methylnitronitrosoguanidine and anethole

methylnitronitrosoguanidine has been researched along with anethole* in 1 studies

Other Studies

1 other study(ies) available for methylnitronitrosoguanidine and anethole

Article	Year
Anti-genotoxicity of trans-anethole and eugenol in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2001, Volume: 39, Issue:5 The naturally occurring flavouring agents trans-anethole and eugenol were evaluated for antigenotoxic effects in mice. The test doses of trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg weight) were administered by gavage 2 and 20 h before the genotoxins were injected intraperitoneally. Anti-genotoxic effects were assessed in the mouse bone marrow micronucleus test. Pretreatment with trans-anethole and eugenol led to significant antigenotoxic effects against cyclophosphamide (CPH), procarbazine (PCB), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and urethane (URE). In addition, trans-anethole inhibited the genotoxicity of ethyl methane sulfonate (EMS). Both trans-anethole and eugenol exerted dose-related antigenotoxic effects against PCB and URE. There was no significant increase in genotoxicity when trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg body weight) were administered alone. Topics: Allylbenzene Derivatives; Animals; Anisoles; Bone Marrow; Cyclophosphamide; Dose-Response Relationship, Drug; Erythrocytes; Ethyl Methanesulfonate; Eugenol; Flavoring Agents; Injections, Intraperitoneal; Male; Methylnitronitrosoguanidine; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Procarbazine; Urethane	2001

Article

Year

Anti-genotoxicity of trans-anethole and eugenol in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2001, Volume: 39, Issue:5

The naturally occurring flavouring agents trans-anethole and eugenol were evaluated for antigenotoxic effects in mice. The test doses of trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg weight) were administered by gavage 2 and 20 h before the genotoxins were injected intraperitoneally. Anti-genotoxic effects were assessed in the mouse bone marrow micronucleus test. Pretreatment with trans-anethole and eugenol led to significant antigenotoxic effects against cyclophosphamide (CPH), procarbazine (PCB), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and urethane (URE). In addition, trans-anethole inhibited the genotoxicity of ethyl methane sulfonate (EMS). Both trans-anethole and eugenol exerted dose-related antigenotoxic effects against PCB and URE. There was no significant increase in genotoxicity when trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg body weight) were administered alone.

Topics: Allylbenzene Derivatives; Animals; Anisoles; Bone Marrow; Cyclophosphamide; Dose-Response Relationship, Drug; Erythrocytes; Ethyl Methanesulfonate; Eugenol; Flavoring Agents; Injections, Intraperitoneal; Male; Methylnitronitrosoguanidine; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Procarbazine; Urethane

2001