Compounds > methylmalonyl-coenzyme a
Page last updated: 2024-09-03

methylmalonyl-coenzyme a and erythromycin

methylmalonyl-coenzyme a has been researched along with erythromycin in 18 studies

Compound Research Comparison

Studies
(methylmalonyl-coenzyme a)		Trials
(methylmalonyl-coenzyme a)		Recent Studies (post-2010)
(methylmalonyl-coenzyme a)		Studies
(erythromycin)		Trials
(erythromycin)		Recent Studies (post-2010) (erythromycin)
14503514,5241,1381,926

Protein Interaction Comparison

ProteinTaxonomymethylmalonyl-coenzyme a (IC50)erythromycin (IC50)
30S ribosomal protein S6Escherichia coli K-121.156
30S ribosomal protein S7Escherichia coli K-121.156
50S ribosomal protein L15Escherichia coli K-121.156
Cytochrome P450 3A4Homo sapiens (human)1.045
50S ribosomal protein L10Escherichia coli K-121.156
50S ribosomal protein L11Escherichia coli K-121.156
50S ribosomal protein L7/L12Escherichia coli K-121.156
50S ribosomal protein L19Escherichia coli K-121.156
50S ribosomal protein L1Escherichia coli K-121.156
50S ribosomal protein L20Escherichia coli K-121.156
50S ribosomal protein L27Escherichia coli K-121.156
50S ribosomal protein L28Escherichia coli K-121.156
50S ribosomal protein L29Escherichia coli K-121.156
50S ribosomal protein L31Escherichia coli K-121.156
50S ribosomal protein L31 type BEscherichia coli K-121.156
50S ribosomal protein L32Escherichia coli K-121.156
50S ribosomal protein L33Escherichia coli K-121.156
50S ribosomal protein L34Escherichia coli K-121.156
50S ribosomal protein L35Escherichia coli K-121.156
50S ribosomal protein L36Escherichia coli K-121.156
30S ribosomal protein S10Escherichia coli K-121.156
30S ribosomal protein S11Escherichia coli K-121.156
30S ribosomal protein S12Escherichia coli K-121.156
30S ribosomal protein S13Escherichia coli K-121.156
30S ribosomal protein S16Escherichia coli K-121.156
30S ribosomal protein S18Escherichia coli K-121.156
30S ribosomal protein S19Escherichia coli K-121.156
30S ribosomal protein S20Escherichia coli K-121.156
30S ribosomal protein S2Escherichia coli K-121.156
30S ribosomal protein S3Escherichia coli K-121.156
30S ribosomal protein S4Escherichia coli K-121.156
30S ribosomal protein S5Escherichia coli K-121.156
30S ribosomal protein S8Escherichia coli K-121.156
30S ribosomal protein S9Escherichia coli K-121.156
50S ribosomal protein L13Escherichia coli K-121.156
50S ribosomal protein L14Escherichia coli K-121.156
50S ribosomal protein L16Escherichia coli K-121.156
50S ribosomal protein L23Escherichia coli K-121.156
30S ribosomal protein S15Escherichia coli K-121.156
50S ribosomal protein L17Escherichia coli K-121.156
50S ribosomal protein L21Escherichia coli K-121.156
50S ribosomal protein L30Escherichia coli K-121.156
50S ribosomal protein L6Escherichia coli K-121.156
30S ribosomal protein S14Escherichia coli K-121.156
30S ribosomal protein S17Escherichia coli K-121.156
30S ribosomal protein S1Escherichia coli K-121.156
50S ribosomal protein L18Escherichia coli K-121.156
50S ribosomal protein L2Escherichia coli K-121.156
50S ribosomal protein L3Escherichia coli K-121.156
50S ribosomal protein L24Escherichia coli K-121.156
50S ribosomal protein L4Escherichia coli K-121.156
50S ribosomal protein L22Escherichia coli K-121.156
50S ribosomal protein L5Escherichia coli K-121.156
30S ribosomal protein S21Escherichia coli K-121.156
50S ribosomal protein L25Escherichia coli K-121.156
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.039
50S ribosomal protein L36 2Escherichia coli K-121.156

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's8 (44.44)18.2507
2000's6 (33.33)29.6817
2010's2 (11.11)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Hunaiti, AA; Kolattukudy, PE1
Kao, CM; Katz, L; Khosla, C1
Cane, DE1
Aparicio, JF; Caffrey, P; Leadlay, PF; Loughran, MS; Marsden, AF; Staunton, J1
Leadlay, PF; Roberts, GA; Staunton, J1
Cane, D; Ebert-Khosla, S; Khosla, C; Pieper, R1
Donadio, S; Jackson, M; Kakavas, S; Katz, L; Pereda, A; Ruan, X; Shivakumar, A; Stassi, DL; Staver, MJ; Summers, RG; Zeidner, D1
Bycroft, M; Grice, P; Hanefeld, U; Leadlay, PF; Staunton, J; Timoney, M; Weissman, KJ1
Cane, DE; Fu, H; Khosla, C; Lau, J1
Admiraal, SJ; Cane, DE; Gramajo, H; Khosla, C; Pfeifer, BA1
Ferber, D1
Carney, JR; Dayem, LC; Kealey, JT; Kennedy, J; Murli, S1
Kealey, JT; Kennedy, J; Murli, S1
Brikun, IA; Cernota, WH; Reeves, AR; Weber, JM; Wesley, RK1
Brikun, IA; Cernota, WH; Gonzalez, MC; Leach, BI; Reeves, AR; Weber, JM1
Boghigian, BA; Pfeifer, BA; Zhang, H1
Jiang, M; Pfeifer, BA1
Chen, K; Chen, Y; Khan, S; Li, B; Ren, S; Wu, H; Wu, P; Zhang, B; Zhang, L; Zhang, Y1

Other Studies

18 other study(ies) available for methylmalonyl-coenzyme a and erythromycin

ArticleYear
Source of methylmalonyl-coenzyme A for erythromycin synthesis: methylmalonyl-coenzyme A mutase from Streptomyces erythreus.
    Antimicrobial agents and chemotherapy, 1984, Volume: 25, Issue:2

    Topics: Acyl Coenzyme A; Bacterial Proteins; Chromatography, DEAE-Cellulose; Erythromycin; Hydrogen-Ion Concentration; Isomerases; Kinetics; Malonyl Coenzyme A; Methylmalonyl-CoA Mutase; Streptomyces; Vitamin B 12

1984
Engineered biosynthesis of a complete macrolactone in a heterologous host.
    Science (New York, N.Y.), 1994, Jul-22, Volume: 265, Issue:5171

    Topics: Acyl Coenzyme A; Base Sequence; Binding Sites; Cloning, Molecular; Drug Design; Erythromycin; Escherichia coli; Genes, Bacterial; Genetic Engineering; Genetic Vectors; Molecular Sequence Data; Multienzyme Complexes; Multigene Family; Mutation; Oleandomycin; Recombinant Proteins; Streptomyces; Structure-Activity Relationship

1994
Polyketide biosynthesis: molecular recognition or genetic programming?
    Science (New York, N.Y.), 1994, Jan-21, Volume: 263, Issue:5145

    Topics: Acetyl Coenzyme A; Acyl Coenzyme A; Anthraquinones; Anti-Bacterial Agents; Cell-Free System; Erythromycin; Malonyl Coenzyme A; Multienzyme Complexes; Naphthacenes; Streptomyces

1994
Stereospecific acyl transfers on the erythromycin-producing polyketide synthase.
    Science (New York, N.Y.), 1994, Jan-21, Volume: 263, Issue:5145

    Topics: Acetyl Coenzyme A; Acyl Coenzyme A; Erythromycin; Malonyl Coenzyme A; Molecular Conformation; Multienzyme Complexes; Racemases and Epimerases; Saccharopolyspora; Stereoisomerism; Substrate Specificity

1994
Heterologous expression in Escherichia coli of an intact multienzyme component of the erythromycin-producing polyketide synthase.
    European journal of biochemistry, 1993, May-15, Volume: 214, Issue:1

    Topics: Acyl Coenzyme A; Amino Acid Sequence; Base Sequence; Binding Sites; Chromatography, Gel; DNA, Bacterial; Erythromycin; Escherichia coli; Gene Expression; Genes, Bacterial; Genetic Engineering; Molecular Sequence Data; Molecular Weight; Multienzyme Complexes; Protein Processing, Post-Translational; Recombinant Proteins; Saccharopolyspora

1993
Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates.
    Biochemistry, 1996, Feb-20, Volume: 35, Issue:7

    Topics: Acyl Coenzyme A; Carboxylic Acids; Erythromycin; Kinetics; Multienzyme Complexes; NADP; Phosphates; Streptomyces; Substrate Specificity

1996
Acyltransferase domain substitutions in erythromycin polyketide synthase yield novel erythromycin derivatives.
    Journal of bacteriology, 1997, Volume: 179, Issue:20

    Topics: Acyl Coenzyme A; Acyltransferases; Amino Acid Sequence; Cloning, Molecular; Erythromycin; Genetic Vectors; Molecular Sequence Data; Molecular Structure; Multienzyme Complexes; Plasmids; Recombinant Proteins; Saccharopolyspora; Transformation, Genetic

1997
The molecular basis of Celmer's rules: the stereochemistry of the condensation step in chain extension on the erythromycin polyketide synthase.
    Biochemistry, 1997, Nov-11, Volume: 36, Issue:45

    Topics: Acyl Coenzyme A; Catalysis; Deuterium; Erythromycin; Gas Chromatography-Mass Spectrometry; Lactones; Magnetic Resonance Spectroscopy; Multienzyme Complexes; Saccharopolyspora; Solvents; Stereoisomerism; Substrate Specificity

1997
Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units.
    Biochemistry, 1999, Feb-02, Volume: 38, Issue:5

    Topics: Acyl Coenzyme A; Acyltransferases; Amino Acid Sequence; Erythromycin; Escherichia coli; Isoenzymes; Molecular Sequence Data; Multienzyme Complexes; Plasmids; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sirolimus; Stereoisomerism; Streptomyces; Substrate Specificity; Thiolester Hydrolases

1999
Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli.
    Science (New York, N.Y.), 2001, Mar-02, Volume: 291, Issue:5509

    Topics: Acyl Coenzyme A; Bacterial Proteins; Cloning, Molecular; Erythromycin; Escherichia coli; Multienzyme Complexes; Promoter Regions, Genetic; Recombinant Fusion Proteins; Saccharopolyspora; Transferases (Other Substituted Phosphate Groups); Transformation, Bacterial

2001
Microbiology. Possible new route to polyketide synthesis.
    Science (New York, N.Y.), 2001, Mar-02, Volume: 291, Issue:5509

    Topics: Acyl Coenzyme A; Bacillus subtilis; Erythromycin; Escherichia coli; Genetic Engineering; Multienzyme Complexes; Pantetheine; Patents as Topic; Protein Engineering; Recombinant Proteins; Saccharopolyspora

2001
Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production.
    Journal of industrial microbiology & biotechnology, 2003, Volume: 30, Issue:8

    Topics: Acyl Coenzyme A; Carbon Isotopes; Chromosomes, Bacterial; Erythromycin; Escherichia coli; Gene Expression Regulation, Bacterial; Industrial Microbiology; Intramolecular Transferases; Molecular Biology; Multienzyme Complexes; Plasmids; Propionates

2003
6-Deoxyerythronolide B analogue production in Escherichia coli through metabolic pathway engineering.
    Biochemistry, 2003, Dec-09, Volume: 42, Issue:48

    Topics: Acetoacetates; Acyl Coenzyme A; Bacterial Proteins; Bacteriocins; Butyrates; DNA Glycosylases; DNA-Binding Proteins; Erythromycin; Escherichia coli; Escherichia coli Proteins; Gene Expression Regulation, Bacterial; Genetic Engineering; Multienzyme Complexes; Peptides; Plasmids; Racemases and Epimerases

2003
Engineering precursor flow for increased erythromycin production in Aeromicrobium erythreum.
    Metabolic engineering, 2004, Volume: 6, Issue:4

    Topics: Actinobacteria; Acyl Coenzyme A; Bacterial Proteins; Erythromycin; Gene Deletion; Gene Expression Regulation, Bacterial; Methyltransferases

2004
Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production.
    Metabolic engineering, 2007, Volume: 9, Issue:3

    Topics: Acyl Coenzyme A; Bacterial Proteins; Chromosomes, Bacterial; Erythromycin; Genetic Engineering; Open Reading Frames; Saccharopolyspora

2007
Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli.
    Biotechnology and bioengineering, 2010, Feb-15, Volume: 105, Issue:3

    Topics: Acyl Coenzyme A; Coenzyme A-Transferases; Erythromycin; Escherichia coli; Escherichia coli Proteins; Gene Deletion; Gene Dosage; Gene Expression; Macrolides; Methylmalonyl-CoA Decarboxylase; Methylmalonyl-CoA Mutase

2010
Metabolic and pathway engineering to influence native and altered erythromycin production through E. coli.
    Metabolic engineering, 2013, Volume: 19

    Topics: Acyl Coenzyme A; Erythromycin; Escherichia coli; Glycerol; Metabolic Engineering

2013
Polyketide Starter and Extender Units Serve as Regulatory Ligands to Coordinate the Biosynthesis of Antibiotics in Actinomycetes.
    mBio, 2021, 10-26, Volume: 12, Issue:5

    Topics: Acyl Coenzyme A; Anti-Bacterial Agents; Bacterial Proteins; Biosynthetic Pathways; Erythromycin; Ligands; Polyketide Synthases; Promoter Regions, Genetic; Saccharopolyspora

2021