methyllycaconitine has been researched along with aconitine in 403 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.25) | 18.7374 |
| 1990's | 58 (14.39) | 18.2507 |
| 2000's | 187 (46.40) | 29.6817 |
| 2010's | 138 (34.24) | 24.3611 |
| 2020's | 19 (4.71) | 2.80 |
| Authors | Studies |
|---|---|
| Albuquerque, EX; Alkondon, M; Pereira, EF; Wonnacott, S | 1 |
| Cockcroft, VB; Lunt, GG; Smillie, FS; Ward, JM; Wonnacott, S | 1 |
| Albuquerque, EX; Lunt, GG; Macallan, DR; Rapoport, H; Swanson, KL; Wonnacott, S | 1 |
| Barrantes, GE; Murphy, CT; Westwick, J; Wonnacott, S | 1 |
| Blagbrough, IS; Cooper, G; Hardick, DJ; Potter, BV; Scott-Ward, T; Wonnacott, S | 1 |
| Barrantes, GE; Westwick, J; Wonnacott, S | 1 |
| Cheney, CD; Manners, GD; Panter, KE; Pfister, JA | 1 |
| Khan, IM; Printz, MP; Taylor, P; Yaksh, TL | 1 |
| Khan, IM; Taylor, P; Yaksh, TL | 1 |
| Manners, GD; Panter, KE; Pfister, JA | 1 |
| Albuquerque, EX; Alkondon, M | 1 |
| Chiappinelli, VA; Wolf, KM; Yum, L | 1 |
| Brioni, JD; Kim, DJ; O'Neill, AB | 1 |
| Blagbrough, IS; Coates, PA; Lewis, T; Potter, BV; Rowan, MG | 1 |
| Correa, LD; Lloyd, GK; Rao, TS; Reid, RT | 1 |
| Briggs, CA; McKenna, DG | 1 |
| Albuquerque, EX; Alkondon, M; Aracava, Y; Barbosa, CT; Maelicke, A | 1 |
| Hutson, P; Sullivan, JP; Wilkie, GI; Wonnacott, S | 1 |
| Blagbrough, IS; Coates, PA; Lewis, T; Pearson, DP; Potter, BV; Rowan, MG | 1 |
| Blagbrough, IS; Cooper, G; Critchley, T; Hardick, DJ; Potter, BV; Wonnacott, S | 1 |
| Albuquerque, EX; Alkondon, M; Pereira, EF | 2 |
| Changeux, JP; Léna, C | 1 |
| Bertrand, D; Bertrand, S; Binzoni, T; Palma, E | 1 |
| Dezaki, K; Kimura, I; Tsuneki, H | 3 |
| Blank, U; Clauss, W; Rückes, C; Weber, WM | 1 |
| Delbono, O; Grigorenko, E; Messi, ML; Renganathan, M | 1 |
| Akaike, A; Kaneko, S; Kimura, J; Kochiyama, H; Kume, T; Maeda, T; Shimohama, S | 1 |
| Felix, R; Levin, ED | 1 |
| Atluri, P; Drisdel, RC; Fox, AP; Green, WN; Harkins, AB; Ko, E; Rakhilin, S; Rangwala, F; Salman, SS | 1 |
| Beaudet, AL; Dani, JA; De Biasi, M; Goldberg, L; Göldner, FM; Lorenzo, I; Orr-Urtreger, A; Patrick, JW; Saeki, M | 1 |
| Blagbrough, IS; Davies, AR; Hardick, DJ; Potter, BV; Wolstenholme, AJ; Wonnacott, S | 2 |
| Dempster, J; Marshall, IG; Prior, C; Tian, L | 1 |
| Bertrand, D; Bertrand, S; Buisson, B; Changeux, JP; Corringer, PJ; Devillers-Thiéry, A; Edelstein, SJ; Palma, E | 1 |
| Role, LW; Yu, CR | 2 |
| Arneric, SP; Delbono, O; Gopalakrishnan, M; Messi, ML; Molinari, EJ; Renganathan, M; Sullivan, JP | 1 |
| Nomikos, GG; Schilström, B; Svensson, HM; Svensson, TH | 1 |
| Eusebi, F; Maggi, L; Miledi, R; Palma, E | 1 |
| Kehoe, J; McIntosh, JM | 1 |
| Buhler, AV; Dunwiddie, TV; Frazier, CJ; Weiner, JL | 1 |
| Gandía, L; García, AG; García-Palomero, E; Hernández-Guijo, JM; Herrero, CJ; López, MG; Mayorgas, I; McIntosh, JM; Montiel, C; Olivares, R; Olivera, BM; Villarroya, M | 1 |
| Dezaki, K; Kimura, I; Nojima, H; Tsuneki, H | 1 |
| Clarke, PB; Gioanni, Y; Lepousé, C; Rougeot, C; Thierry, AM; Vidal, C | 1 |
| Bertrand, D; Hefft, S; Hulo, S; Muller, D | 1 |
| Arneric, SP; Briggs, CA; Gopalakrishnan, M; McKenna, DG; Monteggia, LM; Roch, JM; Sullivan, JP; Touma, E | 1 |
| Fryer, J; Herl, J; Leonard, SS; Lucero, L; Lukas, RJ; Peng, JH | 1 |
| Ballivet, M; Barabino, B; Eusebi, F; Maggi, L; Palma, E | 1 |
| Bertrand, D; Chiodini, FC; Hulo, S; Muller, D; Tassonyi, E | 1 |
| Breese, GR; Criswell, HE; Yang, X | 2 |
| Dezaki, K; Kimura, I | 1 |
| Blagbrough, IS; Collins, AC; Davies, AR; Marks, MJ; Potter, BV; Whiteaker, P; Wolstenholme, AJ; Wonnacott, S | 1 |
| Bergmeier, SC; Free, RB; Lapinsky, DJ; McKay, DB | 1 |
| Dobelis, P; Madl, JE; Manners, GD; Pfister, JA; Walrond, JP | 1 |
| Nordberg, A; Svensson, AL | 1 |
| Albuquerque, EX; Alkondon, M; Eisenberg, HM; Pereira, EF | 1 |
| Costa, E; Javaid, JI; Lecca, D; Shim, I | 1 |
| Fujii, S; Jia, Y; Sumikawa, K; Yang, A | 1 |
| Dani, JA; Ji, D | 1 |
| Blondel, A; Moser, PC; Sanger, DJ | 1 |
| Berg, DK; Cuevas, J; Roth, AL | 1 |
| Kastellakis, A; Nomikos, G; Panagis, G; Spyraki, C | 1 |
| Davis, CB; Lee, DH; Shank, RP; Wang, HY | 1 |
| Grillner, P; Svensson, TH | 1 |
| Changeux, JP; Klink, R; Korn, H; Léna, C; Tsuneki, H | 1 |
| Gardner, DR; Lee, ST; Manners, GD; Panter, KE; Pfister, JA | 1 |
| Adams, CE; Breese, CR; Collins, AC; Gillen, KM; Lee, MJ; Leonard, S; Logel, J; Marks, MJ; Sullivan, B | 1 |
| Shao, Z; Yakel, JL | 1 |
| Gommans, J; Shoaib, M; Stolerman, IP | 1 |
| Baker, CM; Dávila-García, MI; Ebert, SN; Ferreira, M; Gillis, RA; Kellar, KJ; Perry, DC; Yasuda, RP | 1 |
| Breese, CR; Lee, MJ; Leonard, S; Strook, ML | 1 |
| Bertrand, D; Buisson, B | 1 |
| Chiappinelli, VA; El-Bogdadi, DG; Nong, Y; Sorenson, EM | 1 |
| Fujii, S; Sumikawa, K | 2 |
| Blagbrough, IS; Clough, MS; Davies, AR; Earley, FG; Hardick, DJ; Lind, RJ; Potter, BV; Reynolds, SE; Wolstenholme, AJ; Wonnacott, S | 1 |
| Hodgkiss, JP; Kelly, JS | 1 |
| Ito, S; Kasai, Y; Nakazato, Y; Ohta, T; Yonekubo, K | 1 |
| Acosta, S; Miles, R; Strahlendorf, HK; Strahlendorf, JC | 1 |
| Bertrand, D; Buisson, B; Changeux, JP; Fryer, JD; Galzi, JL; Lucero, L; Lukas, RJ; Puchacz, E | 1 |
| Tuominen, RK; Vainio, PJ | 1 |
| Gündisch, D; Imming, P; Klaperski, P; Seitz, G; Stubbs, MT | 1 |
| Fischbach, GD; Ford, B; Liu, Y; Mann, MA | 1 |
| Cherubini, E; Maggi, L; Sher, E | 1 |
| Genzen, JR; McGehee, DS; Van Cleve, W | 1 |
| Markou, A; Paterson, NE | 1 |
| Hatanaka, H; Ikeuchi, T; Nakayama, H; Numakawa, T | 1 |
| Buccafusco, JJ; Jonnala, RR | 1 |
| Hatton, GI; Yang, QZ | 1 |
| Bettany, JH; Levin, ED | 1 |
| Bergmeier, SC; Bryant, DL; Free, RB; Ismail, KA; Lapinsky, DJ; McKay, DB; McKay, SB; Thomasy, SM | 1 |
| Desai, SA; Eddins, D; Lee, JW; Lyford, LK; Rosenberg, RL | 1 |
| Buccafusco, JJ; Jonnala, RR; Terry, AV | 1 |
| Dourado, M; Sargent, PB | 1 |
| Collins, AC; Marks, M; McIntosh, JM; Mogg, AJ; Whiteaker, P; Wonnacott, S | 1 |
| Lee, TJ; Si, ML | 1 |
| Bray, C; Meizel, S; Son, JH | 1 |
| Bergmeier, SC; Ismail, KA | 1 |
| Bunker, GL; Nishi, R | 1 |
| Ayers, JT; Crooks, PA; Deaciuc, AG; Dwoskin, LP; Grinevich, VP; Zhu, J | 1 |
| Bradaïa, A; Trouslard, J | 1 |
| Bunnemann, B; Chiamulera, C; Merlo Pich, E; Mugnaini, M; Tarter, G; Tessari, M | 1 |
| Arason, KM; Bergmeier, SC; Bryant, DL; Free, RB; Ismail, KA; Lapinsky, DJ; McKay, DB; Thomasy, SM | 1 |
| Laviolette, SR; van der Kooy, D | 1 |
| Addy, NA; Levin, ED; Nakijama, A | 1 |
| Gardner, DR; James, LF; Lee, ST; Panter, KE; Pfister, JA; Schoch, TK; Stegelmeier, BL | 1 |
| File, SE; Genn, RF; Tucci, SA | 1 |
| Meizel, S; Son, JH | 1 |
| Freir, DB; Herron, CE | 1 |
| Meyer, EM; Papke, RL; Uteshev, VV | 1 |
| George, AA; Kuo, YP; Lukas, RJ; Peng, JH; Purandare, MS; Schroeder, KM; Wu, J; Zhao, L | 1 |
| Ayers, JT; Crooks, PA; Dwoskin, LP; Grinevich, VP; Haubner, AJ; Sumithran, SP | 1 |
| Gardner, DR; Hall, JO; Panter, KE; Stegelmeier, BL | 1 |
| File, SE; Genn, RF; Marco, E; Tucci, S | 1 |
| Mameli-Engvall, M; Nomikos, GG; Rawal, N; Schilström, B; Svensson, TH | 1 |
| Alreja, M; Hajszan, T; Leranth, C; Wu, M | 1 |
| Bräuner-Osborne, H; Falch, E; Frølund, B; Jensen, AA; Krogsgaard-Larsen, P; Mikkelsen, I | 1 |
| Elgoyhen, AB; Plazas, PV; Verbitsky, M | 1 |
| Marszalec, W; Moriguchi, S; Narahashi, T; Yeh, JZ; Zhao, X | 1 |
| Höglund, AU; Kommalage, M | 1 |
| Al-Namaeh, M; Manaye, KF; Taylor, RE; Tizabi, Y | 1 |
| Boess, F; Schiegel, E; Schneider, R; Schreiber, R; Selbach, K; Van Kampen, M | 1 |
| Baker, ER; Millar, NS; Sher, E; Zwart, R | 1 |
| Reid, RT; Sabbagh, MN | 1 |
| de Châtel, R; Göõz, M; Göõz, P; Smolka, AJ; Szalay, KS; Tóth, M; Vakkuri, O | 1 |
| Crawford, N; Finlayson, K; Kelly, JS; Marston, HM; Sharkey, J; Spratt, C; Young, JW | 1 |
| Kohama, K; Li, S; Nakamura, A; Tanaka, H; Xin, H; Ye, LH; Zhang, X; Zhao, T | 1 |
| Allen, DD; Ayers, JT; Crooks, PA; Deaciuc, AG; Dwoskin, LP; Grinevich, VP; Sumithran, SP; Wilkins, LH; Xu, R | 1 |
| Bellack, AS; Chilton, M; Deutsch, SI; Mastropaolo, J; Rosse, RB | 1 |
| Harris, BR; Littleton, JM; Mulholland, PJ; Prendergast, MA; Self, RL | 1 |
| Crooks, PA; Dwoskin, LP; Grinevich, VP; Miller, DK; Norrholm, SD; Zheng, G | 1 |
| Barker, D; Brimble, MA; McLeod, MD; Savage, GP | 1 |
| Arason, KM; Bergmeier, SC; Bryant, DL; Ismail, KA; McKay, DB; McKay, S | 1 |
| Krishtal, O; Lalo, U; North, RA; Pankratov, Y | 1 |
| de Fiebre, CM; de Fiebre, NE; Martin, SE | 1 |
| Amano, T; Inoue, A; Matsubayashi, H; Nakata, Y; Sakai, N; Sasa, M; Seki, T | 1 |
| Saar, R; Salgado, VL | 1 |
| Bertrand, D; Liu, X; Ogier, R; Raggenbass, M; Tribollet, E | 1 |
| Choi, SS; Han, EJ; Kwon, MS; Lee, HK; Lee, JY; Seo, YJ; Shim, EJ; Suh, HW | 1 |
| Frenz, CM; Gueorguiev, VD; Ronald, KM; Sabban, EL | 1 |
| Cui, W; Hu, G; Wang, H; Yin, X | 1 |
| Ashenafi, S; Criado, JM; Fuente, A; Heredia, M; Riolobos, AS; Yajeya, J | 1 |
| Arias, E; Beach, JW; Buccafusco, JJ; Doad, GS; Fujii, T; Kawashima, K; Masai, M; Misawa, H; Sood, A; Terry, AV | 1 |
| Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y | 1 |
| Ellsworth, K; Javedan, SP; Kimura, R; Lukas, RJ; Marxer-Miller, S; Murray, TA; Song, C; Wakui, M; Wu, J | 1 |
| Ahtee, L; Nuutinen, S; Tuominen, RK | 1 |
| Barker, D; Brimble, MA; Carland, JE; Chebib, M; Chu, CP; Lin, DH; McLeod, MD; Savage, GP | 1 |
| Abbruscato, TJ; Allen, DD; Lockman, PR; Van der Schyf, CJ | 1 |
| Chen, L; Sokabe, M | 1 |
| Chiappinelli, VA; Guo, JZ; Liu, Y; Sorenson, EM | 1 |
| Davis, JA; Gould, TJ | 1 |
| Frazier, CJ; King, MA; Meyer, EM; Papke, RL; Thinschmidt, JS | 1 |
| Cilia, J; Cluderay, JE; Jones, DN; Kew, JN; Reavill, C; Robbins, MJ; Southam, E | 1 |
| Lajtha, A; Rossi, S; Sershen, H; Shearman, E; Singer, S | 1 |
| Camarasa, J; Chipana, C; Escubedo, E; Pérez-Sánchez, M; Pubill, D | 1 |
| Araki, H; Gomita, Y; Jin, C; Kawasaki, H; Kawasaki, Y; Motoshima, S; Suemaru, K | 1 |
| Hamaue, N; Jia, Y; Sumikawa, K; Yamazaki, Y | 1 |
| Cavun, S; Savci, V; Yalcin, M; Yilmaz, MS | 1 |
| Freedman, R; Hashimoto, K; Iyo, M; Stevens, KE | 1 |
| Arias, E; Gallego-Sandín, S; García, AG; López, MG; Villarroya, M | 1 |
| Crooks, PA; Deaciuc, AG; Dwoskin, LP; Sumithran, SP; Wilkins, LH; Xu, R; Zhu, J | 1 |
| Giocomo, LM; Hasselmo, ME | 1 |
| Leslie, FM; O'Leary, KT | 1 |
| Matteoni, C; Nistri, A; Sokolova, E | 1 |
| Bugaj-Gaweda, B; Buhr, JD; Jack, BA; McCormack, TJ; Papke, RL; Schiff, HC; Stokes, C; Waber, AJ; Wang, D | 1 |
| Arias, E; Buccafusco, JJ; Jonnala, RR; Li, XD; Mruthinti, S | 1 |
| Boselli, E; Chassard, D; Duflo, F; Ryvlin, P | 1 |
| Bardo, MT; Champtiaux, N; Kalivas, PW | 1 |
| Brown, S; Changeux, JP; Damaj, MI; Martin, B; Walters, CL | 1 |
| Isgor, C; Ma, Z; Pearson, E; Tao, R | 1 |
| Fu, J; McLaughlin, JT; Rosenberg, RL; Sproul, AD | 1 |
| Chen, JT; Chen, XT; Lou, ZY; Luo, L; Ruan, DY; Sun, LG; Wang, HL; Wang, M; Wang, S | 1 |
| Levin, ED; Nott, A | 1 |
| Guan, X; Nakauchi, S; Sumikawa, K | 1 |
| Briggs, CA; Gubbins, EJ; Marks, MJ; Meyer, MD; Putman, CB; Surowy, CS; Thimmapaya, R | 1 |
| Armengaud, C; Dacher, M; Déglise, P; Gauthier, M; Grünewald, B; Kljucevic, P; Niggebrügge, C; Thany, SH | 1 |
| Crawford, N; Finlayson, K; Kelly, JS; Kerr, LE; Marston, HM; Sharkey, J; Spratt, C; Young, JW | 1 |
| Icenogle, L; Levin, ED; Pocivavsek, A | 1 |
| Filip, M; McCreary, AC; Przegaliński, E; Zaniewska, M | 1 |
| Alfonso, M; Campos, F; Durán, R; Faro, LR; Vidal, L | 1 |
| Carney, SL; Serres, F | 1 |
| Changeux, JP; de Kerchove D'Exaerde, A; Picciotto, MR; Zanardi, A; Zanetti, L; Zoli, M | 1 |
| Hatori, E; Hosokawa, Y; Kashiwagi, M; Kuribayashi, J; Kuwana, S; Sakuraba, S; Takeda, J; Tsujita, M | 1 |
| Camarasa, J; Chipana, C; Escubedo, E; Pubill, D | 1 |
| Chen, HK; Su, CK | 1 |
| Klein, RC; Yakel, JL | 1 |
| Caballero-Rivera, D; Lasalde-Dominicci, JA; Navedo, MF; Nieves-Cintrón, M | 1 |
| Anderson, DJ; Bitner, RS; Curzon, P; Decker, MW; Fox, GB; Gopalakrishnan, M; Nikkel, AL | 1 |
| Abraham, P; Damaj, MI; Ivy Carroll, F; Ma, W; Martin, BR; Navarro, HA; Wolckenhauer, SA | 1 |
| Kesner, RP; Vago, DR | 1 |
| Ai, L; Hughes, JA; King, MA; Liu, J; Meyer, EM; Papke, RL; Ren, K; Thinschmidt, J | 1 |
| Erturk, M; Yalcin, M | 1 |
| Aguilar, MI; Azari, MF; Chebib, M; Chu, C; Hou, X; Kerr, ML; Loiacono, R; Maksel, D; Mehrani, H; Ng, J; Small, DH; Unabia, S | 1 |
| Arason, KM; Bergmeier, SC; Bryant, DL; Chang, C; El-Hajj, RA; González-Cestari, TF; McKay, DB; McKay, SB; Orac, CM; Pulipaka, AB; Swaan, PW; Zhu, MX | 1 |
| El Kouhen, R; Gopalakrishnan, M; Hu, M; Li, J; Puttfarcken, PS; Schurdak, ME | 1 |
| Besson, M; Cazala, P; Changeux, JP; Cloëz-Tayarani, I; Cormier, A; David, V; Faure, P; Granon, S; Mameli-Engvall, M; Maubourguet, N | 1 |
| Lestage, P; Lopez-Hernandez, G; Morain, P; Papke, RL; Placzek, AN; Thinschmidt, JS; Trocme-Thibierge, C | 1 |
| Fujita, Y; Hashimoto, K; Ishima, T; Iyo, M; Kobashi, T; Matsuo, M; Takahagi, M; Tsukada, H | 1 |
| Caggiula, AR; Donny, EC; Liu, X; Palmatier, MI; Sved, AF | 1 |
| Bardo, MT; Bruntz, RC; Dwoskin, LP; Stairs, DJ; Zhu, J | 1 |
| Boyd, RT; Dávila-García, MI; Langley, R; Mishra, NC; Nandi, JS; Pena-Philippides, JC; Razani-Boroujerdi, S; Singh, SP; Sopori, ML | 1 |
| Jensen, AA; Liljefors, T; Zlotos, DP | 1 |
| Ago, Y; Baba, A; Hashimoto, H; Kawasaki, T; Koda, K; Matsuda, T | 1 |
| Davis, JA; Gould, TJ; Kenney, JW | 1 |
| De Biasi, M; Gangitano, D; Main, A; Salas, R | 1 |
| Andersson, A; Engberg, G; Erhardt, S; Linderholm, KR; Olsson, E; Olsson, S; Snodgrass, R | 1 |
| Anderson, DJ; Bertrand, D; Bunnelle, W; Du, J; Gopalakrishnan, M; Marguerat, A; Surber, B; Surowy, C; Tribollet, E | 1 |
| Hollingworth, RM; Salgado, VL; Tan, J | 1 |
| Arredondo, J; Chernyavsky, AI; Grando, SA; Karlsson, E; Piser, T | 1 |
| Bergmeier, SC; Huang, J; McKay, DB; McKay, S; Orac, CM | 1 |
| Moore, C; Ramage, AG; Wang, Y | 2 |
| Robles, N; Sabriá, J | 1 |
| Billinton, A; Bingham, S; Chessell, IP; Clayton, NM; Hatcher, JP; Hille, CJ; Medhurst, SJ | 1 |
| Cook, D; Gardner, DR; Green, BT; Panter, KE; Pfister, JA; Stegelmeier, BL; Welch, KD | 3 |
| Dacher, M; Gauthier, M | 1 |
| Bencan, Z; Levin, ED | 1 |
| Lehr, MA; Li, JG; Liu-Chen, LY; Woodruff-Pak, DS | 1 |
| Boyle, DL; Firestein, GS; Pavlov, VA; Tracey, KJ; Waldburger, JM | 1 |
| Engel, J; Jerlhag, E; Kuzmin, A; Liljequist, S | 1 |
| Bowlby, MR; Dunlop, J; Friis, S; Mathes, C; Sunesen, M | 1 |
| Hu, J; Jin, G; Liu, Q; Lucero, L; Lukas, RJ; Wu, J; Yang, K; Zhen, X; Zheng, C | 1 |
| Araki, H; Gomita, Y; Kitamura, Y; Sagara, H; Sendo, T; Shibata, K; Suemaru, K; Yae, T | 1 |
| Fu, XW; Lindstrom, J; Spindel, ER | 1 |
| Cai, GJ; Chen, AF; Kong, Y; Le, YY; Liu, C; Liu, X; Shen, FM; Su, DF | 1 |
| Chaudhury, D; Escanilla, O; Linster, C | 1 |
| Berez, C; Brotherton, T; Christopher, NC; Davis, K; Levin, ED; Montalvo-Ortiz, J; Perkins, A; Qazi, M; Williams, P | 1 |
| Amar, M; Baux, G; Fossier, P; Frégnac, Y; Lucas-Meunier, E; Monier, C | 1 |
| Good, CH; Lupica, CR | 1 |
| Hotta, H; Kawashima, K; Uchida, S | 1 |
| Eisenach, JC; Gurun, MS; Parker, R; Vincler, M | 1 |
| Araki, H; Cui, R; Kohnomi, S; Li, B; Suemaru, K | 1 |
| Abdrakhmanova, GR; Baydyuk, M; Hernandez, S; Kellar, KJ; Xiao, Y | 1 |
| Cook, D; Gardner, DR; Green, BT; Lee, ST; Pfister, JA; Welch, KD | 1 |
| Brotherton, J; Cannady, R; Gotschlich, E; Kolia, N; Lau, E; Levin, ED; Wee, B; Weir, R | 1 |
| Liu, Q; Lukas, RJ; Murray, TA; Whiteaker, P; Wu, J | 1 |
| Cook, D; Davis, TZ; Gardner, DR; Green, BT; Lee, ST; Panter, KE; Pfister, JA; Stegelmeier, BL; Welch, KD | 1 |
| Thany, SH | 1 |
| Agrawal, R; Nath, C; Shukla, R; Tyagi, E | 1 |
| Anand, R; Kuryatov, A; Lindstrom, JM; Moss, SJ; Mukherjee, J | 1 |
| Crooks, PA; Dhawan, GK; Dwoskin, LP; Siripurapu, KB; Smith, AM; Zhang, Z | 1 |
| Agriello, E; Bouzat, C; De Rosa, MJ; Dionisio, L; Esandi, Mdel C | 1 |
| Camarasa, J; Escubedo, E; Pubill, D; Ratés, SG | 1 |
| Chang, A; Hernandez, C; Klann, E; Pautler, RG; Serrano, F; Sweatt, JD | 1 |
| Freeling, J; Lacroix, C; Li, YF | 1 |
| Gusev, AG; Uteshev, VV | 1 |
| Huang, LT; Lodge, D; Sherwood, JL; Sun, YJ; Wang, Y | 1 |
| Arias, HR; Feuerbach, D; Gu, RX; Wei, DQ | 1 |
| Cook, D; Davis, TZ; Gardner, DR; Green, BT; Pfister, JA; Stegelmeier, BL; Welch, KD | 1 |
| Izumi, T; Ohmura, Y; Tsutsui-Kimura, I; Yamaguchi, T; Yoshida, T; Yoshioka, M | 1 |
| Araki, H; Choshi, T; Goda, M; Hibino, S; Kawasaki, H; Kohnomi, S; Suemaru, K | 1 |
| Löf, E; Olausson, P; Söderpalm, B; Stomberg, R; Taylor, JR | 1 |
| Gould, TJ; Raybuck, JD | 1 |
| Bardo, MT; Beckmann, JS; Crooks, PA; Denehy, ED; Dwoskin, LP; Horton, DB; Nickell, JR; Siripurapu, KB; Vartak, A | 1 |
| Baratti, CM; Blake, MG; Boccia, MM; Krawczyk, MC | 1 |
| del Barrio, L; Egea, J; García, AG; López, MG; Parada, E; Romero, A | 1 |
| Gnegy, ME; Jutkiewicz, EM; Kim, MN; Zhang, M | 1 |
| Bugert, P; Klüter, H; Schedel, A; Schloss, P; Thornton, S | 1 |
| Do, SC; Faber, DS; Grove, CL; McIntosh, JM; Szabo, TM; Waldeck, RF | 1 |
| Saeed Dar, M; Taslim, N | 1 |
| Feng, B; Guo, HJ; He, XS; Jia, D; Li, XQ; Liu, SB; Xing, JH; Zhao, MG | 1 |
| Buhlman, L; Jin, G; Khan, GM; Lukas, RJ; McIntosh, JM; Nichols, RA; Whiteaker, P; Wu, J; Yang, K | 1 |
| Aleti, R; Bhyrapuneni, G; Boggavarapu, R; Kandikere, V; Komarneni, P; Muddana, N; Mukkanti, K; Nirogi, R | 1 |
| Besenfelder, S; Bugert, P; Klüter, H; Schedel, A; Thornton, S | 1 |
| Hahn, B; Shoaib, M; Stolerman, IP | 1 |
| Gill, JK; Millar, NS; Savolainen, M; Sher, E; Young, GT; Zwart, R | 1 |
| Ho, YS; Lee, CH; Wu, CH | 1 |
| Cook, D; Gardner, DR; Green, BT; Welch, KD | 1 |
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| Chang, YJ; Chin-Sheng, H; Ho, YS; Kuo, LJ; Lien, YC; Lin, FY; Liu, HH; Wang, W; Wei, PL; Wu, CH | 1 |
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| Bai, X; Dong, H; Du, K; Han, H; Hou, L; Hu, S; Huang, Y; Li, S; Lu, Y; Mu, J; Pei, Y; Wang, W; Xiong, L; Zhang, Z; Zhao, Y | 1 |
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| DeCuir, D; Gordon, CJ; Kellar, KJ; Levin, ED; Rezvani, AH; Sexton, HG; Timofeeva, O; Xiao, Y | 1 |
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| Bhyrapuneni, G; Kandikere, V; Komarneni, P; Muddana, N; Nirogi, R; Saralaya, R | 1 |
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| Colmena, I; de Pascual, R; Gandía, L; Lagrota-Candido, J; Leite, PE; Nanclares, C; Quirico-Santos, T; Santos, WC | 1 |
| Baier, CJ; Barrantes, FJ; Bouzat, C; Caviedes, P; Dionisio, L; Franco, DL; Gallegos, CE; Mongiat, LA | 1 |
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| Bregestovski, P; Chroni-Tzartou, D; Giastas, P; Tzartos, SJ; Zarkadas, E; Zouridakis, M | 1 |
| Bi, J; Liu, Y; Liu, Z; Wang, Y; Wei, L; Xie, Z; Yang, H; Zheng, X; Zhu, Z | 1 |
| Cheng, Z; Jing-Lin, Z; Li-Sha, G; Wen-Wu, Z; Xing-Xing, C; Xue-Si, C; Yue-Chun, L | 1 |
| Kanaoka, Y; Kataoka, Y; Koga, M; Kubo, N; Ohishi, K; Ohkido, Y; Sugiyama, K; Yamauchi, A | 1 |
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| Araki, H; Kiyoi, T; Suemaru, K; Tanaka, A; Tanaka, M; Tasaka, Y; Yasunaga, D | 1 |
| Babri, S; Mahmoudi, J; Sadigh-Eteghad, S; Shanehbandi, D; Talebi, M | 1 |
| Chatzidaki, A; Dage, J; Fouillet, A; Li, J; Millar, NS; Sher, E; Ursu, D | 1 |
| Emadi, S; Liu, Q; Sierks, MR; Wu, J; Xie, X | 1 |
| Ding, F; Peng, W | 1 |
| Isaeva, EV; Lushnikova, IV; Lykhmus, OY; Patseva, MA; Savotchenko, AV; Skibo, GG; Skok, MV; Voytenko, LP | 1 |
| Cahuzac, ELM; Lewis, AS; Mineur, YS; Picciotto, MR; Smith, PH | 1 |
| Bardo, MT; Beckmann, JS; Crooks, PA; Dwoskin, LP; Horton, DB; McIntosh, JM; Meyer, AC; Pivavarchyk, M; Smith, AM; Wooters, TE; Zheng, G | 1 |
| Cao, H; Chi, F; Huang, SH; Jong, A; Liu, LQ; Peng, L; Wang, SF; Wu, CH; Yu, JY; Zhang, B | 1 |
| Graepel, R; Lopes, F; McDougall, JJ; McKay, DM; Petri, B; Reyes, JL; Sharkey, KA; Wang, A | 1 |
| Cook, D; Gardner, DR; Green, BT; Pfister, JA; Welch, KD | 1 |
| Choe, ES; Choi, MJ; Lee, JY; Lee, YJ; Seo, JW; Yoon, SS | 1 |
| Ji, FH; Meng, XW; Peng, K; Zhu, YJ | 1 |
| Cheng, MH; Fan, BS; Han, B; Wu, ZT; Yu, JG; Zhang, EH | 1 |
| Akiyama, I; Hayashi, S; Kadowaki, M; Nakashima, A; Ono, Y; Osuga, Y; Saito, S; Shima, T; Ushijima, A; Yamada-Nomoto, K; Yoshino, O | 1 |
| Café-Mendes, CC; de Sá Lima, L; Ferreira, ZS; Garay-Malpartida, HM; Malta, MB; Marcourakis, T; Markus, RP; Scavone, C | 1 |
| de Moura, FB; McMahon, LR | 1 |
| Bo, J; Gu, X; Huo, W; Lei, Y; Liu, Y; Ma, Z; Sun, R; Zhang, W; Zhang, Z | 1 |
| Huang, SH; Jong, A; Li, L; Liu, L; Mao, DA; Wu, CH; Yu, J; Zhang, B | 1 |
| Gonon, AT; Kiss, A; Mahdi, A; Pernow, J; Podesser, BK; Tratsiakovich, Y; Yang, J | 1 |
| Gardner, DR; Green, BT; Pfister, JA; Stonecipher, CA; Welch, KD | 1 |
| Bradley, J; Ornato, JP; Peberdy, MA; Ravindra, N; Sun, P; Tang, W; Tang, Z; Wang, J; Yang, Z; Zhao, S | 1 |
| Abdollahi, AR; Dehpour, AR; Ejtemaei Mehr, S; Faghir-Ghanesefat, H; Mokhtari, T; Rahimi, N; Yarmohammadi, F | 1 |
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| Guan, ZZ; Tan, LC; Xiao, Y; Xiu, J; Zhao, L | 1 |
| Bailey, A; Bailey, CP; Georgiou, P; Heal, DJ; Wonnacott, S; Wright, VL | 1 |
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| Hashidume, N; Kanaoka, Y; Kataoka, Y; Koga, M; Tashiro, T; Yamauchi, A | 1 |
| Cheng, Y; Li, X; Wang, R; Xu, Y | 1 |
| Chao, X; Cheng, Z; De-Pu, Z; Guang-Yi, C; Jia, L; Jia-Feng, L; Li-Sha, G; Maoping, C; Wen-Wu, Z; Xiaohong, G; Yue-Chun, L | 1 |
| Deben, D; Geyer, MA; Grim, A; Groenink, L; Higa, KK; Milienne-Petiot, M; Twamley, EW; Young, JW | 1 |
| Jiang, Z; Luo, F; Peng, Q; Qu, L; Song, Z; Yan, J | 1 |
| Abdallah, DM; Al-Shorbagy, MY; El-Abhar, HS; Ibrahim, SM | 1 |
| Bennett, GL; Cook, D; Davis, TZ; Gardner, DR; Green, BT; Keele, JW; Lee, ST; Pfister, JA; Stegelmeier, BL; Stonecipher, CA; Welch, KD | 1 |
| Bo, J; Gu, X; Hou, B; Huo, W; Lei, Y; Liu, Y; Liu, Z; Ma, Z; Mao, Y; Sun, R; Sun, Y; Zhang, W; Zhang, Y; Zhang, Z | 1 |
| Cook, D; Gardner, DR; Green, BT; Lee, ST; Pfister, JA; Stonecipher, CA; Welch, KD | 1 |
| Abbaszadeh-Kasbi, A; Afshari, K; Dehdashtian, A; Dehpour, AR; Haddadi, NS; Jazaeri, SZ; Khodaei, N; Momeni, M | 1 |
| Chang, R; Chen, Y; Feng, H; Gong, X; Ji, L; Wang, X; Wei, H; Yu, D; Zhang, M | 1 |
| Cecon, E; Chollet, AM; Dam, J; Danober, L; Delagrange, P; Gautier, C; Jockers, R; Luka, M | 1 |
| Bertrand, D; Fedele, E; Gulisano, W; Paes, D; Palmeri, A; Peng, Y; Prickaerts, J; Puzzo, D; Rebosio, C; van Goethem, NP; Wennogle, LP | 1 |
| Abd-Alhaseeb, MM; El-Gowilly, SM; El-Mas, MM; Fouda, MA; Sallam, MY | 1 |
| Feng, DF; Li, HJ; Pan, YB; Sun, ZL; Xu, MH | 1 |
| Gao, C; Guo, Y; Han, R; Li, J; Qiao, X; Sun, L; Sun, X; Zhang, G | 1 |
| Kim, B; Kim, JW; Lim, CW; Park, S; Qi, J; Zhao, J; Zhou, Z | 1 |
| Absalom, N; Chebib, M; Halliday, JI; Indurthi, D; Karim, N; McLeod, MD; Qudah, T; Quek, GX | 1 |
| Apryani, E; Deng, MY; Han, QQ; Shoaib, RM; Wang, YX; Wang, ZY; Wei, DQ; Zhao, MJ | 1 |
| de Moura, FB; Hiranita, T; McMahon, LR | 1 |
| Akiyama, T; Inagaki, M; Kawada, T; Li, M; Sugimachi, M; Uemura, K; Zheng, C | 1 |
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| Fujigaki, H; Fujigaki, S; Hasegawa, M; Hirakawa, M; Hoshi, M; Kosuge, A; Kubota, H; Kunisawa, K; Kurahashi, H; Mori, Y; Mouri, A; Murakami, R; Nabeshima, T; Nakano, T; Niijima, M; Saito, K; Yamamoto, Y | 1 |
| Antonelli, MC; Castillo Díaz, F; Dalto, JF; Medina, JH; Pastor, V; Sanabria, VC | 1 |
| Bailey, CP; Heal, DJ; Palandri, J; Smith, SL; Wonnacott, S | 1 |
| Dai, ZX; He, B; Huang, CX; Qian, YS; Tang, YH; Wang, T; Wang, X; Wang, YC; Zhang, SD; Zhang, SJ; Zhang, YJ; Zhao, HY; Zhao, QY | 1 |
| Aydın, B; Cabadak, H; Önder Narin, G | 1 |
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| Baxter, MG; Upright, NA | 1 |
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| Balle, T; Chebib, M; Gallagher, R; McLeod, MD; Qudah, T | 1 |
| Hayashi, S; Kadowaki, M; Kanauchi, Y; Lee, J; Yamamoto, T; Yoshida, M; Zhang, Y | 1 |
| Chu, Z; Luo, S; Shan, H; Tan, Y; Zhangsun, D; Zhu, X | 1 |
2 review(s) available for methyllycaconitine and aconitine
| Article | Year |
|---|---|
[Desensitizing function of calcium mobilized by the postsynaptic neuronal-type nicotinic acetylcholine receptors at the neuromuscular junction].
Topics: Aconitine; Animals; Calcium; Calcium Signaling; Choline; Excitatory Postsynaptic Potentials; Mice; Neuromuscular Junction; Nicotine; Receptors, Nicotinic | 1999 |
Effects of methyllycaconitine and related analogues on bovine adrenal alpha3beta4* nicotinic acetylcholine receptors.
Topics: Aconitine; Adrenal Glands; Animals; Cattle; Cells, Cultured; Inhibitory Concentration 50; Models, Chemical; Nicotinic Antagonists; Receptors, Nicotinic | 2002 |
401 other study(ies) available for methyllycaconitine and aconitine
| Article | Year |
|---|---|
Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist.
Topics: Aconitine; Animals; Bacterial Toxins; Bungarotoxins; Cells, Cultured; Cyanobacteria Toxins; Female; Hippocampus; Marine Toxins; Membrane Potentials; Microcystins; Neurons; Nicotinic Antagonists; Pregnancy; Rats; Rats, Inbred Strains; Toxins, Biological | 1992 |
Methyllycaconitine: a selective probe for neuronal alpha-bungarotoxin binding sites.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anura; Binding, Competitive; Bungarotoxins; Humans; In Vitro Techniques; Models, Molecular; Muscles; Neurons; Rats; Receptors, Cholinergic; Receptors, Nicotinic | 1990 |
Methyllycaconitine and (+)-anatoxin-a differentiate between nicotinic receptors in vertebrate and invertebrate nervous systems.
Topics: Aconitine; Aconitum; Animals; Bacterial Toxins; Binding, Competitive; Brain; Bungarotoxins; Cyanobacteria Toxins; Ganglia; Grasshoppers; Kinetics; Marine Toxins; Microcystins; Nicotine; Rats; Receptors, Nicotinic; Species Specificity; Tropanes | 1988 |
Nicotine increases intracellular calcium in rat hippocampal neurons via voltage-gated calcium channels.
Topics: Aconitine; Alkaloids; Animals; Azocines; Calcium; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Fura-2; Hippocampus; Membrane Potentials; Nicotine; Quinolizines; Rats; Rats, Inbred Strains; Time Factors | 1995 |
Conversion of the sodium channel activator aconitine into a potent alpha 7-selective nicotinic ligand.
Topics: Aconitine; Animals; Binding Sites; Binding, Competitive; Brain; Bungarotoxins; Dopamine; Dose-Response Relationship, Drug; Ligands; Membranes; Rats; Receptors, Nicotinic; Sodium Channel Blockers; Structure-Activity Relationship; Tetrodotoxin; Veratridine | 1995 |
Nicotinic acetylcholine receptors in primary cultures of hippocampal neurons: pharmacology and Ca++ permeability.
Topics: Aconitine; Animals; Binding Sites; Bungarotoxins; Calcium; Cells, Cultured; Hippocampus; Kinetics; Neurons; Nicotine; Permeability; Potassium Chloride; Rats; Receptors, Nicotinic | 1994 |
Reversal of tall larkspur (Delphinium barbeyi) poisoning in cattle with physostigmine.
Topics: Aconitine; Administration, Oral; Animals; Cattle; Cattle Diseases; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Male; Physostigmine; Plant Extracts; Plant Poisoning; United States; United States Food and Drug Administration | 1994 |
Augmented responses to intrathecal nicotinic agonists in spontaneous hypertension.
Topics: Aconitine; Alkaloids; Animals; Azocines; Blood Pressure; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Injections, Spinal; Male; Mecamylamine; Motor Activity; Nicotine; Nicotinic Agonists; Quinolizines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spinal Cord; Stereotyped Behavior | 1994 |
Cardiovascular and behavioral responses to nicotinic agents administered intrathecally.
Topics: Aconitine; Alkaloids; Animals; Atropine; Azocines; Behavior, Animal; Blood Pressure; Bungarotoxins; Cardiovascular System; Dihydro-beta-Erythroidine; Ganglionic Stimulants; Heart Rate; Injections, Spinal; Lobeline; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Nociceptors; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sensitivity and Specificity; Spinal Cord; Trimethaphan | 1994 |
Effective dose in cattle of toxic alkaloids from tall larkspur (Delphinium barbeyi).
Topics: Aconitine; Alkaloids; Animal Feed; Animals; Cattle; Cattle Diseases; Lethal Dose 50; Male; Plant Poisoning; Plants, Toxic | 1994 |
Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes.
Topics: Acetylcholine; Aconitine; Animals; Bungarotoxins; Cells, Cultured; Evoked Potentials; Female; Hippocampus; Kinetics; Neurons; Pregnancy; Rats; Receptors, Nicotinic | 1993 |
Nicotinic acetylcholine receptors in separate brain regions exhibit different affinities for methyllycaconitine.
Topics: Aconitine; Animals; Brain; Bungarotoxins; Carbachol; Chick Embryo; Extracellular Space; Ganglia, Parasympathetic; In Vitro Techniques; Iodine Radioisotopes; Muscle, Skeletal; Nicotine; Radioligand Assay; Rats; Receptors, Nicotinic | 1996 |
Nicotine cue: lack of effect of the alpha 7 nicotinic receptor antagonist methyllycaconitine.
Topics: Aconitine; Animals; Conditioning, Operant; Cues; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic | 1996 |
An HPLC assay for the norditerpenoid alkaloid methyllycaconitine, a potent nicotinic acetylcholine receptor antagonist.
Topics: Aconitine; Alkaloids; Calibration; Chromatography, High Pressure Liquid; Nicotinic Antagonists; Plants, Medicinal; Seeds; Spectrophotometry, Ultraviolet | 1995 |
Evaluation of anti-nociceptive effects of neuronal nicotinic acetylcholine receptor (NAChR) ligands in the rat tail-flick assay.
Topics: Aconitine; Animals; Chromatography, High Pressure Liquid; Electrochemistry; Evaluation Studies as Topic; Injections, Intraventricular; Injections, Subcutaneous; Ligands; Male; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 1996 |
Effect of MK-801 at the human alpha 7 nicotinic acetylcholine receptor.
Topics: Aconitine; Animals; Bungarotoxins; Dizocilpine Maleate; Evaluation Studies as Topic; Excitatory Amino Acid Antagonists; Humans; Mecamylamine; Oocytes; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Xenopus laevis | 1996 |
Ligand-gated ion channels in acutely dissociated rat hippocampal neurons with long dendrites.
Topics: Acetylcholine; Aconitine; Animals; Bungarotoxins; Dendrites; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Hippocampus; Ion Channel Gating; Lead; Ligands; N-Methylaspartate; Neurons; Olfactory Bulb; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Toxins, Biological | 1996 |
Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes.
Topics: Acetylcholine; Aconitine; Animals; Calcium; Choline; Dihydro-beta-Erythroidine; Hippocampus; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pempidine; Potassium Chloride; Rats; Receptors, Nicotinic; Synaptosomes | 1996 |
Preliminary synthetic studies of methyllycaconitine, a potent nicotinic acetylcholine receptor antagonist: rapid syntheses of AE-bicyclic analogues.
Topics: Aconitine; Insecticides; Molecular Structure | 1996 |
Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal alpha-bungarotoxin binding sites: importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor binding.
Topics: Aconitine; Alkaloids; Animals; Binding Sites; Binding, Competitive; Brain; Bungarotoxins; Cell Membrane; Magnetic Resonance Spectroscopy; Protein Binding; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Succinimides | 1996 |
Mapping the location of functional nicotinic and gamma-aminobutyric acidA receptors on hippocampal neurons.
Topics: Aconitine; Animals; Cells, Cultured; Colchicine; Hippocampus; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Nicotinic | 1996 |
Role of Ca2+ ions in nicotinic facilitation of GABA release in mouse thalamus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Action Potentials; Alkaloids; Animals; Arousal; Atropine; Azocines; Bacterial Toxins; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Channel Blockers; Calcium Channels; Carbachol; Cations, Divalent; Cyanobacteria Toxins; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; GABA Antagonists; gamma-Aminobutyric Acid; Ion Transport; Lobeline; Marine Toxins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcystins; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Potassium; Pyridazines; Pyridines; Quinolizines; Receptors, GABA-A; Receptors, Nicotinic; Tetrodotoxin; Thalamic Nuclei | 1997 |
Neuronal nicotinic alpha 7 receptor expressed in Xenopus oocytes presents five putative binding sites for methyllycaconitine.
Topics: Aconitine; Animals; Binding Sites; Female; Ion Channel Gating; Kinetics; Neurons; Nicotinic Antagonists; Oocytes; Receptors, Nicotinic; Xenopus laevis | 1996 |
Neuronal nicotinic receptor operates slow Ca2+ mobilization at mouse muscle endplate.
Topics: Aconitine; Animals; Calcium; Dose-Response Relationship, Drug; Male; Mice; Motor Endplate; Neuromuscular Junction; Receptors, Nicotinic; Time Factors | 1997 |
Effects of nicotine on human nasal epithelium: evidence for nicotinic receptors in non-excitable cells.
Topics: Absorption; Aconitine; Amiloride; Calcium; Calcium Channel Blockers; Cells, Cultured; Extracellular Space; Humans; Intracellular Membranes; Nasal Mucosa; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Osmolar Concentration; Receptors, Nicotinic; Sodium; Tetrodotoxin; Verapamil | 1997 |
Activation of alpha7 nicotinic acetylcholine receptor promotes survival of spinal cord motoneurons.
Topics: Acetylcholine; Aconitine; Animals; Calcium; Cell Survival; Egtazic Acid; Motor Neurons; Nicotine; Rats; Receptors, Nicotinic; Spinal Cord | 1997 |
Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7-neuronal receptors and neuronal CNS receptors.
Topics: Aconitine; Animals; Bungarotoxins; Cell Survival; Cells, Cultured; Cerebral Cortex; Cysteine; Dihydro-beta-Erythroidine; Excitatory Amino Acid Antagonists; Glutamic Acid; Ionomycin; Ionophores; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Antagonists; Rats; Receptors, Nicotinic; S-Nitrosothiols; Toxins, Biological | 1997 |
Nicotinic antagonist administration into the ventral hippocampus and spatial working memory in rats.
Topics: Aconitine; Animals; Cholinergic Antagonists; Dihydro-beta-Erythroidine; Female; Hippocampus; Maze Learning; Memory, Short-Term; Neuromuscular Blocking Agents; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Seizures; Space Perception; Tubocurarine | 1997 |
Neuronal alpha-bungarotoxin receptors differ structurally from other nicotinic acetylcholine receptors.
Topics: Acetylcholine; Aconitine; Alkylation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding Sites; Bungarotoxins; Centrifugation, Density Gradient; Cholinergic Agents; Cross-Linking Reagents; Neoplasm Proteins; Nerve Tissue Proteins; Nicotine; Patch-Clamp Techniques; PC12 Cells; Rats; Receptors, Nicotinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Structure-Activity Relationship; Succinimides | 1997 |
Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding Sites; Bungarotoxins; Hippocampus; Mice; Mice, Knockout; Mice, Neurologic Mutants; Nerve Tissue Proteins; Nicotine; Rats; Receptors, Nicotinic; Sequence Deletion; Time Factors | 1997 |
Structure-activity studies of bicyclic and tricyclic analogues of methyllycaconitine.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Brain; Cell Membrane; Kinetics; Molecular Structure; Neurons; Rats; Receptors, Nicotinic; Structure-Activity Relationship; Toxins, Biological | 1997 |
Hexamethonium- and methyllycaconitine-induced changes in acetylcholine release from rat motor nerve terminals.
Topics: Acetylcholine; Aconitine; Animals; Calcium; Evoked Potentials; Hexamethonium; In Vitro Techniques; Ion Channel Gating; Male; Motor Endplate; Nicotinic Antagonists; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley | 1997 |
Paradoxical allosteric effects of competitive inhibitors on neuronal alpha7 nicotinic receptor mutants.
Topics: Acetylcholine; Aconitine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Substitution; Animals; Binding, Competitive; Bungarotoxins; Dihydro-beta-Erythroidine; Evoked Potentials; Leucine; Mutagenesis, Site-Directed; Neurons; Oocytes; Receptors, Nicotinic; Recombinant Proteins; Xenopus | 1997 |
[Slow Ca2+ (RAMIC) mobilization operated by postsynaptic neuronal nicotinic receptor regulates synaptic function at the mouse neuromuscular junction].
Topics: Acetylcholine; Aconitine; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Male; Mice; Mice, Inbred Strains; Neuromuscular Junction; Nicotinic Antagonists; Protein Kinase C; Receptors, Nicotinic; Signal Transduction; Synapses | 1997 |
Functional contribution of the alpha7 subunit to multiple subtypes of nicotinic receptors in embryonic chick sympathetic neurones.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antisense Elements (Genetics); Bungarotoxins; Calcium; Chick Embryo; Chlorides; Dose-Response Relationship, Drug; Electric Conductivity; Ganglia, Sympathetic; Gene Deletion; Insecticides; Ion Channel Gating; Kinetics; Mutagenesis; Neurons; Patch-Clamp Techniques; Receptors, Nicotinic | 1998 |
Functional contribution of the alpha5 subunit to neuronal nicotinic channels expressed by chick sympathetic ganglion neurones.
Topics: Acetylcholine; Aconitine; Alkaloids; Animals; Antisense Elements (Genetics); Azocines; Bungarotoxins; Chick Embryo; Dose-Response Relationship, Drug; Electrophysiology; Ganglia, Sympathetic; Gene Deletion; Insecticides; Ion Channel Gating; Mutagenesis; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Receptors, Nicotinic | 1998 |
Up-regulation of human alpha7 nicotinic receptors by chronic treatment with activator and antagonist ligands.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Benzylidene Compounds; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Dimethylphenylpiperazinium Iodide; Humans; Insecticides; Iodine Radioisotopes; Kidney; Kinetics; Ligands; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Receptors, Nicotinic; Transfection; Up-Regulation | 1998 |
Nicotine and food induced dopamine release in the nucleus accumbens of the rat: putative role of alpha7 nicotinic receptors in the ventral tegmental area.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dopamine; Food; Microdialysis; Nerve Endings; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Rats; Receptors, Nicotinic; Ventral Tegmental Area | 1998 |
Effects of fluoxetine on wild and mutant neuronal alpha 7 nicotinic receptors.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Membrane; Chickens; Female; Fluoxetine; Membrane Potentials; Neurons; Oocytes; Point Mutation; Receptors, Nicotinic; Xenopus laevis | 1998 |
Two distinct nicotinic receptors, one pharmacologically similar to the vertebrate alpha7-containing receptor, mediate Cl currents in aplysia neurons.
Topics: Acetylcholine; Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Aplysia; Azocines; Bungarotoxins; Cations; Chlorides; Choline; Cholinergic Antagonists; Conotoxins; Dihydro-beta-Erythroidine; Electric Conductivity; Glycine Agents; Insecticides; Ion Channel Gating; Mollusk Venoms; Nicotinic Agonists; Nicotinic Antagonists; Oligopeptides; Patch-Clamp Techniques; Peptides; Quinolizines; Receptors, Nicotinic; Strychnine; Vertebrates | 1998 |
Synaptic potentials mediated via alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal interneurons.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Electrophysiology; Excitatory Postsynaptic Potentials; Hippocampus; Insecticides; Interneurons; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission | 1998 |
alpha-bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices.
Topics: Aconitine; Animals; Bungarotoxins; Hippocampus; In Vitro Techniques; Interneurons; Muscarinic Antagonists; Patch-Clamp Techniques; Rats; Receptors, Nicotinic; Sodium Channels; Synaptic Transmission | 1998 |
Unmasking the functions of the chromaffin cell alpha7 nicotinic receptor by using short pulses of acetylcholine and selective blockers.
Topics: Acetylcholine; Aconitine; Adrenal Medulla; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Bungarotoxins; Calcium; Cattle; Cholinergic Agents; Chromaffin Cells; Conotoxins; Female; Membrane Potentials; Mollusk Venoms; Nicotinic Antagonists; Oligopeptides; Oocytes; Rats; Receptors, Nicotinic; Xenopus laevis | 1998 |
Nicotinic receptors in the rat prefrontal cortex: increase in glutamate release and facilitation of mediodorsal thalamo-cortical transmission.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Animals; Autoradiography; Cerebral Cortex; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Insecticides; Locomotion; Male; Mecamylamine; Microdialysis; Neural Pathways; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Reaction Time; Receptors, Nicotinic; Synaptic Transmission; Thalamus; Tritium | 1999 |
Synaptic transmission at nicotinic acetylcholine receptors in rat hippocampal organotypic cultures and slices.
Topics: Aconitine; Animals; Bungarotoxins; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Antagonists; Hippocampus; Nicotinic Antagonists; Organ Culture Techniques; Picrotoxin; Piperazines; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission; Tubocurarine | 1999 |
Gain of function mutation of the alpha7 nicotinic receptor: distinct pharmacology of the human alpha7V274T variant.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Substitution; Animals; Atropine; Choline; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Genetic Variation; Humans; Lobeline; Mecamylamine; Membrane Potentials; Muscarinic Antagonists; Mutation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Pyridines; Pyrrolidines; Receptors, Nicotinic; Threonine; Tubocurarine; Valine; Xenopus | 1999 |
Methyllycaconitine-sensitive neuronal nicotinic receptor-operated slow Ca2+ signal by local application or perfusion of ACh at the mouse neuromuscular junction.
Topics: Acetylcholine; Aconitine; Administration, Topical; Animals; Calcium Channels; Calcium Signaling; Electrophysiology; Male; Mice; Motor Endplate; Neuromuscular Junction; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Perfusion; Receptors, Nicotinic; Tetrodotoxin | 1999 |
Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line.
Topics: Acetylcholine; Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Azocines; Blotting, Northern; Bungarotoxins; Carbachol; Dimethylphenylpiperazinium Iodide; DNA, Complementary; Gene Expression; Humans; Insecticides; Iodine Radioisotopes; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Plasmids; Protein Synthesis Inhibitors; Quinolizines; Receptors, Nicotinic; Recombinant Proteins; RNA, Messenger; Tetracycline; Transfection; Tubocurarine; Tumor Cells, Cultured; Up-Regulation | 1999 |
Characterisation of the binding of [3H]methyllycaconitine: a new radioligand for labelling alpha 7-type neuronal nicotinic acetylcholine receptors.
Topics: Aconitine; Animals; Binding, Competitive; Brain; Bungarotoxins; Cell Membrane; Cholinergic Agents; Male; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 1999 |
Nicotinic acetylcholine receptors assembled from the alpha7 and beta3 subunits.
Topics: Aconitine; Animals; Bungarotoxins; Chick Embryo; Mutagenesis, Site-Directed; Oocytes; Protein Conformation; Receptors, Nicotinic; Xenopus | 1999 |
Modulation of synaptic transmission by nicotine and nicotinic antagonists in hippocampus.
Topics: Aconitine; Animals; Dihydro-beta-Erythroidine; Hippocampus; In Vitro Techniques; Mecamylamine; Neural Inhibition; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1999 |
Action of ethanol on responses to nicotine from cerebellar interneurons and medial septal neurons: relationship to methyllycaconitine inhibition of nicotine responses.
Topics: Aconitine; Animals; Central Nervous System Depressants; Cerebellum; Ethanol; Interneurons; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Septal Nuclei | 1999 |
Action of ethanol on responses to nicotine from cerebellar Purkinje neurons: relationship to methyllycaconitine (MLA) inhibition of nicotine responses.
Topics: Aconitine; Animals; Bungarotoxins; Ethanol; Iontophoresis; Male; Nicotine; Nicotinic Antagonists; Purkinje Cells; Rats; Rats, Sprague-Dawley | 1999 |
Methyllycaconitine-, alpha-bungarotoxin-sensitive neuronal nicotinic receptor operates slow calcium signal in skeletal muscle end plate.
Topics: Acetylcholine; Aconitine; Aniline Compounds; Animals; Bungarotoxins; Calcium; Choline; Hexamethonium; Mice; Muscle, Skeletal; Neuromuscular Junction; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Xanthenes | 1999 |
An autoradiographic study of the distribution of binding sites for the novel alpha7-selective nicotinic radioligand [3H]-methyllycaconitine in the mouse brain.
Topics: Aconitine; Animals; Autoradiography; Binding Sites; Brain; Bungarotoxins; Iodine Radioisotopes; Ligands; Male; Mice; Mice, Inbred C57BL; Receptors, Nicotinic; Tissue Distribution; Tritium | 1999 |
Ring E analogs of methyllycaconitine (MLA) as novel nicotinic antagonists.
Topics: Aconitine; Alkaloids; Animals; Cattle; Chromaffin Cells; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 1999 |
Effects of Delphinium alkaloids on neuromuscular transmission.
Topics: Acetylcholine; Aconitine; Action Potentials; Alkaloids; Animals; Delphinium; Dose-Response Relationship, Drug; Drug Interactions; Hindlimb; In Vitro Techniques; Insecticides; Intercostal Muscles; Lizards; Muscle Contraction; Muscle, Skeletal; Neuromuscular Junction; Time Factors | 1999 |
Beta-estradiol attenuate amyloid beta-peptide toxicity via nicotinic receptors.
Topics: Aconitine; Amyloid beta-Peptides; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cell Survival; Cholinesterase Inhibitors; Estradiol; Formazans; Humans; Mecamylamine; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; PC12 Cells; Pyridines; Rats; Receptors, Nicotinic; Tetrazolium Salts; Tumor Cells, Cultured | 1999 |
Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks.
Topics: Acetylcholine; Aconitine; Adolescent; Adult; alpha7 Nicotinic Acetylcholine Receptor; Bicuculline; Cerebral Cortex; Child; Choline; Dihydro-beta-Erythroidine; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Insecticides; Interneurons; Male; Middle Aged; Nerve Net; Neural Inhibition; Organ Culture Techniques; Patch-Clamp Techniques; Quisqualic Acid; Receptors, Nicotinic; Stimulation, Chemical; Tetrodotoxin | 2000 |
Striatal application of nicotine, but not of lobeline, attenuates dopamine release in freely moving rats.
Topics: Aconitine; Animals; Cocaine; Corpus Striatum; Dopamine; Kinetics; Lobeline; Male; Mecamylamine; Microdialysis; Nerve Endings; Nicotine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2000 |
Nicotine reverses GABAergic inhibition of long-term potentiation induction in the hippocampal CA1 region.
Topics: Aconitine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Aminobutyric Acid; Hippocampus; Insecticides; Interneurons; Long-Term Potentiation; Muscimol; Neural Pathways; Nicotine; Nicotinic Agonists; Pyramidal Cells; Pyridines; Rats; Receptors, GABA-A; Receptors, Nicotinic | 2000 |
Inhibition and disinhibition of pyramidal neurons by activation of nicotinic receptors on hippocampal interneurons.
Topics: Acetylcholine; Aconitine; Action Potentials; Animals; Bicuculline; GABA Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Mecamylamine; Neural Inhibition; Nicotinic Antagonists; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Nicotinic; Synaptic Transmission; Tetrodotoxin | 2000 |
Characterisation of the effects of nicotine in the five-choice serial reaction time task in rats: antagonist studies.
Topics: Aconitine; Animals; Dihydro-beta-Erythroidine; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Reaction Time | 2000 |
Two distinct classes of functional 7-containing nicotinic receptor on rat superior cervical ganglion neurons.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Antibodies, Monoclonal; Bungarotoxins; Choline; Gene Expression; In Vitro Techniques; Insecticides; Iodine Radioisotopes; Membrane Potentials; Neurons; Nootropic Agents; Patch-Clamp Techniques; Rats; Receptors, Nicotinic; RNA, Messenger; Superior Cervical Ganglion; Vasodilator Agents | 2000 |
Effects of methyllycaconitine (MLA), an alpha 7 nicotinic receptor antagonist, on nicotine- and cocaine-induced potentiation of brain stimulation reward.
Topics: Aconitine; Animals; Cocaine; Dopamine Uptake Inhibitors; Hypothalamic Area, Lateral; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reward; Ventral Tegmental Area | 2000 |
Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors.
Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Azocines; Binding, Competitive; Cerebral Cortex; Guinea Pigs; Hippocampus; Kinetics; Male; Nicotine; Peptide Fragments; Quinolizines; Radioligand Assay; Rats; Rats, Long-Evans; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Synaptic Membranes; Tritium | 2000 |
Nicotine-induced excitation of midbrain dopamine neurons in vitro involves ionotropic glutamate receptor activation.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Action Potentials; Animals; Dihydro-beta-Erythroidine; Dopamine; In Vitro Techniques; Insecticides; Mecamylamine; Neurons; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Ventral Tegmental Area | 2000 |
Calcium mobilization elicited by two types of nicotinic acetylcholine receptors in mouse substantia nigra pars compacta.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Action Potentials; Animals; Benzoates; Bungarotoxins; Calcium; Calcium Channel Blockers; Choline; Dihydro-beta-Erythroidine; Endoplasmic Reticulum; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Glycine; In Vitro Techniques; Indoles; Insecticides; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neurons; Nicotine; Nicotinic Agonists; Nifedipine; Nootropic Agents; Patch-Clamp Techniques; Polyamines; Presynaptic Terminals; Receptors, Nicotinic; Substantia Nigra; Tetrodotoxin; Tyrosine 3-Monooxygenase | 2000 |
Three new toxic norditerpenoid alkaloids from the low larkspur Delphinium nuttallianum.
Topics: Aconitine; Alkaloids; Animals; Biological Assay; Diterpenes; Gas Chromatography-Mass Spectrometry; Lethal Dose 50; Magnetic Resonance Spectroscopy; Male; Mice; Plant Leaves; Plant Stems; Plants, Toxic; Utah | 2000 |
Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia.
Topics: Aconitine; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Animals; Antipsychotic Agents; Brain; Bridged Bicyclo Compounds, Heterocyclic; Child; Female; Haloperidol; Humans; Male; Middle Aged; Nicotine; Nicotinic Agonists; Pyridines; Rats; Receptors, Nicotinic; Regression Analysis; Schizophrenia; Smoking | 2000 |
Single channel properties of neuronal nicotinic ACh receptors in stratum radiatum interneurons of rat hippocampal slices.
Topics: Acetylcholine; Aconitine; Animals; Dihydro-beta-Erythroidine; Electrophysiology; Hippocampus; In Vitro Techniques; Interneurons; Ion Channels; Male; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Nicotinic | 2000 |
Antagonism of the discriminative and aversive stimulus properties of nicotine in C57BL/6J mice.
Topics: Aconitine; Animals; Avoidance Learning; Behavior, Animal; Dihydro-beta-Erythroidine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Reinforcement, Psychology; Taste | 2000 |
Evidence of a functional alpha7-neuronal nicotinic receptor subtype located on motoneurons of the dorsal motor nucleus of the vagus.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Autoradiography; Bungarotoxins; Fluorescein-5-isothiocyanate; Fluorescent Antibody Technique, Indirect; Male; Microinjections; Motor Neurons; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stomach; Vagotomy; Vagus Nerve | 2001 |
The effect of nicotine and haloperidol co-treatment on nicotinic receptor levels in the rat brain.
Topics: Aconitine; Animals; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Dopamine Antagonists; Haloperidol; Insecticides; Male; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Muscarinic; Receptors, Nicotinic; Schizophrenia; Smoking; Spiperone; Tritium | 2001 |
Chronic exposure to nicotine upregulates the human (alpha)4((beta)2 nicotinic acetylcholine receptor function.
Topics: Acetylcholine; Aconitine; Cell Line; Dose-Response Relationship, Drug; Electrophysiology; Humans; Ion Channels; Kidney; Nicotine; Nicotinic Antagonists; Patch-Clamp Techniques; Protein Synthesis Inhibitors; Receptors, Nicotinic; Time Factors; Transfection; Up-Regulation | 2001 |
alpha7-Containing nicotinic receptors are segregated to the somatodendritic membrane of the cholinergic neurons in the avian nucleus semilunaris.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain Chemistry; Chickens; Choline O-Acetyltransferase; Dendrites; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Neurons; Nicotinic Antagonists; Quinoxalines; Receptors, Nicotinic; Superior Colliculi | 2001 |
Nicotine accelerates reversal of long-term potentiation and enhances long-term depression in the rat hippocampal CA1 region.
Topics: Aconitine; Animals; Excitatory Postsynaptic Potentials; Hippocampus; Insecticides; Long-Term Potentiation; Membrane Potentials; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley | 2001 |
Acute and chronic nicotine exposure reverse age-related declines in the induction of long-term potentiation in the rat hippocampus.
Topics: Aconitine; Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Excitatory Postsynaptic Potentials; Hippocampus; Insecticides; Long-Term Potentiation; Membrane Potentials; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2001 |
[3H]-Methyllycaconitine: a high affinity radioligand that labels invertebrate nicotinic acetylcholine receptors.
Topics: Aconitine; Animals; Aphids; Binding, Competitive; Decapodiformes; Diptera; Manduca; Moths; Radioligand Assay; Receptors, Nicotinic; Tritium | 2001 |
Effect of FK960, a putative cognitive enhancer, on synaptic transmission in CA1 neurons of rat hippocampus.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bungarotoxins; Cognition; Excitatory Postsynaptic Potentials; Hippocampus; Male; Membrane Potentials; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Piperazines; Psychotropic Drugs; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Nicotinic; Synaptic Transmission | 2001 |
Heterogeneity of neuronal nicotinic acetylcholine receptors in 5-HT-containing chemoreceptor cells of the chicken aorta.
Topics: Acetylcholine; Aconitine; Algorithms; Animals; Aorta, Thoracic; Bungarotoxins; Chemoreceptor Cells; Chickens; Dimethylphenylpiperazinium Iodide; Epithelial Cells; Hexamethonium; Male; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Serotonin | 2001 |
Choline blocks AMPA-induced dark cell degeneration of Purkinje neurons: potential role of the alpha7 nicotinic receptor.
Topics: Aconitine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha7 Nicotinic Acetylcholine Receptor; Animals; Choline; Excitatory Amino Acid Agonists; Extracellular Space; Female; Gluconates; Insecticides; Lidocaine; Male; Meglumine; Nerve Degeneration; Neurotoxins; Nicotine; Nootropic Agents; Organ Culture Techniques; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Nicotinic; Sodium; Sodium Channels; Sodium Chloride; Tetrodotoxin | 2001 |
Neurotoxicity of channel mutations in heterologously expressed alpha7-nicotinic acetylcholine receptors.
Topics: Aconitine; Animals; Binding, Competitive; Bungarotoxins; Cell Death; Cell Line; Chickens; Electrophysiology; Humans; Ion Channels; Mice; Mutation; Neuroblastoma; Neurons; Nicotinic Agonists; Rats; Receptors, Nicotinic; Transfection | 2001 |
Cotinine binding to nicotinic acetylcholine receptors in bovine chromaffin cell and rat brain membranes.
Topics: Aconitine; Animals; Binding Sites; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cattle; Cell Membrane; Chromaffin Cells; Cotinine; Frontal Lobe; Hippocampus; Male; Nicotine; Nicotinic Agonists; Pyridines; Rats; Rats, Wistar; Receptors, Nicotinic | 2001 |
Syntheses and evaluation of halogenated cytisine derivatives and of bioisosteric thiocytisine as potent and selective nAChR ligands.
Topics: Aconitine; Alkaloids; Animals; Azocines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Cell Membrane; Drug Evaluation, Preclinical; Halogens; Ligands; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship | 2001 |
Neuregulins increase alpha7 nicotinic acetylcholine receptors and enhance excitatory synaptic transmission in GABAergic interneurons of the hippocampus.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Bungarotoxins; Cell Separation; Cells, Cultured; Cholinergic Agents; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Interneurons; Iodine Radioisotopes; Male; Neuregulin-1; Nicotinic Antagonists; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission; Tetrodotoxin | 2001 |
Regulation of GABA release by nicotinic acetylcholine receptors in the neonatal rat hippocampus.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Bicuculline; Bridged-Ring Compounds; Dihydro-beta-Erythroidine; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Insecticides; Membrane Potentials; Nicotine; Nicotinic Agonists; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Quinoxalines; Rats; Rats, Wistar; Receptors, Nicotinic; Spiro Compounds | 2001 |
Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes.
Topics: Acetylcholine; Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cell Size; Cells, Cultured; DNA Primers; Electrophysiology; Ganglia, Spinal; Gene Expression; Insecticides; Neurons, Afferent; Nicotine; Nicotinic Agonists; Pyridines; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger; Vasodilator Agents | 2001 |
The nicotinic antagonist methyllycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat.
Topics: Aconitine; Animals; Behavior, Animal; Brain; Disease Models, Animal; Electric Stimulation; Electrodes, Implanted; Male; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Reward; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2001 |
Nicotine-induced phosphorylation of extracellular signal-regulated protein kinase and CREB in PC12h cells.
Topics: Aconitine; Animals; Benzylamines; Bungarotoxins; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Hexamethonium; Insecticides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nifedipine; PC12 Cells; Phosphorylation; Potassium; ras Proteins; Rats; Receptors, Nicotinic; Sulfonamides; Tubocurarine | 2001 |
Relationship between the increased cell surface alpha7 nicotinic receptor expression and neuroprotection induced by several nicotinic receptor agonists.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Binding Sites; Binding, Competitive; Bungarotoxins; Cell Survival; Dose-Response Relationship, Drug; Insecticides; Iodine Radioisotopes; Models, Biological; Nerve Growth Factors; Neurons; Neuroprotective Agents; Nicotinic Agonists; Nicotinic Antagonists; PC12 Cells; Rats; Receptors, Nicotinic; Up-Regulation | 2001 |
Synaptic potentials mediated by alpha 7 nicotinic acetylcholine receptors in supraoptic nucleus.
Topics: Acetylcholine; Aconitine; Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; In Vitro Techniques; Male; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Supraoptic Nucleus; Synaptic Transmission | 2002 |
Ventral hippocampal alpha 7 nicotinic receptor blockade and chronic nicotine effects on memory performance in the radial-arm maze.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dose-Response Relationship, Drug; Female; Hippocampus; Insecticides; Maze Learning; Memory; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2001 |
Structure-activity studies with ring E analogues of methyllycaconitine on bovine adrenal alpha3beta4* nicotinic receptors.
Topics: Aconitine; Adrenal Medulla; Animals; Binding, Competitive; Catecholamines; Cattle; Chromaffin Cells; Dose-Response Relationship, Drug; Molecular Structure; Receptors, Nicotinic; Synaptic Transmission | 2002 |
Permeant but not impermeant divalent cations enhance activation of nondesensitizing alpha(7) nicotinic receptors.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Barium; Cadmium; Calcium; Cations, Divalent; Chick Embryo; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Synergism; Insecticides; Ion Channel Gating; Magnesium; Mutagenesis, Site-Directed; Oocytes; Receptors, Nicotinic; Strontium; Xenopus; Zinc | 2002 |
Nicotine increases the expression of high affinity nerve growth factor receptors in both in vitro and in vivo.
Topics: Aconitine; Animals; Blotting, Western; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Antagonism; Hippocampus; Infusions, Intravenous; Male; Mecamylamine; Neurons; Nicotine; PC12 Cells; Rats; Rats, Wistar; Receptors, Nicotinic | 2002 |
Properties of nicotinic receptors underlying Renshaw cell excitation by alpha-motor neurons in neonatal rat spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Animals; Animals, Newborn; Dihydro-beta-Erythroidine; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Interneurons; Motor Neurons; Nicotinic Antagonists; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Synaptic Transmission | 2002 |
Methyllycaconitine is a potent antagonist of alpha-conotoxin-MII-sensitive presynaptic nicotinic acetylcholine receptors in rat striatum.
Topics: Aconitine; Animals; Autoradiography; Binding, Competitive; Calcium Channel Blockers; Conotoxins; Dopamine; In Vitro Techniques; Male; Neostriatum; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Presynaptic; Synaptosomes | 2002 |
Alpha7-nicotinic acetylcholine receptors on cerebral perivascular sympathetic nerves mediate choline-induced nitrergic neurogenic vasodilation.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Basilar Artery; Calcium; Cells, Cultured; Cerebral Arteries; Choline; Electric Stimulation; Female; Ganglia, Parasympathetic; In Vitro Techniques; Male; Nicotine; Nitric Oxide; Nitroarginine; Potassium Chloride; Receptors, Nicotinic; Superior Cervical Ganglion; Swine; Sympathetic Nervous System; Tetrodotoxin; Vasodilation | 2002 |
A nicotinic acetylcholine receptor is involved in the arosome reaction of human sperm initiated by recombinant human ZP3.
Topics: Acetylcholine; Aconitine; Acrosome Reaction; alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Conotoxins; Egg Proteins; Humans; Male; Membrane Glycoproteins; Nicotinic Antagonists; Progesterone; Receptors, Cell Surface; Receptors, Nicotinic; Recombinant Proteins; Zona Pellucida Glycoproteins | 2002 |
Structure-activity studies with ring E analogues of methyllycaconitine. Synthesis and evaluation of enantiopure isomers of selective antagonist at the alpha3 nicotinic receptor.
Topics: Aconitine; Animals; Binding, Competitive; Brain; Bungarotoxins; Chromatography, Thin Layer; In Vitro Techniques; Indicators and Reagents; Magnetic Resonance Spectroscopy; Membranes; Nicotinic Antagonists; Rats; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 2002 |
Developmental cell death in vivo: rescue of neurons independently of changes at target tissues.
Topics: Aconitine; Animals; Apoptosis; Bungarotoxins; Cell Survival; Cells, Cultured; Chick Embryo; Choroid; Ciliary Body; Cytoprotection; Ganglia, Sensory; Iris; Nerve Growth Factors; Neurofilament Proteins; Neurons; Nicotinic Agonists; Peptide Fragments; Receptors, Nicotinic; Synapses | 2002 |
bis-Azaaromatic quaternary ammonium analogues: ligands for alpha4beta2* and alpha7* subtypes of neuronal nicotinic receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Aza Compounds; Binding, Competitive; Brain; In Vitro Techniques; Indicators and Reagents; Ligands; Magnetic Resonance Spectroscopy; Neurons; Nicotinic Antagonists; Quaternary Ammonium Compounds; Rats; Receptors, Nicotinic; Rubidium Radioisotopes; Structure-Activity Relationship; Synaptosomes; Thalamus | 2002 |
Nicotinic receptors regulate the release of glycine onto lamina X neurones of the rat spinal cord.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Alkaloids; Anesthetics, Local; Animals; Animals, Newborn; Azocines; Bicuculline; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Drug Interactions; Excitatory Amino Acid Antagonists; Glycine; Glycine Agents; Hexamethonium; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Quinolizines; Rats; Rats, Wistar; Receptors, Nicotinic; Spinal Cord; Strychnine; Tetrodotoxin; Time Factors; Tubocurarine | 2002 |
Upregulation of [3H]methyllycaconitine binding sites following continuous infusion of nicotine, without changes of alpha7 or alpha6 subunit mRNA: an autoradiography and in situ hybridization study in rat brain.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Autoradiography; Binding Sites; Brain; In Situ Hybridization; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; RNA, Messenger; Up-Regulation | 2002 |
The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor.
Topics: 2-Amino-5-phosphonovalerate; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Conditioning, Operant; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Microinjections; Motivation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Reinforcement, Psychology; Reward; Ventral Tegmental Area | 2003 |
Nicotinic mechanisms of memory: effects of acute local DHbetaE and MLA infusions in the basolateral amygdala.
Topics: Aconitine; Amygdala; Animals; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Female; Maze Learning; Memory; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Nicotinic | 2003 |
Evaluation of vaccination against methyllycaconitine toxicity in mice.
Topics: Aconitine; Animals; Animals, Domestic; Binding, Competitive; Biological Assay; Delphinium; Dose-Response Relationship, Drug; Immunity, Active; Lethal Dose 50; Mice; Plant Extracts; Plant Poisoning; Random Allocation; Survival Analysis; Vaccination | 2003 |
Methyllycaconitine (MLA) blocks the nicotine evoked anxiogenic effect and 5-HT release in the dorsal hippocampus: possible role of alpha7 receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anxiety; Behavior, Animal; Cholinergic Antagonists; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Interpersonal Relations; Male; Motor Activity; Nicotine; Nicotinic Antagonists; Random Allocation; Rats; Receptors, Nicotinic; Serotonin; Time Factors | 2003 |
Evidence suggesting that the mouse sperm acrosome reaction initiated by the zona pellucida involves an alpha7 nicotinic acetylcholine receptor.
Topics: Acetylcholine; Aconitine; Acrosome Reaction; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Cholinergic Antagonists; Conotoxins; Hot Temperature; Male; Mice; Nicotinic Antagonists; Receptors, Nicotinic; Solubility; Sperm Motility; Spermatozoa; Zona Pellucida | 2003 |
Nicotine enhances the depressive actions of A beta 1-40 on long-term potentiation in the rat hippocampal CA1 region in vivo.
Topics: Aconitine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Electrophysiology; Hippocampus; Injections, Intraventricular; Long-Term Potentiation; Male; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Rats; Rats, Wistar; Receptors, Nicotinic | 2003 |
Regulation of neuronal function by choline and 4OH-GTS-21 through alpha 7 nicotinic receptors.
Topics: Aconitine; Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Anabasine; Animals; Choline; In Vitro Techniques; Neurons; Nicotinic Antagonists; Nootropic Agents; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tritium | 2003 |
Functional properties of homomeric, human alpha 7-nicotinic acetylcholine receptors heterologously expressed in the SH-EP1 human epithelial cell line.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Calcium; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Transfection | 2003 |
N-n-alkylpyridinium analogs, a novel class of nicotinic receptor antagonists: selective inhibition of nicotine-evoked [3H] dopamine overflow from superfused rat striatal slices.
Topics: Aconitine; Animals; Brain; Cell Membrane; Corpus Striatum; Dopamine; In Vitro Techniques; Nicotine; Nicotinic Antagonists; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tritium | 2003 |
The toxicity and kinetics of larkspur alkaloid, methyllycaconitine, in mice.
Topics: Aconitine; Animals; Brain; Cattle; Chromatography, High Pressure Liquid; Delphinium; Dose-Response Relationship, Drug; Drug Residues; Half-Life; Injections, Intravenous; Insecticides; Kidney; Liver; Male; Metabolic Clearance Rate; Mice; Muscle, Skeletal; Random Allocation; Tissue Distribution | 2003 |
Do different mechanisms underlie two anxiogenic effects of systemic nicotine?
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anxiety; Behavior, Animal; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Piperazines; Pyridines; Rats; Receptor, Serotonin, 5-HT1A; Receptors, Nicotinic; Serotonin Antagonists; Social Behavior | 2003 |
Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes.
Topics: Aconitine; Action Potentials; Analysis of Variance; Animals; Brain; Dihydro-beta-Erythroidine; Dopamine; Dose-Response Relationship, Drug; Male; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oncogene Proteins v-fos; Protein Subunits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Nicotinic | 2003 |
Nicotine recruits a local glutamatergic circuit to excite septohippocampal GABAergic neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Acyclovir; Animals; Animals, Newborn; Atropine; Bicuculline; Bungarotoxins; Carrier Proteins; Cell Count; Choline; Chromones; Cycloleucine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Electric Conductivity; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Hippocampus; Immunohistochemistry; In Vitro Techniques; Male; Membrane Potentials; Membrane Transport Proteins; Microscopy, Electron; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parvalbumins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Resorcinols; Septum of Brain; Synapses; Tetrodotoxin; Tubocurarine; Valine; Vesicular Glutamate Transport Protein 2; Vesicular Transport Proteins | 2003 |
Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors.
Topics: Aconitine; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Cells, Cultured; Humans; N-Methylscopolamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parasympatholytics; Pyridines; Rats; Receptors, Nicotinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Tritium | 2003 |
Functional expression and properties of a nicotinic alpha9/5-HT3A chimeric receptor.
Topics: Aconitine; Animals; Atropine; DNA, Complementary; Membrane Potentials; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Rats; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Serotonin Antagonists; Strychnine; Xenopus laevis | 2003 |
Unique mechanism of action of Alzheimer's drugs on brain nicotinic acetylcholine receptors and NMDA receptors.
Topics: Acetylcholine; Aconitine; Alzheimer Disease; Animals; Brain Chemistry; Bungarotoxins; Dihydro-beta-Erythroidine; Female; GTP-Binding Proteins; Hexamethonium; Mecamylamine; Nicotinic Agonists; Nicotinic Antagonists; Nootropic Agents; Patch-Clamp Techniques; Pregnancy; Protein Kinases; Pyrrolidinones; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2003 |
Nicotinic acetylcholinergic receptors regulate the intraspinal release of acetylcholine in male rats.
Topics: Acetylcholine; Aconitine; Animals; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mecamylamine; Microdialysis; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Time Factors | 2003 |
Protective effects of nicotine on ethanol-induced toxicity in cultured cerebellar granule cells.
Topics: Aconitine; Animals; Cells, Cultured; Central Nervous System Depressants; Cerebellum; Culture Media; Dihydro-beta-Erythroidine; Ethanol; Female; L-Lactate Dehydrogenase; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2003 |
AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Avoidance Learning; Behavior, Animal; Bridged-Ring Compounds; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Male; Maze Learning; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Recognition, Psychology; Social Behavior; Spiro Compounds; Trichlorfon | 2004 |
Pharmacological properties of alpha 9 alpha 10 nicotinic acetylcholine receptors revealed by heterologous expression of subunit chimeras.
Topics: Aconitine; Animals; Cell Line; Chimera; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Humans; Mice; Protein Binding; Protein Subunits; Rats; Receptors, Nicotinic; Xenopus laevis | 2004 |
Effects of donepezil treatment on rat nicotinic acetylcholine receptor levels in vivo and in vitro.
Topics: Aconitine; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Hippocampus; In Vitro Techniques; Indans; Male; Nicotinic Agonists; Nicotinic Antagonists; Pheochromocytoma; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2003 |
Endogenous ouabain-like factor (OLF) secretion is modulated by nicotinic mechanisms in rat adrenocortical cells.
Topics: Acetylcholine; Aconitine; Adrenal Cortex; Animals; Cardenolides; Digoxin; Dose-Response Relationship, Drug; Drug Synergism; Hexamethonium; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Physostigmine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Saponins | 2004 |
Nicotine improves sustained attention in mice: evidence for involvement of the alpha7 nicotinic acetylcholine receptor.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Conditioning, Operant; Genotype; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Psychomotor Performance; Radioligand Assay; Reaction Time; Receptors, Nicotinic; Synaptic Membranes; Synaptosomes | 2004 |
Nicotinic acetylcholine receptor alpha7 subunit mediates migration of vascular smooth muscle cells toward nicotine.
Topics: Aconitine; Actins; alpha7 Nicotinic Acetylcholine Receptor; Animals; Basilar Artery; Cell Line; Chemotaxis; Cytoskeleton; Down-Regulation; Forecasting; Guinea Pigs; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Nicotine; Phosphorylation; Pseudopodia; Receptors, Nicotinic; Stereoisomerism | 2004 |
Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.
Topics: Aconitine; Animals; Binding Sites; Binding, Competitive; Brain; Choline; Dopamine; Ligands; Male; Molecular Structure; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Structure-Activity Relationship | 2004 |
Behavioral consequences of methyllycaconitine in mice: a model of alpha7 nicotinic acetylcholine receptor deficiency.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Binding Sites; Brain; Injections, Intraperitoneal; Male; Mice; Models, Animal; Motor Activity; Nicotinic Antagonists; Receptors, Nicotinic | 2004 |
(-)-nicotine ameliorates corticosterone's potentiation of N-methyl-d-aspartate receptor-mediated cornu ammonis 1 toxicity.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Survival; Corticosterone; Disease Models, Animal; Drug Interactions; Hippocampus; In Vitro Techniques; Male; Mifepristone; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2004 |
Lobeline analogs with enhanced affinity and selectivity for plasmalemma and vesicular monoamine transporters.
Topics: Aconitine; Animals; Biological Transport; Carrier Proteins; Cells, Cultured; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Ganglionic Stimulants; Humans; Iodine Radioisotopes; Kinetics; Lobeline; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuropeptides; Nicotine; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Rats; Rats, Sprague-Dawley; Rubidium; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters; Tetrabenazine; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2004 |
Synthesis of tricyclic analogues of methyllycaconitine using ring closing metathesis to append a B ring to an AE azabicyclic fragment.
Topics: Aconitine; Aza Compounds; Bridged Bicyclo Compounds; Cyclization; Delphinium; Molecular Structure | 2004 |
Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the alpha3beta4* nicotinic acetylcholine receptors through modifications to the ester.
Topics: Aconitine; Alkaloids; Animals; Binding, Competitive; Catecholamines; Cell Line; Diterpenes; Esters; Nicotinic Antagonists; Receptors, Nicotinic; Structure-Activity Relationship | 2004 |
Methyllycaconitine, alpha-bungarotoxin and (+)-tubocurarine block fast ATP-gated currents in rat dorsal root ganglion cells.
Topics: Aconitine; Adenosine Triphosphate; Animals; Bungarotoxins; Cell Line; Dose-Response Relationship, Drug; Ganglia, Spinal; Humans; Ion Channel Gating; Purinergic P2 Receptor Antagonists; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X3; Tubocurarine | 2004 |
The alpha7 nicotinic acetylcholine receptor-selective antagonist, methyllycaconitine, partially protects against beta-amyloid1-42 toxicity in primary neuron-enriched cultures.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Animals, Newborn; Brain; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Mice; Neurons; Nicotinic Antagonists; Peptide Fragments; Receptors, Nicotinic; Tetrazolium Salts; Thiazoles | 2004 |
Involvement of alpha7- and alpha4beta2-type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: a patch clamp and single-cell PCR study using acutely dissociated nigral neurons.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Atropine; Cells, Cultured; Dihydro-beta-Erythroidine; Dopamine; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Polymerase Chain Reaction; Rats; Rats, Wistar; Receptors, Nicotinic; Substantia Nigra | 2004 |
Desensitizing and non-desensitizing subtypes of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in cockroach neurons.
Topics: Acetylcholine; Aconitine; Animals; Atropine; Bungarotoxins; Cockroaches; Dihydro-beta-Erythroidine; Electrophysiology; Guanidines; Imidazoles; Inhibitory Concentration 50; Kinetics; Macrolides; Neonicotinoids; Neurons; Nicotinic Antagonists; Nitro Compounds; Receptors, Nicotinic; Thiazoles | 2004 |
Identified spinal motoneurons of young rats possess nicotinic acetylcholine receptors of the heteromeric family.
Topics: Acetylcholine; Aconitine; Age Factors; Animals; Animals, Newborn; Autoradiography; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Choline O-Acetyltransferase; Dihydro-beta-Erythroidine; Immunohistochemistry; In Vitro Techniques; Iodine Isotopes; Lysine; Membrane Potentials; Motor Neurons; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Tritium; Tubocurarine | 2004 |
Role of nicotinic acetylcholine receptors in the regulation of kainic acid-induced hippocampal cell death in mice.
Topics: Aconitine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; CD11b Antigen; Cell Count; Cell Death; Drug Interactions; Excitatory Amino Acid Agonists; Extracellular Signal-Regulated MAP Kinases; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Injections, Intra-Articular; Kainic Acid; Macrophage-1 Antigen; Male; Mice; Mice, Inbred ICR; Neurons; Nicotinic Antagonists; Phosphorylation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Nicotinic; Staining and Labeling | 2004 |
Nicotine and epibatidine triggered prolonged rise in calcium and TH gene transcription in PC12 cells.
Topics: Aconitine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; Dideoxyadenosine; Dose-Response Relationship, Drug; Egtazic Acid; Luciferases; Nicotine; PC12 Cells; Promoter Regions, Genetic; Pyridines; Rats; Recombinant Fusion Proteins; Time Factors; Transcription, Genetic; Tyrosine 3-Monooxygenase | 2004 |
Desensitization of alpha7 nicotinic receptors potentiated the inhibitory effect on M-current induced by stimulation of muscarinic receptors in rat superior cervical ganglion neurons.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Cells, Cultured; Choline; Drug Synergism; Membrane Potentials; Muscarinic Agonists; Neurons; Nicotinic Antagonists; Nootropic Agents; Patch-Clamp Techniques; Pilocarpine; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Stimulation, Chemical; Superior Cervical Ganglion | 2005 |
Beta-Amyloid peptide25-35 depresses excitatory synaptic transmission in the rat basolateral amygdala "in vitro".
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Amygdala; Amyloid beta-Peptides; Anesthetics, Local; Animals; Bicuculline; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Interactions; Elapid Venoms; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; In Vitro Techniques; Male; Membrane Potentials; Neural Inhibition; Neurons; Nicotinic Antagonists; Nifedipine; Peptide Fragments; Rats; Rats, Wistar; Synaptic Transmission; Tetrodotoxin; Valine | 2005 |
Novel analogs of choline as potential neuroprotective agents.
Topics: Aconitine; Animals; Cell Culture Techniques; Cell Survival; Choline; Dihydro-beta-Erythroidine; Ethanolamines; Fibroblasts; Horses; Humans; Neuroprotective Agents; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic | 2004 |
Antinociceptive effects of choline against acute and inflammatory pain.
Topics: Aconitine; Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Atropine; Bungarotoxins; Central Nervous System; Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Inflammation; Mice; Morphine; Muscarinic Antagonists; Nicotinic Antagonists; Nociceptors; Pain; Pain Measurement; Reaction Time; Receptors, Nicotinic | 2005 |
Role of alpha7-nicotinic acetylcholine receptors in tetanic stimulation-induced gamma oscillations in rat hippocampal slices.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Bicuculline; Biological Clocks; Bungarotoxins; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Electrophysiology; GABA Antagonists; Hippocampus; In Vitro Techniques; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Spectrum Analysis; Time Factors | 2005 |
Time and brain region specific up-regulation of low affinity neuronal nicotinic receptors during chronic nicotine administration in mice.
Topics: Aconitine; Animals; Binding Sites; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cerebral Cortex; Corpus Striatum; Hippocampus; Male; Mesencephalon; Mice; Mice, Inbred Strains; Neurons; Nicotine; Nicotinic Agonists; Pyridines; Radioligand Assay; Receptors, Nicotinic; Time Factors; Tritium; Up-Regulation | 2005 |
Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors.
Topics: Aconitine; Animals; Magnetic Resonance Spectroscopy; Nicotinic Antagonists; Receptors, Nicotinic; Spectrometry, Mass, Electrospray Ionization; Xenopus | 2005 |
Chronic nicotine exposure alters blood-brain barrier permeability and diminishes brain uptake of methyllycaconitine.
Topics: Aconitine; Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Drug Administration Schedule; Infusion Pumps, Implantable; Male; Nicotine; Rats; Rats, Inbred F344 | 2005 |
Presynaptic modulation of synaptic transmission by pregnenolone sulfate as studied by optical recordings.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Analysis of Variance; Animals; Benzylidene Compounds; Bicuculline; Bungarotoxins; Calcium; Calcium Channel Blockers; Diagnostic Imaging; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ethylenediamines; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Haloperidol; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Pregnenolone; Presynaptic Terminals; Pyridines; Rats; Rats, Wistar; Synaptic Transmission; Tetrodotoxin; Time Factors | 2005 |
Synaptically released and exogenous ACh activates different nicotinic receptors to enhance evoked glutamatergic transmission in the lateral geniculate nucleus.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aconitine; Analysis of Variance; Animals; Bicuculline; Bungarotoxins; Calcium; Calcium Channel Blockers; Chick Embryo; Conotoxins; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Antagonists; GABA Antagonists; Geniculate Bodies; Glutamic Acid; In Vitro Techniques; Magnesium; Membrane Potentials; Neurons; Nicotinic Antagonists; Patch-Clamp Techniques; Quinoxalines; Receptors, Nicotinic; Synapses; Synaptic Transmission; Time Factors | 2005 |
The effects of DHBE and MLA on nicotine-induced enhancement of contextual fear conditioning in C57BL/6 mice.
Topics: Aconitine; Animals; Association Learning; Brain; Conditioning, Classical; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Electroshock; Fear; Male; Mice; Nicotine; Receptors, Nicotinic | 2006 |
Septal innervation regulates the function of alpha7 nicotinic receptors in CA1 hippocampal interneurons.
Topics: Acetyl-CoA C-Acetyltransferase; Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Benzylidene Compounds; Choline O-Acetyltransferase; Electric Stimulation; Excitatory Amino Acid Agonists; Functional Laterality; Hippocampus; Immunohistochemistry; In Vitro Techniques; Interneurons; Kainic Acid; Male; Membrane Potentials; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Sepharose; Septum of Brain; Tritium | 2005 |
Reversal of isolation-rearing-induced PPI deficits by an alpha7 nicotinic receptor agonist.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Male; Nicotinic Agonists; Rats; Receptors, Nicotinic; Reflex, Startle; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Social Isolation | 2005 |
The effects of cholinergic and dopaminergic antagonists on nicotine-induced cerebral neurotransmitter changes.
Topics: Aconitine; Animals; Atropine; Benzazepines; Brain Chemistry; Cerebral Cortex; Dopamine; Dopamine Antagonists; Hippocampus; Male; Microdialysis; Neurotransmitter Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Parasympatholytics; Rats; Rats, Sprague-Dawley; Salicylamides; Serotonin | 2005 |
Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of alpha7 nicotinic receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antioxidants; Blotting, Western; Body Temperature; Body Weight; Calcium; Cell Membrane; Central Nervous System Stimulants; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Immunohistochemistry; Isoquinolines; Male; Methamphetamine; Mice; Microglia; Motor Activity; Neostriatum; Neurotoxicity Syndromes; Nicotinic Antagonists; Radioligand Assay; Reactive Oxygen Species; Receptors, Nicotinic; Synaptic Vesicles; Synaptosomes; Tyrosine 3-Monooxygenase | 2005 |
Effects of alpha4beta2 and alpha7 nicotinic acetylcholine receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Conditioning, Operant; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2005 |
Nicotine-induced switch in the nicotinic cholinergic mechanisms of facilitation of long-term potentiation induction.
Topics: Acetylcholinesterase; Aconitine; Animals; Animals, Newborn; Antibodies, Monoclonal; Cholinergic Fibers; Denervation; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Hippocampus; Immunohistochemistry; Immunotoxins; In Vitro Techniques; Long-Term Potentiation; N-Glycosyl Hydrolases; Neural Inhibition; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Phosphinic Acids; Picrotoxin; Propanolamines; Quinoxalines; Rats; Receptors, Nicotinic; Ribosome Inactivating Proteins, Type 1; Saporins; Valine | 2005 |
The involvement of central cholinergic system in the pressor effect of intracerebroventricularly injected U-46619, a thromboxane A2 analog, in conscious normotensive rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Central Nervous System; Choline; Fatty Acids, Unsaturated; Heart Rate; Hydrazines; Hypothalamus, Posterior; Injections, Intraventricular; Male; Mecamylamine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Thromboxane A2, Prostaglandin H2; Time Factors; Vasoconstrictor Agents | 2005 |
Tropisetron improves deficient inhibitory auditory processing in DBA/2 mice: role of alpha 7 nicotinic acetylcholine receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Auditory Perceptual Disorders; Disease Models, Animal; Drug Interactions; Evoked Potentials, Auditory; Indoles; Male; Mice; Mice, Inbred DBA; Nicotinic Antagonists; Receptors, Nicotinic; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Time Factors; Tropisetron | 2005 |
Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors.
Topics: Aconitine; Amyloid beta-Peptides; Apoptosis; Benzopyrans; Cell Culture Techniques; Cell Line, Tumor; Cholinesterase Inhibitors; Chromones; Donepezil; Dose-Response Relationship, Drug; Enzyme Inhibitors; Galantamine; Humans; Indans; L-Lactate Dehydrogenase; Morpholines; Neuroblastoma; Neuroprotective Agents; Nicotine; Nitriles; Okadaic Acid; Phenylcarbamates; Phosphatidylinositol 3-Kinases; Piperidines; Proto-Oncogene Proteins c-bcl-2; Receptors, Nicotinic; Rivastigmine | 2005 |
Introduction of unsaturation into the N-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: effect on affinity and selectivity.
Topics: Aconitine; Animals; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Drug Design; Drug Evaluation, Preclinical; Electric Stimulation; Humans; Male; Molecular Structure; Nicotine; Nicotinic Antagonists; Nomifensine; Protein Binding; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reward; Rubidium; Structure-Activity Relationship; Synaptosomes | 2005 |
Nicotinic modulation of glutamatergic synaptic transmission in region CA3 of the hippocampus.
Topics: Aconitine; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamates; Hippocampus; In Vitro Techniques; Male; Mecamylamine; Neurons, Afferent; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission | 2005 |
Enhanced nicotinic acetylcholine receptor-mediated [3H]norepinephrine release from neonatal rat hypothalamus.
Topics: Aconitine; Animals; Animals, Newborn; Benzylamines; Dose-Response Relationship, Drug; Hypothalamus; In Vitro Techniques; Male; Neurons, Afferent; Neurotransmitter Agents; Nicotinic Antagonists; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tubocurarine | 2006 |
Desensitization of neuronal nicotinic receptors of human neuroblastoma SH-SY5Y cells during short or long exposure to nicotine.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Cell Line, Tumor; Conotoxins; Dose-Response Relationship, Drug; Humans; Kinetics; Membrane Potentials; Neuroblastoma; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Up-Regulation | 2005 |
Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes.
Topics: Acetylcholine; Aconitine; Algorithms; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Anabasine; Animals; Azocines; Bridged Bicyclo Compounds; Choline; Dose-Response Relationship, Drug; Female; Humans; Macaca mulatta; Mecamylamine; Membrane Potentials; Microinjections; Molecular Sequence Data; Mutation; Nicotinic Antagonists; Oocytes; Pyridines; Quinolizines; Receptors, Nicotinic; RNA, Complementary; Sequence Alignment; Sequence Homology, Amino Acid; Structural Homology, Protein; Xenopus laevis | 2005 |
Effect of amyloid peptides on the increase in TrkA receptor expression induced by nicotine in vitro and in vivo.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Brain; Bungarotoxins; Dose-Response Relationship, Drug; Male; Nerve Growth Factor; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; PC12 Cells; Peptide Fragments; Rats; Rats, Wistar; Receptor, trkA; Receptors, Nicotinic | 2005 |
Spinal muscarinic and nicotinic subtypes activated by clonidine in postincisional pain.
Topics: Aconitine; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Clonidine; Diamines; Dihydro-beta-Erythroidine; Injections, Spinal; Male; Muscarinic Agonists; Nicotinic Agonists; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Muscarinic; Receptors, Nicotinic; Spine | 2005 |
Contribution of dihydro-beta-erythroidine sensitive nicotinic acetylcholine receptors in the ventral tegmental area to cocaine-induced behavioral sensitization in rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Cocaine; Dihydro-beta-Erythroidine; Male; Microinjections; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereotaxic Techniques; Stereotyped Behavior; Ventral Tegmental Area | 2006 |
The beta2 but not alpha7 subunit of the nicotinic acetylcholine receptor is required for nicotine-conditioned place preference in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Choice Behavior; Conditioning, Psychological; Dihydro-beta-Erythroidine; Female; Heterozygote; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motivation; Premedication; Receptors, Nicotinic; Reinforcement Schedule; Social Environment; Tobacco Use Disorder | 2006 |
Evidence of reuptake inhibition responsible for mecamylamine-evoked increases in extracellular serotonin.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aconitine; Animals; Citalopram; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Mecamylamine; Microdialysis; Nicotinic Antagonists; Raphe Nuclei; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists; Wakefulness | 2006 |
Role of the outer beta-sheet in divalent cation modulation of alpha7 nicotinic receptors.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Amino Acid Substitution; Animals; Barium; Calcium; Cations, Divalent; Cysteine; Dose-Response Relationship, Drug; Female; Membrane Potentials; Models, Molecular; Molecular Sequence Data; Mutation; Nicotinic Antagonists; Oocytes; Protein Structure, Secondary; Receptors, Nicotinic; Strontium; Xenopus laevis | 2006 |
Reparatory effects of nicotine on NMDA receptor-mediated synaptic plasticity in the hippocampal CA1 region of chronically lead-exposed rats.
Topics: Aconitine; Animals; Central Nervous System Stimulants; Child; Dihydro-beta-Erythroidine; Female; Hippocampus; Humans; Lead Poisoning, Nervous System; Long-Term Potentiation; Male; Neuronal Plasticity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pentanoic Acids; Picrotoxin; Random Allocation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Synaptic Transmission | 2006 |
Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Behavior, Animal; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Combinations; Female; Hippocampus; Maze Learning; Memory; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Nicotinic; Time Factors | 2006 |
Nicotine reverses consolidated long-term potentiation in the hippocampal CA1 region.
Topics: Aconitine; Analysis of Variance; Animals; Dihydro-beta-Erythroidine; Dose-Response Relationship, Radiation; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Ethers, Cyclic; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Okadaic Acid; Oxazoles; Rats; Rats, Sprague-Dawley | 2006 |
Untranslated region-dependent exclusive expression of high-sensitivity subforms of alpha4beta2 and alpha3beta2 nicotinic acetylcholine receptors.
Topics: 5' Untranslated Regions; Acetylcholine; Aconitine; Animals; Chlorisondamine; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Estradiol; Female; Ferrets; Gene Expression; Membrane Potentials; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Protein Isoforms; Protein Subunits; Receptors, Nicotinic; Tubocurarine; Xenopus laevis | 2006 |
Involvement of alpha-bungarotoxin-sensitive nicotinic receptors in long-term memory formation in the honeybee (Apis mellifera).
Topics: Aconitine; Animals; Association Learning; Bees; Bungarotoxins; Cholinergic Agents; Conditioning, Classical; Mecamylamine; Memory; Receptors, Nicotinic; Signal Transduction; Smell | 2006 |
Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.
Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Attention Deficit Disorder with Hyperactivity; Azocines; Behavior, Animal; Choice Behavior; Cognition Disorders; Dose-Response Relationship, Drug; Mice; Mice, Knockout; Nicotinic Antagonists; Protein Binding; Quinolizines; Reaction Time; Receptors, Nicotinic; Tritium | 2007 |
Ventral hippocampal alpha7 and alpha4beta2 nicotinic receptor blockade and clozapine effects on memory in female rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Clozapine; Dihydro-beta-Erythroidine; Female; Hippocampus; Maze Learning; Memory; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2006 |
Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats.
Topics: Aconitine; Animals; Arachidonic Acids; Azetidines; Benzamides; Benzoxazines; Camphanes; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dihydro-beta-Erythroidine; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Male; Mecamylamine; Morpholines; Naphthalenes; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Polyunsaturated Alkamides; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Nicotinic | 2006 |
In vivo effects of the anatoxin-a on striatal dopamine release.
Topics: Aconitine; Animals; Bungarotoxins; Corpus Striatum; Cyanobacteria Toxins; Dopamine; Dose-Response Relationship, Drug; Female; Mecamylamine; Microdialysis; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tropanes | 2006 |
Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor.
Topics: Aconitine; Antibodies; Brain-Derived Neurotrophic Factor; Carbazoles; Carbon Isotopes; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Humans; Indole Alkaloids; Mecamylamine; Neuroblastoma; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptor, trkB; Thymidine; Time Factors | 2006 |
Inhibition of both alpha7* and beta2* nicotinic acetylcholine receptors is necessary to prevent development of sensitization to cocaine-elicited increases in extracellular dopamine levels in the ventral striatum.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Basal Ganglia; Central Nervous System Stimulants; Cocaine; Dopamine; Extracellular Fluid; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotinic Antagonists; Receptors, Nicotinic | 2006 |
Association of nicotinic acetylcholine receptors with central respiratory control in isolated brainstem-spinal cord preparation of neonatal rats.
Topics: Aconitine; Animals; Animals, Newborn; Bungarotoxins; Dihydro-beta-Erythroidine; Mecamylamine; Membrane Potentials; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Respiratory Center | 2006 |
Protection against MDMA-induced dopaminergic neurotoxicity in mice by methyllycaconitine: involvement of nicotinic receptors.
Topics: Aconitine; Analysis of Variance; Animals; Cocaine; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Male; Mice; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Neuroprotective Agents; Neurotoxicity Syndromes; Nicotinic Agonists; Nicotinic Antagonists; Radioligand Assay; Reactive Oxygen Species; Receptors, Nicotinic; Synaptosomes; Tritium | 2006 |
Endogenous activation of nicotinic receptors underlies sympathetic tone generation in neonatal rat spinal cord in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aconitine; Animals; Animals, Newborn; Autonomic Fibers, Preganglionic; Cholinergic Fibers; Dihydro-beta-Erythroidine; Dimethylphenylpiperazinium Iodide; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Glycine; In Vitro Techniques; Interneurons; Kynurenic Acid; Mecamylamine; Nerve Tissue Proteins; Nicotinic Agonists; Nicotinic Antagonists; Organophosphonates; Phenylalanine; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spinal Cord; Splanchnic Nerves; Sympathetic Fibers, Postganglionic; Synaptic Transmission | 2006 |
Functional somato-dendritic alpha7-containing nicotinic acetylcholine receptors in the rat basolateral amygdala complex.
Topics: Acetylcholine; Aconitine; Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Amygdala; Animals; Carbachol; Choline; Cholinergic Agents; Dendritic Cells; Evoked Potentials; Fear; Gene Expression Regulation; Memory; Neurons; Nicotinic Antagonists; Patch-Clamp Techniques; Photolysis; Rats; Receptors, Nicotinic | 2006 |
Contribution of valine 7' of TMD2 to gating of neuronal alpha3 receptor subtypes.
Topics: Acetylcholine; Aconitine; Animals; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Ion Channel Gating; Membrane Potentials; Mutagenesis; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oocytes; Patch-Clamp Techniques; Protein Structure, Tertiary; Rats; Receptors, Nicotinic; Time Factors; Valine; Xenopus laevis | 2006 |
Antisense knockdown of the rat alpha7 nicotinic acetylcholine receptor produces spatial memory impairment.
Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Behavior, Animal; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Male; Maze Learning; Memory Disorders; Nicotinic Antagonists; Oligodeoxyribonucleotides, Antisense; Protein Binding; Quinolizines; Rats; Rats, Long-Evans; Receptors, Nicotinic; Space Perception; Time Factors; Tritium | 2006 |
Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs.
Topics: Aconitine; Analgesics; Animals; Anticonvulsants; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Data Interpretation, Statistical; In Vitro Techniques; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Pain Measurement; Pyridines; Rats; Reaction Time; Receptors, Nicotinic; Seizures | 2007 |
Cholinergic modulation of Pavlovian fear conditioning in rats: differential effects of intrahippocampal infusion of mecamylamine and methyllycaconitine.
Topics: Aconitine; Animals; Cholinergic Fibers; Conditioning, Classical; Fear; Hippocampus; Male; Mecamylamine; Microinjections; Nicotinic Antagonists; Rats; Rats, Long-Evans; Receptors, Nicotinic | 2007 |
alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzylidene Compounds; Cell Line; Gene Transfer Techniques; Hippocampus; In Vitro Techniques; Maze Learning; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Phosphorylation; Protein Binding; Pyridines; Rats; Receptors, Nicotinic; Space Perception; tau Proteins | 2007 |
The involvement of the central cholinergic system in the pressor and bradycardic effects of centrally administrated melittin in normotensive conscious rats.
Topics: Aconitine; Animals; Atropine; Blood Pressure; Bradycardia; Brain; Bungarotoxins; Cholinergic Agents; Cholinergic Fibers; Consciousness; Drug Interactions; Heart Rate; Hemicholinium 3; Injections, Intraventricular; Male; Mecamylamine; Melitten; Nicotinic Antagonists; Parasympatholytics; Phospholipases A; Rats; Rats, Sprague-Dawley | 2007 |
The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Bungarotoxins; Cell Line, Tumor; Cell Membrane; Female; Fluorescence Polarization; Hippocampus; Humans; Membrane Fluidity; Membrane Lipids; Neuroblastoma; Oocytes; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Surface Plasmon Resonance; tau Proteins; Transfection; Xenopus laevis | 2007 |
Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development.
Topics: Aconitine; Algorithms; Animals; Cattle; Chromaffin Cells; Drug Design; Humans; Inhibitory Concentration 50; Models, Molecular; Neurosecretion; Nicotinic Antagonists; Quantitative Structure-Activity Relationship; Receptors, Nicotinic; Regression Analysis | 2007 |
High content screen microscopy analysis of A beta 1-42-induced neurite outgrowth reduction in rat primary cortical neurons: neuroprotective effects of alpha 7 neuronal nicotinic acetylcholine receptor ligands.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Animals, Newborn; Benzamides; Bridged Bicyclo Compounds; Cell Count; Cells, Cultured; Cerebral Cortex; Cholinergic Agents; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Memantine; Neurites; Neurons; Nicotinic Antagonists; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2007 |
Long-term effects of chronic nicotine exposure on brain nicotinic receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Mice; Mice, Inbred C57BL; Nicotine; Receptors, Nicotinic; Ventral Tegmental Area | 2007 |
Partial agonist and neuromodulatory activity of S 24795 for alpha7 nAChR responses of hippocampal interneurons.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Cholinergic Agonists; Cholinergic Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Female; Hippocampus; In Vitro Techniques; Indoles; Inhibitory Concentration 50; Interneurons; Male; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Pyridinium Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Xenopus | 2007 |
Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective alpha7 nicotinic receptor agonist SSR180711.
Topics: Aconitine; Analysis of Variance; Animals; Behavior, Animal; Brain; Bridged Bicyclo Compounds, Heterocyclic; Cognition Disorders; Drug Administration Schedule; Drug Interactions; Male; Mice; Mice, Inbred ICR; Nicotinic Antagonists; Phencyclidine | 2008 |
Reinforcement enhancing effect of nicotine and its attenuation by nicotinic antagonists in rats.
Topics: Aconitine; Analysis of Variance; Animals; Conditioning, Operant; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Infusion Pumps; Infusions, Intravenous; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Photic Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement Schedule; Reinforcement, Psychology; Visual Perception | 2007 |
Individual differences in response to novelty predict prefrontal cortex dopamine transporter function and cell surface expression.
Topics: Aconitine; Animals; Behavior, Animal; Binding, Competitive; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Exploratory Behavior; Male; Motor Activity; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenotype; Prefrontal Cortex; Presynaptic Terminals; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Synaptosomes; Tobacco Use Disorder | 2007 |
T cells express alpha7-nicotinic acetylcholine receptor subunits that require a functional TCR and leukocyte-specific protein tyrosine kinase for nicotine-induced Ca2+ response.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Calcium; CD3 Complex; Cell Membrane; Humans; Immunoprecipitation; Jurkat Cells; Leukocytes; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Neurons; Nicotine; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-fyn; Pyridines; Rats; Receptors, Antigen, T-Cell; Receptors, Nicotinic; RNA, Small Interfering; T-Lymphocytes | 2007 |
Pharmacological characteristics and binding modes of caracurine V analogues and related compounds at the neuronal alpha7 nicotinic acetylcholine receptor.
Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding Sites; Binding, Competitive; Cell Line; Humans; Ion Channels; Ligands; Membrane Potentials; Mice; Models, Molecular; Molecular Structure; Mutation; Neurons; Nicotinic Antagonists; Radioligand Assay; Rats; Receptors, Nicotinic; Receptors, Serotonin, 5-HT3; Recombinant Fusion Proteins; Serotonin 5-HT3 Receptor Antagonists; Structure-Activity Relationship | 2007 |
Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice.
Topics: Aconitine; Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Animals, Outbred Strains; Apomorphine; Behavior, Animal; Cholinesterase Inhibitors; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Galantamine; Indans; Male; Mecamylamine; Mice; Neural Inhibition; Nicotinic Antagonists; Piperidines; Receptors, Nicotinic; Reflex, Startle; Risperidone; Social Isolation | 2008 |
Hippocampal alpha4beta2 nicotinic acetylcholine receptor involvement in the enhancing effect of acute nicotine on contextual fear conditioning.
Topics: Aconitine; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Classical; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Interactions; Fear; Female; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic | 2007 |
Decreased withdrawal symptoms but normal tolerance to nicotine in mice null for the alpha7 nicotinic acetylcholine receptor subunit.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Cocaine; Disease Models, Animal; Drug Tolerance; Exploratory Behavior; Female; Male; Maze Learning; Mecamylamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotinic Antagonists; Receptors, Nicotinic; Substance Withdrawal Syndrome | 2007 |
Activation of rat ventral tegmental area dopamine neurons by endogenous kynurenic acid: a pharmacological analysis.
Topics: Aconitine; Action Potentials; Analysis of Variance; Animals; Biphenyl Compounds; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Microdialysis; Neurons; Nicotinic Antagonists; Propionates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric; Time Factors; Ventral Tegmental Area | 2007 |
[3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; Bungarotoxins; Cell Line; Humans; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Spiro Compounds | 2008 |
Neural actions of imidacloprid and their involvement in resistance in the Colorado potato beetle, Leptinotarsa decemlineata (Say).
Topics: Aconitine; Animals; Central Nervous System; Coleoptera; Imidazoles; Insecticide Resistance; Insecticides; Molecular Structure; Neonicotinoids; Nitro Compounds; Pyridines | 2008 |
Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; beta Catenin; Cell Adhesion; Cells, Cultured; Gene Expression Regulation; Humans; Immunoglobulin G; Keratinocytes; Models, Biological; Okadaic Acid; Pemphigus; Phosphorylation; Receptor, Muscarinic M1; Receptors, Nicotinic; src-Family Kinases | 2008 |
The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki-Miyaura cross-coupling reaction.
Topics: Aconitine; Cross-Linking Reagents; Hydrogenation; Molecular Structure; Protein Binding; Receptors, Cholinergic; Stereoisomerism; Structure-Activity Relationship | 2008 |
Cardiovascular effects of activation of central alpha7 and alpha4beta2 nAChRs: a role for vasopressin in anaesthetized rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Heart Rate; Male; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Vasopressins | 2008 |
Effects of moderate chronic ethanol consumption on hippocampal nicotinic receptors and associative learning.
Topics: Aconitine; Alcoholism; Animals; Association Learning; Central Nervous System Depressants; Ethanol; Hippocampus; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Tritium | 2008 |
Activation of the alpha7-nicotinic acetylcholine receptor reverses complete freund adjuvant-induced mechanical hyperalgesia in the rat via a central site of action.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzofurans; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Models, Animal; Nicotinic Antagonists; Pain; Pain Measurement; Quinuclidines; Rats; Receptors, Nicotinic; Weight-Bearing | 2008 |
The effect of 7,8-methylenedioxylycoctonine-type diterpenoid alkaloids on the toxicity of methyllycaconitine in mice.
Topics: Aconitine; Alkaloids; Animals; Area Under Curve; Diterpenes; Half-Life; Lethal Dose 50; Male; Mice; Molecular Structure; Muscle, Skeletal | 2008 |
Involvement of NO-synthase and nicotinic receptors in learning in the honey bee.
Topics: Aconitine; Animals; Association Learning; Bees; Behavior, Animal; Conditioning, Psychological; Enzyme Inhibitors; Habituation, Psychophysiologic; NG-Nitroarginine Methyl Ester; Nicotinic Antagonists; Nitric Oxide Synthase; Receptors, Nicotinic; Reward; Sucrose; Sweetening Agents; Time Factors | 2008 |
The role of alpha7 and alpha4beta2 nicotinic receptors in the nicotine-induced anxiolytic effect in zebrafish.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Dihydro-beta-Erythroidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Immobility Response, Tonic; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Swimming; Zebrafish; Zebrafish Proteins | 2008 |
Young and older good learners have higher levels of brain nicotinic receptor binding.
Topics: Acetylcholine; Aconitine; Aging; Analysis of Variance; Animals; Behavior, Animal; Binding, Competitive; Blinking; Brain; Bridged-Ring Compounds; Cholinesterase Inhibitors; Conditioning, Classical; Dose-Response Relationship, Drug; Epinephrine; Female; Galantamine; Learning; Nicotinic Antagonists; Protein Binding; Rabbits; Radioligand Assay; Receptors, Nicotinic; Spiro Compounds; Tritium | 2010 |
Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Arthritis, Rheumatoid; Benzamides; Blotting, Western; Bridged Bicyclo Compounds; Cells, Cultured; Cytokines; Humans; Immunohistochemistry; Interleukin-6; NF-kappa B; Osteoarthritis; Polymerase Chain Reaction; Proteins; Receptors, Nicotinic; RNA, Messenger; Synovial Membrane | 2008 |
Effects of subunit selective nACh receptors on operant ethanol self-administration and relapse-like ethanol-drinking behavior.
Topics: Aconitine; Administration, Oral; Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Central Nervous System Agents; Conditioning, Operant; Conotoxins; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Ethanol; Male; Mecamylamine; Nicotinic Antagonists; Protein Subunits; Rats; Rats, Wistar; Receptors, Nicotinic; Recurrence; Self Administration; Ventral Tegmental Area | 2009 |
Characterization of compounds on nicotinic acetylcholine receptor alpha7 channels using higher throughput electrophysiology.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Area Under Curve; Cell Line, Transformed; Cholinergic Agents; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Isoxazoles; Membrane Potentials; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Phenylurea Compounds; Rats; Receptors, Nicotinic | 2009 |
Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons.
Topics: Acetylcholine; Aconitine; Action Potentials; Alkaloids; Animals; Azocines; Brain; Choline; Dihydro-beta-Erythroidine; Dopamine; Dose-Response Relationship, Drug; Gene Expression; Kinetics; Mecamylamine; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Protein Subunits; Quinolizines; Rats; Rats, Wistar; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2009 |
Nicotinic acetylcholine alpha4beta2 receptor regulates the motivational effect of intracranial self stimulation behavior in the runway method.
Topics: Aconitine; Animals; Behavior, Animal; Conditioning, Operant; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Electric Stimulation; Male; Medial Forebrain Bundle; Motivation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Reward; Running; Self Stimulation | 2008 |
Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells.
Topics: Acetylcholine; Aconitine; Age Factors; alpha7 Nicotinic Acetylcholine Receptor; Animals; Autocrine Communication; Bronchi; Cells, Cultured; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Genistein; Gestational Age; Lung; Macaca mulatta; Mecamylamine; Membrane Potentials; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Receptors, Nicotinic; Up-Regulation; Vanadates | 2009 |
Investigation of the susceptibility of various strains of mice to methyllycaconitine toxicosis.
Topics: Aconitine; Animals; Delphinium; Gene Expression Regulation; Immunoblotting; Lethal Dose 50; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Plant Extracts; Random Allocation; Receptors, Nicotinic; Species Specificity | 2009 |
Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Base Sequence; Cell Line; China; DNA Primers; Interleukin-1beta; Macrophages, Peritoneal; Mice; Nicotinic Agonists; Nicotinic Antagonists; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Shock, Septic; Solanaceous Alkaloids; Tumor Necrosis Factor-alpha; Vagotomy | 2009 |
Bulbar acetylcholine enhances neural and perceptual odor discrimination.
Topics: Acetylcholine; Aconitine; Action Potentials; Analysis of Variance; Animals; Cholinesterase Inhibitors; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Muscarinic Antagonists; Neostigmine; Neurons; Nicotinic Antagonists; Odorants; Olfactory Bulb; Olfactory Perception; Rats; Rats, Sprague-Dawley; Scopolamine | 2009 |
Chronic underactivity of medial frontal cortical beta2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Cerebral Cortex; Chronic Disease; Clozapine; Dihydro-beta-Erythroidine; Female; Maze Learning; Memory Disorders; Memory, Short-Term; Microinjections; Nicotinic Antagonists; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2009 |
Involvement of nicotinic and muscarinic receptors in the endogenous cholinergic modulation of the balance between excitation and inhibition in the young rat visual cortex.
Topics: Acetylcholine; Aconitine; Animals; Cerebral Cortex; Electric Stimulation; Electrophysiology; Excitatory Postsynaptic Potentials; Lidocaine; Luminescent Measurements; Membrane Potentials; Neural Conduction; Neural Inhibition; Neural Pathways; Neurons; Neurosecretion; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Synaptic Transmission; Visual Cortex | 2009 |
Properties of distinct ventral tegmental area synapses activated via pedunculopontine or ventral tegmental area stimulation in vitro.
Topics: Aconitine; Afferent Pathways; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bicuculline; Dihydro-beta-Erythroidine; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; In Vitro Techniques; Nicotine; Nicotinic Antagonists; Patch-Clamp Techniques; Pedunculopontine Tegmental Nucleus; Picrotoxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Nicotinic; Strontium; Synapses; Synaptic Transmission; Ventral Tegmental Area | 2009 |
Long-term nicotine treatment reduces cerebral cortical vasodilation mediated by alpha4beta2-like nicotinic acetylcholine receptors in rats.
Topics: Aconitine; Animals; Cerebral Cortex; Cerebrovascular Circulation; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Male; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Regional Blood Flow; Time Factors; Vasodilation | 2009 |
The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of alpha7 nicotinic acetylcholine receptor.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytidine Diphosphate Choline; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Inflammation; Injections; Male; Nicotinic Agonists; Nicotinic Antagonists; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Time Factors; Tumor Necrosis Factor-alpha | 2009 |
Tropisetron attenuates naloxone-induced place aversion in single-dose morphine-treated rats: role of alpha7 nicotinic receptors.
Topics: Aconitine; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Indoles; Male; Mecamylamine; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Nicotinic Agonists; Nicotinic Antagonists; Ondansetron; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin Antagonists; Tropisetron | 2009 |
Rat neuronal nicotinic acetylcholine receptors containing alpha7 subunit: pharmacological properties of ligand binding and function.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Line; Cerebral Cortex; Gene Expression; Hippocampus; Humans; Inhibitory Concentration 50; Ligands; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Protein Binding; Rats; Receptors, Nicotinic | 2009 |
The biogeographical distribution of duncecap larkspur (Delphinium occidentale) chemotypes and their potential toxicity.
Topics: Aconitine; Alkaloids; Delphinium; Diterpenes; Geography; Plants, Toxic | 2009 |
Nicotinic antagonist effects in the mediodorsal thalamic nucleus: regional heterogeneity of nicotinic receptor involvement in cognitive function.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Clozapine; Cognition; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Interactions; Female; Maze Learning; Mediodorsal Thalamic Nucleus; Memory; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2009 |
Nicotinic acetylcholine receptor alpha7 subunits with a C2 cytoplasmic loop yellow fluorescent protein insertion form functional receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Choline; Cytoplasm; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; Iodine Radioisotopes; Luminescent Proteins; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Patch-Clamp Techniques; Protein Binding; Receptors, Nicotinic; Transfection | 2009 |
Serum elimination profiles of methyllycaconitine and deltaline in cattle following oral administration of larkspur (Delphinium barbeyi).
Topics: Aconitine; Alkaloids; Animals; Area Under Curve; Cattle; Cattle Diseases; Delphinium; Diterpenes; Half-Life; Male; Plant Poisoning; Plants, Toxic | 2009 |
Agonist actions of clothianidin on synaptic and extrasynaptic nicotinic acetylcholine receptors expressed on cockroach sixth abdominal ganglion.
Topics: Acetylcholine; Aconitine; Analysis of Variance; Animals; Biophysics; Cockroaches; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Postsynaptic Potentials; Ganglia, Invertebrate; Gene Expression Regulation; Guanidines; Male; Neonicotinoids; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Receptors, Nicotinic; Synapses; Thiazoles | 2009 |
Inhibitory role of cholinergic system mediated via alpha7 nicotinic acetylcholine receptor in LPS-induced neuro-inflammation.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Cytokines; Dihydro-beta-Erythroidine; Encephalitis; Gene Expression Regulation; Inflammation Mediators; Lipopolysaccharides; Neuroimmunomodulation; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Oxotremorine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2010 |
Mutations of cytosolic loop residues impair assembly and maturation of alpha7 nicotinic acetylcholine receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Sequence; Animals; Bungarotoxins; Cell Line; Chickens; Gene Expression; Humans; Immunoprecipitation; Intracellular Membranes; Intracellular Signaling Peptides and Proteins; Leucine; Mutation; Neuroblastoma; Protein Binding; Radioisotopes; Receptors, Nicotinic; Structure-Activity Relationship; Transfection | 2009 |
The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices.
Topics: Aconitine; Allosteric Regulation; Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Norepinephrine; Picolines; Rats; Rats, Sprague-Dawley; Tritium | 2009 |
Alpha 7 nicotinic acetylcholine receptor modulates lymphocyte activation.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Calcium; Cells, Cultured; Choline O-Acetyltransferase; Flow Cytometry; Humans; Indicators and Reagents; Lymphocyte Activation; Microscopy, Confocal; Nicotinic Agonists; Nicotinic Antagonists; Phytohemagglutinins; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Thymidine | 2009 |
The involvement of nicotinic receptor subtypes in the locomotor activity and analgesia induced by methamphetamine in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Dihydro-beta-Erythroidine; Drug Administration Schedule; Drug Interactions; Male; Methamphetamine; Mice; Motor Activity; Nicotine; Receptors, Nicotinic | 2009 |
NADPH oxidase mediates beta-amyloid peptide-induced activation of ERK in hippocampal organotypic cultures.
Topics: Acetophenones; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hippocampus; NADPH Oxidases; Nicotine; Onium Compounds; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2009 |
Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors.
Topics: Aconitine; Adrenergic alpha-Antagonists; Alkaloids; Analysis of Variance; Animals; Atropine; Azocines; Blood Pressure; Bradycardia; Cardiovascular Physiological Phenomena; Dihydro-beta-Erythroidine; Heart Rate; Hexamethonium; Male; Mice; Muscarinic Antagonists; Nicotinic Agonists; Nicotinic Antagonists; Prazosin; Quinolizines; Receptors, Nicotinic | 2010 |
Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea].
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Choline; Drug Synergism; Female; Hypothalamic Area, Lateral; Isoxazoles; Male; Membrane Potentials; Neurons; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2010 |
Activation of presynaptic alpha7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study.
Topics: 2-Amino-5-phosphonovalerate; Aconitine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ring Compounds; D-Aspartic Acid; Glutamic Acid; Hippocampus; Male; N-Methylaspartate; Neurons; Nicotine; Nicotinic Antagonists; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Receptors, Presynaptic; Spiro Compounds | 2010 |
Different interaction between the agonist JN403 and the competitive antagonist methyllycaconitine with the human alpha7 nicotinic acetylcholine receptor.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Binding Sites; Carbamates; Cells, Cultured; Humans; Hydrogen Bonding; Kinetics; Ligands; Models, Molecular; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Quinuclidines; Receptors, Nicotinic; Thermodynamics | 2010 |
A toxicokinetic comparison of norditerpenoid alkaloids from Delphinium barbeyi and D. glaucescens in cattle.
Topics: Aconitine; Administration, Oral; Alkaloids; Animals; Cattle; Cattle Diseases; Delphinium; Diterpenes; Linear Models; Male; Plant Poisoning; Plants, Toxic | 2011 |
Endogenous acetylcholine modulates impulsive action via alpha4beta2 nicotinic acetylcholine receptors in rats.
Topics: Acetylcholine; Aconitine; Animals; Behavior, Animal; Choice Behavior; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Impulsive Behavior; Male; Nicotine; Rats; Rats, Wistar; Reaction Time; Receptors, Nicotinic | 2010 |
Ameliorating effects of tropisetron on dopaminergic disruption of prepulse inhibition via the alpha(7) nicotinic acetylcholine receptor in Wistar rats.
Topics: Aconitine; Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Apomorphine; Brain; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Indoles; Inhibition, Psychological; Male; Mecamylamine; Models, Biological; Nicotinic Antagonists; Ondansetron; Proto-Oncogene Proteins c-fos; Psychoacoustics; Rats; Rats, Wistar; Receptors, Nicotinic; Reflex, Startle; Serotonin Antagonists; Stereotyped Behavior; Tropisetron | 2010 |
Nicotinic acetylcholine receptors are required for the conditioned reinforcing properties of sucrose-associated cues.
Topics: Aconitine; Animals; Cues; Male; Mecamylamine; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement Schedule; Reinforcement, Psychology; Reward; Sucrose | 2010 |
The role of nicotinic acetylcholine receptors in the medial prefrontal cortex and hippocampus in trace fear conditioning.
Topics: Aconitine; Analysis of Variance; Animals; Conditioning, Classical; Dihydro-beta-Erythroidine; Fear; Freezing Reaction, Cataleptic; Hippocampus; Male; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Receptors, Nicotinic | 2010 |
The novel pyrrolidine nor-lobelane analog UKCP-110 [cis-2,5-di-(2-phenethyl)-pyrrolidine hydrochloride] inhibits VMAT2 function, methamphetamine-evoked dopamine release, and methamphetamine self-administration in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aconitine; Amphetamine-Related Disorders; Animals; Behavior, Animal; Cell Membrane; Conditioning, Operant; Corpus Striatum; Dopamine; Drug Tolerance; Lobeline; Male; Methamphetamine; Nicotine; Protein Binding; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Reinforcement, Psychology; Self Administration; Synaptic Vesicles; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2010 |
Hippocampal α7 nicotinic receptors modulate memory reconsolidation of an inhibitory avoidance task in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Avoidance Learning; Choline; Hippocampus; Inhibition, Psychological; Male; Memory; Mice; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic | 2010 |
Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Apoptosis; Benzamides; Bridged Bicyclo Compounds; Cells, Cultured; Cytoprotection; Drug Evaluation, Preclinical; Heme Oxygenase-1; Humans; Janus Kinase 2; Nicotinic Agonists; Nicotinic Antagonists; Oncogene Protein v-akt; Oxidative Stress; Reactive Oxygen Species; Receptors, Nicotinic; Signal Transduction; Time Factors | 2010 |
The sensitizing effect of acute nicotine on amphetamine-stimulated behavior and dopamine efflux requires activation of β2 subunit-containing nicotinic acetylcholine receptors and glutamate N-methyl-D-aspartate receptors.
Topics: Aconitine; Amphetamine; Animals; Behavior, Animal; Benzazepines; Central Nervous System Stimulants; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Female; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Varenicline | 2011 |
Human platelets express functional alpha7-nicotinic acetylcholine receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Benzamides; Blood Platelets; Bridged Bicyclo Compounds; Bungarotoxins; Calcium; Cell Line; Humans; Megakaryocytes; Nicotinic Agonists; Nicotinic Antagonists; Platelet Activation; Platelet Aggregation; Receptors, Fibrinogen; Receptors, Nicotinic; RNA, Messenger | 2011 |
Fast synaptic transmission in the goldfish CNS mediated by multiple nicotinic receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Axons; Bungarotoxins; Central Nervous System; Conotoxins; Dihydro-beta-Erythroidine; Electric Stimulation; Excitatory Postsynaptic Potentials; Goldfish; Humans; Kinetics; Male; Neurons; Nicotinic Antagonists; Receptors, Nicotinic; Rhombencephalon; Synaptic Transmission | 2011 |
The role of nicotinic acetylcholine receptor (nAChR) α7 subtype in the functional interaction between nicotine and ethanol in mouse cerebellum.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Ataxia; Benzamides; Bridged Bicyclo Compounds; Cerebellum; Dose-Response Relationship, Drug; Ethanol; Infusions, Intraventricular; Male; Mice; Nicotine; Receptors, Nicotinic | 2011 |
Blocking α4β2 and α7 nicotinic acetylcholine receptors inhibits the reinstatement of morphine-induced CPP by drug priming in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Cholinergic Antagonists; Conditioning, Operant; Dihydro-beta-Erythroidine; Drug Interactions; Extinction, Psychological; Male; Mice; Mice, Inbred BALB C; Morphine; Motor Activity; Narcotics; Nicotine; Nicotinic Agonists; Reaction Time; Receptors, Nicotinic; Reinforcement, Psychology; Time Factors | 2011 |
Functional nicotinic acetylcholine receptors containing α6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neurons.
Topics: 4-Aminopyridine; Acetylcholine; Aconitine; Animals; Animals, Newborn; Bungarotoxins; Calcium; Conotoxins; Dihydro-beta-Erythroidine; Dopamine; Drug Interactions; Excitatory Amino Acid Agents; Female; GABA Agents; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Knockout; Neurons; Nicotine; Nicotinic Antagonists; Potassium Channel Blockers; Presynaptic Terminals; Protein Binding; Rats; Rats, Wistar; Receptors, Nicotinic; Synaptosomes; Ventral Tegmental Area | 2011 |
Quantification of methyllycaconitine, selective α7 nicotinic receptor antagonist, in rodent plasma and brain tissue by liquid chromatography tandem mass spectrometry--application to neuropharmacokinetics of methyllycaconitine in rats.
Topics: Aconitine; Animals; Brain; Brain Chemistry; Chromatography, Liquid; Linear Models; Rats; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2011 |
Cholinergic drugs inhibit in vitro megakaryopoiesis via the alpha7-nicotinic acetylcholine receptor.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Blotting, Western; Cell Differentiation; Cell Line; Cholinergic Agents; Down-Regulation; Flow Cytometry; Gene Expression Regulation; Humans; Integrin beta3; Megakaryocyte Progenitor Cells; Nicotine; Nicotinic Antagonists; Phorbol Esters; Platelet Membrane Glycoprotein IIb; Polymerase Chain Reaction; Receptors, Nicotinic; RNA, Messenger; Signal Transduction; Thrombopoiesis | 2011 |
Selective nicotinic receptor antagonists: effects on attention and nicotine-induced attentional enhancement.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Behavior, Animal; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Interactions; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 2011 |
Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.
Topics: Acetylcholine; Aconitine; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding Sites; Computer Simulation; Electrophysiology; Humans; Membrane Transport Modulators; Mice; Models, Molecular; Molecular Structure; Mutation, Missense; Naphthalenes; Nicotinic Agonists; Patch-Clamp Techniques; Quinolines; Receptors, Nicotinic; Sulfonamides; Xenopus laevis | 2011 |
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
Topics: Aconitine; Anticarcinogenic Agents; Catechin; Humans; Molecular Targeted Therapy; Neoplasms; Nicotinic Antagonists; Receptors, Nicotinic; Signal Transduction; Smoking; Terpenes | 2011 |
The acute toxicity of the death camas (Zigadenus species) alkaloid zygacine in mice, including the effect of methyllycaconitine coadministration on zygacine toxicity.
Topics: Aconitine; Alkaloids; Animals; Delphinium; Lethal Dose 50; Livestock; Male; Mice; Nevada; Pharmacokinetics; Plant Poisoning; Seasons; Utah; Zigadenus | 2011 |
Potentiation of the actions of acetylcholine, epibatidine, and nicotine by methyllycaconitine at fetal muscle-type nicotinic acetylcholine receptors.
Topics: Acetylcholine; Aconitine; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cholinesterase Inhibitors; Diterpenes; Drug Synergism; Fetus; Humans; Ligands; Membrane Potentials; Muscles; Neostigmine; Nicotine; Nicotinic Agonists; Pyridines; Receptors, Nicotinic; Structure-Activity Relationship | 2011 |
Nicotine's central cardiovascular actions: receptor subtypes involved and their possible physiological role in anaesthetized rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Anesthesia; Animals; Antidiuretic Hormone Receptor Antagonists; Cardiovascular System; Dihydro-beta-Erythroidine; Male; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2011 |
Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures.
Topics: Aconitine; Amino Acid Motifs; Animals; Benzylidene Compounds; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Carrier Proteins; Computer Simulation; Imidazoles; Lobeline; Lymnaea; Models, Molecular; Neonicotinoids; Nicotinic Agonists; Nicotinic Antagonists; Nitro Compounds; Protein Binding; Pyridines; Surface Properties | 2011 |
Pharmacological characterization of native α7 nicotinic ACh receptors and their contribution to depolarization-elicited exocytosis in human chromaffin cells.
Topics: Acetylcholine; Aconitine; Adolescent; Adult; Aged; alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Cell Membrane; Cells, Cultured; Chromaffin Cells; Exocytosis; Female; Humans; Male; Middle Aged; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Receptors, Nicotinic; Secretory Vesicles; Young Adult | 2012 |
Decreased α4β2 nicotinic receptor number in the absence of mRNA changes suggests post-transcriptional regulation in the spontaneously hypertensive rat model of ADHD.
Topics: Aconitine; Animals; Attention Deficit Disorder with Hyperactivity; Azetidines; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; In Vitro Techniques; Kinetics; Male; Membranes; Nicotinic Agonists; Nicotinic Antagonists; Protein Processing, Post-Translational; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thermodynamics | 2011 |
Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin.
Topics: Aconitine; Adjuvants, Anesthesia; Analgesics; Animals; Antihypertensive Agents; Atropine; Cobra Neurotoxin Proteins; Drug Interactions; Formaldehyde; Male; Mecamylamine; Naloxone; Narcotic Antagonists; Nicotinic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic | 2011 |
Activation of nicotinic cholinergic receptors prevents ventilator-induced lung injury in rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Anesthesia; Animals; Benzamides; Bridged Bicyclo Compounds; Enzyme-Linked Immunosorbent Assay; Interleukin-6; Lung; Male; Nicotinic Agonists; Nicotinic Antagonists; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Substance P; Ventilator-Induced Lung Injury | 2011 |
Nicotinic excitatory postsynaptic potentials in hippocampal CA1 interneurons are predominantly mediated by nicotinic receptors that contain α4 and β2 subunits.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Aconitine; Animals; Biophysics; CA1 Region, Hippocampal; Channelrhodopsins; Cholinergic Fibers; Diagonal Band of Broca; Dihydro-beta-Erythroidine; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Interneurons; Light; Mice; Neural Pathways; Nicotine; Nicotinic Antagonists; Optics and Photonics; Patch-Clamp Techniques; Quinoxalines; Receptors, Nicotinic; Transduction, Genetic; Voltage-Sensitive Dye Imaging | 2011 |
NNK enhances cell migration through α7-nicotinic acetylcholine receptor accompanied by increased of fibronectin expression in gastric cancer.
Topics: Aconitine; Adenocarcinoma; alpha7 Nicotinic Acetylcholine Receptor; Carcinogens; Cell Line, Tumor; Cell Movement; Fibronectins; Genetic Vectors; Humans; Nitrosamines; Plasmids; Receptors, Nicotinic; RNA Interference; Stomach Neoplasms; Transfection; Up-Regulation | 2012 |
α7-Containing and non-α7-containing nicotinic receptors respond differently to spillover of acetylcholine.
Topics: Acetylcholine; Aconitine; Anesthetics, Local; Animals; Biophysical Phenomena; Cadmium Chloride; Calcium Channel Blockers; Chick Embryo; Cholinesterase Inhibitors; Conotoxins; Echothiophate Iodide; Excitatory Postsynaptic Potentials; Female; Ganglia, Parasympathetic; Lidocaine; Male; Models, Biological; Neurons; Nicotinic Antagonists; omega-Conotoxin GVIA; Patch-Clamp Techniques; Protein Subunits; Receptors, Nicotinic; Time Factors | 2011 |
Plasticity of prefrontal attention circuitry: upregulated muscarinic excitability in response to decreased nicotinic signaling following deletion of α5 or β2 subunits.
Topics: Acetylcholine; Aconitine; Age Factors; Analysis of Variance; Animals; Atropine; Dihydro-beta-Erythroidine; Intracellular Signaling Peptides and Proteins; Male; Membrane Potentials; Mice; Mice, Knockout; Neuronal Plasticity; Neurons; Neuropeptides; Neurotransmitter Agents; Nicotine; Nicotinic Antagonists; Orexins; Patch-Clamp Techniques; Prefrontal Cortex; Receptors, Muscarinic; Receptors, Nicotinic; Signal Transduction; Up-Regulation | 2011 |
Effects of preconditioning on the resistance to acute hypobaric hypoxia and their correction with selective antagonists of nicotinic receptors.
Topics: Aconitine; Adaptation, Physiological; Air Pressure; Animals; Asphyxia; Hypoxia; Male; Mecamylamine; Nicotinic Antagonists; Rats; Receptors, Nicotinic | 2011 |
Activation of cholinergic anti-inflammatory pathway contributes to the protective effects of 100% oxygen inhalation on zymosan-induced generalized inflammation in mice.
Topics: Aconitine; Animals; Cytokines; Kidney; Kidney Function Tests; Liver; Liver Function Tests; Lung; Male; Mecamylamine; Mice; Mice, Inbred ICR; Myocardium; Nicotinic Antagonists; Oxygen; Receptors, Nicotinic; Respiratory Insufficiency; Systemic Inflammatory Response Syndrome; Vagotomy; Zymosan | 2012 |
Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Conditioning, Psychological; Cues; Fear; Hippocampus; Injections, Intraventricular; Male; Maze Learning; Mice; Mice, Inbred C57BL; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic | 2012 |
Regulation of GABAergic inputs to CA1 pyramidal neurons by nicotinic receptors and kynurenic acid.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; CA1 Region, Hippocampal; GABAergic Neurons; In Vitro Techniques; Kynurenic Acid; Kynurenine; Male; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Schizophrenia; Sodium Channel Blockers; Synaptic Transmission; Tetrodotoxin | 2012 |
Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats.
Topics: Aconitine; Animals; Azetidines; Body Temperature Regulation; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Nicotine; Nicotinic Antagonists; Pyridines; Rats; Receptors, Nicotinic | 2012 |
Endogenously released ACh and exogenous nicotine differentially facilitate long-term potentiation induction in the hippocampal CA1 region of mice.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Animals, Newborn; Biophysics; CA1 Region, Hippocampal; Dihydro-beta-Erythroidine; Electric Stimulation; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Receptors, Nicotinic; Synaptic Potentials | 2012 |
Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.
Topics: Aconitine; Adrenergic beta-Antagonists; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Cell Line; Disease Models, Animal; Immune Tolerance; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Nicotinic Agonists; Nicotinic Antagonists; Pneumonia, Bacterial; Pseudomonas aeruginosa; Pseudomonas Infections; Pulmonary Edema; Receptors, Nicotinic; Signal Transduction | 2012 |
Paired nanoinjection and electrophysiology assay to screen for bioactivity of compounds using the Drosophila melanogaster giant fiber system.
Topics: Aconitine; Animals; Citrates; Drosophila melanogaster; Drug Evaluation, Preclinical; Insecticides; Nanotechnology; Nerve Fibers; Nicotinic Antagonists | 2012 |
Nicotine exposure and the progression of chronic kidney disease: role of the α7-nicotinic acetylcholine receptor.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood Pressure; Chronic Disease; Disease Models, Animal; Disease Progression; Kidney Diseases; Male; NADPH Oxidase 4; NADPH Oxidases; Nephrectomy; Nicotine; Nicotinic Antagonists; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Transforming Growth Factor beta | 2012 |
Methyllycaconitine: a non-radiolabeled ligand for mapping α7 neuronal nicotinic acetylcholine receptors - in vivo target localization and biodistribution in rat brain.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Benzofurans; Binding Sites; Brain; Brain Chemistry; Bridged Bicyclo Compounds; Dose-Response Relationship, Drug; Ligands; Male; Nicotinic Antagonists; Quinuclidines; Rats; Rats, Wistar; Receptors, Nicotinic | 2012 |
Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Ulcer Agents; Benzamides; Fenclonine; Indoles; Indomethacin; Intestinal Diseases; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Morpholines; Ondansetron; Receptors, Nicotinic; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides; Ulcer | 2012 |
Activation of the alpha-7 nicotinic acetylcholine receptor (α7 nAchR) reverses referred mechanical hyperalgesia induced by colonic inflammation in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds; Colitis; Dose-Response Relationship, Drug; Drug Antagonism; Hyperalgesia; Male; Mice; Mice, Inbred Strains; Molecular Targeted Therapy; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pain Threshold; Pain, Referred; Random Allocation; Receptors, Nicotinic | 2012 |
Nicotine enhances both excitatory and inhibitory synaptic inputs to inspiratory-activated airway vagal preganglionic neurons.
Topics: Acetylcholine; Aconitine; Animals; Animals, Newborn; Dihydro-beta-Erythroidine; Excitatory Postsynaptic Potentials; Glycine; Neostigmine; Neurons; Nicotine; Patch-Clamp Techniques; Rats; Receptors, Nicotinic; Vagus Nerve | 2013 |
Identifying the binding site of novel methyllycaconitine (MLA) analogs at α4β2 nicotinic acetylcholine receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amino Acid Substitution; Animals; Binding Sites; Cysteine; Dose-Response Relationship, Drug; Ethyl Methanesulfonate; Female; Membrane Potentials; Models, Chemical; Models, Molecular; Molecular Structure; Mustard Compounds; Mutagenesis, Site-Directed; Oocytes; Protein Binding; Protein Conformation; Rats; Receptors, Nicotinic; Recombinant Proteins; Structure-Activity Relationship; Xenopus | 2010 |
Acetylcholine precursor choline evokes NMDA-dependent epileptoid activity in rat hippocampal CA1 area.
Topics: Aconitine; Action Potentials; Animals; CA1 Region, Hippocampal; Choline; Dizocilpine Maleate; Epilepsy; Excitatory Amino Acid Antagonists; In Vitro Techniques; Nicotinic Antagonists; Pyramidal Tracts; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2011 |
The α7 nicotinic acetylcholine receptor ligands methyllycaconitine, NS6740 and GTS-21 reduce lipopolysaccharide-induced TNF-α release from microglia.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Azabicyclo Compounds; Benzylidene Compounds; Furans; Lipopolysaccharides; Male; MAP Kinase Signaling System; Microglia; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tumor Necrosis Factor-alpha | 2012 |
Nicotine-induced enhancement of responding for conditioned reinforcement in rats: role of prior nicotine exposure and α4β2 nicotinic receptors.
Topics: Aconitine; Animals; Conditioning, Operant; Dihydro-beta-Erythroidine; Male; Mecamylamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Rats; Rats, Long-Evans; Receptors, Nicotinic; Reinforcement Schedule | 2013 |
Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials.
Topics: Aconitine; Animals; Calcium Signaling; Event-Related Potentials, P300; Evoked Potentials, Auditory; Humans; Male; Mice; Nicotine; Nicotinic Antagonists; Receptors, Nicotinic | 2012 |
Noradrenergic but not cholinergic modulation of olfactory bulb during processing of near threshold concentration stimuli.
Topics: Aconitine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alprenolol; Animals; Carbachol; Choice Behavior; Cholinergic Agonists; Habituation, Psychophysiologic; Male; Muscarinic Antagonists; Nicotinic Antagonists; Norepinephrine; Odorants; Olfactory Bulb; Olfactory Perception; Phentolamine; Rats; Rats, Sprague-Dawley; Scopolamine; Sensory Thresholds | 2012 |
Role of α7- and α4β2-nAChRs in the neuroprotective effect of nicotine in stress-induced impairment of hippocampus-dependent memory.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Dihydro-beta-Erythroidine; Disease Models, Animal; Drug Delivery Systems; Hippocampus; Male; Maze Learning; Memory Disorders; Neuroprotective Agents; Nicotine; Nicotinic Antagonists; Rats; Rats, Wistar; Receptors, Nicotinic; Stress, Psychological; Time Factors | 2013 |
Presynaptic α4β2 nicotinic acetylcholine receptors increase glutamate release and serotonin neuron excitability in the dorsal raphe nucleus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Aconitine; Animals; Animals, Newborn; Atropine; Bicuculline; Cadmium Chloride; Chelating Agents; Cholinergic Agonists; Dihydro-beta-Erythroidine; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Indoles; Male; Muscarinic Antagonists; Nicotine; Nicotinic Antagonists; Patch-Clamp Techniques; Physostigmine; Presynaptic Terminals; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Nicotinic; Ryanodine; Serotonergic Neurons; Serotonin; Sodium Channel Blockers; Tetrodotoxin | 2012 |
Effect of α₇ nicotinic acetylcholine receptor agonists and antagonists on motor function in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Anabasine; Animals; Diterpenes; Male; Mice; Motor Activity; Muscle, Skeletal; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic | 2013 |
3,4-Methylenedioxy-methamphetamine induces in vivo regional up-regulation of central nicotinic receptors in rats and potentiates the regulatory effects of nicotine on these receptors.
Topics: Aconitine; Animals; Blotting, Western; Brain; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration Schedule; Drug Synergism; Immunoprecipitation; Injections, Subcutaneous; Male; N-Methyl-3,4-methylenedioxyamphetamine; Nicotine; Nicotinic Agonists; Paroxetine; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Serotonin Plasma Membrane Transport Proteins; Time Factors; Up-Regulation | 2013 |
The role of the α7 subunit of the nicotinic acetylcholine receptor in the acute toxicosis of methyllycaconitine in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Female; Lethal Dose 50; Logistic Models; Male; Mice; Mice, Knockout; Toxicity Tests, Acute | 2013 |
Activation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT₁a receptor antagonist.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anxiety; Behavior, Animal; Benzamides; Bridged Bicyclo Compounds; Drug Interactions; Isoxazoles; Learning; Male; Memory Disorders; Nicotinic Agonists; Nicotinic Antagonists; Phenylurea Compounds; Piperazines; Rats; Scopolamine; Serotonin 5-HT1 Receptor Antagonists | 2013 |
In hippocampal oriens interneurons anti-Hebbian long-term potentiation requires cholinergic signaling via α7 nicotinic acetylcholine receptors.
Topics: Aconitine; Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; CA1 Region, Hippocampal; Cholinergic Neurons; Dihydro-beta-Erythroidine; Excitatory Postsynaptic Potentials; Interneurons; Long-Term Potentiation; Mice; Mice, Transgenic; Nicotinic Antagonists; Patch-Clamp Techniques; Receptors, Nicotinic; Synapses | 2013 |
Improvement of attentional function with antagonism of nicotinic receptors in female rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Dihydro-beta-Erythroidine; Dizocilpine Maleate; Female; Nicotine; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2013 |
Nicotine primes the effect of cocaine on the induction of LTP in the amygdala.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amygdala; Animals; Bridged-Ring Compounds; Cocaine; Dihydro-beta-Erythroidine; Dopamine Uptake Inhibitors; Drug Synergism; Histone Deacetylase Inhibitors; Hydroxamic Acids; Long-Term Potentiation; Male; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Spiro Compounds; Time Factors; Vorinostat | 2013 |
PHA-543613 preserves blood-brain barrier integrity after intracerebral hemorrhage in mice.
Topics: Aconitine; Androstadienes; Animals; beta Catenin; Blood-Brain Barrier; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Hemorrhage; Claudin-3; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred Strains; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinuclidines; Receptors, Nicotinic; Signal Transduction; Wortmannin | 2013 |
The role of the α7 subunit of the nicotinic acetylcholine receptor on motor coordination in mice treated with methyllycaconitine and anabasine.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Anabasine; Animals; Female; Hand Strength; Lethal Dose 50; Male; Mice; Mice, Knockout | 2013 |
High-resolution spatio-temporal bioactivity of a novel peptide revealed by optical imaging in rat orbitofrontal cortex in vitro: possible implications for neurodegenerative diseases.
Topics: Acetylcholinesterase; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dose-Response Relationship, Drug; Drug Synergism; Male; Neurodegenerative Diseases; Optical Imaging; Peptide Fragments; Prefrontal Cortex; Rats | 2013 |
Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cell Survival; Cells, Cultured; Glutamic Acid; Indoles; Neuroprotective Agents; Nicotinic Agonists; Nicotinic Antagonists; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Signal Transduction; Swine; Tropisetron | 2013 |
Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agonists; Cholinergic Antagonists; Cognition; Female; Iontophoresis; Macaca mulatta; Male; Mecamylamine; Microscopy, Immunoelectron; N-Methylaspartate; Phenols; Piperidines; Prefrontal Cortex; Quinuclidines; Receptors, Nicotinic; Spatial Behavior; Synapses; Visual Perception | 2013 |
Anti-inflammation of spirocyclopiperazinium salt compound LXM-10 targeting α7 nAChR and M4 mAChR and inhibiting JAK2/STAT3 pathway in rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Inflammation Mediators; Interleukin-6; Janus Kinase 2; Male; Muscarinic Antagonists; Nicotinic Antagonists; Phosphorylation; Piperazines; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M4; Signal Transduction; Spiro Compounds; STAT3 Transcription Factor; Tropicamide; Tumor Necrosis Factor-alpha | 2013 |
Flattening plasma corticosterone levels increases the prevalence of serotonergic dorsal raphe neurons inhibitory responses to nicotine in adrenalectomised rats.
Topics: Aconitine; Action Potentials; Adrenalectomy; Animals; Corticosterone; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Male; Neural Inhibition; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Wistar; Serotonergic Neurons; Serotonin; Serotonin Antagonists | 2013 |
Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed.
Topics: Aconitine; Animals; Binding Sites; Cysteine; Escherichia coli; Female; Ligands; Maleimides; Mutagenesis, Site-Directed; Nicotinic Antagonists; Oocytes; Protein Binding; Protein Conformation; Rats; Receptors, Nicotinic; Recombinant Proteins; Xenopus laevis | 2013 |
Effects of blockade of α4β2 and α7 nicotinic acetylcholine receptors on cue-induced reinstatement of nicotine-seeking behaviour in rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Conditioning, Operant; Cues; Dihydro-beta-Erythroidine; Drug-Seeking Behavior; Extinction, Psychological; Food; Male; Nicotine; Nicotinic Antagonists; Rats; Receptors, Nicotinic; Reinforcement Schedule; Self Administration | 2014 |
Contribution of CA3 and CA1 pyramidal neurons to the tonic α7 nAChR-dependent glutamatergic input to CA1 pyramidal neurons.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Pyramidal Cells; Rats, Sprague-Dawley; Sodium Channel Blockers; Synaptic Transmission; Tetrodotoxin | 2013 |
The effects of nicotine and tobacco particulate matter on dopamine uptake in the rat brain.
Topics: Aconitine; Animals; Brain; Dihydro-beta-Erythroidine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Mecamylamine; Nicotiana; Nicotine; Nicotinic Antagonists; Norepinephrine Plasma Membrane Transport Proteins; Organ Specificity; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger; Smoking; Tobacco Smoke Pollution | 2014 |
Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells.
Topics: Aconitine; Animals; Cell Line; Cell Line, Tumor; Gene Expression Regulation; Humans; Mecamylamine; Nicotine; Nicotinic Antagonists; PC12 Cells; Racemases and Epimerases; Rats; Receptors, Nicotinic; Signal Transduction; TOR Serine-Threonine Kinases | 2013 |
Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Classical; Gene Regulatory Networks; Genetic Variation; Mice; Mice, Inbred C57BL; Nicotine; Nucleus Accumbens; Phenotype; Quantitative Trait Loci; Quinuclidines; Reward; RNA, Messenger | 2014 |
Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish.
Topics: Aconitine; Alkaloids; Animals; Azocines; Cholinergic Agents; Conotoxins; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Maze Learning; Mecamylamine; Memory; Muscarinic Antagonists; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Quinolizines; Receptors, Nicotinic; Scopolamine; Swimming; Zebrafish; Zebrafish Proteins | 2014 |
SLURP-1, an endogenous α7 nicotinic acetylcholine receptor allosteric ligand, is expressed in CD205(+) dendritic cells in human tonsils and potentiates lymphocytic cholinergic activity.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antibodies; Antigens, CD; Antigens, Ly; Cell Line, Transformed; Cell Proliferation; Choline O-Acetyltransferase; Dendritic Cells; Gene Expression Regulation; Humans; Lectins, C-Type; Lymphocytes; Minor Histocompatibility Antigens; Mitogens; Nicotinic Antagonists; Palatine Tonsil; Phytohemagglutinins; Radioimmunoassay; Receptors, Cell Surface; RNA, Messenger; Tonsillitis; Urokinase-Type Plasminogen Activator | 2014 |
Possible involvement of endogenous opioid system located downstream of α7 nicotinic acetylcholine receptor in mice with physical dependence on nicotine.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Biomarkers; Corticosterone; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Nicotine; Opioid Peptides; Substance Withdrawal Syndrome; Tobacco Use Disorder | 2014 |
α7 nicotinic acetylcholine receptors control cytochrome c release from isolated mitochondria through kinase-mediated pathways.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Androstadienes; Animals; Benzamides; Bridged Bicyclo Compounds; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cytochromes c; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nicotinic Agonists; Nicotinic Antagonists; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; src-Family Kinases; Superoxides; Wortmannin | 2014 |
Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Buspirone; Female; Heme Oxygenase-1; Interleukin-1beta; Intestinal Mucosa; Intestines; Malondialdehyde; Membrane Proteins; Mice; Nicotinic Antagonists; Peroxidase; Piperazines; Receptor, Serotonin, 5-HT1A; Reperfusion Injury; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Tumor Necrosis Factor-alpha | 2014 |
CDP-choline attenuates scopolamine induced disruption of prepulse inhibition in rats: involvement of central nicotinic mechanism.
Topics: Aconitine; Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cytidine Diphosphate Choline; Male; Mecamylamine; Nicotinic Antagonists; Prepulse Inhibition; Rats, Sprague-Dawley; Reflex, Startle; Scopolamine | 2014 |
A potentially novel nicotinic receptor in Aplysia neuroendocrine cells.
Topics: Acetylcholine; Aconitine; Action Potentials; Animals; Aplysia; Conotoxins; Dihydro-beta-Erythroidine; Hexamethonium; Mecamylamine; Neuroendocrine Cells; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Strychnine; Transcriptome | 2014 |
The novel α7 nicotinic acetylcholine receptor agonist EVP-6124 enhances dopamine, acetylcholine, and glutamate efflux in rat cortex and nucleus accumbens.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Prefrontal Cortex; Quinuclidines; Rats; Rats, Sprague-Dawley; Thiophenes | 2014 |
Selective activation of α7 nicotinic acetylcholine receptor (nAChRα7) inhibits muscular degeneration in mdx dystrophic mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Bupivacaine; Cell Death; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Male; Mice, Inbred C57BL; Mice, Inbred mdx; Mice, Knockout; Muscle, Skeletal; Muscular Dystrophy, Animal; Muscular Dystrophy, Duchenne; Necrosis; Nicotinic Agonists; Nicotinic Antagonists; Regeneration | 2014 |
Corticosterone affects the differentiation of a neuronal cerebral cortex-derived cell line through modulation of the nicotinic acetylcholine receptor.
Topics: Aconitine; Animals; Cell Cycle; Cell Line; Cell Membrane; Cell Proliferation; Cerebral Cortex; Corticosterone; Mice; Neurogenesis; Neurons; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Patch-Clamp Techniques; Receptors, Nicotinic | 2014 |
(R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function.
Topics: Aconitine; Animals; Blotting, Western; Brain; Excitatory Amino Acid Antagonists; Ketamine; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; PC12 Cells; Phosphorylation; Prefrontal Cortex; Rats; Rats, Wistar; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Functional expression of α7-nicotinic acetylcholine receptors by muscle afferent neurons.
Topics: Aconitine; Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; Capsaicin; Cholinergic Neurons; Conotoxins; Dihydro-beta-Erythroidine; Ganglia, Spinal; Male; Muscle, Skeletal; Neurons, Afferent; Rats; Rats, Sprague-Dawley | 2014 |
Does hepatic vagus nerve modulate the progression of biliary fibrosis in rats?
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Aspartate Aminotransferases; Chemokine CCL2; Disease Models, Animal; Disease Progression; Epithelium; Hepatocytes; Liver; Liver Cirrhosis, Biliary; Male; Myofibroblasts; Nicotinic Antagonists; Rats, Sprague-Dawley; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Vagotomy; Vagus Nerve | 2014 |
Crystal structures of free and antagonist-bound states of human α9 nicotinic receptor extracellular domain.
Topics: Acetylcholine; Aconitine; Action Potentials; Animals; Bungarotoxins; Crystallography, X-Ray; Gene Expression; Humans; Models, Molecular; Mutation; Nicotine; Oocytes; Patch-Clamp Techniques; Pichia; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Receptors, Nicotinic; Recombinant Proteins; RNA, Complementary; Xenopus laevis | 2014 |
Methyllycaconitine alleviates amyloid-β peptides-induced cytotoxicity in SH-SY5Y cells.
Topics: Aconitine; Amyloid beta-Peptides; Autophagy; Cell Line, Tumor; Cell Proliferation; Humans; Peptide Fragments; Signal Transduction; TOR Serine-Threonine Kinases | 2014 |
Protective role of the cholinergic anti-inflammatory pathway in a mouse model of viral myocarditis.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Cytokines; Enterovirus B, Human; Gene Expression Regulation; Interleukin-6; Mice; Mice, Inbred BALB C; Myocarditis; Nicotine; Signal Transduction; STAT3 Transcription Factor; Survival Analysis; Tumor Necrosis Factor-alpha | 2014 |
Varenicline aggravates plaque formation through α7 nicotinic acetylcholine receptors in ApoE KO mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Apolipoproteins E; Benzazepines; Body Weight; Cardiovascular Diseases; Cholesterol; Disease Models, Animal; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotinic Agonists; Plaque, Atherosclerotic; Quinoxalines; Varenicline | 2014 |
Administration of nicotinic receptor antagonists during the period of memory consolidation affects passive avoidance learning and modulates synaptic efficiency in the CA1 region in vivo.
Topics: Aconitine; Animals; Avoidance Learning; CA1 Region, Hippocampal; Dihydro-beta-Erythroidine; Electrodes, Implanted; Excitatory Postsynaptic Potentials; Male; Mecamylamine; Memory Consolidation; Nicotinic Antagonists; Rats, Wistar; Receptors, Nicotinic; Synapses | 2015 |
Involvement of stimulation of α7 nicotinic acetylcholine receptors in the suppressive effect of tropisetron on dextran sulfate sodium-induced colitis in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Indoles; Inflammation Mediators; Male; Mice, Inbred ICR; Peroxidase; Tropisetron | 2015 |
Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25-35-mediated cognitive deficits in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Galantamine; Gene Expression Regulation; Male; Maze Learning; Mice; Mice, Inbred BALB C; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Psychomotor Performance; Quinuclidines; RNA, Messenger; Time Factors | 2015 |
Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons.
Topics: Aconitine; Cells, Cultured; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Isoxazoles; Neurons; Phenylurea Compounds; Receptors, Nicotinic; Single-Cell Analysis | 2015 |
A novel nicotinic mechanism underlies β-amyloid-induced neurotoxicity.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cells, Cultured; Dihydro-beta-Erythroidine; Dose-Response Relationship, Drug; Hippocampus; Humans; Immunoprecipitation; L-Lactate Dehydrogenase; Mecamylamine; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Atomic Force; Neurons; Neuroprotective Agents; Nicotinic Antagonists; Patch-Clamp Techniques; Receptors, Nicotinic | 2015 |
Biomolecular recognition of antagonists by α7 nicotinic acetylcholine receptor: Antagonistic mechanism and structure-activity relationships studies.
Topics: Aconitine; Algorithms; alpha7 Nicotinic Acetylcholine Receptor; Binding Sites; Computer-Aided Design; Crystallography, X-Ray; Drug Design; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Mutation; Nicotinic Antagonists; Pattern Recognition, Automated; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Surface Properties | 2015 |
Hippocampal GABAergic interneurons coexpressing alpha7-nicotinic receptors and connexin-36 are able to improve neuronal viability under oxygen-glucose deprivation.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Animals, Newborn; Carbenoxolone; Connexins; GABA Antagonists; gamma-Aminobutyric Acid; Gap Junction delta-2 Protein; Gene Expression Regulation; Glucose; Glutamate Decarboxylase; Hippocampus; Hypoxia; In Vitro Techniques; Interneurons; Mefloquine; Mitochondria; Nicotinic Antagonists; Organ Culture Techniques; Patch-Clamp Techniques; Pyridazines; Rats; Rats, Wistar; Synaptic Transmission | 2015 |
Modulation of aggressive behavior in mice by nicotinic receptor subtypes.
Topics: Aconitine; Aggression; Animals; Behavior, Animal; Dihydro-beta-Erythroidine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic | 2015 |
r-bPiDI, an α6β2* Nicotinic Receptor Antagonist, Decreases Nicotine-Evoked Dopamine Release and Nicotine Reinforcement.
Topics: Aconitine; Animals; Behavior, Animal; Conotoxins; Corpus Striatum; Dopamine; Male; Nicotine; Nicotinic Antagonists; Picolines; Pyridinium Compounds; Rats, Sprague-Dawley; Receptors, Nicotinic | 2015 |
Alpha7 nicotinic acetylcholine receptor is required for blood-brain barrier injury-related CNS disorders caused by Cryptococcus neoformans and HIV-1 associated comorbidity factors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood-Brain Barrier; Central Nervous System Stimulants; Coinfection; Cryptococcus neoformans; HIV Envelope Protein gp41; HIV Infections; HIV-1; Inflammation; Meningitis, Cryptococcal; Methamphetamine; Mice; Mice, Knockout; NF-kappa B; Nicotinic Antagonists | 2015 |
Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant-Induced Monoarthritis in Mice.
Topics: Aconitine; Adjuvants, Immunologic; alpha7 Nicotinic Acetylcholine Receptor; Animals; Apolipoproteins E; Arthritis, Experimental; Bridged-Ring Compounds; Cell Movement; Cell Proliferation; Disease Models, Animal; Disease Progression; Freund's Adjuvant; Inflammation; Injections, Intra-Articular; Lipopolysaccharides; Male; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nicotinic Antagonists; Peptide Fragments; Pyrroles; Spiro Compounds; Xanthones | 2016 |
The effect of administering multiple doses of tall larkspur (Delphinium barbeyi) to cattle.
Topics: Aconitine; Alkaloids; Animals; Cattle; Cattle Diseases; Delphinium; Diterpenes; Plant Poisoning; Plants, Toxic; United States | 2015 |
Differential discriminative-stimulus effects of cigarette smoke condensate and nicotine in nicotine-discriminating rats.
Topics: Aconitine; Animals; Dihydro-beta-Erythroidine; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Male; Nicotine; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Smoking; Time Factors | 2016 |
Attenuation of neuroinflammation by dexmedetomidine is associated with activation of a cholinergic anti-inflammatory pathway in a rat tibial fracture model.
Topics: Aconitine; Adrenergic alpha-2 Receptor Agonists; alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Dexmedetomidine; Disease Models, Animal; Encephalitis; Hippocampus; Interleukin-1beta; Male; Microglia; Neuroprotective Agents; NF-kappa B; Rats; Rats, Sprague-Dawley; Tibial Fractures; Tumor Necrosis Factor-alpha | 2016 |
Diurnal Variation of the Peripheral Cholinergic Antiinflammatory Function in Mice.
Topics: Acetylcholine; Aconitine; Animals; Circadian Rhythm; Corticosterone; Cytokines; Disease Models, Animal; Hormone Antagonists; Inflammation; Kidney; Lipopolysaccharides; Liver; Mice; Mice, Inbred C57BL; Mifepristone; Nicotinic Antagonists; Vesicular Acetylcholine Transport Proteins | 2016 |
Alpha-7 nicotinic acetylcholine receptor (nAChR) agonist inhibits the development of endometriosis by regulating inflammation.
Topics: Aconitine; Adult; alpha7 Nicotinic Acetylcholine Receptor; Animals; Ascitic Fluid; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Endometriosis; Endometrium; Female; Gene Expression Regulation; Humans; Interleukin-1beta; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Mice; Nicotine; Primary Cell Culture; Quinuclidines; RNA, Messenger; Severity of Illness Index; Signal Transduction | 2016 |
Chronic nicotine treatment decreases LPS signaling through NF-κB and TLR-4 modulation in the hippocampus.
Topics: Aconitine; Animals; Hippocampus; Inflammation; Lipopolysaccharides; Male; Mecamylamine; NF-kappa B; Nicotine; Nicotinic Agonists; Rats, Wistar; Receptors, Nicotinic; Signal Transduction; Toll-Like Receptor 4 | 2017 |
The contribution of α4β2 and non-α4β2 nicotinic acetylcholine receptors to the discriminative stimulus effects of nicotine and varenicline in mice.
Topics: Aconitine; Alkaloids; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azocines; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cocaine; Dihydro-beta-Erythroidine; Discrimination, Psychological; Dopamine Uptake Inhibitors; Hypnotics and Sedatives; Ibogaine; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Midazolam; Nerve Tissue Proteins; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Quinolizines; Receptors, Nicotinic; Varenicline | 2017 |
Spinal activation of alpha7-nicotinic acetylcholine receptor attenuates posttraumatic stress disorder-related chronic pain via suppression of glial activation.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Chronic Pain; Comorbidity; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Neuroglia; Quinuclidines; Random Allocation; Rats, Sprague-Dawley; Spinal Cord; Stress Disorders, Post-Traumatic; Touch | 2017 |
Alpha7 nicotinic acetylcholine receptor is required for amyloid pathology in brain endothelial cells induced by Glycoprotein 120, methamphetamine and nicotine.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Biomarkers; Blood-Brain Barrier; Brain; Cell Movement; Cellular Senescence; Endothelial Cells; HIV Envelope Protein gp120; HL-60 Cells; Humans; Methamphetamine; Mice, Inbred C57BL; Monocytes; Nicotine; Protein Transport; Receptor for Advanced Glycation End Products; S100 Proteins; Time Factors | 2017 |
Vagal nerve stimulation reduces infarct size via a mechanism involving the alpha-7 nicotinic acetylcholine receptor and downregulation of cardiac and vascular arginase.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Arginase; Arginine; Down-Regulation; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nicotinic Antagonists; Random Allocation; Rats; Rats, Sprague-Dawley; Vagus Nerve Stimulation | 2017 |
Serum toxicokinetics after intravenous and oral dosing of larkspur toxins in goats.
Topics: Aconitine; Administration, Intravenous; Administration, Oral; Animals; Delphinium; Diterpenes; Goats; Plant Poisoning; Toxicokinetics | 2017 |
Improved Outcomes of Cardiopulmonary Resuscitation in Rats Treated With Vagus Nerve Stimulation and Its Potential Mechanism.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Cardiopulmonary Resuscitation; Male; Myocardial Reperfusion Injury; Myocardium; Pyridines; Random Allocation; Rats; Rats, Sprague-Dawley; Vagus Nerve Stimulation | 2018 |
The expression, localization and function of α7 nicotinic acetylcholine receptor in rat corpus cavernosum.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Atropine; Dose-Response Relationship, Drug; Electric Stimulation; Guanethidine; Male; NG-Nitroarginine Methyl Ester; Nicotine; Penis; Phenylephrine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2017 |
Effects of α7 Nicotinic Receptor Activation on Cell Survival in Rat Organotypic Hippocampal Slice Cultures.
Topics: Aconitine; Animals; Cell Survival; Hippocampus; Neurotoxicity Syndromes; Nicotinic Agonists; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Synaptic Transmission; Temporal Lobe | 2018 |
Protection against the Neurotoxic Effects of β-Amyloid Peptide on Cultured Neuronal Cells by Lovastatin Involves Elevated Expression of α7 Nicotinic Acetylcholine Receptors and Activating Phosphorylation of Protein Kinases.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Animals; Animals, Newborn; Butadienes; Cell Death; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cholesterol; Humans; Lovastatin; Malondialdehyde; MAP Kinase Signaling System; Nerve Tissue Proteins; Neurons; Neuroprotection; Neuroprotective Agents; Neurotoxins; Nitriles; Phosphorylation; Protein Kinases; Rats, Sprague-Dawley; RNA, Messenger; RNA, Small Interfering; Superoxide Dismutase | 2018 |
Inhibition of alpha7 nicotinic receptors in the ventral hippocampus selectively attenuates reinstatement of morphine-conditioned place preference and associated changes in AMPA receptor binding.
Topics: Aconitine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha7 Nicotinic Acetylcholine Receptor; Analgesics, Opioid; Animals; Conditioning, Classical; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extinction, Psychological; Hippocampus; Mice; Morphine; Nicotinic Antagonists; Opioid-Related Disorders; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recurrence; Tritium | 2019 |
Effects of alpha-7 nicotinic allosteric modulator PNU 120596 on depressive-like behavior after lipopolysaccharide administration in mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antidepressive Agents; Calcium-Binding Proteins; Cholinergic Agents; Depressive Disorder; Disease Models, Animal; Hippocampus; Inflammation; Isoxazoles; Lipopolysaccharides; Male; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Motor Activity; Phenylurea Compounds; Prefrontal Cortex | 2018 |
Varenicline is a smoking cessation drug that blocks alveolar expansion in mice intratracheally administrated porcine pancreatic elastase.
Topics: Aconitine; Administration, Inhalation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Emphysema; Mice, Inbred C57BL; Nicotinic Agonists; Pancreatic Elastase; Pulmonary Alveoli; Smoking Cessation; Varenicline | 2018 |
α7 Nicotinic acetylcholine receptor contributes to the alleviation of lung ischemia-reperfusion injury by transient receptor potential vanilloid type 1 stimulation.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Apoptosis; Benzamides; Bridged Bicyclo Compounds; Capsaicin; Disease Models, Animal; Down-Regulation; Humans; Lung; Lung Injury; Male; Mice; Mice, Knockout; Reperfusion Injury; Treatment Outcome; TRPV Cation Channels | 2018 |
The cholinergic anti-inflammatory pathway ameliorates acute viral myocarditis in mice by regulating CD4
Topics: Aconitine; Acute Disease; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Cholinergic Agents; Coxsackievirus Infections; Flow Cytometry; Inflammation; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Myocarditis; Myocardium; Nicotine; Nicotinic Antagonists; Spleen; Th1 Cells; Th17 Cells | 2018 |
Nicotine improves probabilistic reward learning in wildtype but not alpha7 nAChR null mutants, yet alpha7 nAChR agonists do not improve probabilistic learning.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Male; Mice; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Punishment | 2018 |
[Low-intensity pulsed ultrasound pretreatment inhibits HMGB1 expression and attenuates lung ischemia-reperfusion injury in rats
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; HMGB1 Protein; Interleukin-1; Interleukin-6; Lung; Male; Nicotinic Antagonists; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Ultrasonic Therapy; Ultrasonic Waves | 2018 |
Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.
Topics: Acetylcholine; Aconitine; Acute Kidney Injury; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinesterase Inhibitors; Galantamine; Inflammation; Mice; Mice, Inbred BALB C; Signal Transduction; Zymosan | 2018 |
Sex-dependent differences for larkspur (Delphinium barbeyi) toxicosis in yearling Angus cattle1.
Topics: Aconitine; Alkaloids; Animal Husbandry; Animals; Cattle; Cattle Diseases; Delphinium; Diterpenes; Female; Male; North America; Plant Poisoning; Plants, Toxic; Sex Factors; Walking | 2019 |
Perioperative activation of spinal α7 nAChR promotes recovery from preoperative stress-induced prolongation of postsurgical pain.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Anxiety; Astrocytes; Bridged Bicyclo Compounds, Heterocyclic; Chronic Pain; Cytokines; Hyperalgesia; Isoxazoles; Male; Microglia; Nicotinic Agonists; Phenylurea Compounds; Preoperative Period; Quinuclidines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spine; Stress, Psychological | 2019 |
Evaluation of noninvasive specimens to diagnose livestock exposure to toxic larkspur (Delphinium spp.).
Topics: Aconitine; Alkaloids; Animals; Cattle; Cattle Diseases; Chromatography, High Pressure Liquid; Delphinium; Diterpenes; Livestock; Male; Plant Poisoning; Plants, Toxic; Specimen Handling; United States | 2019 |
Acute Activation of α7-Nicotinic Receptors by Nicotine Improves Rodent Skin Flap Survival Through Nitrergic System.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Arginine; Graft Survival; Guanidines; NG-Nitroarginine Methyl Ester; Nicotine; Nitric Oxide; Rats; Rats, Sprague-Dawley; Skin Transplantation; Surgical Flaps | 2019 |
Activation of alpha7 acetylcholine receptors reduces neuropathic pain by decreasing dynorphin A release from microglia.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dynorphins; Injections, Spinal; Male; Microglia; Neuralgia; Nicotinic Agonists; Nicotinic Antagonists; Quinuclidines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves | 2019 |
Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; HEK293 Cells; Humans; Isoxazoles; Ligands; Phenylurea Compounds; Pyridines; Pyridinium Compounds; Quinuclidines; Thiophenes | 2019 |
Antagonizing α7 nicotinic receptors with methyllycaconitine (MLA) potentiates receptor activity and memory acquisition.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cognition; Disease Models, Animal; Glutamic Acid; Hippocampus; Humans; Long-Term Potentiation; Memory; Nicotinic Antagonists; Rats; Receptors, Nicotinic | 2019 |
Brainstem cholinergic pathways diminish cardiovascular and neuroinflammatory actions of endotoxemia in rats: Role of NFκB/α7/α4β2AChRs signaling.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Azetidines; Bradycardia; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Fibers; Dihydro-beta-Erythroidine; Endotoxemia; Hypotension; Infusions, Intraventricular; Lipopolysaccharides; Male; Medulla Oblongata; Neural Pathways; Neurogenic Inflammation; NF-kappa B; Nicotine; Pyridines; Quinuclidines; Rats; Receptors, Nicotinic; Signal Transduction; Solitary Nucleus; Tachycardia | 2019 |
Effect of α7nAChR on learning and memory dysfunction in a rat model of diffuse axonal injury.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Cognitive Dysfunction; Diffuse Axonal Injury; Disease Models, Animal; Learning; Male; Maze Learning; Memory; Rats; Rats, Sprague-Dawley | 2019 |
α7 Nicotinic Acetylcholine Receptor Mediates the Neuroprotection of Remote Ischemic Postconditioning in a Rat Model of Asphyxial Cardiac Arrest.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Asphyxia; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Heart Arrest; Hippocampus; Humans; Hypoxia, Brain; Ischemic Postconditioning; Male; Neuroprotection; NF-kappa B; Quinuclidines; Rats; Signal Transduction; STAT3 Transcription Factor; Treatment Outcome | 2020 |
Nicotine attenuates concanavalin A-induced liver injury in mice by regulating the α7-nicotinic acetylcholine receptor in Kupffer cells.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cells, Cultured; Concanavalin A; Disease Models, Animal; Hepatitis, Autoimmune; Humans; Kupffer Cells; Liver; Male; Mice; NF-kappa B; Nicotine; Primary Cell Culture; Protective Agents; Signal Transduction | 2020 |
AE Succinimide, an Analogue of Methyllycaconitine, When Bound Generates a Nonconducting Conformation of the α4β2 Nicotinic Acetylcholine Receptor.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding Sites; Membrane Potentials; Nicotinic Antagonists; Oocytes; Protein Subunits; Receptors, Nicotinic; Succinimides; Xenopus laevis | 2020 |
Lemairamin, isolated from the Zanthoxylum plants, alleviates pain hypersensitivity via spinal α7 nicotinic acetylcholine receptors.
Topics: Aconitine; Acrylamides; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; beta-Endorphin; Cancer Pain; Female; Formaldehyde; Hyperalgesia; Injections, Spinal; Interleukin-10; Male; Mice; Microglia; Minocycline; Naloxone; Neuralgia; Rats; Rats, Wistar; Spinal Cord; Zanthoxylum | 2020 |
The discriminative stimulus effects of epibatidine in C57BL/6J mice.
Topics: Aconitine; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dihydro-beta-Erythroidine; Discrimination Learning; Male; Mecamylamine; Mice; Mice, Inbred C57BL; Pyridines | 2020 |
Impact of Peripheral α7-Nicotinic Acetylcholine Receptors on Cardioprotective Effects of Donepezil in Chronic Heart Failure Rats.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood Pressure; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Electrocardiography; Heart Failure; Hemodynamics; Male; Myocardial Infarction; Nicotinic Antagonists; Random Allocation; Rats; Rats, Sprague-Dawley | 2021 |
Activation of α7nACh receptor protects against acute pancreatitis through enhancing TFEB-regulated autophagy.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Benzamides; Bridged Bicyclo Compounds; Ceruletide; Ethanol; Fatty Acids, Monounsaturated; Injections, Intraperitoneal; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Pancreatitis; Signal Transduction | 2020 |
Exploring the Mechanism on the Medullary Visceral Zone Inhibiting the Cholinergic Anti-inflammatory Pathway Induced by Sepsis.
Topics: Aconitine; Animals; Apoptosis; CD4 Antigens; Choline O-Acetyltransferase; Cytokines; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Fluorescent Antibody Technique; Heart Rate; In Situ Nick-End Labeling; Inflammation; Interleukin-2 Receptor alpha Subunit; Kaplan-Meier Estimate; Male; Neurons; Rats; Sepsis; Th17 Cells; Tyrosine 3-Monooxygenase | 2020 |
Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Depression; Disease Models, Animal; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex | 2021 |
Prefrontal cortex nicotinic receptor inhibition by methyllycaconitine impaired cocaine-associated memory acquisition and retrieval.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Central Nervous System Sensitization; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Disease Models, Animal; Dopamine Uptake Inhibitors; Memory Consolidation; Mental Recall; Nicotinic Antagonists; Prefrontal Cortex; Rats; Rats, Wistar | 2021 |
Contrasting effects of the α7 nicotinic receptor antagonist methyllycaconitine in different rat models of heroin reinstatement.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Addictive; Conditioning, Psychological; Cues; Drug-Seeking Behavior; Extinction, Psychological; Heroin; Heroin Dependence; Male; Nicotinic Antagonists; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reinforcement, Psychology; Reward; Self Administration | 2021 |
The Role of α7nAChR-Mediated Cholinergic Anti-Inflammatory Pathway in Vagal Nerve Regulated Atrial Fibrillation.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Atrial Fibrillation; Cardiac Pacing, Artificial; Case-Control Studies; Disease Models, Animal; Dogs; Heart Atria; Interleukin-6; Neuroimmunomodulation; NF-kappa B; Nicotinic Antagonists; Pulmonary Veins; Refractory Period, Electrophysiological; STAT3 Transcription Factor; Tumor Necrosis Factor-alpha; Vagus Nerve; Vagus Nerve Stimulation | 2021 |
Studies on the role of alpha 7 nicotinic acetylcholine receptors in K562 cell proliferation and signaling.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Calcium; Cell Proliferation; Cell Survival; Gene Expression; Humans; K562 Cells; Leukemia; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Signal Transduction | 2021 |
Nicotine Enhances Object Recognition Memory via Stimulating α4β2 and α7 Nicotinic Acetylcholine Receptors in the Medial Prefrontal Cortex of Mice.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dihydro-beta-Erythroidine; Male; Mecamylamine; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Prefrontal Cortex; Receptors, Nicotinic; Recognition, Psychology | 2021 |
Effects of nicotinic antagonists on working memory performance in young rhesus monkeys.
Topics: Aconitine; Animals; Conditioning, Operant; Dihydro-beta-Erythroidine; Female; Macaca mulatta; Male; Mecamylamine; Memory, Short-Term; Muscarinic Antagonists; Nicotinic Antagonists; Scopolamine | 2021 |
Palonosetron/Methyllycaconitine Deactivate Hippocampal Microglia 1, Inflammasome Assembly and Pyroptosis to Enhance Cognition in a Novel Model of Neuroinflammation.
Topics: Aconitine; Alzheimer Disease; Amyloid beta-Peptides; Animals; CARD Signaling Adaptor Proteins; Cognition; Diet, Western; Disease Models, Animal; Hippocampus; Humans; Inflammasomes; Inflammation; Insulin Resistance; Interleukin-18; Lipopolysaccharides; Microglia; Palonosetron; Peptide Fragments; Pyroptosis; Rats; Receptors, Serotonin, 5-HT3; Risk Factors; Spatial Memory | 2021 |
Novel methyllycaconitine analogues selective for the α4β2 over α7 nicotinic acetylcholine receptors.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dose-Response Relationship, Drug; Molecular Structure; Oocytes; Receptors, Nicotinic; Structure-Activity Relationship; Xenopus laevis | 2021 |
Cholinergic anti-inflammatory pathway ameliorates murine experimental Th2-type colitis by suppressing the migration of plasmacytoid dendritic cells.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Caspase 3; Caspase Inhibitors; Central Nervous System Stimulants; Cholinergic Neurons; Colitis, Ulcerative; Colon; Dendritic Cells; Deoxyglucose; Disease Models, Animal; Enzyme Inhibitors; Janus Kinase 2; Mice, Inbred BALB C; Neuroimmunomodulation; Neuropeptides; Nicotine; Oxazolone; rac1 GTP-Binding Protein; STAT3 Transcription Factor; Th2 Cells; Tyrphostins; Vagus Nerve | 2022 |
Inflammation Regulation via an Agonist and Antagonists of α7 Nicotinic Acetylcholine Receptors in RAW264.7 Macrophages.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Benzamides; Bridged Bicyclo Compounds; Cell Survival; Conotoxins; Cytokines; Gene Expression Regulation; Interleukin-6; Lipopolysaccharides; Mice; Nicotinic Agonists; Nicotinic Antagonists; RAW 264.7 Cells | 2022 |