methylglucamine-iodoxamate and meglumine-iotroxinate

Topics: Cholangiography; Cholecystography; Contrast Media; Humans; Iodipamide; Iodobenzoates; Triiodobenzoic Acids

The meglumine salts of iodoxamic and iotroxamic acids are recently developed intravenous cholangiographic media. In several studies these two media have been shown to be significantly better than meglumine iodipamide and meglumine ioglycamate for opacification of the biliary tree and incidence of adverse effects. As part of a multi-centre double-blind trial 100 patients were given iodoxamate or iotroxamate. Comparisons of opacification, side effects and renal excretion of contrast were made. The results showed no statistically significant difference in biliary tree opacification; more frequent renal excretion of contrast with iodoxamate; and contrary to previous reports a slightly higher incidence of side effects with iotroxamate.

Topics: Biliary Tract; Cholangiography; Contrast Media; Humans; Iodipamide; Iodobenzoates; Triiodobenzoic Acids

A double-blind comparison of two recently introduced cholangiocholecystographic agents was carried out in 80 patients. Both agents proved to be equally effective in opacifying the gall-bladder and the bile ducts. The visualization of the bile ducts after cholecystectomy was slightly better after meglumine iotroxate administration. Both agents showed evidence of hepatic toxicity in mild or moderate degree. However, there were 3 cases in which adverse hepatotoxic reactions t meglumine iodoxamate have been observed. Careful observation of patients receiving this drug is advised.

Topics: Chemical and Drug Induced Liver Injury; Cholangiography; Cholecystography; Clinical Trials as Topic; Contrast Media; Double-Blind Method; Female; Humans; Iodipamide; Iodobenzoates; Liver Function Tests; Male; Radiographic Image Enhancement; Triiodobenzoic Acids

Topics: Cholangiography; Cholecystectomy; Contrast Media; Double-Blind Method; Female; Humans; Iodipamide; Iodobenzoates; Male; Triiodobenzoic Acids