Page last updated: 2024-09-04

methylenecyclopropylglycine and glycine

methylenecyclopropylglycine has been researched along with glycine in 19 studies

Compound Research Comparison

Studies
(methylenecyclopropylglycine)
Trials
(methylenecyclopropylglycine)
Recent Studies (post-2010)
(methylenecyclopropylglycine)
Studies
(glycine)
Trials
(glycine)
Recent Studies (post-2010) (glycine)
1901635,1637568,415

Protein Interaction Comparison

ProteinTaxonomymethylenecyclopropylglycine (IC50)glycine (IC50)
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)1.4852
Sodium- and chloride-dependent glycine transporter 1Homo sapiens (human)106
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)0.3253
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)0.3253
Sodium- and chloride-dependent glycine transporter 2Homo sapiens (human)128

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.26)18.7374
1990's2 (10.53)18.2507
2000's0 (0.00)29.6817
2010's9 (47.37)24.3611
2020's7 (36.84)2.80

Authors

AuthorsStudies
Bartlett, K; Ghisla, S; Jackson, S; Melde, K; Sherratt, HS1
Boschert, W; Ghisla, S; Melde, K; Zeller, HD1
Boschert, W; Buettner, H; Ghisla, S; Melde, K; Wolf, HP1
Pulla, P1
Carter, MD; Graham, LA; Isenberg, SL; Johnson, D; Johnson, RC; Mathews, TP; Pirkle, JL; Thomas, JD1
Carter, MD; Graham, LA; Harden, LA; Hayes, SR; Isenberg, SL; Johnson, D; Johnson, RC; Mathews, TP; Pirkle, JL; Takeoka, GR; Thomas, JD1
Bhushan, G; Caldwell, KL; Carter, MD; Chakrabarti, A; Chang, A; Chauhan, LS; Chhabra, M; Dhariwal, AC; Dwivedi, M; Earhart, KC; Goel, K; Graham, LA; Haberling, DL; Hall, PL; Harden, LA; Isenberg, SL; Jarrett, JM; Johnson, D; Johnson, R; Khare, S; Kumar, A; Kumar, AR; Kumar, M; Kumar, S; Laserson, KF; Mathews, TP; Mittal, V; Paden, C; Pandey, R; Papanna, M; Pirkle, JL; Pradhan, A; Queen, K; Schier, JG; Sejvar, JJ; Sharer, JD; Shrivastava, A; Singh, P; Singh, R; Singh, RS; Sivaperumal, P; Somashekar, D; Srikantiah, P; Takeoka, GR; Thomas, JD; Tong, S; Valentin, L; Velayudhan, A; Venkatesh, S; Whitney, A; Yadav, R1
Camporez, JG; Cline, GW; Kahn, M; Perry, RJ; Qiu, Y; Shulman, GI; Vatner, DF; Zhang, XM1
Carter, MD; Harden, LA; Isenberg, SL; Johnson, RC; Mathews, TP; Mojica, MA; Pirkle, JL; Sanford, AA; Takeoka, GR; Thomas, JD1
Carter, MD; Isenberg, SL; Johnson, RC; Laughlin, S; Mathews, TP; Mojica, MA; Pirkle, JL; Sanford, AA; Thomas, JD1
Asthana, S; Das, M; Dixit, S; Kumar, A; Singh, SP; Srivastava, A; Tripathi, A1
Bochnia, M; Cavalleri, JV; Janzen, N; Sander, J; Sander, S; Terhardt, M; Wensch-Dorendorf, M; Zeyner, A; Ziegler, J; Zuraw, A1
Jiang, Y; Qu, H; Wang, Y; Xiao, Y; Yang, B; Yang, J; Zhang, P; Zhu, X1
Janzen, N; Sander, J; Terhardt, M1
Bochnia, M; Sander, J; Stief, B; Zeyner, A; Ziemssen, E1
Ramakrishna, UV; Sinha, PK; Sinha, SN; Thakur, CP1
Brumarová, R; Dobešová, D; Friedecký, D; Jahn, P; Kopecká, A; Tóthová, K1
El-Khatib, AH; Lamp, J; Weigel, S1
Aboling, S; El-Khatib, AH; Engel, AM; Fischer-Tenhagen, C; Klevenhusen, F; Pieper, R; Sachse, B; Schäfer, B; Weigel, S; Weiss, M1

Other Studies

19 other study(ies) available for methylenecyclopropylglycine and glycine

ArticleYear
Metabolic consequences of methylenecyclopropylglycine poisoning in rats.
    The Biochemical journal, 1991, Mar-01, Volume: 274 ( Pt 2)

    Topics: Acyl Coenzyme A; Animals; Biotransformation; Carboxylic Acids; Chromatography, High Pressure Liquid; Cyclopropanes; Fasting; Glycine; Hypoglycemic Agents; Kinetics; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains

1991
Mechanisms of enzyme inhibition by hypoglycin, methylenecyclopropylglycine and their metabolites.
    Progress in clinical and biological research, 1990, Volume: 321

    Topics: Animals; Cyclopropanes; Fatty Acid Desaturases; Glycine; Hypoglycins; Kidney; Structure-Activity Relationship; Swine

1990
Mechanism of hypoglycaemic action of methylenecyclopropylglycine.
    The Biochemical journal, 1989, May-01, Volume: 259, Issue:3

    Topics: Acyl-CoA Dehydrogenases; Animals; Blood Glucose; Cyclopropanes; Enoyl-CoA Hydratase; Glycine; Hypoglycemic Agents; Male; Rats; Rats, Inbred Strains

1989
Toxicology. A child-killing toxin emerges from shadows.
    Science (New York, N.Y.), 2015, Apr-03, Volume: 348, Issue:6230

    Topics: Adolescent; Animals; Blood Glucose; Cause of Death; Child; Child Mortality; Child, Preschool; Coma; Cyclopropanes; Death, Sudden; Eating; Encephalitis; Glucose; Glycine; Humans; Hypoglycemia; India; Litchi; Memory Disorders; Mental Disorders; Rats; Seizures; Toxins, Biological

2015
Quantification of metabolites for assessing human exposure to soapberry toxins hypoglycin A and methylenecyclopropylglycine.
    Chemical research in toxicology, 2015, Sep-21, Volume: 28, Issue:9

    Topics: Animals; Cyclopropanes; Environmental Exposure; Glycine; Humans; Hypoglycins; Rats; Sapindus

2015
Quantification of Toxins in Soapberry (Sapindaceae) Arils: Hypoglycin A and Methylenecyclopropylglycine.
    Journal of agricultural and food chemistry, 2016, Jul-13, Volume: 64, Issue:27

    Topics: Chromatography, High Pressure Liquid; Cyclopropanes; Fruit; Glycine; Hypoglycins; Sapindaceae; Tandem Mass Spectrometry

2016
Association of acute toxic encephalopathy with litchi consumption in an outbreak in Muzaffarpur, India, 2014: a case-control study.
    The Lancet. Global health, 2017, Volume: 5, Issue:4

    Topics: Acute Febrile Encephalopathy; Adolescent; Case-Control Studies; Child; Cyclopropanes; Disease Outbreaks; Female; Fruit; Glycine; Humans; Hypoglycins; India; Litchi; Male; Neurotoxicity Syndromes; Odds Ratio

2017
    The Biochemical journal, 2018, 03-20, Volume: 475, Issue:6

    Topics: Animals; Cyclopropanes; Gluconeogenesis; Glucose; Glycine; Hypoglycemia; Liver; Male; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Signal Transduction

2018
Quantitative HPLC-MS/MS analysis of toxins in soapberry seeds: Methylenecyclopropylglycine and hypoglycin A.
    Food chemistry, 2018, Oct-30, Volume: 264

    Topics: Chromatography, High Pressure Liquid; Cyclopropanes; Fruit; Glycine; Hypoglycins; Sapindus; Seeds; Tandem Mass Spectrometry

2018
Quantification of hypoglycin A and methylenecyclopropylglycine in human plasma by HPLC-MS/MS.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018, Sep-15, Volume: 1095

    Topics: Chromatography, High Pressure Liquid; Cyclopropanes; Glycine; Humans; Hypoglycins; Limit of Detection; Linear Models; Plant Poisoning; Reproducibility of Results; Sapindaceae; Tandem Mass Spectrometry

2018
Methylenecyclopropyl glycine, not pesticide exposure as the primary etiological factor underlying hypoglycemic encephalopathy in Muzaffarpur, India.
    Toxicology letters, 2019, Volume: 301

    Topics: Acute Disease; Acute Febrile Encephalopathy; Animals; Cyclopropanes; DDT; Disease Models, Animal; Fruit; Glycine; Hypoglycemia; India; Litchi; Malathion; Male; Pesticide Residues; Pesticides; Rats; Rats, Wistar

2019
Detection of MCPG metabolites in horses with atypical myopathy.
    PloS one, 2019, Volume: 14, Issue:2

    Topics: Acer; Animals; Chromatography, High Pressure Liquid; Cyclopropanes; Female; Glycine; Horse Diseases; Horses; Male; Metabolic Networks and Pathways; Muscular Diseases; Plant Poisoning; Seeds; Tandem Mass Spectrometry

2019
Detection of toxic methylenecyclopropylglycine and hypoglycin A in litchi aril of three Chinese cultivars.
    Food chemistry, 2020, Oct-15, Volume: 327

    Topics: China; Chromatography, High Pressure Liquid; Cyclopropanes; Food Analysis; Fruit; Glycine; Hypoglycins; Litchi; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2020
Study on the Metabolic Effects of Repeated Consumption of Canned Ackee.
    Journal of agricultural and food chemistry, 2020, Dec-09, Volume: 68, Issue:49

    Topics: Adult; Blighia; Cyclopropanes; Fatty Acids; Female; Food, Preserved; Fruit; Glycine; Humans; Hypoglycins

2020
Methylenecyclopropylglycine and hypoglycin A intoxication in three Pére David's Deers (Elaphurus davidianus) with atypical myopathy.
    Veterinary medicine and science, 2021, Volume: 7, Issue:3

    Topics: Acer; Animals; Cyclopropanes; Deer; Female; Gastrointestinal Contents; Glycine; Hypoglycins; Male; Muscular Diseases; Rumen; Serum; Urine

2021
A recurring disease outbreak following litchi fruit consumption among children in Muzaffarpur, Bihar-A comprehensive investigation on factors of toxicity.
    PloS one, 2020, Volume: 15, Issue:12

    Topics: Child; Cyclopropanes; Disease Outbreaks; Encephalitis; Fruit; Glycine; Humans; India; Litchi; Mass Spectrometry; Organophosphates; Pesticides; Poisoning

2020
Dynamics of acylcarnitines, hypoglycin A, méthylènecyclopropylglycine and their metabolites in a Kladruber stallion with atypical myopathy.
    The veterinary quarterly, 2022, Volume: 42, Issue:1

    Topics: Acyl-CoA Dehydrogenases; Animals; Carnitine; Creatine Kinase; Cyclopropanes; Fatty Acids; Glycine; Horse Diseases; Horses; Hypoglycins; Male; Muscular Diseases

2022
A sensitive LC-MS/MS method for the quantification of the plant toxins hypoglycin A and methylenecyclopropylglycine and their metabolites in cow's milk and urine and application to farm milk samples from Germany.
    Analytical and bioanalytical chemistry, 2023, Volume: 415, Issue:10

    Topics: Acer; Animals; Cattle; Chromatography, High Pressure Liquid; Chromatography, Liquid; Farms; Female; Germany; Glycine; Humans; Milk; Tandem Mass Spectrometry

2023
Detection of Hypoglycin A and MCPrG Metabolites in the Milk and Urine of Pasture Dairy Cows after Intake of Sycamore Seedlings.
    Journal of agricultural and food chemistry, 2023, Jul-19, Volume: 71, Issue:28

    Topics: Acer; Animals; Cattle; Female; Glycine; Horse Diseases; Horses; Humans; Hypoglycins; Lactation; Milk; Seedlings

2023