methylnitrosourea has been researched along with ethylnitrosourea in 175 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 120 (68.57) | 18.7374 |
| 1990's | 39 (22.29) | 18.2507 |
| 2000's | 12 (6.86) | 29.6817 |
| 2010's | 4 (2.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Singer, B | 2 |
| Kuśmierek, JT; Singer, B | 1 |
| Beniashvili, DSh; Dimant, IN | 2 |
| Bosch, DA; Ebels, EJ | 1 |
| Neale, S | 1 |
| Thielmann, HW | 1 |
| Reygers, U; Thielmann, HW; Vosberg, HP | 1 |
| Merrifield, RK; Shooter, KV | 1 |
| Smith, BJ | 1 |
| Thust, R | 2 |
| Swenberg, JA | 1 |
| Fraenkel-Conrat, H; Singer, B; Sun, L | 1 |
| Lijinsky, W; Taylor, HW | 1 |
| Cravioto, H; Yoshida, J | 1 |
| Garner, RC; Martin, CN; Pickering, C | 1 |
| Jänisch, W; Scholtze, P; Schreiber, D; Warzok, R | 1 |
| Beniashvili, DSh | 1 |
| Brimer, PA; Hsie, AW; O'Neill, JP; Schröder, CH; Thielmann, HW | 1 |
| Blaufuss, EM; Schreiber, D; Warzok, R | 1 |
| Iustratova, LS; Kuklin, VV | 1 |
| Shooter, KV; Slade, TA | 1 |
| Gerlach, H; Holzhausen, HJ; Schreiber, D | 1 |
| Aleksandrov, VA; Schreiber, D | 1 |
| Couch, DB; Hsie, AW | 1 |
| Frei, JV; Lawley, PD; Swenson, DH; Warren, W | 1 |
| Jensen, DE | 1 |
| Vasil'eva, SV | 1 |
| Pozharisskiĭ, KM | 1 |
| Alexandrov, VA | 1 |
| Bosch, DA | 2 |
| Goth-Goldstein, R | 2 |
| Balakhonov, AV | 1 |
| Lawley, PD; Warren, W | 2 |
| Ostrovskaia, LA; Vermel', EM | 1 |
| Denlinger, RH; Koestner, A | 1 |
| Eisen, JD; Sanger, WG | 1 |
| Catalano, A; Huang, PH | 1 |
| Salamon, DP; Wani, AA; Yamasaki, EF | 1 |
| Fujimori, K; Inoue, K; Maekawa, A; Nakazawa, K; Shibutani, M; Takanaka, A | 1 |
| Bouffler, SD; Godfrey, DB; Johnson, RT; Musk, SR; Raman, MJ | 1 |
| Tokuda, K | 1 |
| Li, YQ; O'Connor, PJ; Potten, CS; Winton, DJ | 1 |
| Blonsky, KS; Lee, GS; Morgan, AR; Savage, EA; Van On, DL; von Borstel, RC | 1 |
| Fan, CY; Li, YQ; O'Connor, PJ; Potten, CS; Winton, DJ | 1 |
| Link, A; Tempel, K | 1 |
| Deorukhakar, VV; Murthy, MS | 1 |
| Kroese, ED; Meerman, JH; Mohn, GR; Zeilmaker, MJ | 1 |
| Beniashvili, DS | 1 |
| Anders, A; Barnekow, A; Schartl, M; Schmidt, CR | 1 |
| Berger, MR; Klenner, T; Rao, NU; Schmähl, D; Sosnovsky, G; Wingen, F | 1 |
| Faustman, EM; Gage, D; Kirby, Z; Varnum, M | 1 |
| Aquilina, G; Bignami, M; Dogliotti, E; Montesano, R; Wild, CP; Zijno, A | 1 |
| Kovatch, RM; Lijinsky, W; Saavedra, JE | 1 |
| Diwan, BA; Ohshima, M; Rice, JM | 1 |
| Drinkwater, NR; Eckert, KA; Ingle, CA; Klinedinst, DK | 1 |
| Brent, TP | 2 |
| Nakabeppu, Y; Otsuka, M; Sekiguchi, M | 1 |
| Cooper, CS; Newbold, RF; Shiner, AC | 1 |
| Rajewsky, MF; Samson, L; Thomale, J | 1 |
| Fox, M; Margison, GP | 1 |
| Jensen, JC; Thilly, WG | 1 |
| Anderson, LM; Rice, JM | 1 |
| Hickson, ID; Robson, CN | 1 |
| Hsie, AW; Schröder, CH; Thielmann, HW | 1 |
| Kanduc, D; Quagliariello, E | 1 |
| Kadlubar, FF; Kumari, L; Lehman, TA; Milo, GE; Noyes, I; Oldham, JW; West, RW | 1 |
| Brambilla, G; Gazzaniga, GM; Martelli, A; Robbiano, L | 1 |
| Lunn, G; Sansone, EB | 1 |
| Berger, MR; Kaufmann, M; Petru, E; Zeller, WJ | 1 |
| Lantos, PL | 1 |
| Mandel, R; Ryser, HJ | 1 |
| Crosby, RM; Richardson, FC; Richardson, KK; Skopek, TR; Swenberg, JA | 1 |
| Mitchel, RE; Morrison, DP | 1 |
| Goth-Goldstein, R; Hughes, M | 1 |
| Borzelleca, JF; Carchman, RA; Charles, JL; Condie, LW; Jacobson-Kram, D | 1 |
| Herrera, RJ; Luckett, DC; Mukherjee, AB | 1 |
| Conrad, J; Eisenbrand, G; Müller, N | 1 |
| Hellwig, D; Mennel, HD; Simon, H | 1 |
| Holtzman, S; Meade, M; Shellabarger, CJ; Stone, JP | 1 |
| De Brij, RJ; Den Engelse, L; Menkveld, GJ; Tates, AD | 1 |
| Bach, B; Mendel, J; Schwarz, H; Thust, R | 1 |
| Furuta, K; Hayashi, Y; Maekawa, A; Matsuoka, C; Mitsumori, K; Ogiu, T; Onodera, H; Tanigawa, H | 1 |
| Beland, FA; Heflich, RH; Morris, SM; White, GL | 1 |
| Akhmatullina, NB; Chulanova, KG; Rapoport, IA | 1 |
| Abe, H; Allen, N; Clendenon, NR; Swenberg, JA | 1 |
| Jänisch, W; Schmidt, T | 1 |
| Alexandrov, VA; Timoshenko, IV; Turusov, VS | 1 |
| Marushige, K; Marushige, Y | 2 |
| Likhachev, AJ | 1 |
| Kleihues, P; Rajewsky, MF | 1 |
| Deen, DF; Marton, LJ; Oredsson, SM | 1 |
| Enomoto, T; Hata, S; Kanzaki, T; Kimura, S; Kusafuka, T; Miyamoto, S; Nomura, T; Shibata, K; Sobue, K; Tanaka, H | 1 |
| Schrotel, KR; Skare, JA | 1 |
| Natarajan, AT; Simons, JW; van Zeeland, AA; Vogel, EW | 1 |
| Dornish, JM; Markussen, G; Smith-Kielland, I | 1 |
| Hadi, SM; Rizvi, RY | 1 |
| Kaina, B | 1 |
| Bertolotto, A; Giordana, MT; Magrassi, ML; Mauro, A; Migheli, A; Schiffer, D | 1 |
| Osorio, L; Sapse, AM; Snyder, G | 1 |
| Berger, MR; Eisenbrand, G; Floride, J; Schmähl, D; Schreiber, J | 1 |
| Nomura, T | 1 |
| Chen, BP; Rice, JM; Wei, SJ | 1 |
| Medcalf, AS; Wade, MH | 1 |
| Brésil, H; Ivanov, MN; Likhachev, AJ; Margison, GP; Montesano, R; Planche-Martel, G | 1 |
| Danilenko, II | 1 |
| Frei, JV; Lawley, PD | 1 |
| Becci, PJ; Grubbs, CJ; Moon, RC; Thompson, HJ | 1 |
| Habs, M; Ivankovic, S; Schmähl, D; Zeller, WJ | 1 |
| De Bernardo, E | 1 |
| Dzhalilov, KD; Mukhamedov, SM; Vallamatov, ST | 1 |
| Davnichenko, LS; Rapoport, IA; Vasil'eva, SV | 1 |
| Arlett, CF; Teo, IA | 1 |
| Montgomery, CS; Russell, LB | 1 |
| Crathorn, AR; Shooter, KV | 1 |
| D'Ambrosio, SM; Mhaskar, DN; Raber, JM | 1 |
| Mendel, J; Schwarz, H; Thust, R | 1 |
| Lijinsky, W | 1 |
| Barciszewski, J; Ebel, JP; Giegé, R; Romby, P | 1 |
| Mendel, J; Schwarz, H; Thust, R; Warzok, R | 1 |
| Brennand, J; Fox, M; McMillan, S | 1 |
| Cohadon, F | 1 |
| Jenssen, D; Ramel, C | 1 |
| de Groot, AJ; Jansen, JG; Lohman, PH; Mohn, GR; van Teijlingen, CM; van Zeeland, AA; Vrieling, H | 1 |
| Faustman, EM; Kidney, JK | 1 |
| Capucci, MS; De Groot, A; Hoffmann, ME; Natarajan, AT | 1 |
| Faustman, EM; Seeley, MR | 3 |
| Dycaico, MJ; Hamner, RT; Kretz, PL; Lundberg, KS; Matthews, CD; Provost, GS; Rogers, BJ; Short, JM | 1 |
| Aquilina, G; Branch, P; Karran, P; Zhukovskaya, N | 1 |
| Jansen, JG; Lohman, PH; Mohn, GR; van Teijlingen, CM; van Zeeland, AA; Vrieling, H | 1 |
| Hamilton, JW; McCaffrey, J | 1 |
| Anver, MR; Lijinsky, W; Moschel, RC; Pegg, AE | 1 |
| Kodama, M; Ohashi, M; Sano, A; Takitani, S | 1 |
| Blomeke, B; Bowman, ED; Kato, S; Petruzzelli, S; Shields, PG; Turteltaub, KW; Weston, A | 1 |
| Dougherty, CD; Guzman, RC; Huang, TT; Nandi, S; Swanson, SM; Tsukamoto, T | 1 |
| Ashby, J; Guttenplan, JB; Paton, D; Tinwell, H | 1 |
| Cunningham, JM; Delaney, CA; Di Matteo, M; Dunger, A; Green, IC; Green, MH | 1 |
| Baan, RA; Bergmans, A; van Delft, JH | 1 |
| Brooks, T; Carr, GJ; Douglas, GR; Gorelick, NJ; Liegibel, UM; Lockhart, AC; Margolin, BH; Piegorsch, WW; Suzuki, T; Thybaud, V; van Delft, JH | 1 |
| Abril, N; Pueyo, C; Vidal, A | 1 |
| Arceo, C; Carrasco, G; Cruces, MP; Olvera, O; Pimentel, E; Zimmering, S | 1 |
| Engelbergs, J; Galhoff, A; Rajewsky, MF; Thomale, J | 1 |
| Futakuchi, M; Hasegawa, R; Ito, N; Lijinsky, W; Mizoguchi, Y; Shirai, T; Yamaguchi, T | 1 |
| Baan, RA; Bergmans, A; Howard, L; Tates, AD; van Dam, FJ; van Delft, JH; Winton, DJ | 1 |
| González-Beltrán, F; Morales-Ramírez, P | 1 |
| Gichner, T; Plewa, MJ; Ptácek, O; Stavreva, DA | 1 |
| Ehling, UH; Sega, GA; Sotomayor, RE | 1 |
| Favor, J | 1 |
| Engelbergs, J; Rajewsky, MF; Schweer, T; Thomale, J | 1 |
| Engelbergs, J; Rajewsky, MF; Thomale, J | 1 |
| Arceo, C; Olvera, O; Zimmering, S | 1 |
| Elsner, M; Guldbakke, B; Lenzen, S; Munday, R; Tiedge, M | 1 |
| Harbach, PR; Swenson, DH; Trzos, RJ | 1 |
| Cruz-Vallejo, V; Morales-Ramírez, P; Rodríguez-Reyes, R | 1 |
| Beenken, K; Cai, Z; Fix, D | 1 |
| de Andrade, HH; Reguly, ML; Sinigaglia, M | 1 |
| Bowman, KJ; Farmer, PB; Jones, GD; Le Pla, RC | 1 |
| Baumgardt, P; de Andrade, HH; Dihl, RR; do Amaral, VS; Lehmann, M; Reguly, ML; Sinigaglia, M | 1 |
| Hunsicker, PR; Russell, LB; Russell, WL | 1 |
| Doak, SH; Jenkins, GJ; Johnson, GE; Parry, EM; Parry, JM; Quick, E | 1 |
| Akay, A; Cuppen, E; Feitsma, H | 1 |
| Avlasevich, S; Bemis, JC; Bryce, SM; Dertinger, SD; Franklin, D; Hyrien, O; Macgregor, JT; Palis, J; Phonethepswath, S; Raja, S; Torous, DK; Weller, P | 1 |
| Moon, KY | 1 |
| Donovan, P; Smith, G | 1 |
| Abraham, L; Bodger, OG; Dearfield, KL; Gollapudi, BB; Heflich, RH; Hixon, JG; Johnson, GE; Lovell, DP; MacGregor, JT; Pottenger, LH; Soeteman-Hernández, LG; Tanir, JY; Thompson, CM; Thybaud, V; van Benthem, J; White, PA; Zeiger, E | 1 |
9 review(s) available for methylnitrosourea and ethylnitrosourea
| Article | Year |
|---|---|
Mutagenicity of nitrosamides and nitrosamidines in micro-organisms and plants.
Topics: Alkylating Agents; Bacteria; Bacteriophages; Carcinogens; Coliphages; DNA Repair; DNA Replication; Ethylnitrosourea; Fungi; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Mutation; Neurospora crassa; Nitroso Compounds; Plants | 1976 |
Chemical- and virus-induced brain tumors.
Topics: Adenoviridae; Alkylation; Alpharetrovirus; Animals; Brain Neoplasms; Carcinogens; Disease Models, Animal; DNA, Neoplasm; Ethylnitrosourea; Humans; Methylnitrosourea; Neoplasms, Experimental; Oncogenic Viruses; Papillomaviridae; Polycyclic Compounds; Polyomaviridae; Retroviridae; Tumor Virus Infections | 1977 |
[Successes of experimental oncology and problems of the study of the morphogenesis of tumors].
Topics: 2-Acetylaminofluorene; 9,10-Dimethyl-1,2-benzanthracene; Aflatoxins; Animals; Azoxymethane; Benzopyrenes; Brain Neoplasms; Carcinogens; Cricetinae; Dimethylhydrazines; Dogs; Esophageal Neoplasms; Ethionine; Ethylnitrosourea; Female; Hematopoietic System; Intestinal Neoplasms; Liver Neoplasms; Lung Neoplasms; Male; Mammary Neoplasms, Experimental; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitrosamines; Nitroso Compounds; Nitrosoguanidines; o-Aminoazotoluene; p-Dimethylaminoazobenzene; Precancerous Conditions; Rats; Skin Neoplasms; Stomach Neoplasms; Urinary Bladder Neoplasms | 1975 |
Development of nitrosourea-induced brain tumours--with a special note on changes occurring during latency.
Topics: Animals; Brain Neoplasms; Ethylnitrosourea; Female; Male; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasm Invasiveness; Neoplastic Stem Cells; Phenotype; Precancerous Conditions; Pregnancy; Time Factors | 1986 |
DNA repair induced by alkylating carcinogens.
Topics: 1,2-Dimethylhydrazine; Aging; Alkylating Agents; Animals; Carcinogens; Cricetinae; Dimethylhydrazines; Dimethylnitrosamine; DNA Repair; Ethylnitrosourea; Mesocricetus; Methylation; Methylnitrosourea; Rats | 1983 |
Chemical neuro-oncogenesis: role of structural DNA modifications, DNA repair and neural target cell population.
Topics: Alkylating Agents; Alkylation; Animals; Brain; Brain Neoplasms; Carcinogens; Cell Count; DNA; DNA Repair; Ethylnitrosourea; Female; Fetal Diseases; Humans; Methylnitrosourea; Pregnancy | 1984 |
Transgenic systems for in vivo mutation analysis.
Topics: Animals; Bacteriophage lambda; DNA Mutational Analysis; DNA, Recombinant; Ethylnitrosourea; Genes, Bacterial; Genetic Vectors; Lac Operon; Methylnitrosourea; Mice; Mice, Transgenic; Mutagenesis, Site-Directed; Organ Specificity; Point Mutation; Repressor Proteins | 1993 |
Mechanisms of mutation induction in germ cells of the mouse as assessed by the specific locus test.
Topics: Alleles; Animals; Chlorambucil; DNA Repair; Ethylnitrosourea; Female; Gene Conversion; Genetic Markers; Germ-Line Mutation; Loss of Heterozygosity; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Mutant Strains; Mitosis; Mosaicism; Mutagenicity Tests; Recombination, Genetic; Spermatogenesis; Spermatogonia | 1999 |
Role of DNA repair in carcinogen-induced ras mutation.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Base Sequence; Carcinogens; DNA; DNA Repair; Ethylnitrosourea; Female; Genes, ras; Mammary Neoplasms, Experimental; Methylnitrosourea; Models, Genetic; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Sprague-Dawley | 2000 |
166 other study(ies) available for methylnitrosourea and ethylnitrosourea
| Article | Year |
|---|---|
O2-alkylcytidine--a new major product of neutral, aqueous reaction of cytidine with carcinogens.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Cytidine; Ethylnitrosourea; Hydrogen-Ion Concentration; Methylnitrosourea; Nitrosourea Compounds; Spectrophotometry, Ultraviolet | 1976 |
Sites of alkylation of poly(U) by agents of varying carcinogenicity and stability of products.
Topics: Alkylating Agents; Alkylation; Carcinogens; Chemical Phenomena; Chemistry; Ethyl Methanesulfonate; Ethylnitrosourea; Hydrogen-Ion Concentration; Methylation; Methylnitrosourea; Models, Chemical; Nitrosoguanidines; Phosphoric Acids; Poly U; Ribose; Sulfuric Acids; Uridine | 1976 |
[Various aspects of transplacental blastomogenesis in rabbits].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrenes; Ethylnitrosourea; Female; Kidney Neoplasms; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Neurilemmoma; Pregnancy; Rabbits; Sciatic Nerve | 1978 |
Temporary cell cycle arrest in neural and extraneural developing rat tissues after exposure to methyl--and ethylnitrosourea.
Topics: Animals; Animals, Newborn; Ethylnitrosourea; Methylnitrosourea; Mitosis; Nerve Tissue; Nitrosourea Compounds; Rats; Rats, Inbred Strains | 1976 |
Detection of strand breaks in phiX 174 RFI and PM2 DNA reacted with ultimate and proximate carcinogens.
Topics: Benz(a)Anthracenes; Carcinogens; Coliphages; DNA, Bacterial; DNA, Superhelical; Ethylnitrosourea; Fluorenes; Methylnitrosourea; Molecular Biology | 1977 |
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans: some N-nitroso compounds.
Topics: Animals; Butylamines; Carcinogens; Diethylnitrosamine; Dimethylnitrosamine; Ethanolamines; Ethylamines; Ethylnitrosourea; Folic Acid; Humans; Methylamines; Methylnitrosourea; Morpholines; Nicotine; Nitrosamines; Nitroso Compounds; Piperidines; Proline; Propylamines; Research Design; Sarcosine; Streptozocin | 1978 |
Carcinogen-induced DNA repair in nucleotide-permeable Escherichia coli cells. Induction of DNA repair by the carcinogens methyl and ethyl nitrosourea and methyl methanesulfonate.
Topics: Carcinogens; DNA Nucleotidyltransferases; DNA Repair; DNA Replication; Escherichia coli; Ethylnitrosourea; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mitomycins; Nitrosourea Compounds; Nucleotides; Permeability; Radiation Effects; Ultraviolet Rays | 1975 |
An assay for phosphotriester formation in the reaction of alkylating agents with deoxyribosenucleic acid in vitro and in vivo.
Topics: Animals; Coliphages; DNA, Viral; Ethyl Methanesulfonate; Ethylnitrosourea; Liver; Mathematics; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mice; Molecular Weight; Nitrosourea Compounds; Sulfuric Acids | 1976 |
Inactivation and mutation of coliphage T4 by aliphatic nitrosamides and methanesulphonates: in vitro recovery of infectivity of T4 inactivated by isopropyl methanesulphonate.
Topics: Coliphages; Ethylnitrosourea; Mesylates; Methylnitrosourea; Mutagens; Nitrosourea Compounds; Phenotype; Viral Plaque Assay | 1976 |
[Long-term cultures of experimental CNS tumours as models in neurooncological research (author's transl)].
Topics: Animals; Brain Neoplasms; Bucladesine; Cell Division; Cell Transformation, Neoplastic; Culture Techniques; Ethylnitrosourea; Glioma; Methylnitrosourea; Neoplasms, Experimental; Neurilemmoma; Rats; Rats, Inbred Strains; Time Factors | 1976 |
Effects of alkylation of phosphodiesters and of bases of infectivity and stability of tobacco mosaic virus RNA.
Topics: Alkylation; Centrifugation, Density Gradient; Ethylnitrosourea; Hydrogen-Ion Concentration; Methylnitrosourea; RNA, Viral; Tobacco Mosaic Virus; Virulence | 1975 |
Induction of neurogenic tumors by nitrosotrialkylureas in rats.
Topics: Animals; Drug Stability; Ethylnitrosourea; Female; Hydrogen-Ion Concentration; Male; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Nerve Tissue; Nitrosourea Compounds; Rats; Solutions; Water | 1975 |
Nitrosourea-induced brain tumors: an in vivo and in vitro tumor model system.
Topics: Animals; Brain Neoplasms; Cell Division; Cells, Cultured; Disease Models, Animal; Ethylnitrosourea; Female; Glioma; Immunosuppression Therapy; Male; Methylnitrosourea; Neoplasm Transplantation; Neoplasms, Experimental; Neurilemmoma; Nitrosourea Compounds; Pregnancy; Rats; Rats, Inbred Strains; Thymus Gland; Time Factors; Transplantation, Isogeneic | 1978 |
Mutagenicity of methyl-, ethyl-, propyl- and butylnitrosourea towards Escherichia coli WP2 strains with varying DNA repair capabilities.
Topics: DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Methylnitrosourea; Mutagens; Nitrosourea Compounds; Structure-Activity Relationship | 1979 |
[Experiments on rhesus-monkeys (Macaca mulatta) with the carcinogens methyl- and ethylnitrosourea (author's transl)].
Topics: Animals; Ethylnitrosourea; Female; Fetus; Haplorhini; Macaca mulatta; Male; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pregnancy; Time Factors | 1977 |
[Comparative study of the action of carcinogenic substances that induce transplacental blastomogenesis in rabbits].
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrenes; Carcinogens; Ethylnitrosourea; Female; Male; Methylnitrosourea; Neoplasms, Experimental; Neurilemmoma; Placenta; Pregnancy; Rabbits; Time Factors | 1978 |
Relationship between DNA alkylation and specific-locus mutation induction by N-methyl- and N-ethyl-N-nitrosourea in cultured Chinese hamster ovary cells (CHO/HGPRT system).
Topics: Alkylating Agents; Alkylation; Animals; Cell Line; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; Ethylnitrosourea; Methylnitrosourea; Mutation; Nitrosourea Compounds; Phenotype; Structure-Activity Relationship | 1979 |
Tumors of the rat kidney induced by nitrosourea compounds.
Topics: Animals; Basement Membrane; Epithelium; Ethylnitrosourea; Female; Kidney; Kidney Cortex; Kidney Glomerulus; Kidney Neoplasms; Kidney Tubules; Male; Methylnitrosourea; Nitrosourea Compounds; Rats | 1979 |
[Effect of mutagenic factors on the variability of cultures of Actinomyces griseus--preducer of the antibiotic grisin].
Topics: Anti-Bacterial Agents; Aziridines; Ethylnitrosourea; Methylnitrosourea; Mutagens; Nitrosoguanidines; Streptomyces; Streptothricins | 1977 |
The stability of methyl and ethyl phosphotriesters in DNA in vivo.
Topics: Animals; Brain Chemistry; Chemical Phenomena; Chemistry; DNA; DNA Repair; Ethylnitrosourea; Kidney; Liver; Lung; Male; Methylnitrosourea; Mice; Organ Specificity; Spleen; Thymus Gland; Time Factors | 1977 |
[Morphology of heart tumors in rats induced by methyl- and ethylnitrosourea].
Topics: Animals; Ethylnitrosourea; Female; Heart Atria; Heart Neoplasms; Heart Ventricles; Male; Methylnitrosourea; Nitrosourea Compounds; Rats; Rats, Inbred Strains | 1978 |
[Combined transplacental carcinogenic action of N-nitrosomethylurea (NMU) and N-nitrosoethylurea (NEU) in rats].
Topics: Animals; Brain Neoplasms; Carcinogens; Dose-Response Relationship, Drug; Drug Interactions; Ethylnitrosourea; Female; Gestational Age; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Placenta; Pregnancy; Rats; Teratogens | 1978 |
Mutagenicity and cytotoxicity of congeners of two classes of nitroso compounds in Chinese hamster ovary cells.
Topics: Cell Line; Cell Survival; Dose-Response Relationship, Drug; Ethylnitrosourea; Hypoxanthine Phosphoribosyltransferase; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Nitroso Compounds; Nitrosourea Compounds | 1978 |
The significance of some modifying factors during transplacental blastomogenesis by ethylnitrosourea in rabbits.
Topics: Animals; Antigens; Ethylnitrosourea; Female; Kidney Neoplasms; Male; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nerve Tissue; Nitrosourea Compounds; Peripheral Nervous System Neoplasms; Physical Stimulation; Pregnancy; Rabbits; Sciatic Nerve | 1978 |
Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid
Topics: Alkylation; Animals; Carcinogens; DNA; Ethyl Methanesulfonate; Ethylnitrosourea; Lymphoma; Methylnitrosourea; Mice; Neoplasms, Experimental; Thymus Neoplasms; Tissue Distribution | 1978 |
Reaction of DNA with alkylating agents. Differential alkylation of poly[dA-dT[ by methylnitrosourea and ethylnitrosourea.
Topics: Alkylation; Binding Sites; Ethylnitrosourea; Magnesium; Methylnitrosourea; Nitrosourea Compounds; Organophosphates; Oxygen; Poly dA-dT; Polydeoxyribonucleotides | 1978 |
[Differences in the mutagenic effectiveness of N-nitrosomethyl- and N-nitrosoethylurea acting on bacterial DNA in vivo].
Topics: Base Sequence; DNA, Bacterial; Ethylnitrosourea; Methylnitrosourea; Mutagens; Nitrosourea Compounds; Salmonella typhimurium | 1976 |
Some results and prospects of transplacental carcinogenesis studies.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abnormalities, Drug-Induced; Animals; Brain; Brain Neoplasms; Disease Models, Animal; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Methylnitrosourea; Neoplasms, Experimental; Nervous System Diseases; Nitrosourea Compounds; Organ Specificity; Placenta; Pregnancy; Rats | 1976 |
Screening of potential chemical carcinogens by means of mammalian cells in vitro.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Cell Division; Cells, Cultured; Cricetinae; DDT; Diethylnitrosamine; Dimethylnitrosamine; Drug Evaluation, Preclinical; Ethylnitrosourea; Female; Guinea Pigs; In Vitro Techniques; Methylnitrosourea; Mice; Neoplasms, Experimental; Pregnancy; Rats | 1976 |
Short and long term effects of methyl- and ethylnitrosourea (MNU & ENU) on the developing nervous system of the rat. II. Short term effects: concluding remarks on chemical neuro-oncogenesis.
Topics: Age Factors; Animals; Animals, Newborn; Chromosomes; Dose-Response Relationship, Drug; Ethylnitrosourea; Methylnitrosourea; Mitosis; Neoplasms, Experimental; Nitrosourea Compounds; Organ Specificity; Rats; Rats, Inbred Strains; Time Factors | 1977 |
Short and long term effects of methyl- and ethylnitrosourea (MNU & ENU) on the developing nervous system of the rat. I. Long term effects: the induction of (multiple) gliomas.
Topics: Age Factors; Animals; Animals, Newborn; Brain Neoplasms; Ethylnitrosourea; Female; Glioma; Male; Meningioma; Methylnitrosourea; Neoplasms, Experimental; Neoplasms, Multiple Primary; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Spinal Cord Neoplasms | 1977 |
Repair of DNA damaged by alkylating carcinogens is defective in xeroderma pigmentosum-derived fibroblasts.
Topics: Alkylating Agents; Carcinogens; Cell Division; DNA; DNA Repair; Ethylnitrosourea; Fibroblasts; Guanine Nucleotides; Humans; Kinetics; Methylnitrosourea; Nitrosourea Compounds; Xeroderma Pigmentosum | 1977 |
[Effect of neurotropic carcinogenic agents nitrosomethyl- and nitrosoethylurea on rat embryo cerebral cortex development].
Topics: Animals; Brain; Brain Diseases; Cerebral Cortex; Ethylnitrosourea; Female; Gestational Age; Maternal-Fetal Exchange; Methylnitrosourea; Nitrosourea Compounds; Pregnancy; Rats | 1977 |
Specific excision of ethylated purines from DNA of Escherichia coli treated with N-ethyl-N-nitrosourea.
Topics: Adenine; DNA Replication; DNA, Bacterial; Escherichia coli; Ethanol; Ethylnitrosourea; Guanine; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds | 1975 |
[Growth kinetics of transplantable mammary gland tumors in mice].
Topics: Adenocarcinoma; Animals; Cell Transformation, Neoplastic; Ethylnitrosourea; Kinetics; Male; Mammary Neoplasms, Experimental; Mathematics; Methylnitrosourea; Mice; Mice, Inbred A; Mice, Inbred C3H; Neoplasm Transplantation; Nitrosourea Compounds; Time Factors | 1975 |
Induction of neurogenic and lymphoid neoplasms by the feeding of threshold levels of methyl- and ethylnitrousourea precursors to adult rats.
Topics: Animals; Brain Neoplasms; Ethylnitrosourea; Female; Lymphoma; Mammary Neoplasms, Experimental; Methylnitrosourea; Methylurea Compounds; Neoplasms, Experimental; Nitrites; Nitrosourea Compounds; Peripheral Nervous System Neoplasms; Pituitary Neoplasms; Rats; Urea | 1975 |
Clastogenic effects of methylnitrosourea and ethylnitrosourea on chromosomes from human fibroblast cell lines.
Topics: Cell Line; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Drug; Ethylnitrosourea; Methylnitrosourea; Mitotic Index; Nitrosourea Compounds | 1976 |
N-alkyl-N-nitrosourea induced secondary structural changes in DNA from rat embryos and fetal brains in vivo.
Topics: Abnormalities, Drug-Induced; Animals; Brain; DNA; Embryo, Mammalian; Ethylnitrosourea; Female; Fetus; Methylnitrosourea; Neoplasms, Experimental; Nucleic Acid Conformation; Pregnancy; Rats; Rats, Wistar | 1992 |
Mutational activation of H-ras oncogene transformability by alkylnitrosourea-induced DNA damage.
Topics: 3T3 Cells; Alkylation; Animals; Base Sequence; Cell Transformation, Neoplastic; DNA; DNA Damage; Ethylnitrosourea; Gene Expression Regulation; Genes, ras; Methylnitrosourea; Mice; Molecular Sequence Data; Mutation | 1992 |
Neurochemical and histological analysis of motor dysfunction observed in rats with methylnitrosourea-induced experimental cerebellar hypoplasia.
Topics: Acetylcholine; Amines; Amino Acids; Animals; Animals, Newborn; Cell Division; Cerebellum; Choline; DNA; Ethylnitrosourea; Female; Hydroxyindoleacetic Acid; Male; Methylnitrosourea; Neurotransmitter Agents; Psychomotor Performance; Rats; Rats, Inbred Strains; RNA | 1992 |
Mammalian cells share a common pathway for the relief of DNA replication arrest by O6-alkyl guanine, incorporated 6-thioguanine and UV photoproducts.
Topics: Alkylating Agents; Animals; Cell Survival; Deer; DNA Damage; DNA Replication; Ethylnitrosourea; Genes; Methylnitrosourea; Methyltransferases; Mice; Nitrogen Mustard Compounds; Sister Chromatid Exchange; Thioguanine; Transfection | 1992 |
[Effect of pretreatment with N-methyl-N-nitrosourea or streptozotocin on the cytotoxicity and the induction of sister chromatid exchanges in human and rodent brain tumor cells treated with chloroethylnitrosourea].
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Drug Resistance; Drug Synergism; Ethylnitrosourea; Glioma; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344; Sister Chromatid Exchange; Streptozocin; Tumor Cells, Cultured | 1992 |
A possible explanation for the differential cancer incidence in the intestine, based on distribution of the cytotoxic effects of carcinogens in the murine large bowel.
Topics: 1,2-Dimethylhydrazine; Animals; Apoptosis; Biotransformation; Carcinogens; Dimethylhydrazines; Ethylnitrosourea; Intestine, Large; Intestine, Small; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Nitroso Compounds | 1992 |
Base alterations in yeast induced by alkylating agents with differing Swain-Scott substrate constants.
Topics: Alkylating Agents; Base Sequence; DNA Mutational Analysis; DNA, Fungal; Ethyl Methanesulfonate; Ethylnitrosourea; Gene Amplification; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Saccharomyces cerevisiae | 1992 |
Target cells for the cytotoxic effects of carcinogens in the murine small bowel.
Topics: 1,2-Dimethylhydrazine; Animals; Dimethylhydrazines; Dimethylnitrosamine; Ethylnitrosourea; Female; Intestine, Small; Male; Methylnitrosourea; Mice; Stem Cells | 1992 |
Inhibition of O6-alkylguanine-DNA alkyltransferase and DNase I activities in vitro by some alkylating substances and antineoplastic agents.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Bisbenzimidazole; Bleomycin; Brain; Chick Embryo; Deoxyribonucleases; DNA Repair; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Doxorubicin; Ethidium; Ethyl Methanesulfonate; Ethylnitrosourea; Hot Temperature; In Vitro Techniques; Liver; Methyl Methanesulfonate; Methylnitrosourea; Methyltransferases; Novobiocin; O(6)-Methylguanine-DNA Methyltransferase; Substrate Specificity; Suramin; X-Rays | 1991 |
Influence of anoxia and respiratory deficiency on the genotoxicity of some direct-acting alkylating agents in yeast.
Topics: Alkylating Agents; Cell Hypoxia; Cell Survival; Ethyl Methanesulfonate; Ethylnitrosourea; Mesylates; Methylnitronitrosoguanidine; Methylnitrosourea; Oxygen; Saccharomyces cerevisiae | 1991 |
Preventive action of thioethers towards in vitro DNA binding and mutagenesis in E. coli K12 by alkylating agents.
Topics: Alkylating Agents; Benzoates; DNA; Escherichia coli; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Sulfides | 1990 |
Morphology of experimental tumors of the sympathetic nervous system.
Topics: Animals; Cricetinae; Ethylnitrosourea; Female; Ganglioneuroma; Mesocricetus; Methylnitrosourea; Microscopy, Electron; Nervous System Neoplasms; Neuroblastoma; Rabbits; Sex Factors; Sympathetic Nervous System | 1990 |
Elevated expression of the cellular src gene in tumors of differing etiologies in Xiphophorus.
Topics: Animals; Ethylnitrosourea; Fish Diseases; Fishes; Genotype; Hybridization, Genetic; Methylnitrosourea; Neoplasms; Neoplasms, Radiation-Induced; Oncogenes; Phosphoproteins; Protein Kinases; Proto-Oncogene Proteins pp60(c-src); Testosterone | 1985 |
Evaluation of spin labeled TEPA and CCNU analogs against osteosarcoma and MNU-induced mammary carcinoma of the SD-rat.
Topics: Animals; Antineoplastic Agents; Azirines; Bone Neoplasms; Cyclic N-Oxides; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Neoplasm Transplantation; Nitrosourea Compounds; Osteosarcoma; Rats; Rats, Inbred Strains; Triethylenephosphoramide | 1989 |
In vitro developmental toxicity of five direct-acting alkylating agents in rodent embryos: structure-activity patterns.
Topics: Alkylating Agents; Analysis of Variance; Animals; Brain; Dose-Response Relationship, Drug; Embryo, Mammalian; Ethyl Methanesulfonate; Ethylnitrosourea; Female; In Vitro Techniques; Maternal-Fetal Exchange; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Pregnancy; Rats; Rats, Inbred Strains | 1989 |
O6-methyltransferase-deficient and -proficient CHO cells differ in their responses to ethyl- and methyl-nitrosourea-induced DNA alkylation.
Topics: Alkylation; Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA; Ethylnitrosourea; Female; Kinetics; Methylnitrosourea; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Ovary; Sister Chromatid Exchange | 1989 |
Carcinogenesis in rats by nitrosodialkylureas containing methyl and ethyl groups given by gavage and in drinking water.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Drinking; Ethylnitrosourea; Female; Male; Methylnitrosourea; Nervous System; Nervous System Neoplasms; Rats; Rats, Inbred F344 | 1989 |
Effects of postnatal administration of tumour-promoting barbiturates on the development of tumours initiated by prenatal exposure of fetal rats and mice to N-alkylnitrosoureas.
Topics: Aging; Animals; Barbiturates; Carcinogens; Cocarcinogenesis; Ethylnitrosourea; Female; Male; Methylnitrosourea; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred F344; Sex Factors | 1989 |
Molecular analysis of mutations induced in human cells by N-ethyl-N-nitrosourea.
Topics: Alkylating Agents; Amino Acid Sequence; Base Sequence; DNA; DNA Mutational Analysis; Ethylnitrosourea; Genes, Viral; Genetic Vectors; Herpesvirus 4, Human; Humans; Methylnitrosourea; Molecular Sequence Data; Mutagens; Mutation; Plasmids; Simplexvirus; Thymidine Kinase | 1988 |
Inactivation of purified human O6-alkylguanine-DNA alkyltransferase by alkylating agents or alkylated DNA.
Topics: Alkylating Agents; DNA; Dose-Response Relationship, Drug; Ethylnitrosourea; Humans; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Streptozocin; Sulfuric Acid Esters | 1986 |
Ability of various alkylating agents to induce adaptive and SOS responses: a study with lacZ fusion.
Topics: Alkylating Agents; Bacterial Proteins; beta-Galactosidase; DNA Glycosylases; DNA Ligases; DNA Repair; Dose-Response Relationship, Drug; Enzyme Induction; Escherichia coli; Ethylnitrosourea; Genes, Bacterial; Genes, Synthetic; Guanine; Lac Operon; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; N-Glycosyl Hydrolases; Polynucleotide Ligases | 1985 |
Morphological transformation of immortalized hamster dermal fibroblasts following treatment with simple alkylating carcinogens.
Topics: Alkylating Agents; Animals; Cell Division; Cell Transformation, Neoplastic; Cricetinae; DNA; DNA Damage; Ethylnitrosourea; Genes, ras; Methylnitrosourea; Mice; Mice, Nude; Neoplasms, Experimental; Sulfuric Acid Esters | 1988 |
Alternative pathways for the in vivo repair of O6-alkylguanine and O4-alkylthymine in Escherichia coli: the adaptive response and nucleotide excision repair.
Topics: Alkylation; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Kinetics; Methylnitrosourea; Mutation; Thymine | 1988 |
Expression of an E.coli O6-alkylguanine DNA alkyltransferase gene in Chinese hamster cells protects against N-methyl and N-ethylnitrosourea induced reverse mutation at the hypoxanthine phosphoribosyl transferase locus.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Escherichia coli; Ethylnitrosourea; Genes; Genes, Bacterial; Hypoxanthine Phosphoribosyltransferase; Kinetics; Methylnitrosourea; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Transfection | 1988 |
Spontaneous and induced chromosomal aberrations and gene mutations in human lymphoblasts: mitomycin C, methylnitrosourea, and ethylnitrosourea.
Topics: Cell Line; Cell Survival; Chromosome Aberrations; Dose-Response Relationship, Drug; Ethylnitrosourea; Humans; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Methylnitrosourea; Mitomycin; Mitomycins; Mutation; Thymidine Kinase | 1986 |
Tumorigenesis in athymic nude mouse skin by chemical carcinogens and ultraviolet light.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Cocarcinogenesis; Disease Susceptibility; Ear Neoplasms; Ethylnitrosourea; Female; Heterozygote; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Radiation-Induced; Skin Neoplasms; Tetradecanoylphorbol Acetate; Ultraviolet Rays | 1987 |
Isolation of alkylating agent-sensitive Chinese hamster ovary cell lines.
Topics: Alkylating Agents; Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA Damage; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Melphalan; Methylnitrosourea; Mitomycin; Mitomycins; Mutation | 1987 |
Formation and removal of DNA adducts after treatment of Chinese hamster ovary cells with N-methyl- and N-ethyl-N-nitrosourea.
Topics: Alkylation; Animals; Cell Line; Cricetinae; DNA; DNA Damage; DNA Mutational Analysis; DNA Repair; Ethylnitrosourea; Methylation; Methylnitrosourea; Time Factors | 1988 |
In vitro and in vivo DNA interaction with carbonyl-labeled (m)ethylnitrosoureas.
Topics: Animals; Carbon Radioisotopes; Cattle; DNA; Ethylnitrosourea; Hydrolysis; Male; Methylnitrosourea; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Thymus Gland | 1988 |
Cocarcinogenicity of saccharin and N-alkylnitrosoureas in cultured human diploid fibroblasts.
Topics: Antigens, Neoplasm; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Ethylnitrosourea; Fibroblasts; Humans; Insulin; Interphase; Methylnitrosourea; Saccharin | 1988 |
Comparative study of DNA damage and repair induced by ten N-nitroso compounds in primary cultures of human and rat hepatocytes.
Topics: Adult; Aged; Animals; Cells, Cultured; DNA Damage; DNA Repair; Ethylnitrosourea; Female; Humans; Liver; Male; Methylnitrosourea; Middle Aged; N-Nitrosopyrrolidine; Nitrosamines; Nitroso Compounds; Nitrosourea Compounds; Rats; Rats, Inbred Strains | 1988 |
Dealing with spills of hazardous chemicals: some nitrosamides.
Topics: Chromatography, High Pressure Liquid; Decontamination; Ethylnitrosourea; Hazardous Waste; Methylnitrosourea; Nitroso Compounds; Nitrosomethylurethane; Sewage; Waste Disposal, Fluid | 1988 |
In vitro evaluation of an estradiol-linked nitrosourea in mammary carcinomas of mouse, rat and man.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Estradiol; Ethylnitrosourea; Female; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred Strains; Middle Aged; Nitrogen Mustard Compounds; Rats; Rats, Inbred Strains; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1988 |
Mechanisms of synergism in the mutagenicity of cadmium and N-methyl-N-nitrosourea in Salmonella typhimurium: the effect of pH.
Topics: Cadmium; Dose-Response Relationship, Drug; Drug Synergism; Ethylnitrosourea; Histidine; Hydrogen-Ion Concentration; Hydrolysis; Methylnitrosourea; Mutagenicity Tests; Salmonella typhimurium | 1987 |
DNA base changes and alkylation following in vivo exposure of Escherichia coli to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.
Topics: Alkylation; Amino Acid Sequence; Base Sequence; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Genes; Genes, Bacterial; Methylnitrosourea; Mutation; Pentosyltransferases; Species Specificity | 1987 |
Inducible DNA-repair systems in yeast: competition for lesions.
Topics: DNA Damage; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Gamma Rays; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Saccharomyces cerevisiae; Ultraviolet Rays | 1987 |
Cell killing by various monofunctional alkylating agents in Chinese hamster ovary cells.
Topics: Alkylating Agents; Animals; Caffeine; Cell Cycle; Cell Line; Cell Survival; Colony-Forming Units Assay; Cricetinae; Cricetulus; Ethylnitrosourea; Female; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Ovary | 1987 |
The kinetics of in vivo sister chromatid exchange induction in mouse bone marrow cells by ethylnitrosourea and methylnitrosourea.
Topics: Animals; Bone Marrow; Bromodeoxyuridine; DNA Repair; Dose-Response Relationship, Drug; Ethylnitrosourea; Kinetics; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Regression Analysis; Sister Chromatid Exchange | 1986 |
Spontaneous and induced sister-chromatid exchanges in cultured mosquito cells.
Topics: Aedes; Animals; Bromodeoxyuridine; Cell Line; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Sister Chromatid Exchange; Species Specificity | 1986 |
Studies on the stability of trialkyl phosphates and di-(2'deoxythymidine) phosphotriesters in alkaline and neutral solution. A model study for hydrolysis of phosphotriesters in DNA and on the influence of a beta hydroxyethyl ester group.
Topics: Alkylation; DNA; Drug Stability; Ethylnitrosourea; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Methylnitrosourea; Organophosphorus Compounds; Solutions; Structure-Activity Relationship; Thymine Nucleotides | 1986 |
Chemotherapy in intracerebrally transplanted tumors induced with transplacental administration of ethylnitrosourea in rats.
Topics: Animals; Brain Neoplasms; Drug Administration Schedule; Ethylnitrosourea; Female; Lomustine; Methylnitrosourea; Neoplasm Transplantation; Placenta; Pregnancy; Rats; Spinal Cord Neoplasms | 1986 |
Carcinogenic responses to chemicals applied directly to rat mammary glands in situ.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Adenocarcinoma; Animals; Carcinogens; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Inbred Strains | 1985 |
Formation and stability of alkylated pyrimidines and purines (including imidazole ring-opened 7-alkylguanine) and alkylphosphotriesters in liver DNA of adult rats treated with ethylnitrosourea or dimethylnitrosamine.
Topics: Alkylation; Animals; Chromatography, High Pressure Liquid; Dimethylnitrosamine; DNA; Ethylnitrosourea; Kinetics; Liver; Male; Methylation; Methylnitrosourea; Phosphates; Purines; Pyrimidines; Rats | 1986 |
Detection of a deuterium isotope effect in di- and trisubstituted alkylphenylnitrosoureas. An SCE study in Chinese hamster V79-E cells.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Deuterium; Ethylnitrosourea; In Vitro Techniques; Methylnitrosourea; Nitrosourea Compounds; Sister Chromatid Exchange | 1985 |
Organ-specific carcinogenicity of N-methyl-N-nitrosourea in F344 and ACI/N rats.
Topics: Animals; Brain Neoplasms; Ethylnitrosourea; Female; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Organ Specificity; Rats; Rats, Inbred ACI; Rats, Inbred F344; Species Specificity; Spinal Cord Neoplasms | 1985 |
The differential effect of benzamide upon the toxicity and mutations produced in Chinese hamster ovary cells by N-methyl nitrosourea, N-ethyl nitrosourea and N-hydroxy-2-aminofluorene.
Topics: Animals; Benzamides; Cell Line; Cricetinae; Cricetulus; Drug Synergism; Ethylnitrosourea; Female; Fluorenes; Hypoxanthine Phosphoribosyltransferase; Methylnitrosourea; Mutagenicity Tests; Mutagens; Mutation; Nitrosourea Compounds; Ovary | 1985 |
[A comparative study of the mutagenic effect of nitrosoalkylurea on influenza virus].
Topics: Animals; Ethylnitrosourea; Hemagglutinins, Viral; Hot Temperature; Methylnitrosourea; Mice; Mutagens; Nitrosourea Compounds; Orthomyxoviridae; Species Specificity; Virulence | 1974 |
[Lysosomal enzymes in nitrosamine induced nervous system tumors of rats (author's transl)].
Topics: Acid Phosphatase; Animals; Brain; Brain Neoplasms; Ethylnitrosourea; Female; Glioma; Glucuronidase; Hexosaminidases; Lysosomes; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Oligodendroglioma; Pregnancy; Rats; Sulfatases | 1974 |
[Tumour induction with alkyl-nitrosoureas in ribbed newts (Pleurodeles waltlii) (author's transl)].
Topics: Animals; Disease Models, Animal; Ethylnitrosourea; Female; Fibrosarcoma; Hemangioma; Hemangiosarcoma; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Pleurodeles; Salamandridae; Sarcoma, Experimental; Wilms Tumor | 1980 |
Nephroblastoma and renal mesenchymal tumor induced in rats by N-nitrosoethyl- and N-nitrosomethylurea.
Topics: Animals; Ethylnitrosourea; Female; Kidney Neoplasms; Mesenchymoma; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats; Wilms Tumor | 1980 |
Template properties of DNA alkylated with N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea.
Topics: Alkylation; Animals; Cattle; DNA; DNA-Directed RNA Polymerases; Escherichia coli; Ethylnitrosourea; Kinetics; Methylnitrosourea; Nitrosourea Compounds; Structure-Activity Relationship; Templates, Genetic; Thymus Gland; Transcription, Genetic | 1983 |
Influence of polyamine depletion caused by alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on alkylation- and carbamoylation-induced cytotoxicity in 9L rat brain tumor cells in vitro.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carboxy-Lyases; Carmustine; Cell Line; Cell Survival; Drug Synergism; Eflornithine; Ethylnitrosourea; Lomustine; Methylnitrosourea; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats | 1983 |
Antiteratogenic effects of tumor inhibitors, caffeine, antipain, and retinoic acid in mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antipain; Caffeine; Carcinogens; Ethylnitrosourea; Female; Fetus; Hydroxamic Acids; Methylnitrosourea; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Oligopeptides; Pregnancy; Teratogens; Tretinoin; Urethane | 1983 |
Alkaline elution of rat testicular DNA: detection of DNA strand breaks after in vivo treatment with chemical mutagens.
Topics: Animals; Dimethyl Sulfoxide; DNA, Single-Stranded; Edetic Acid; Ethyl Methanesulfonate; Ethylnitrosourea; Hydrogen-Ion Concentration; Male; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Phenols; Polyethylene Glycols; Rats; Testis; Time Factors | 1984 |
Relationship between cell killing, chromosomal aberrations, sister-chromatid exchanges and point mutations induced by monofunctional alkylating agents in Chinese hamster cells. A correlation with different ethylation products in DNA.
Topics: Alkylating Agents; Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Crossing Over, Genetic; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Methyl Methanesulfonate; Methylnitrosourea; Mutation; Sister Chromatid Exchange; Sulfuric Acid Esters | 1984 |
Inhibition of protein A24 lyase by nitrosoureas.
Topics: Animals; Carcinoma, Ehrlich Tumor; Carmustine; Cyanates; Ethyl Methanesulfonate; Ethylnitrosourea; Histones; Isocyanates; Lyases; Methyl Methanesulfonate; Methylnitrosourea; Nitrosourea Compounds; Ubiquitins | 1984 |
Effect of alkylation with N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea on the secondary structure of DNA.
Topics: Alkylation; Animals; Cattle; Chemical Phenomena; Chemistry; DNA; Ethylnitrosourea; Hydrolysis; Kinetics; Methylnitrosourea; Nitrosourea Compounds; Nucleic Acid Conformation; Nucleic Acid Denaturation; Thymus Gland | 1984 |
Suppression of cross-link formation in chloroethylnitrosourea-treated DNA by an activity in extracts of human leukemic lymphoblasts.
Topics: Antineoplastic Agents; Cell Line; DNA, Neoplasm; Ethylnitrosourea; Guanine; Humans; Kinetics; Leukemia, Lymphoid; Methylnitrosourea; Methyltransferases; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase | 1984 |
Alkylation of isolated chromatin with N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea.
Topics: Alkylation; Animals; Carbon Radioisotopes; Chromatin; DNA; Ethylnitrosourea; Kinetics; Liver; Methylnitrosourea; Nitrosourea Compounds; Osmolar Concentration; Rats; Structure-Activity Relationship | 1983 |
Cross-resistance studies with V79 Chinese hamster cells adapted to the mutagenic or clastogenic effect of N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Drug Resistance; Ethyl Methanesulfonate; Ethylnitrosourea; Lung; Methyl Methanesulfonate; Methylnitronitrosoguanidine; Methylnitrosourea; Mutagens; Thioguanine; Ultraviolet Rays | 1983 |
Biochemical and histochemical evaluation of glycosaminoglycans in brain tumors induced in rats by nitrosourea derivatives.
Topics: Age Factors; Animals; Brain Neoplasms; Ethylnitrosourea; Glioma; Glycosaminoglycans; Histocytochemistry; Methylnitrosourea; Nitrosourea Compounds; Rats | 1983 |
Self-consistent-field comparative studies of some nitrosoureas and nitrosamides.
Topics: Chemical Phenomena; Chemistry; Ethylnitrosourea; Methylnitrosourea; Models, Molecular; Nitroso Compounds; Nitrosourea Compounds; Structure-Activity Relationship | 1984 |
Alkylation of the O6 of guanine is only one of many chemical events that may initiate carcinogenesis.
Topics: Alkylating Agents; Animals; Carcinogens; Cell Transformation, Neoplastic; DNA; Ethylnitrosourea; Guanine; Methylnitrosourea; Neoplasms, Experimental | 1984 |
Evaluation of new estrogen-linked 2-chloroethylnitrosoureas. I. Short term anticancer efficacy in methylnitrosourea-induced rat mammary carcinoma and hormonal activity in mice.
Topics: Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Estrogens; Ethylnitrosourea; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred Strains; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Uterus | 1984 |
Timing of chemically induced neoplasia in mice revealed by the antineoplastic action of caffeine.
Topics: 4-Nitroquinoline-1-oxide; Animals; Caffeine; DNA Repair; Ethylnitrosourea; Female; Hydroxamic Acids; Lung Neoplasms; Maternal-Fetal Exchange; Methylnitrosourea; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Nitroquinolines; Pregnancy; Time Factors; Urethane | 1980 |
Comparative effects of methyl- and ethylnitrosourea on DNA directing cell-free DNA-dependent synthesis of beta-galactosidase.
Topics: Bacteriophages; beta-Galactosidase; Cell-Free System; Cyanates; DNA; DNA, Viral; Ethylnitrosourea; Galactosidases; Methylnitrosourea; Nitrosourea Compounds | 1980 |
Comparison of mutagenicity of N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea in human diploid fibroblasts.
Topics: Cells, Cultured; Diploidy; Ethylnitrosourea; Fibroblasts; Humans; Methylnitrosourea; Mutagens; Nitrosourea Compounds | 1983 |
Carcinogenicity of single doses of N-nitroso-N-methylurea and N-nitroso-N-ethylurea in Syrian golden hamsters and the persistence of alkylated purines in the DNA of various tissues.
Topics: Alkylation; Animals; Carbon Radioisotopes; Cricetinae; DNA; Ethylnitrosourea; Mesocricetus; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds | 1983 |
[Role of lipids and the mutagenic activity of nitrosoalkylureas].
Topics: Candida; Ethylnitrosourea; Genetic Variation; Lipid Metabolism; Methylnitrosourea; Mutagens; Nitrosourea Compounds; Time Factors | 1982 |
Thymomas induced by simple alkylating agents in C57BL/Cbi mice: kinetics of the dose response.
Topics: Alkylating Agents; Animals; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; Kinetics; Methylnitrosourea; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Rats; Thymoma; Thymus Neoplasms | 1980 |
Carcinogenicity of N-methyl-N-nitrosourea and N-ethyl-N-nitrosourea when applied to a localized area of the hamster trachea.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Ethylnitrosourea; Male; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Papilloma; Trachea; Tracheal Neoplasms | 1981 |
Experimental chemical production of brain tumors.
Topics: Animals; Brain Neoplasms; Carmustine; Ethylnitrosourea; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Rats | 1982 |
Natural cytotoxicity against chemically induced neurogenic rat tumors.
Topics: Age Factors; Animals; Brain Neoplasms; Cell Division; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Ethylnitrosourea; Female; Glioma; Immunity, Innate; Male; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Neurilemmoma; Rats; Spleen; T-Lymphocytes | 1982 |
[Comparative features of methos of inducing auxotrophic mutants of cholera and nonagglutinating vibrios].
Topics: Aziridines; Ethylnitrosourea; Genetic Techniques; Methylnitrosourea; Mutagens; Mutation; Nitrosoguanidines; Species Specificity; Vibrio; Vibrio cholerae | 1980 |
[Para-aminobenzoic acid intensification of DNA repair processes in Escherichia coli K-12].
Topics: 4-Aminobenzoic Acid; Aminobenzoates; DNA Repair; DNA, Bacterial; Drug Interactions; Escherichia coli; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Stimulation, Chemical | 1982 |
The response of a variety of human fibroblast cell strains to the lethal effects of alkylating agents.
Topics: Alkylating Agents; Cell Survival; DNA; Ethylnitrosourea; Fibroblasts; Humans; Methylnitronitrosoguanidine; Methylnitrosourea | 1982 |
Supermutagenicity of ethylnitrosourea in the mouse spot test: comparisons with methylnitrosourea and ethylnitrosourethane.
Topics: Animals; Crosses, Genetic; Dose-Response Relationship, Drug; Ethylnitrosourea; Female; Male; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mutagenicity Tests; Mutagens; Nitrosomethylurethane; Nitrosourea Compounds | 1982 |
The alkaline hydrolysis of phosphotriesters in alkylated mammalian DNA.
Topics: Alkylation; Animals; Carbon Radioisotopes; DNA; Ethylnitrosourea; Hydrolysis; Liver; Methylnitrosourea; Mice; Nitrosourea Compounds; Organophosphates; Organophosphorus Compounds | 1982 |
In vivo quantitation of N-3 and N-7 alkylpurines induced by alkylnitrosoureas.
Topics: Alkylation; Animals; Biotransformation; Centrifugation, Density Gradient; DNA; Ethylnitrosourea; Mammary Glands, Animal; Methylnitrosourea; Nitrosourea Compounds; Purines; Rats; Rats, Inbred Strains | 1982 |
Alkylarylnitrosoureas--stability in aqueous solution, partition coefficient, alkylating activity and its relationship to SCE induction in Chinese hamster V 79-E cells.
Topics: Alkylating Agents; Animals; Cell Line; Cricetinae; Cricetulus; Drug Stability; Ethylnitrosourea; Lung; Methylnitrosourea; Nitrosourea Compounds; Sister Chromatid Exchange; Solutions; Structure-Activity Relationship | 1982 |
Comparison of the carcinogenic effectiveness in mouse skin of methyl- and ethylnitrosourea, nitrosourethane and nitrosonitro-guanidine and the effect of deuterium labeling.
Topics: Administration, Topical; Alkylating Agents; Animals; Deuterium; Ethylnitrosourea; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Neoplasms, Experimental; Nitroso Compounds; Nitrosoguanidines; Nitrosomethylurethane; Skin Neoplasms | 1982 |
Chemical probes for tRNA tertiary structure. Comparative alkylation of tRNA with methylnitrosourea, ethylnitrosourea and dimethylsulfate.
Topics: Alkylating Agents; Alkylation; Ethylnitrosourea; Methylnitrosourea; Nitrosourea Compounds; RNA, Transfer; Seeds; Structure-Activity Relationship; Sulfuric Acid Esters; Sulfuric Acids | 1982 |
Nitrosated urea pesticide metabolites and other nitrosamides. Activity in clastogenicity and SCE assays, and aberration kinetics in Chinese hamster V79-E cells.
Topics: Animals; Cell Line; Chromosome Aberrations; Chromosomes; Cricetinae; Cricetulus; Crossing Over, Genetic; Dose-Response Relationship, Drug; Ethylnitrosourea; Fibroblasts; Methylnitrosourea; Nitrosourea Compounds; Pesticides; Phenylurea Compounds; Sister Chromatid Exchange; Time Factors | 1980 |
Effects of metabolic inhibitors on cel lethality and mutation induction in Chinese hamster cells. II. The effect of posttreatment with non-toxic concentrations of thymidine.
Topics: Animals; Azaguanine; Cell Line; Cricetinae; Cricetulus; Deoxycytidine; Ethylnitrosourea; Lung; Methylnitrosourea; Mutation; Thioguanine; Thymidine; Ultraviolet Rays | 1981 |
[Principal fields of research into the pathogenesis of gliomas (author's transl)].
Topics: Animals; Brain Neoplasms; DNA Tumor Viruses; Dogs; Ethylnitrosourea; Female; Glioma; Humans; Male; Methylnitrosourea; Neoplasms, Experimental; Rats; Retroviridae | 1981 |
Inability of Chinese hamster ovary cells to excise O6-alkylguanine.
Topics: Adenine; Alkylating Agents; Animals; Cricetinae; Cricetulus; DNA; DNA Repair; Ethylnitrosourea; Female; Guanine; Methylnitrosourea; Ovary; Pyrimidine Dimers; Time Factors | 1980 |
Relationship between chemical damage of DNA and mutations in mammalian cells. I. Dose-response curves for the induction of 6-thioguanine-resistant mutants by low doses of monofunctional alkylating agents, X-rays and UV radiation in V79 Chinese hamster cel
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Ethyl Methanesulfonate; Ethylnitrosourea; Lung; Methyl Methanesulfonate; Methylnitrosourea; Mutation; Ultraviolet Rays; X-Rays | 1980 |
Formation and persistence of DNA adducts in pouch skin fibroblasts and liver tissue of rats exposed in vivo to the monofunctional alkylating agents N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.
Topics: Alkylating Agents; Animals; Chromatography, High Pressure Liquid; DNA Damage; DNA Repair; Ethylnitrosourea; Fibroblasts; Liver; Male; Methylnitrosourea; Rats; Rats, Wistar; Skin | 1994 |
Modulation of nitrosourea toxicity in rodent embryonic cells by O6-benzylguanine, a depletor of O6-methylguanine-DNA methyltransferase.
Topics: Animals; Cell Differentiation; Cells, Cultured; DNA Adducts; Ethylnitrosourea; Female; Guanine; Mesencephalon; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Pregnancy; Rats; Rats, Sprague-Dawley | 1995 |
Streptozotocin-induced toxicity in CHO-9 and V79 cells.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cricetulus; DNA; DNA Replication; Ethylnitrosourea; Guanine; Methylnitrosourea; Mutagens; Streptozocin; Thymidine | 1995 |
Toxicity of four alkylating agents on in vitro rat embryo differentiation and development.
Topics: Abnormalities, Drug-Induced; Animals; Cell Differentiation; Cells, Cultured; Central Nervous System; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Forelimb; Methyl Methanesulfonate; Methylnitrosourea; Rats | 1995 |
DNA replication arrest and tolerance to DNA methylation damage.
Topics: DNA Damage; DNA Replication; DNA, Neoplasm; Ethylnitrosourea; HeLa Cells; Humans; Methylation; Methylnitrosourea; Phenotype; Signal Transduction | 1994 |
Molecular analysis of hprt gene mutations in skin fibroblasts of rats exposed in vivo to N-methyl-N-nitrosourea or N-ethyl-N-nitrosourea.
Topics: Amino Acid Sequence; Animals; Base Sequence; Ethylnitrosourea; Fibroblasts; Hypoxanthine Phosphoribosyltransferase; Male; Methylnitrosourea; Molecular Sequence Data; Point Mutation; Rats; Rats, Wistar; Skin | 1994 |
Comparison of effects of direct-acting DNA methylating and ethylating agents on inducible gene expression in vivo.
Topics: Alkylating Agents; Animals; Carcinogens; Chick Embryo; DNA; DNA Damage; Enzyme Induction; Ethyl Methanesulfonate; Ethylnitrosourea; Genes; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Mutagenesis, Site-Directed; Phosphoenolpyruvate Carboxykinase (GTP) | 1994 |
Effects of inhibition of O6-alkylguanine-DNA alkyltransferase in rats on carcinogenesis by methylnitrosourea and ethylnitrosourea.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Ethylnitrosourea; Female; Guanine; Liver; Methylnitrosourea; Methyltransferases; Neoplasms, Experimental; O(6)-Methylguanine-DNA Methyltransferase; Rats; Rats, Inbred F344 | 1994 |
High-performance liquid chromatographic determination of N-nitroso-N-alkylureas by pre-column fluorescence derivatization and application to blood analysis.
Topics: Acetonitriles; Animals; Calcium Chloride; Chromatography, High Pressure Liquid; Ethylnitrosourea; Fluorescence; Humans; Methylnitrosourea; Nitrosourea Compounds; o-Phthalaldehyde; Rabbits; Sulfides; Taurine | 1993 |
7-Alkyldeoxyguanosine adduct detection by two-step HPLC and the 32P-postlabeling assay.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Deoxyguanine Nucleotides; DNA; Ethylnitrosourea; Guanosine Monophosphate; Humans; Methylnitrosourea; Phosphorus Radioisotopes | 1993 |
N-Ethyl-N-nitrosourea induces mammary cancers in the pituitary-isografted mouse which are histologically and genotypically distinct from those induced by N-methyl-N-nitrosourea.
Topics: Animals; Base Sequence; Carcinogens; Cocarcinogenesis; Ethylnitrosourea; Female; Gene Expression Regulation, Neoplastic; Genotype; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Pituitary Gland, Anterior; Structure-Activity Relationship; Transplantation, Isogeneic | 1996 |
Unexpected genetic toxicity to rodents of the N',N'-dimethyl analogues of MNU and ENU.
Topics: Alkylating Agents; Animals; Bone Marrow; Cells, Cultured; Dose-Response Relationship, Drug; Ethylnitrosourea; Half-Life; Hydrolysis; Male; Methylnitrosourea; Mice; Mice, Inbred CBA; Micronucleus Tests; Mutagens; Salmonella typhimurium; Structure-Activity Relationship | 1996 |
Comparison of inhibition of glucose-stimulated insulin secretion in rat islets of Langerhans by streptozotocin and methyl and ethyl nitrosoureas and methanesulphonates. Lack of correlation with nitric oxide-releasing or O6-alkylating ability.
Topics: Alkylating Agents; Animals; Cyclic GMP; Ethyl Methanesulfonate; Ethylnitrosourea; Glucose; Guanine; Insulin; Islets of Langerhans; Methyl Methanesulfonate; Methylnitrosourea; Nitric Oxide; Rats; Rats, Sprague-Dawley; Streptozocin; Structure-Activity Relationship | 1995 |
Germ-cell mutagenesis in lambda lacZ transgenic mice treated with ethylating and methylating agents: comparison with specific-locus test.
Topics: Animals; Bacteriophage lambda; Epididymis; Ethyl Methanesulfonate; Ethylnitrosourea; Lac Operon; Male; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Transgenic; Mutagenesis; Mutagenicity Tests; Mutagens; Spermatozoa; Vas Deferens | 1997 |
Sources of variability in data from a positive selection lacZ transgenic mouse mutation assay: an interlaboratory study.
Topics: Animals; Data Interpretation, Statistical; Ethyl Methanesulfonate; Ethylnitrosourea; International Cooperation; Laboratories; Lac Operon; Male; Mesylates; Methyl Methanesulfonate; Methylnitrosourea; Mice; Mice, Transgenic; Mutagenicity Tests; Mutagens; Spermatozoa | 1997 |
The influence of DNA repair by Ogt alkyltransferase on the distribution of alkylnitrosourea-induced mutations in Escherichia coli.
Topics: Base Sequence; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Methylnitrosourea; Methyltransferases; Molecular Sequence Data; Mutagens; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 1997 |
On the recovery of single spots with the flr phenotype in the wing spot test in Drosophila.
Topics: Animals; Chromium Compounds; Drosophila melanogaster; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Gamma Rays; Male; Methylnitrosourea; Mutagenicity Tests; Mutagens; Phenotype; Wings, Animal; X-Rays | 1997 |
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.
Topics: Alkylation; Animals; Animals, Genetically Modified; DNA Adducts; DNA Repair; DNA, Neoplasm; Ethylnitrosourea; Female; Genes, ras; Guanine; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylnitrosourea; O(6)-Methylguanine-DNA Methyltransferase; Point Mutation; Rats; Transcription, Genetic | 1998 |
Studies of initiation and promotion of carcinogenesis by N-nitroso compounds.
Topics: Animals; Carcinogens; Carcinoma, Transitional Cell; Diethylnitrosamine; Ethylnitrosourea; Male; Methylnitrosourea; Mutagens; Neoplasms, Experimental; Nitrosamines; Phenobarbital; Rats; Rats, Inbred F344; Survival Rate; Urinary Bladder Neoplasms | 1998 |
Evaluation of P19 cells for studying mechanisms of developmental toxicity: application to four direct-acting alkylating agents.
Topics: Alkylating Agents; Aminobutyrates; Animals; Antineoplastic Agents, Alkylating; Carcinoma, Embryonal; Cell Differentiation; Cell Division; Dimethyl Sulfoxide; Ethyl Methanesulfonate; Ethylnitrosourea; gamma-Aminobutyric Acid; Male; Mesencephalon; Methyl Methanesulfonate; Methylnitrosourea; Mice; Neurons; Tretinoin; Tumor Cells, Cultured | 1998 |
Gene-mutation assays in lambda lacZ transgenic mice: comparison of lacZ with endogenous genes in splenocytes and small intestinal epithelium.
Topics: Alkylating Agents; Animals; Ethyl Methanesulfonate; Ethylnitrosourea; Genetic Markers; Hypoxanthine Phosphoribosyltransferase; Intestinal Mucosa; Intestine, Small; Lac Operon; Methylnitrosourea; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutagenicity Tests; Mutagens; Mutation; Spleen | 1998 |
Effects of O6-benzylguanine on growth and differentiation of P19 embryonic carcinoma cells treated with alkylating agents.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Embryonal; Cell Differentiation; Cell Division; Cell Survival; DNA Repair; Ethyl Methanesulfonate; Ethylnitrosourea; Guanine; Mesencephalon; Methyl Methanesulfonate; Methylnitrosourea; Mice; Neurons; O(6)-Methylguanine-DNA Methyltransferase; Rats; Tretinoin; Tumor Cells, Cultured | 1998 |
In vivo repair during G1 of DNA lesions eliciting sister chromatid exchanges induced by methylnitrosourea or ethylnitrosourea in BrdU substituted or unsubstituted DNA in murine salivary gland cells.
Topics: Animals; Bromodeoxyuridine; Cell Division; DNA Damage; DNA Repair; Drug Synergism; Ethylnitrosourea; G1 Phase; Isoproterenol; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mutagens; Salivary Glands; Sister Chromatid Exchange | 1999 |
Comparison of DNA damage in plants as measured by single cell gel electrophoresis and somatic leaf mutations induced by monofunctional alkylating agents.
Topics: Alkylating Agents; DNA Damage; DNA, Plant; Electrophoresis; Environmental Monitoring; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Nicotiana; Nucleic Acid Conformation; Plant Leaves; Plant Roots; Plants, Toxic | 1999 |
Differential sensitivities of spermatogonial and postspermatogonial cell stages of the mouse to induction of unscheduled DNA synthesis by ethyl- and methyl-nitrosourea.
Topics: Animals; Autoradiography; Cell Cycle; DNA Mutational Analysis; DNA Repair; Ethylnitrosourea; Male; Methylnitrosourea; Mice; Spermatogonia | 1999 |
DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.
Topics: Adenocarcinoma; Alkylating Agents; Animals; Carcinogens; DNA; DNA Adducts; DNA Repair; Drug Resistance, Neoplasm; Ethylnitrosourea; Female; Genes, ras; Guanine; Humans; Mammary Neoplasms, Experimental; Methylnitrosourea; Mutagens; Mutation; Rats | 2000 |
Chlorophyllin [CHLN] and the mutagenicity of monofunctional alkylating agents in Drosophila: the action of CHLN need not include an influence on metabolic activation.
Topics: Alkylating Agents; Animals; Antimutagenic Agents; Chlorophyllides; Diethylnitrosamine; Dose-Response Relationship, Drug; Drosophila; Ethylnitrosourea; Female; Male; Methyl Methanesulfonate; Methylnitrosourea; Mutagenesis; Mutagenicity Tests; Wings, Animal | 2000 |
Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin.
Topics: 3-O-Methylglucose; Alkylating Agents; Alkylation; Animals; Biological Transport; Biotransformation; Cell Line; Cell Survival; Ethyl Methanesulfonate; Ethylnitrosourea; Glucose Transporter Type 2; Islets of Langerhans; Kinetics; Methyl Methanesulfonate; Methylnitrosourea; Monosaccharide Transport Proteins; Rats; Recombinant Proteins; Streptozocin; Transfection | 2000 |
The relationship between alkylation of specific DNA bases and induction of sister chromatid exchange.
Topics: Alkylating Agents; Alkylation; Animals; Cell Line; Cricetinae; Cricetulus; DNA; DNA Methylation; Ethyl Methanesulfonate; Ethylnitrosourea; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Sister Chromatid Exchange | 1980 |
Differences in sensitivity of murine spermatogonia and somatic cells in vivo to sister-chromatid exchange induction by nitrosoureas.
Topics: Animals; Bone Marrow Cells; Ethylnitrosourea; Male; Methylnitrosourea; Mice; Mice, Inbred BALB C; Nitrosourea Compounds; Salivary Glands; Sensitivity and Specificity; Sister Chromatid Exchange; Spermatogonia | 2001 |
Overexpression of Ogt reduces MNU and ENU induced transition, but not transversion, mutations in E. coli.
Topics: Alkylating Agents; Alkylation; Bacterial Proteins; Escherichia coli; Escherichia coli Proteins; Ethylnitrosourea; Gene Expression; Methylnitrosourea; Methyltransferases; Mutagenesis | 2001 |
Effect of vanillin on toxicant-induced mutation and mitotic recombination in proliferating somatic cells of Drosophila melanogaster.
Topics: Alkylating Agents; Animals; Antimutagenic Agents; Benzaldehydes; Cell Proliferation; Crosses, Genetic; Drosophila melanogaster; Drug Synergism; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Flavoring Agents; Male; Methylnitrosourea; Mitosis; Mosaicism; Mutagenicity Tests; Mutation; Recombination, Genetic | 2004 |
Phosphate alkylation in different DNA substrates: the role of local DNA sequence and electrophile character in determining the nonrandom nature of phosphotriester adduct formation.
Topics: Alkylating Agents; Alkylation; Autoradiography; Buffers; Cell Line; Culture Media; DNA; Electrophoresis, Polyacrylamide Gel; Ethylnitrosourea; Humans; Methylnitrosourea; Oligonucleotides; Oxygen; Phosphates; Sulfuric Acid Esters | 2006 |
Vanillin as a modulator agent in SMART test: inhibition in the steps that precede N-methyl-N-nitrosourea-, N-ethyl-N-nitrosourea-, ethylmethanesulphonate- and bleomycin-genotoxicity.
Topics: Alkylating Agents; Animals; Antimutagenic Agents; Benzaldehydes; Bleomycin; Chromosomes; Crosses, Genetic; Dose-Response Relationship, Drug; Drosophila melanogaster; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Genetic Markers; Male; Methylnitrosourea; Mutagenicity Tests; Mutation; Recombination, Genetic | 2006 |
Comparison of the genetic effects of equimolar doses of ENU and MNU: while the chemicals differ dramatically in their mutagenicity in stem-cell spermatogonia, both elicit very high mutation rates in differentiating spermatogonia.
Topics: Alkylating Agents; Animals; Ethylnitrosourea; Germ-Line Mutation; Male; Methylnitrosourea; Mice; Mice, Inbred C3H; Mutagenicity Tests; Mutagens; Mutation; Spermatogenesis; Spermatogonia; Stem Cells | 2007 |
Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens.
Topics: Alkylating Agents; Cell Line; Chromosome Aberrations; DNA; DNA Adducts; DNA Damage; Ethyl Methanesulfonate; Ethylnitrosourea; Humans; Hypoxanthine Phosphoribosyltransferase; Lymphocytes; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; Point Mutation | 2007 |
Alkylation damage causes MMR-dependent chromosomal instability in vertebrate embryos.
Topics: Alkylating Agents; Alkylation; Animals; Cell Death; Chromosomal Instability; Chromosome Aberrations; DNA Damage; DNA Mismatch Repair; DNA Replication; DNA-Binding Proteins; Embryo, Nonmammalian; Ethylnitrosourea; Gene Deletion; Methylnitrosourea; Mutagens; Mutation; Zebrafish | 2008 |
Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzo(a)pyrene; Erythrocytes; Ethylnitrosourea; Membrane Proteins; Methylnitrosourea; Mutagenicity Tests; Mutagens; Mutation; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2010 |
N-nitroso-N-methylurea and N-nitroso-N-ethylurea induce upregulation of cellular NF-kappa B activity through protein kinase C-dependent pathway in human malignant keratinocytes.
Topics: Carcinogens; Cell Adhesion; Cell Count; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Ethylnitrosourea; Genes, Reporter; Humans; Keratinocytes; Methylnitrosourea; NF-kappa B; Phosphorylation; Protein Kinase C; Signal Transduction; Up-Regulation | 2010 |
Mutagenicity of N-ethyl-N-nitrosourea, N-methyl-N-nitrosourea, methyl methanesulfonate and ethyl methanesulfonate in the developing Syrian hamster fetus.
Topics: Animals; Cricetinae; Ethyl Methanesulfonate; Ethylnitrosourea; Female; Fetus; Maternal-Fetal Exchange; Mesocricetus; Methyl Methanesulfonate; Methylnitrosourea; Mutagenicity Tests; Mutagens; Pregnancy; Pregnancy, Animal | 2010 |
The removal of alkylation products from the DNA of Escherichia coli cells treated with the carcinogens N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: influence of growth conditions and DNA repair defects.
Topics: Adenine; Alkylating Agents; Alkylation; Carcinogens; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Methylation; Methylnitrosourea | 1980 |
Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment.
Topics: Animals; Benchmarking; Databases, Factual; Dose-Response Relationship, Drug; Ecotoxicology; Ethyl Methanesulfonate; Ethylnitrosourea; Humans; Methyl Methanesulfonate; Methylnitrosourea; Mutagens; No-Observed-Adverse-Effect Level; Risk Assessment | 2014 |