schubert, I | 1 |
| Aquilina, G; Bignami, M; Fiumicino, S; Martinelli, S; Oshimura, M; Overkamp, WJ; Wild, CP; Zdzienicka, MZ; Zijno, A | 1 |
| Engelbergs, J; Galhoff, A; Rajewsky, MF; Thomale, J | 1 |
| Ali, RB; Ayi, TC; Chuang, LS; Li, BF; Oh, HK; Teo, AK | 1 |
| Cooper, DP; Delker, DA; Papanikolaou, A; Povey, A; Rosenberg, DW; Shank, RC | 1 |
| Faustman, EM; Seeley, MR | 1 |
| Kaina, B | 1 |
| Dobrzańska, M; Kraszewska, E; Tudek, B | 1 |
| Beyersmann, D; Eichhorn, U; Hartwig, A; Iwitzki, F; Kaina, B; Schlepegrell, R | 1 |
| Aquilina, G; Bignami, M; Branch, P; Fiumicino, S; Humbert, O; Karran, P; Oda, S; Zijno, A | 1 |
| Aquilina, G; Bignami, M; Crompton, NE; Jiricny, J; Lettieri, T; Marra, G; Palombo, F | 1 |
| Allay, E; Gerson, SL; Veigl, M | 1 |
| Bochert, G; Platzek, T | 1 |
| Kyrtopoulos, SA; Psaroudi, MC | 1 |
| Arends, MJ; Brookes, RA; Clarke, AR; Margison, GP; Sansom, OJ; Toft, NJ; Winton, DJ; Wood, M | 1 |
| Aquilina, G; Bignami, M; Karran, P; O'Driscoll, M | 1 |
| Engelbergs, J; Rajewsky, MF; Schweer, T; Thomale, J | 1 |
| Boley, SE; Maher, VM; McCormick, JJ; McManus, TP | 1 |
| Engelward, BP; Smith, SA | 1 |
| Christmann, M; Kaina, B | 1 |
| Brennand, J; Fox, M | 1 |
| Eckert, KA; Khare, V | 1 |
| Fukushima, S | 1 |
| Hidaka, M; Sekiguchi, M; Takagi, Y; Takano, TY | 1 |
| Kramarenko, II; Loginova, MIu; Tronov, VA | 1 |
| Hidaka, M; Komori, K; Lim, TH; Nakatsu, Y; Sanada, M; Sekiguchi, M; Takagi, Y; Tsuzuki, T | 1 |
| Bamborschke, S; Doerjer, G; Kleihues, P | 1 |
| Aquilina, G; Dogliotti, E; Fortini, P; Lupari, E; Marcon, F; Ventura, I | 1 |
| Fujikane, R; Hidaka, M; Sanada, M; Sekiguchi, M | 1 |
| Clement, JM; Collins, LB; Nakamura, J; Sharma, V; Swenberg, JA; Zhang, Z | 1 |
| Amin, SG; Belinsky, SA; Collins, LB; Crowell, RE; Desai, D; Gilliland, FD; Jauregui, AR; Juri, DE; Leng, S; Lin, Y; Liu, Y; Picchi, MA; Stidley, CA; Swenberg, JA; Tellez, CS; Thomas, CL; Wathelet, MG; Wu, G; Zhang, X | 1 |
4 review(s) available for methylnitrosourea and guanine
| Article | Year |
|---|---|
The current evidence for an adaptive response to alkylating agents in mammalian cells, with special reference to experiments with in vitro cell cultures.
Topics: Alkylating Agents; Animals; Bacterial Proteins; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; DNA Glycosylases; DNA Ligases; DNA Repair; Drug Resistance; Escherichia coli; Guanine; Haplorhini; Kidney; Liver; Mammals; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mice; Mutation; N-Glycosyl Hydrolases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Placenta; Rats | 1985 |
Enhanced repair of O6-alkylguanine in mammalian tissues.
Topics: 2-Acetylaminofluorene; Adenine; Aflatoxin B1; Aflatoxins; Alkylating Agents; Alkylation; Animals; Carcinogens; Cricetinae; Dimethylnitrosamine; DNA; DNA Repair; Dose-Response Relationship, Drug; Gerbillinae; Guanine; Hepatectomy; Liver; Methylnitrosourea; Mice; Rats; Rodentia; Species Specificity | 1984 |
Embryotoxicity induced by alkylating agents: 7. Low dose prenatal-toxic risk estimation based on NOAEL risk factor approach, dose-response relationships, and DNA adducts using methylnitrosourea as a model compound.
Topics: Abnormalities, Drug-Induced; Algorithms; Alkylating Agents; Alkylation; Animals; DNA; DNA Damage; Dose-Response Relationship, Drug; Embryo, Mammalian; Ethyl Methanesulfonate; Female; Fetal Death; Guanine; Methylnitrosourea; Mice; Models, Theoretical; Pregnancy; Risk Factors; Toxicology | 1993 |
Unmasking a killer: DNA O(6)-methylguanine and the cytotoxicity of methylating agents.
Topics: Alkylating Agents; Animals; Cell Survival; DNA; DNA Damage; DNA Repair; Guanine; Humans; Mesylates; Methylnitronitrosoguanidine; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Tumor Cells, Cultured | 2000 |
138 other study(ies) available for methylnitrosourea and guanine
| Article | Year |
|---|---|
DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by O(6)-methylguanine.
Topics: Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA; DNA Polymerase I; Escherichia coli; Genetic Code; Guanine; Methylation; Methylnitrosourea; Polydeoxyribonucleotides; Sulfuric Acid Esters; Templates, Genetic; Thymidine Monophosphate | 1979 |
Distribution of O6-methylguanine in rat DNA following pretreatment in vivo with methylnitrosourea.
Topics: Animals; Brain; DNA; Guanine; Kidney; Liver; Methylation; Methylnitrosourea; Nitrosourea Compounds; Rats | 1979 |
O6-methylguanine accumulates in DNA of mammary glands after administration of N-methyl-N-nitrosourea to rats.
Topics: Animals; Brain; DNA; DNA Repair; Female; Guanine; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylation; Methylnitrosourea; Nitrosourea Compounds; Rats; Urinary Bladder | 1979 |
Rapid determination of methylated purines in DNA treated with N-methyl-N-nitrosourea using high-performance liquid chromatography.
Topics: Adenine; Chromatography, High Pressure Liquid; DNA; Guanine; Methylation; Methylnitrosourea; Nitrosourea Compounds | 1979 |
The excision of N-methyl-N-nitrosourea-induced lesions from the DNA of Chinese hamster cells as measured by the loss of sites sensitive to an enzyme extract that excises 3-methylpurines but not O6-methylguanine.
Topics: Animals; Cell Line; Cricetinae; Deoxyribonucleases; DNA; Guanine; Methylnitrosourea; Micrococcus; Nitrosourea Compounds; Purines; Structure-Activity Relationship | 1979 |
Mechanism of perinatal tumor induction by neuro-oncogenic alkylnitrosoureas and dialkylaryltriazenes.
Topics: Animals; Brain; DNA; DNA Repair; Female; Fetus; Guanine; Liver; Maternal-Fetal Exchange; Methylation; Methylnitrosourea; Neoplasms, Experimental; Nervous System Diseases; Nitrosourea Compounds; Pregnancy; Rats; Triazenes | 1979 |
The stability of methylated purines and of methylphosphotriesters in the DNA of V79 cells after treatment with N-methyl-N-nitrosourea.
Topics: Adenine; Animals; Cells, Cultured; Cricetinae; Cricetulus; DNA; DNA Repair; Esters; Guanine; Methylnitrosourea; Nitrosourea Compounds; Purines | 1979 |
N-Methyl-N-nitrosourea mediated conversion of O6-methylguanine to xanthine.
Topics: Animals; Dealkylation; Deamination; Guanine; In Vitro Techniques; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Rats; Xanthines | 1978 |
Enzymatic removal of O6-methylguanine from DNA by mammalian cell extracts.
Topics: Animals; Brain; Cattle; Chromatin; DNA; Guanine; Intestinal Mucosa; Kidney; Liver; Lung; Methylnitrosourea; Thymus Gland | 1978 |
Alkylation of rat liver DNA by dimethylnitrosamine: effect of dosage on O6-methylguanine levels.
Topics: Alkylating Agents; Animals; Dimethylnitrosamine; DNA; Dose-Response Relationship, Drug; Female; Guanine; Liver; Liver Neoplasms; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats | 1977 |
Excision of O6-methylguanine from DNA of various mouse tissues following a single injection of N-methyl-Nitrosourea.
Topics: Animals; Brain; DNA; Female; Guanine; Kinetics; Liver; Methylnitrosourea; Mice; Mice, Inbred Strains; Nitrosourea Compounds; Organ Specificity; Species Specificity | 1977 |
Repair excision of alkylated bases from DNA in vivo.
Topics: Alkylating Agents; Animals; Brain; Carcinogens; DNA Repair; Guanine; Kidney; Liver; Methylnitrosourea; Neoplasms, Experimental; Nitrosamines; Rats | 1976 |
Effect of chronic administration of dimethylnitrosamine on the excision of O6-methylguanine from rat liver DNA.
Topics: Adenine; Alkylation; Animals; Dimethylnitrosamine; DNA; DNA Repair; Guanine; Liver; Male; Methylnitrosourea; Nitrosamines; Rats | 1976 |
Specific excision of ethylated purines from DNA of Escherichia coli treated with N-ethyl-N-nitrosourea.
Topics: Adenine; DNA Replication; DNA, Bacterial; Escherichia coli; Ethanol; Ethylnitrosourea; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds | 1975 |
Methylation of DNA in various organs of C57B1 mice by a carcinogenic dose of N-methyl-N-nitrosourea and stabiltty of some methylation products up to 18 hours.
Topics: Adenine; Animals; Bone Marrow; Carbon Radioisotopes; Chromatography, Affinity; Chromatography, Paper; DNA; Female; Guanine; Injections, Intraperitoneal; Intestine, Small; Kidney; Liver; Lung; Methylation; Methylnitrosourea; Mice; Mice, Inbred C57BL; Nitrosourea Compounds; Spleen; Thymus Gland; Time Factors; Tritium | 1975 |
Chemical carcinogenesis in the nervous system. Preferential accumulation of O6-methylguanine in rat brain deoxyribonucleic acid during repetitive administration of N-methyl-N-nitrosourea.
Topics: Animals; Brain; DNA; Female; Guanine; Intestinal Mucosa; Kidney; Liver; Methylnitrosourea; Nitrosourea Compounds; Rats; Spleen; Time Factors | 1975 |
Exhaustion and recovery of repair excision of O6-methylguanine from rat liver DNA.
Topics: Animals; Carcinogens; DNA; DNA Repair; Female; Guanine; Liver; Methyl Methanesulfonate; Methylnitrosourea; Nitrosourea Compounds; Radiation Effects; Rats; Time Factors; X-Rays | 1976 |
Fidelity of replication of the leading and the lagging DNA strands opposite N-methyl-N-nitrosourea-induced DNA damage in human cells.
Topics: Animals; Cell Line; DNA; DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; DNA, Bacterial; Genes, Bacterial; Genetic Vectors; Guanine; Herpesvirus 4, Human; Humans; Kidney; Metallothionein; Methylnitrosourea; Mice; Mutagenesis; Plasmids; Promoter Regions, Genetic; Restriction Mapping; Transcription, Genetic; Transfection | 1992 |
Release of N2,3-ethenoguanine from chloroacetaldehyde-treated DNA by Escherichia coli 3-methyladenine DNA glycosylase II.
Topics: Acetaldehyde; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Deoxyguanine Nucleotides; DNA; DNA Glycosylases; DNA Repair; Escherichia coli; Guanine; Kinetics; Methylnitrosourea; N-Glycosyl Hydrolases; Time Factors; Tritium | 1992 |
[The use of an immunohistochemical method for detecting N7-methylguanine in human cells].
Topics: China; Disease Reservoirs; DNA; Epithelial Cells; Epithelium; Esophageal Neoplasms; Esophagus; Guanine; Humans; Immunohistochemistry; Intestinal Mucosa; Intestines; Methylnitrosourea; Sensitivity and Specificity; Silver Staining | 1992 |
Sequence specificity of DNA repair by Escherichia coli Fpg protein.
Topics: Base Sequence; DNA Repair; DNA-Formamidopyrimidine Glycosylase; DNA, Bacterial; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Guanine; Methylation; Methylnitrosourea; Molecular Sequence Data; N-Glycosyl Hydrolases; Oligonucleotide Probes | 1992 |
Formation and repair of O6-methylguanine and methylation of the Ha-ras proto-oncogene by N-methyl-N-nitrosourea are not associated with mammary tumor resistance in the Copenhagen rat.
Topics: Animals; Blotting, Northern; Blotting, Southern; DNA Repair; DNA, Neoplasm; Drug Resistance; Female; Genes, ras; Guanine; Mammary Neoplasms, Experimental; Methylation; Methylnitrosourea; Rats | 1992 |
Preferential methylation of the Ha-ras proto-oncogene by methylnitrosourea in rat mammary glands.
Topics: Animals; Blotting, Northern; Blotting, Southern; DNA; Female; Genes, ras; Guanine; Mammary Glands, Animal; Methylation; Methylnitrosourea; Rats; Rats, Inbred BUF; Restriction Mapping; RNA; Transcription, Genetic | 1991 |
Monoclonal antibody-mediated solid-phase assay for mammalian O6-alkylguanine DNA alkyltransferase activity.
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; DNA; Guanine; Immunoblotting; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Tritium | 1991 |
Exposure of pancreatic islets to different alkylating agents decreases mitochondrial DNA content but only streptozotocin induces long-lasting functional impairment of B-cells.
Topics: Adenine; Alkylating Agents; Animals; Cytochrome b Group; DNA; Dose-Response Relationship, Drug; Glucagon; Glucose; Guanine; Immunoblotting; Insulin; Islets of Langerhans; Male; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mitochondria; RNA, Messenger; Streptozocin | 1991 |
Nearest neighbor effects on carcinogen binding to guanine runs in DNA.
Topics: Aflatoxin B1; Aflatoxins; Autoradiography; Base Sequence; Benzo(a)pyrene; Binding, Competitive; Carcinogens; DNA; Electrophoresis, Agar Gel; Guanine; Hydrogen-Ion Concentration; Hydrolysis; Lomustine; Methylnitrosourea; Molecular Sequence Data; Photochemistry; Plasmids | 1991 |
Embryotoxicity induced by alkylating agents: 6. DNA adduct formation induced by methylnitrosourea in mouse embryos.
Topics: Abnormalities, Drug-Induced; Alkylation; Animals; DNA; DNA Repair; Embryo, Mammalian; Female; Guanine; Methylnitrosourea; Mice; Neoplasms, Experimental; Pregnancy | 1991 |
O6-methylguanine as a modulator of antitumor activity of N-alkyl-N-nitrosoureas in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; DNA Damage; DNA, Neoplasm; Drug Interactions; Drug Resistance; Guanine; Leukemia L1210; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Nucleic Acid Conformation; Time Factors | 1991 |
Enhanced repair of O6-methylguanine DNA adducts in the liver of transgenic mice expressing the ada gene.
Topics: Animals; Dietary Proteins; Dimethylnitrosamine; DNA Repair; Enzyme Induction; Gene Expression; Guanine; Liver; Methylnitrosourea; Methyltransferases; Mice; Mice, Transgenic; O(6)-Methylguanine-DNA Methyltransferase; Time Factors | 1991 |
Mutagenic specificity of N-methyl-N'-nitro-N-nitrosoguanidine in the gpt gene on a chromosome of Chinese hamster ovary cells and of Escherichia coli cells.
Topics: Animals; Cell Line; DNA Repair; Escherichia coli; Genes, Bacterial; Guanine; Kinetics; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagenesis; Plasmids; Polymerase Chain Reaction | 1991 |
Formation of O6,7-dimethylguanine residues in calf thymus deoxyribonucleic acid treated with carcinogenic N-methyl-N-nitrosourea in vitro.
Topics: Animals; Cattle; DNA; Guanine; Methylnitrosourea; Thymus Gland | 1991 |
Effects of vanillin and o-vanillin on induction of DNA-repair networks: modulation of mutagenesis in Escherichia coli.
Topics: Benzaldehydes; DNA Repair; DNA, Bacterial; Escherichia coli; Gene Expression; Genes, Bacterial; Guanine; Methylnitrosourea; Mutation; Plasmids; SOS Response, Genetics; Ultraviolet Rays | 1990 |
Tolerance to O6-methylguanine and 6-thioguanine cytotoxic effects: a cross-resistant phenotype in N-methylnitrosourea-resistant Chinese hamster ovary cells.
Topics: Alkylation; Animals; Cell Line; Cell Survival; Clone Cells; Cricetinae; Cricetulus; DNA; DNA Repair; Drug Resistance; Female; Guanine; Kinetics; Methylnitrosourea; Ovary; Phenotype; Sister Chromatid Exchange; Thioguanine | 1990 |
Methylation of DNA by three N-nitroso compounds: evidence for sequence specific methylation by a common intermediate.
Topics: Base Sequence; Dimethylnitrosamine; DNA; DNA Restriction Enzymes; Guanine; Methylation; Methylnitrosourea; Nitrosamines; Nitroso Compounds; Plasmids; Polydeoxyribonucleotides | 1989 |
Urinary O6-methylguanine excretion in the rat after O6-methylguanine but not N-methylnitrosourea administration.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA; Guanine; Liver; Male; Mass Spectrometry; Methionine; Methylnitrosourea; Purines; Rats; Spectrophotometry, Ultraviolet | 1989 |
Excision repair of O6-methylguanine synthesized at the rat H-ras N-methyl-N-nitrosourea activation site and introduced into Escherichia coli.
Topics: Base Sequence; DNA Repair; Escherichia coli; Guanine; Methylnitrosourea; Molecular Sequence Data; Mutation; Proto-Oncogenes; Transfection | 1989 |
Separation of the SOS-dependent and SOS-independent components of alkylating-agent mutagenesis.
Topics: DNA Repair; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Guanine; Methylnitrosourea; Mutation; Phenotype; Plasmids; Restriction Mapping; Ribosomal Protein S9; SOS Response, Genetics | 1989 |
Expression of mammalian O6-alkylguanine-DNA alkyltransferase in a cell line sensitive to alkylating agents.
Topics: Alkylating Agents; Animals; Carmustine; Cell Division; Cell Line; Cricetinae; Cricetulus; Female; Guanine; Kinetics; Lomustine; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mitoguazone; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Transfection | 1989 |
Interaction of alpha-acetoxy-N-nitrosopyrrolidine with DNA assessed by loss of restriction endonuclease recognition sites and formation of apurinic/apyrimidinic sites.
Topics: Apurinic Acid; Cytosine; Dimethylnitrosamine; DNA; DNA Damage; DNA Restriction Enzymes; Esterases; Guanine; Methylnitrosourea; N-Nitrosopyrrolidine; Nitrosamines; Plasmids; Polynucleotides; Spermidine | 1988 |
Ability of various alkylating agents to induce adaptive and SOS responses: a study with lacZ fusion.
Topics: Alkylating Agents; Bacterial Proteins; beta-Galactosidase; DNA Glycosylases; DNA Ligases; DNA Repair; Dose-Response Relationship, Drug; Enzyme Induction; Escherichia coli; Ethylnitrosourea; Genes, Bacterial; Genes, Synthetic; Guanine; Lac Operon; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; N-Glycosyl Hydrolases; Polynucleotide Ligases | 1985 |
Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.
Topics: Alkylation; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Kinetics; Methylnitrosourea; Mutation; Thymine | 1988 |
Cytotoxicity, mutations and SCEs induced by methylating agents are reduced in CHO cells expressing an active mammalian O6-methylguanine-DNA methyltransferase gene.
Topics: 4-Nitroquinoline-1-oxide; Alkylation; Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Guanine; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Ouabain; Sister Chromatid Exchange | 1987 |
Sequence specificity of guanine alkylation and repair.
Topics: Base Sequence; Chromatography, High Pressure Liquid; DNA Repair; Guanine; In Vitro Techniques; Kinetics; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Oligodeoxyribonucleotides; Structure-Activity Relationship | 1988 |
Increased sensitivity of lymphocytes from patients with systemic autoimmune diseases to DNA alkylation by the methylating carcinogen N-methyl-N-nitrosourea.
Topics: Adult; Alkylation; Arthritis, Rheumatoid; Autoimmune Diseases; Behcet Syndrome; DNA Repair; Guanine; Humans; Lupus Erythematosus, Systemic; Lymphocyte Activation; Methylnitrosourea; Scleroderma, Systemic | 1988 |
Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid.
Topics: Benzopyrans; DNA; Dose-Response Relationship, Drug; Ellagic Acid; Guanine; Methylation; Methylnitrosourea; Mutation; Spermidine | 1986 |
Chinese hamster cells harbouring the Escherichia coli O6-alkylguanine alkyltransferase gene are less susceptible to sister chromatid exchange induction and chromosome damage by methylating agents.
Topics: Alkylating Agents; Animals; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Escherichia coli; Guanine; Methyl Methanesulfonate; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange | 1986 |
Repair of O6-alkylguanine during DNA synthesis in murine bone marrow hematopoietic precursors.
Topics: Animals; Bone Marrow; Bone Marrow Transplantation; DNA; DNA Repair; Guanine; Hematopoietic Stem Cells; Male; Methylnitrosourea; Methyltransferases; Mice; Mice, Inbred Strains; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains | 1987 |
Estrous cycle modification of rat uterine DNA alkylation by N-methyl-N-nitrosourea.
Topics: Alkylation; Animals; DNA Damage; DNA Repair; Estrus; Female; Guanine; Methylnitrosourea; Rats; Time Factors; Uterus | 1987 |
Specific DNA alkylation damage and its repair in carcinogen-treated rat liver and brain.
Topics: Adenine; Alkylating Agents; Animals; Brain; Carcinogens; DNA; DNA Repair; Guanine; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Methyl Methanesulfonate; Methylnitrosourea; Rats; Rats, Inbred Strains | 1986 |
Increased repair of O6-alkylguanine DNA adducts in glioma-derived human cells resistant to the cytotoxic and cytogenetic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Alkylation; Carmustine; Cell Line; Cell Survival; DNA; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Glioma; Guanine; Humans; Methylnitrosourea; Methyltransferases; Nitroso Compounds; O(6)-Methylguanine-DNA Methyltransferase; Sister Chromatid Exchange; Tritium | 1986 |
Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Alkylation; Cell Cycle; Cell Line; Cell Survival; DNA; Drug Resistance; Guanine; Humans; Lymphocytes; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation | 1986 |
A comparison of cell survival, mutation and persistence of putative promutagenic lesions in Chinese hamster cells exposed to BNU or MNU.
Topics: Alkylation; Animals; Cell Survival; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Guanine; Methylnitrosourea; Methyltransferases; Mutation; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Solubility; Time Factors | 1986 |
Adaptive response to alkylating agents in mammalian cells.
Topics: Adaptation, Physiological; Alkylating Agents; Animals; Cell Survival; Guanine; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1986 |
Cell cycle-dependent initiation of hepatocarcinogenesis in rats by methyl(acetoxymethyl)nitrosamine.
Topics: Animals; Carcinogens; Cell Cycle; Cell Division; Dimethylnitrosamine; DNA Repair; DNA Replication; Guanine; Hepatectomy; Hydrocortisone; Liver Neoplasms, Experimental; Male; Methylnitrosourea; Rats; Rats, Inbred F344; Time Factors | 1987 |
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; DNA; Dose-Response Relationship, Drug; Female; Guanine; Mesocricetus; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Pregnancy | 1985 |
The Escherichia coli O6-methylguanine-DNA methyltransferase does not repair promutagenic O6-methylguanine residues when present in Z-DNA.
Topics: DNA Repair; Escherichia coli; Ethidium; Guanine; Kinetics; Methylnitrosourea; Methyltransferases; Nucleic Acid Conformation; O(6)-Methylguanine-DNA Methyltransferase | 1985 |
Genotoxicity of formaldehyde in cultured human bronchial fibroblasts.
Topics: Bronchi; Cells, Cultured; DNA Repair; Drug Synergism; Fibroblasts; Formaldehyde; Guanine; Humans; Methylnitrosourea; Mutagens | 1985 |
Repair of O6-methylguanine, by mammalian cell extracts, in alkylated DNA and poly(dG-m5dC).(poly dG-m5dC) in B and Z forms.
Topics: Alkylation; Animals; DNA Repair; Guanine; Liver Neoplasms, Experimental; Methylnitrosourea; Methyltransferases; Nucleic Acid Conformation; O(6)-Methylguanine-DNA Methyltransferase; Rats | 1985 |
Improved fluorometric method for quantitative high-performance liquid chromatographic analysis of methylated guanine derivatives in DNA.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; DNA; Female; Guanine; Hydrolysis; Liver; Methylnitrosourea; Particle Size; Rats; Spectrometry, Fluorescence; Thymus Gland | 1985 |
In vitro DNA methylation by methylnitrosourea in isolated copper- or silver-preloaded rat liver nuclei.
Topics: Animals; Cell Nucleus; Copper; DNA; Guanine; In Vitro Techniques; Liver; Male; Methylation; Methylnitrosourea; Rats; Rats, Inbred Strains; Silver | 1985 |
Cell proliferation and DNA repair in the liver during early stages of chemical carcinogenesis.
Topics: 2-Acetylaminofluorene; Animals; Carcinogens; Cell Cycle; Cell Division; Clone Cells; DNA Repair; Guanine; Liver; Male; Methylnitrosourea; Mice; Neoplasms, Experimental; Phosphoglycerate Kinase; Precancerous Conditions; Rats; Rats, Inbred Strains; X Chromosome | 1985 |
DNA sequence has an effect on the extent and kinds of alkylation of DNA by a potent carcinogen.
Topics: Adenine; Alkylation; Animals; Base Sequence; Cattle; DNA; Guanine; Methylnitrosourea; Polydeoxyribonucleotides; Structure-Activity Relationship; Thymus Gland; Tritium | 1985 |
Carcinogen-DNA interaction: differential effects of distamycin-a and spermine on the formation of 7-methylguanine in DNA by N-methyl-N-nitrosourea, methylmethanesulfonate, and dimethylsulfate.
Topics: Animals; Carcinogens; Distamycins; DNA; Drug Interactions; Guanine; Liver; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Pyrroles; Rats; Spermine; Sulfuric Acid Esters | 1980 |
The effects of neighboring bases on N-methyl-N-nitrosourea alkylation of DNA.
Topics: Alkylation; Animals; Cattle; DNA; Guanine; Methylnitrosourea; Nitrosourea Compounds; Polydeoxyribonucleotides; Structure-Activity Relationship; Thymus Gland | 1984 |
Repair and replication of DNA containing O6-methylguanine in fetal and adult animal tissues in relation to their susceptibilities to cancer induction by N-nitroso-N-alkylureas.
Topics: Animals; Brain; Carcinogens; DNA Repair; DNA Replication; Female; Fetus; Guanine; Liver; Lung; Methylnitrosourea; Mice; Mice, Inbred C57BL; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Spleen; Thymus Gland | 1984 |
Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts.
Topics: Antineoplastic Agents; Cell Line; DNA, Neoplasm; Ethylnitrosourea; Guanine; Humans; Kinetics; Leukemia, Lymphoid; Methylnitrosourea; Methyltransferases; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase | 1984 |
Alkylation of the O6 of guanine is only one of many chemical events that may initiate carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Ethylnitrosourea; Guanine; Methylnitrosourea; Neoplasms, Experimental | 1984 |
O6-methylguanine repair in liver cells in vivo: comparison between G1- and S-phase of the cell cycle.
Topics: Alkylation; Animals; Cell Cycle; DNA; DNA Repair; Guanine; In Vitro Techniques; Liver; Male; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred Strains | 1984 |
Autoimmune haemolytic disease in mice after exposure to a methylating carcinogen.
Topics: Anemia, Hemolytic, Autoimmune; Animals; DNA; Dose-Response Relationship, Drug; Guanine; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds; Species Specificity; Spleen; Thymoma; Thymus Neoplasms | 1983 |
Persistence of methylated purines in the DNA of various rat fetal and maternal tissues and carcinogenesis in the offspring following a single transplacental dose of N-methyl-N-nitrosourea.
Topics: Adenine; Animals; Brain; DNA; Female; Fetus; Guanine; Kidney; Liver; Methylation; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Placenta; Pregnancy; Purines; Rats; Time Factors | 1983 |
Mode of action of methylating carcinogens: comparative studies of murine and human cells.
Topics: Animals; Carcinogens; Cells, Cultured; DNA; Guanine; Humans; Lymphocytes; Methylation; Methylnitrosourea; Mice; Mice, Inbred Strains; Species Specificity | 1981 |
Effect of pretreatment of rats with N-methyl-N-nitrosourea on the repair of O(6)-methylguanine in liver DNA.
Topics: 1,2-Dimethylhydrazine; Animals; Dimethylhydrazines; DNA Repair; Guanine; Male; Methylation; Methylnitrosourea; Nitrosourea Compounds; Rats | 1981 |
A system in mouse liver for the repair of O6-methylguanine lesions in methylated DNA.
Topics: Amino Acids; Animals; DNA; DNA Repair; Guanine; Kinetics; Liver; Male; Methylation; Methylnitrosourea; Mice; Mice, Inbred C57BL; Proteins | 1981 |
Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents.
Topics: Adolescent; Adult; Alkylating Agents; Ataxia Telangiectasia; Cell Division; Cells, Cultured; Child; DNA; DNA Repair; Female; Guanine; Humans; Infant, Newborn; Kinetics; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea | 1981 |
Inability of Chinese hamster ovary cells to excise O6-alkylguanine.
Topics: Adenine; Alkylating Agents; Animals; Cricetinae; Cricetulus; DNA; DNA Repair; Ethylnitrosourea; Female; Guanine; Methylnitrosourea; Ovary; Pyrimidine Dimers; Time Factors | 1980 |
The persistence in Xenopus laevis DNA of O6-methylguanine produced by exposure to N-methyl-N-nitrosourea.
Topics: Animals; DNA; Female; Guanine; Kidney; Liver; Methylnitrosourea; Nitrosourea Compounds; Xenopus | 1980 |
Metabolism of dimethylnitrosamine and subsequent removal of O6-methylguanine from DNA by isolated rat hepatocytes.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA; Female; Guanine; In Vitro Techniques; Liver; Methylnitrosourea; Rats | 1981 |
Differential effects of procarbazine and methylnitrosourea on the accumulation of O6-methylguanine and the depletion and recovery of O6-alkylguanine-DNA alkyltransferase in rat tissues.
Topics: Animals; DNA; Female; Guanine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Procarbazine; Proteins; Rats; Rats, Sprague-Dawley; RNA | 1994 |
Modulation of nitrosourea toxicity in rodent embryonic cells by O6-benzylguanine, a depletor of O6-methylguanine-DNA methyltransferase.
Topics: Animals; Cell Differentiation; Cells, Cultured; DNA Adducts; Ethylnitrosourea; Female; Guanine; Mesencephalon; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Pregnancy; Rats; Rats, Sprague-Dawley | 1995 |
Streptozotocin-induced toxicity in CHO-9 and V79 cells.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cricetulus; DNA; DNA Replication; Ethylnitrosourea; Guanine; Methylnitrosourea; Mutagens; Streptozocin; Thymidine | 1995 |
Age-related studies on the removal of 7-methylguanine from DNA of mouse kidney tissue following N-methyl-N-nitrosourea treatment.
Topics: Aging; Animals; Cellular Senescence; DNA Damage; DNA Repair; Guanine; Kidney; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL | 1993 |
Nonrandom distribution of O6-methylguanine in H-ras gene sequence from DNA modified with N-methyl-N-nitrosourea.
Topics: Animals; Base Sequence; DNA; Genes, ras; Guanine; Methylnitrosourea; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Rats | 1993 |
A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells.
Topics: Alkylating Agents; B-Lymphocytes; Cell Line; Chromosome Aberrations; Dimethylnitrosamine; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Erythroid Precursor Cells; Guanine; Humans; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea | 1995 |
A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage.
Topics: Cell Survival; DNA Damage; DNA Repair; DNA, Neoplasm; DNA, Satellite; Dose-Response Relationship, Drug; Drug Resistance; Genetic Complementation Test; Guanine; HeLa Cells; Humans; Methylation; Methylnitrosourea; Methyltransferases; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Thioguanine | 1995 |
Aging affects the levels of DNA damage in postmitotic cells.
Topics: Aging; Animals; Chromatography, High Pressure Liquid; DNA; DNA Damage; DNA Glycosylases; DNA Repair; Guanine; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mitosis; N-Glycosyl Hydrolases; RNA, Messenger | 1994 |
The susceptibility of inbred mice to the production of malignant thymoma by N-methyl-N-nitrosourea.
Topics: Age Factors; Animals; Guanine; Major Histocompatibility Complex; Methylnitrosourea; Mice; Mice, Inbred Strains; Species Specificity; Thymoma; Thymus Neoplasms | 1994 |
Rapid repair of O6-methylguanine-DNA adducts protects transgenic mice from N-methylnitrosourea-induced thymic lymphomas.
Topics: Animals; DNA; DNA Repair; Guanine; Lymphoma; Methylnitrosourea; Methyltransferases; Mice; Mice, Transgenic; O(6)-Methylguanine-DNA Methyltransferase; Species Specificity; Thymus Gland; Thymus Neoplasms | 1994 |
Repair resistance of O6-methylguanine in DNA of hamster fibroblasts expressing a bacterial alkyltransferase gene is dependent on chromatin structure.
Topics: Animals; Bacterial Proteins; Cell Nucleus; Chromatin; Clone Cells; Cricetinae; DNA; DNA Damage; DNA Repair; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Guanine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Transcription Factors; Transfection | 1993 |
DNA methylation by N-methyl-N-nitrosourea: methylation pattern changes in single- and double-stranded DNA, and in DNA with mismatched or bulged guanines.
Topics: Autoradiography; Base Sequence; Circular Dichroism; DNA; DNA, Single-Stranded; Guanine; Hot Temperature; Methylation; Methylnitrosourea; Molecular Sequence Data; Nucleic Acid Heteroduplexes | 1993 |
Effects of inhibition of O6-alkylguanine-DNA alkyltransferase in rats on carcinogenesis by methylnitrosourea and ethylnitrosourea.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Ethylnitrosourea; Female; Guanine; Liver; Methylnitrosourea; Methyltransferases; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344 | 1994 |
DNA adduct formation and assessment of aberrant crypt foci in vivo in the rat colon mucosa after treatment with N-methyl-N-nitrosourea.
Topics: Animals; Colon; Colonic Neoplasms; DNA; Dose-Response Relationship, Drug; Guanine; Intestinal Mucosa; Male; Methylnitrosourea; Rats; Rats, Inbred F344; Time Factors; Tritium | 1994 |
Genetic consequences of tolerance to methylation DNA damage in mammalian cells.
Topics: Adenine; Adenine Phosphoribosyltransferase; Animals; Aza Compounds; Base Sequence; Cell Survival; CHO Cells; Cricetinae; DNA; DNA Damage; Drug Resistance; Guanine; Methylation; Methylnitrosourea; Molecular Sequence Data; Mutation; Ouabain; Thioguanine | 1993 |
O6-methylguanine in DNA inhibits replication in vitro by human cell extracts.
Topics: Antigens, Polyomavirus Transforming; Deoxyribonucleases, Type II Site-Specific; DNA Repair; DNA Replication; DNA, Viral; Guanine; HeLa Cells; Humans; Kinetics; Methylation; Methylnitrosourea; Plasmids; Simian virus 40 | 1993 |
Ellagic acid embryoprotection in vitro: distribution and effects on DNA adduct formation.
Topics: Abnormalities, Drug-Induced; Animals; DNA Damage; Ellagic Acid; Embryo, Mammalian; Guanine; Methylnitrosourea; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Solubility; Teratogens; Yolk Sac | 1993 |
Repair of O6-methylguanine in rat pancreatic beta-cells after exposure to N-methyl-N-nitrosourea.
Topics: Animals; Blotting, Northern; Cells, Cultured; CHO Cells; Cricetinae; Guanine; Islets of Langerhans; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Cells, Cultured | 1993 |
A human cell line proficient in O6-methylguanine-DNA-methyltransferase and hypersensitive to alkylating agents.
Topics: Alkylating Agents; Animals; Carcinoma, Hepatocellular; Cell Death; Cell Division; CHO Cells; Cricetinae; DNA Damage; DNA Repair; Drug Hypersensitivity; Drug Resistance; Guanine; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Rats; Tumor Cells, Cultured | 1993 |
Effect of 5-methylcytosine as a neighboring base on methylation of DNA guanine by N-methyl-N-nitrosourea.
Topics: 5-Methylcytosine; Autoradiography; Base Sequence; Cytosine; DNA; DNA Damage; Guanine; Humans; Methylation; Methylnitrosourea; Molecular Sequence Data | 1993 |
Repair of N-methylpurines in the mitochondrial DNA of xeroderma pigmentosum complementation group D cells.
Topics: Blotting, Southern; Cell Line; DNA Damage; DNA Repair; DNA, Mitochondrial; Genetic Complementation Test; Guanine; Humans; Methylation; Methylnitrosourea; Xeroderma Pigmentosum | 1993 |
Alterations in DNA and cell membranes in an initiation process of carcinogenesis by N-nitrosourea.
Topics: Alkylating Agents; Alkylation; Animals; Binding Sites; Carcinogens; Cell Membrane; DNA; Guanine; Hydrogen Bonding; Male; Methylnitrosourea; Neoplasms, Experimental; Organ Specificity; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Stomach | 1995 |
Comparison of inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans by streptozotocin and methyl and ethyl nitrosoureas and methanesulphonates. Lack of correlation with nitric oxide-releasing or O6-alkylating ability.
Topics: Alkylating Agents; Animals; Cyclic GMP; Ethyl Methanesulfonate; Ethylnitrosourea; Glucose; Guanine; Insulin; Islets of Langerhans; Methyl Methanesulfonate; Methylnitrosourea; Nitric Oxide; Rats; Rats, Sprague-Dawley; Streptozocin; Structure-Activity Relationship | 1995 |
The design of agents to control DNA methylation adducts. Enhanced major groove methylation of DNA by an N-methyl-N-nitrosourea functionalized phenyl neutral red intercalator.
Topics: Adenine; Circular Dichroism; DNA Adducts; DNA Methylation; Drug Design; Ethidium; Guanine; Intercalating Agents; Methylnitrosourea; Neutral Red; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1996 |
Glial cell-specific differences in repair of O6-methylguanine.
Topics: Alkylating Agents; Animals; Astrocytes; DNA Damage; DNA Repair; Guanine; Methylnitrosourea; Methyltransferases; Microglia; O(6)-Methylguanine-DNA Methyltransferase; Oligodendroglia; Rats; Time Factors | 1996 |
Formation and persistence of N7- and O6-methyl-guanine in DNA of chick embryo brain cells in ovo following administration of N-nitroso-N-methylurea.
Topics: Animals; Brain; Brain Chemistry; Chick Embryo; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Dose-Response Relationship, Drug; Electrochemistry; Guanine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Time Factors | 1996 |
K-ras codon 12 and 61 point mutations in bromodeoxyuridine- and N-nitrosomethylurea-induced rat renal mesenchymal tumors.
Topics: Adenine; Animals; Bromodeoxyuridine; Carcinogens; Codon; Female; Genes, ras; Guanine; Kidney Neoplasms; Male; Mesenchymoma; Methylnitrosourea; Neoplasms, Experimental; Point Mutation; Polymerase Chain Reaction; Rats | 1996 |
Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents.
Topics: Alkylating Agents; Animals; Cell Division; CHO Cells; Chromosome Aberrations; Cricetinae; DNA Repair; Enzyme Inhibitors; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Thioguanine | 1997 |
Introduction, distribution, and removal of 7-methylguanine in different liver chromatin fractions of young and old mice.
Topics: Age Factors; Animals; Chemical Fractionation; Chromatin; Deoxyribonucleases; DNA Adducts; DNA Methylation; DNA Repair; Guanine; Liver; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Time Factors; Transcription, Genetic | 1997 |
Formation and repair of O6-methylguanine in recombination hot spots of plant chromosomes.
Topics: Alkylating Agents; Chromatids; Chromosome Aberrations; Chromosomes; Deoxyribonucleases, Type II Site-Specific; DNA Repair; DNA, Plant; Fabaceae; Guanine; Immunoblotting; Meristem; Methylnitrosourea; Mutagens; Plant Roots; Plants, Medicinal; Recombination, Genetic; Repetitive Sequences, Nucleic Acid | 1997 |
Removal of O6-methylguanine from plant DNA in vivo is accelerated under conditions of clastogenic adaptation.
Topics: Adaptation, Physiological; Alkylating Agents; Chromosome Aberrations; DNA Adducts; DNA Damage; DNA, Plant; Fabaceae; Guanine; Immunoblotting; Meristem; Methylnitrosourea; Mutagens; Plants, Medicinal | 1997 |
Reversal of methylation tolerance by transfer of human chromosome 2.
Topics: Centromere; Chromosomes, Human, Pair 2; DNA Methylation; DNA Probes; DNA Repair; Drug Resistance; Gene Transfer Techniques; Guanine; HeLa Cells; Humans; Hypoxanthine Phosphoribosyltransferase; Methylnitrosourea; Microsatellite Repeats; Mutagenesis; Mutagens; Sister Chromatid Exchange | 1997 |
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.
Topics: Alkylation; Animals; Animals, Genetically Modified; DNA Adducts; DNA Repair; DNA, Neoplasm; Ethylnitrosourea; Female; Genes, ras; Guanine; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Rats; Transcription, Genetic | 1998 |
Implication of localization of human DNA repair enzyme O6-methylguanine-DNA methyltransferase at active transcription sites in transcription-repair coupling of the mutagenic O6-methylguanine lesion.
Topics: Alkylating Agents; Alkylation; Animals; Antibodies, Monoclonal; Binding Sites; Blotting, Western; Cell Cycle; Cell Line; Cell Nucleus; Deoxyribonuclease I; DNA Damage; DNA Repair; Epitope Mapping; Epitopes, B-Lymphocyte; Guanine; HeLa Cells; Humans; Methylnitrosourea; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Rabbits; Transcription, Genetic | 1998 |
Initial levels of azoxymethane-induced DNA methyl adducts are not predictive of tumor susceptibility in inbred mice.
Topics: Animals; Azoxymethane; Biotransformation; Carcinogens; Cattle; Chromatography, High Pressure Liquid; DNA; DNA Adducts; Guanine; Immunoblotting; Male; Methylnitrosourea; Mice; Mice, Inbred AKR; Mice, Inbred Strains; Neoplasms, Experimental; Predictive Value of Tests | 1998 |
Effects of O6-benzylguanine on growth and differentiation of P19 embryonic carcinoma cells treated with alkylating agents.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Embryonal; Cell Differentiation; Cell Division; Cell Survival; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Guanine; Mesencephalon; Methyl Methanesulfonate; Methylnitrosourea; Mice; Neurons; O(6)-Methylguanine-DNA Methyltransferase; Rats; Tretinoin; Tumor Cells, Cultured | 1998 |
Critical steps in alkylation-induced aberration formation.
Topics: Alkylating Agents; Animals; Cell Cycle; Chromosome Aberrations; DNA Damage; DNA Repair; DNA Replication; Fibroblasts; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mutagens; Nucleic Acid Synthesis Inhibitors; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Sister Chromatid Exchange | 1998 |
Tobacco BY-2 cells excise both 3-methyladenine and 7-methylguanine from methylated DNA.
Topics: Adenine; Animals; Cattle; Cell Line; Chromatography, High Pressure Liquid; DNA; DNA Glycosylases; DNA Methylation; Guanine; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; N-Glycosyl Hydrolases; Nicotiana; Plants, Toxic | 1998 |
Nickel(II) inhibits the repair of O6-methylguanine in mammalian cells.
Topics: Animals; Blotting, Western; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; DNA Repair; Female; Guanine; Humans; Methylnitrosourea; Nickel; O(6)-Methylguanine-DNA Methyltransferase; Transfection | 1998 |
Mismatch repair and differential sensitivity of mouse and human cells to methylating agents.
Topics: 3T3 Cells; Alkylating Agents; Animals; Antineoplastic Agents; Apoptosis; Base Pair Mismatch; Chromosomes, Human, Pair 2; DNA Methylation; DNA Repair; DNA-Binding Proteins; Drug Resistance, Neoplasm; Gene Transfer Techniques; Genotype; Guanine; HeLa Cells; Humans; Melanoma, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; MutS Homolog 2 Protein; Proto-Oncogene Proteins; Species Specificity; Tumor Cells, Cultured | 1999 |
Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15.
Topics: Base Pair Mismatch; Base Sequence; Colonic Neoplasms; DNA Primers; DNA Repair; DNA-Binding Proteins; DNA, Complementary; G2 Phase; Guanine; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Microsatellite Repeats; Mutation; Phenotype; Transfection; Tumor Cells, Cultured | 1999 |
Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; Codon; DNA Adducts; DNA Damage; DNA Methylation; Genes, ras; Guanine; Humans; Lac Operon; Lymphoma; Methylnitrosourea; Mice; Mice, Transgenic; Mutagenesis; Mutagens; O(6)-Methylguanine-DNA Methyltransferase; Organ Specificity; Point Mutation; Spleen; Thymus Gland; Thymus Neoplasms; Transgenes | 1999 |
DNA alkylation studies of combined treatment with methylnitrosourea and ethylmethanesulfonate in mice.
Topics: Alkylating Agents; Alkylation; Animals; DNA; DNA Damage; DNA Methylation; Drug Synergism; Embryo, Mammalian; Ethyl Methanesulfonate; Female; Guanine; Injections, Intraperitoneal; Liver; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Pregnancy | 2000 |
Toxicity, mutation frequency and mutation spectrum induced by dacarbazine in CHO cells expressing different levels of O(6)-methylguanine-DNA methyltransferase.
Topics: Amino Acid Substitution; Animals; CHO Cells; Cricetinae; Dacarbazine; DNA Methylation; DNA Mutational Analysis; Enzyme Induction; Guanine; Humans; Hypoxanthine Phosphoribosyltransferase; Liver Extracts; Male; Methylnitrosourea; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Rats; Rats, Sprague-Dawley | 2000 |
In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Biotransformation; Cisplatin; Cytochrome P-450 Enzyme System; Dacarbazine; DNA Damage; Enzyme Inhibitors; Guanine; Intestine, Small; Methylnitrosourea; Mice; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Temozolomide | 2000 |
DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.
Topics: Adenocarcinoma; Alkylating Agents; Animals; Carcinogens; DNA; DNA Adducts; DNA Repair; Drug Resistance, Neoplasm; Ethylnitrosourea; Female; Genes, ras; Guanine; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Mutagens; Mutation; Rats | 2000 |
Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl-N-nitrosourea: evidence of elimination of p53 by homologous recombination.
Topics: Alleles; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Codon; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblasts; Gene Deletion; Genes, p53; Guanine; Homozygote; Humans; Loss of Heterozygosity; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Recombination, Genetic; Transcriptional Activation | 2000 |
In vivo repair of methylation damage in Aag 3-methyladenine DNA glycosylase null mouse cells.
Topics: Adenine; Animals; Cell Line; DNA Adducts; DNA Damage; DNA Glycosylases; DNA Methylation; DNA Repair; DNA Replication; Gene Deletion; Genotype; Guanine; Guanosine; Methylnitrosourea; Mice; Mice, Knockout; N-Glycosyl Hydrolases | 2000 |
Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Alkylating Agents; Base Pair Mismatch; Carrier Proteins; Cell Line; Cell Nucleus; Cytoplasm; DNA; DNA Damage; DNA Methylation; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Gene Expression Regulation; Guanine; HeLa Cells; Humans; Methylnitronitrosoguanidine; Methylnitrosourea; Mismatch Repair Endonuclease PMS2; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Protein Binding; Proto-Oncogene Proteins; RNA Stability; RNA, Messenger | 2000 |
Evidence for the involvement of lesions other than O6-alkylguanine in mammalian cell mutagenesis.
Topics: Adenine; Alkylating Agents; Animals; Carcinogens; Cricetinae; DNA; DNA Damage; Drug Resistance; Guanine; Hypoxanthine Phosphoribosyltransferase; Methyl Methanesulfonate; Methylnitrosourea; Mutagenesis; Mutagens; Sulfuric Acid Esters; Thioguanine | 1980 |
The 3' --> 5' exonuclease of T4 DNA polymerase removes premutagenic alkyl mispairs and contributes to futile cycling at O6-methylguanine lesions.
Topics: Alkylating Agents; Base Pair Mismatch; Base Sequence; DNA Repair; DNA-Directed DNA Polymerase; Exodeoxyribonucleases; Guanine; Methylnitrosourea; Molecular Sequence Data; Mutagenesis; Oligodeoxyribonucleotides; Substrate Cycling; Substrate Specificity; Templates, Genetic; Viral Proteins | 2001 |
Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Cacodylic Acid; Carcinogens; Cell Division; Cell Transformation, Neoplastic; DNA Mutational Analysis; Female; Guanine; Humans; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Knockout; Mice, Transgenic; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Polymorphism, Single-Stranded Conformational; RNA, Messenger; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms | 2001 |
PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells.
Topics: Apoptosis; Base Pair Mismatch; Cell Line, Tumor; Chromatin; DNA; DNA Damage; DNA Repair Enzymes; DNA Replication; DNA-Binding Proteins; Guanine; HeLa Cells; Humans; Kinetics; Methylnitrosourea; Mutation; MutL Proteins; MutS Homolog 2 Protein; Neoplasm Proteins; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins | 2005 |
[Methylnitrosourea as challenge mutagen in assessment of the DNA mismatch repair (MMR) activity: association with some types of cancer].
Topics: Apoptosis; Chromosome Aberrations; Comet Assay; DNA Mismatch Repair; DNA, Neoplasm; Female; Genital Neoplasms, Female; Guanine; HeLa Cells; Humans; In Vitro Techniques; Lymphocytes; Methylnitrosourea; Microsatellite Instability; Mutagens | 2008 |
A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Apoptosis; Base Pair Mismatch; Caspase 3; DNA; DNA Modification Methylases; DNA Repair Enzymes; Etoposide; Fibroblasts; Gene Expression Regulation; Guanine; Humans; Lung; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Knockout; Mutagenesis; Mutation; MutL Protein Homolog 1; Nuclear Proteins; RNA, Small Interfering; Tumor Suppressor Proteins; Ultraviolet Rays | 2009 |
The removal of alkylation products from the DNA of Escherichia coli cells treated with the carcinogens N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: influence of growth conditions and DNA repair defects.
Topics: Adenine; Alkylating Agents; Alkylation; Carcinogens; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Methylation; Methylnitrosourea | 1980 |
Persistence of alkylated DNA bases in the Mongolian gerbil (Meriones unguiculatus) following a single dose of methylnitrosourea +.
Topics: Alkylating Agents; Animals; Brain; DNA; Female; Gerbillinae; Guanine; Kidney; Liver; Lung; Methylnitrosourea | 1980 |
Pol kappa partially rescues MMR-dependent cytotoxicity of O6-methylguanine.
Topics: Alkylating Agents; Cell Cycle; Cell Line, Tumor; Cell Survival; DNA Mismatch Repair; DNA-Directed DNA Polymerase; Guanine; HeLa Cells; Humans; Immunoblotting; Methylnitrosourea; Mitosis; O(6)-Methylguanine-DNA Methyltransferase; Proliferating Cell Nuclear Antigen; Rad51 Recombinase; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sister Chromatid Exchange; Ultraviolet Rays | 2012 |
The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Apoptosis; Apoptosis Regulatory Proteins; G2 Phase Cell Cycle Checkpoints; Gene Knockdown Techniques; Guanine; HeLa Cells; Humans; M Phase Cell Cycle Checkpoints; Methylnitrosourea; Mice; Molecular Sequence Data; Rats | 2012 |
Molecular dosimetry of endogenous and exogenous O(6)-methyl-dG and N7-methyl-G adducts following low dose [D3]-methylnitrosourea exposures in cultured human cells.
Topics: Cells, Cultured; Deoxyguanosine; Dose-Response Relationship, Drug; Guanine; Humans; Methylnitrosourea | 2014 |
Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.
Topics: Base Sequence; Chromosomes, Human, Pair 15; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Epithelial Cells; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Guanine; Humans; Longitudinal Studies; Lung Neoplasms; Male; Methylation; Methylnitrosourea; Molecular Sequence Data; Polymorphism, Single Nucleotide; Smoking; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2015 |