methylnitronitrosoguanidine has been researched along with 3-methylguanine* in 1 studies
1 other study(ies) available for methylnitronitrosoguanidine and 3-methylguanine
| Article | Year |
|---|---|
DNA alkylation repair and the induction of cell death and sister chromatid exchange in human cells.
Mer- human cells, which lack O6-methylguanine DNA methyltransferase activity, are extremely sensitive to alkylation induced killing, mutation and sister chromatid exchange. We have analyzed a Mer+, a Mer-, and a Mer- revertant HeLa cell line and found that the methyltransferase deficiency correlates with increased levels of mutation and sister chromatid exchange, but does not correlate with increased killing of Mer- HeLa cells by alkylating agents. Furthermore, we show that HeLa Mer- cells repair N-3-methylguanine and N-3-methyladenine just as efficiently as HeLa Mer+ cells. Topics: Adenine; Alkylating Agents; Alkylation; Cell Survival; DNA Repair; Guanine; HeLa Cells; Humans; Methylnitronitrosoguanidine; Purines; Sister Chromatid Exchange | 1987 |