methylnitronitrosoguanidine and 1-8-dinitropyrene

methylnitronitrosoguanidine has been researched along with 1-8-dinitropyrene* in 1 studies

Other Studies

1 other study(ies) available for methylnitronitrosoguanidine and 1-8-dinitropyrene

ArticleYear
Decreased clastogenicity of dinitropyrenes in Chinese hamster lung (CHL) subclone cells with low NADPH-cytochrome P-450 reductase activity.
    Mutation research, 1991, Volume: 264, Issue:1

    Clastogenic potentials of 1,3-, 1,6- and 1,8-dinitropyrenes (DNPs) were compared between Chinese hamster lung (CHL) cells and its subclone MM1 cells, which were recently isolated as menadione-resistant cells after treatment with MNNG. NADPH-cytochrome P-450 reductase activity of the MM1 cells decreased to 50% of that in the parental CHL cells. All 3 DNPs induced chromosomal aberrations without exogenous metabolic activation systems in the CHL cells. 1,6- and 1,8-DNP showed equivalent clastogenic potency: the maximum frequency of cells with chromosomal aberrations was about 50% for both chemicals. The clastogenic potential of 1,3-DNP was lower than that of 1,6- and 1,8-DNP: the maximum frequency of aberrant cells was 10%. In the MM1 cells, in contrast, the frequencies of aberrant cells decreased to about 30% of those observed for the parental CHL cells after treatment with 1,6- and 1,8-DNP, and to the same level as that of the concurrent control after treatment with 1,3-DNP. These results suggest a possibility that the reduced clastogenic effect of 3 DNPs in MM1 cells may correlate with the reduced activity of NADPH-cytochrome P-450 reductase which is thought to contribute to the metabolic conversion of these DNPs to their clastogenic forms in the CHL cells.

    Topics: Animals; Biotransformation; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Drug Resistance; Lung; Methylnitronitrosoguanidine; Mutagenicity Tests; Mutagens; NADPH-Ferrihemoprotein Reductase; Pyrenes; Vitamin K

1991
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