methylene blue has been researched along with zaprinast in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.89) | 18.7374 |
| 1990's | 24 (66.67) | 18.2507 |
| 2000's | 7 (19.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aronson, WJ; Bush, PA; Dorey, FJ; Ignarro, LJ; Rajfer, J | 1 |
| Huxley, VH; Meyer, DJ | 1 |
| Bradley, ME; Buxton, IL; Dalziel, HH; Keef, K; Sanders, KM; Ward, SM; Westfall, DP | 1 |
| Bucher, B; Ouedraogo, S; Paya, D; Stoclet, JC; Tschöpl, M | 1 |
| Barnes, PJ; Crawley, DE; Evans, TW; Liu, SF; Rohde, JA | 1 |
| Hisayama, T; Moritoki, H; Takeuchi, S; Yoshikawa, T | 1 |
| Oe, H; Satake, N; Sawada, T; Shibata, S | 1 |
| Chang, R; Fineman, JR; Soifer, SJ | 1 |
| Oe, H; Satake, N; Shibata, S | 1 |
| Torphy, TJ; Zhou, HL | 1 |
| Satoh, K; Taira, N; Yamada, H; Yoneyama, F | 1 |
| Borg, C; Cavero, I; Mestre, M; Mondot, S | 1 |
| Hester, RK; Koibuchi, Y; Matsuo, M; Satake, N; Sato, N; Shibata, S | 1 |
| Chiyotani, A; Horii, S; Isono, K; Kanemura, T; Kobayashi, K; Sakai, N; Takeuchi, S; Takizawa, T; Tamaoki, J; Yamawaki, I | 1 |
| Faunce, D; Henry, D; Lee, DK; Rimele, T; Sturm, RJ | 1 |
| Brazdil, R; Diocee, BK; Jordan, R; Souness, JE | 1 |
| Eltze, M | 1 |
| Barnette, M; Fine, C; Grous, M; Ormsbee, HS; Torphy, TJ | 1 |
| Edwards, DH; Griffith, TM; Henderson, AH; Lewis, MJ | 1 |
| Byrns, RE; Ignarro, LJ; Wood, KS | 1 |
| Cheng, DY; DeWitt, BJ; Kadowitz, PJ; McMahon, TJ; Nossaman, BD | 1 |
| Abu-Kishk, RA; D'Aloia, MA; Lush, DJ; Noble, AR; Williams, BC | 1 |
| Cheng, X; Pang, CC; Wang, YX | 1 |
| Advenier, C; Naline, E; Palette-Pays, C; Varoquaux, O; Zhang, Y | 1 |
| Donatucci, CF; Hsu, GL; Lue, TF; Martinez-Piñeiro, L; Tanagho, EA; Trigo-Rocha, F | 1 |
| Aronson, WJ; Hohenfellner, M; Ignarro, LJ; Lue, TF; Rajfer, J; Trigo-Rocha, F | 1 |
| Bland-Ward, P; Curtis, MJ; Moore, PK; Pabla, R | 1 |
| Hirafuji, M; Minami, M; Nezu, A; Shinoda, H | 1 |
| Dik, IE; Folkerts, G; Henricks, PA; Nijkamp, FP; Sadeghi-Hashjin, G; Van de Loo, PG; Van der Linde, HJ | 1 |
| Ghofrani, HA; Grimminger, F; Hardebusch, T; Schermuly, RT; Seeger, W; Tadic, A; Voswinckel, R; Weissmann, N | 1 |
| Cummings, JJ; Wang, H | 1 |
| Hamad, AM; Knox, AJ | 1 |
| Lamonaca, D; Tiboni, GM | 1 |
| Amarante, LH; Duarte, ID | 1 |
| Jeong, MS; Kim, CJ; Kim, KW; Park, EY; Park, JW; Shin, BS; Shin, MS; Woo, RS; Zhao, RJ | 1 |
| Fujimoto, S; Mori, M; Tsushima, H | 1 |
36 other study(ies) available for methylene blue and zaprinast
| Article | Year |
|---|---|
Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission.
Topics: Adult; Aged; Arginine; Cyclic GMP; Electric Stimulation; Erectile Dysfunction; Humans; Male; Methylene Blue; Middle Aged; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitroarginine; Organ Culture Techniques; Penile Erection; Penis; Purinones; Synaptic Transmission | 1992 |
Capillary hydraulic conductivity is elevated by cGMP-dependent vasodilators.
Topics: Animals; Atrial Natriuretic Factor; Capillaries; Cyclic GMP; Drug Synergism; Methylene Blue; Nitroprusside; Purinones; Rana pipiens; Vasodilator Agents | 1992 |
Involvement of cyclic GMP in non-adrenergic, non-cholinergic inhibitory neurotransmission in dog proximal colon.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Arginine; Autonomic Nervous System; Colon; Cyclic GMP; Dogs; Electric Stimulation; Female; Gastrointestinal Motility; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Purinones; Signal Transduction; Synaptic Transmission | 1992 |
Role of the L-arginine-NO pathway and of cyclic GMP in electrical field-induced noradrenaline release and vasoconstriction in the rat tail artery.
Topics: Animals; Arginine; Arteries; Atrial Natriuretic Factor; Cyclic GMP; Electric Stimulation; Endothelium, Vascular; In Vitro Techniques; Male; Methylene Blue; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Purinones; Rats; Tail; Vasoconstriction; Vasodilator Agents | 1992 |
Role of nitric oxide and guanosine 3',5'-cyclic monophosphate in mediating nonadrenergic, noncholinergic relaxation in guinea-pig pulmonary arteries.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Arginine; Autonomic Nervous System; Cyclic GMP; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; omega-N-Methylarginine; Oxidopamine; Phosphodiesterase Inhibitors; Purinones; Pyrogallol; Sympathectomy, Chemical | 1992 |
Possible mechanisms of age-associated reduction of vascular relaxation caused by atrial natriuretic peptide.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Aging; Animals; Aorta, Thoracic; Arginine; Atrial Natriuretic Factor; Cyclic GMP; Endothelium, Vascular; Guanylate Cyclase; Hemoglobins; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Purinones; Rats; Rats, Inbred Strains | 1992 |
The mode of vasorelaxing action of melatonin in rabbit aorta.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Dinoprost; In Vitro Techniques; Male; Melatonin; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Purinones; Rabbits; Serotonin | 1991 |
L-Arginine, a precursor of EDRF in vitro, produces pulmonary vasodilation in lambs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Arginine; Blood Pressure; Cardiac Output; Heart Rate; Hypertension, Pulmonary; Isomerism; Methylene Blue; Muscle, Smooth, Vascular; Nitric Oxide; omega-N-Methylarginine; Prostaglandin Endoperoxides, Synthetic; Pulmonary Artery; Purinones; Sheep; Vasodilation | 1991 |
Vasorelaxing action of melatonin in rat isolated aorta; possible endothelium dependent relaxation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta; Endothelium, Vascular; In Vitro Techniques; Male; Melatonin; Methylene Blue; Methysergide; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Purinones; Rats; Rats, Inbred Strains; Verapamil | 1991 |
Relationship between cyclic guanosine monophosphate accumulation and relaxation of canine trachealis induced by nitrovasodilators.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Dogs; Drug Synergism; Female; Guanylate Cyclase; Hemoglobins; Isoproterenol; Male; Methylene Blue; Muscle Relaxation; Nitroglycerin; Nitroprusside; Penicillamine; Purinones; S-Nitroso-N-Acetylpenicillamine; Time Factors; Trachea; Vasodilator Agents | 1991 |
Comparison of the effects of the novel vasodilator FK409 with those of nitroglycerin in isolated coronary artery of the dog.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Coronary Vessels; Dogs; Female; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Nitro Compounds; Nitroglycerin; Prostaglandin Endoperoxides, Synthetic; Purinones; Vasodilator Agents | 1991 |
Nicorandil: differential contribution of K+ channel opening and guanylate cyclase stimulation to its vasorelaxant effects on various endothelin-1-contracted arterial preparations. Comparison to aprikalim (RP 52891) and nitroglycerin.
Topics: Animals; Coronary Vessels; Endothelins; Endothelium, Vascular; Glyburide; Guanylate Cyclase; Heart; Hemodynamics; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Picolines; Potassium Channels; Purinones; Pyrans; Rats; Rats, Inbred Strains; Stimulation, Chemical; Swine; Swine, Miniature; Vasodilator Agents | 1991 |
Characteristics of the vasorelaxing action of (3E)-4-ethyl-2-hydroximino-5-nitro-3-hexamide FK409, a new vasodilator isolated from microbial sources, in isolated rabbit arteries.
Topics: Animals; Arteries; Caffeine; Calcium; Cyclic GMP; Hemoglobins; Histamine; In Vitro Techniques; Inositol Phosphates; Male; Methylene Blue; Nitro Compounds; Nitroglycerin; Norepinephrine; Purinones; Rabbits; Serotonin; Vasoconstriction; Vasodilator Agents | 1991 |
Atrial natriuretic factor inhibits ciliary motility in cultured rabbit tracheal epithelium.
Topics: Animals; Atrial Natriuretic Factor; Captopril; Cells, Cultured; Cilia; Enzyme Inhibitors; Epithelium; Glycopeptides; Indomethacin; Kinetics; Leucine; Leupeptins; Male; Masoprocol; Methylene Blue; Movement; Piroxicam; Purinones; Rabbits; Thiorphan; Trachea | 1991 |
Neutrophil-derived relaxing factor relaxes vascular smooth muscle through a cGMP-mediated mechanism.
Topics: Animals; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; In Vitro Techniques; Male; Methylene Blue; Muscle, Smooth, Vascular; Myocardial Contraction; Neutrophils; Nitric Oxide; Peritoneal Cavity; Phenylephrine; Purinones; Rats; Rats, Inbred Lew; Superoxide Dismutase | 1990 |
Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Cyclic AMP; Cyclic GMP; In Vitro Techniques; Kinetics; Male; Methylene Blue; Muscle Relaxants, Central; Nitric Oxide; Phthalazines; Purinones; Pyridazines; Rats; Rats, Inbred Strains; Theophylline; Vinca Alkaloids | 1989 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pulmonary Artery; Purinones; Pyrans; Pyrroles; Tetraethylammonium Compounds | 1989 |
Cyclic GMP: a potential mediator of neurally- and drug-induced relaxation of opossum lower esophageal sphincter.
Topics: Animals; Cyclic GMP; Electric Stimulation; Esophagogastric Junction; Female; Male; Methylene Blue; Muscle Relaxation; Nitroprusside; Opossums; Purinones | 1989 |
Evidence that cyclic guanosine monophosphate (cGMP) mediates endothelium-dependent relaxation.
Topics: Animals; Aorta, Thoracic; Blood Vessels; Cyclic GMP; Endothelium; In Vitro Techniques; Methylene Blue; Purinones; Rabbits; Vasodilation | 1985 |
Endothelium-dependent modulation of cGMP levels and intrinsic smooth muscle tone in isolated bovine intrapulmonary artery and vein.
Topics: Animals; Cattle; Cyclic AMP; Cyclic GMP; Endothelium; In Vitro Techniques; Indomethacin; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Pulmonary Circulation; Purinones | 1987 |
Analysis of responses to bradykinin in the pulmonary vascular bed of the cat.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Airway Obstruction; Amino Acid Oxidoreductases; Animals; Bradykinin; Bronchi; Cats; Methylene Blue; Nitric Oxide Synthase; Pulmonary Circulation; Purinones; Vasodilation | 1994 |
Cyclic GMP-linked pathway for renin secretion.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Aminoquinolines; Animals; Atrial Natriuretic Factor; Cyclic GMP; Guanylate Cyclase; In Vitro Techniques; Kidney Cortex; Methylene Blue; Nitroprusside; Peptide Fragments; Purinones; Rats; Renin; Second Messenger Systems | 1994 |
Vascular pharmacology of methylene blue in vitro and in vivo: a comparison with NG-nitro-L-arginine and diphenyleneiodonium.
Topics: Acetylcholine; Animals; Aorta; Arginine; Catecholamines; Dose-Response Relationship, Drug; Imidazolines; Methylene Blue; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Nitroprusside; Purinones; Rats; Rats, Sprague-Dawley | 1995 |
Effect of molsidomine and linsidomine on the human isolated bronchus and the guinea-pig isolated trachea.
Topics: Animals; Bronchi; Bronchodilator Agents; Epithelium; Guinea Pigs; Humans; In Vitro Techniques; Isoproterenol; Male; Methylene Blue; Molsidomine; Muscle, Smooth; Nitroprusside; Purinones; Pyridazines; Theophylline; Trachea | 1993 |
Intracellular mechanism of penile erection in monkeys.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alprostadil; Animals; Benzopyrans; Cromakalim; Cyclic AMP; Cyclic GMP; Ethylmaleimide; Macaca nemestrina; Male; Methylene Blue; Nitroprusside; Penile Erection; Penis; Phosphodiesterase Inhibitors; Purinones; Pyrroles; Ultrasonography | 1994 |
Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Arginine; Cyclic GMP; Dogs; Electric Stimulation; Male; Methylene Blue; Nervous System Physiological Phenomena; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pelvis; Penile Erection; Purinones | 1993 |
An endogenous protectant effect of cardiac cyclic GMP against reperfusion-induced ventricular fibrillation in the rat heart.
Topics: Animals; Cyclic GMP; Disease Susceptibility; Electrocardiography; Hemodynamics; In Vitro Techniques; Male; Methylene Blue; Myocardial Reperfusion Injury; Nucleotides, Cyclic; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Wistar; Ventricular Fibrillation | 1995 |
Involvement of platelet cyclic GMP but not cyclic AMP suppression in leukocyte-dependent platelet adhesion to endothelial cells induced by platelet-activating factor in vitro.
Topics: Animals; Blood Platelets; Cyclic AMP; Cyclic GMP; Cyclooxygenase Inhibitors; Endothelium, Vascular; Humans; In Vitro Techniques; Indomethacin; Leukocytes; Methylene Blue; Neutrophils; Nitric Oxide; Nitroprusside; Phosphodiesterase Inhibitors; Platelet Activating Factor; Platelet Adhesiveness; Purinones; Rabbits | 1996 |
Induction of guinea pig airway hyperresponsiveness by inactivation of guanylate cyclase.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Airway Resistance; Analysis of Variance; Animals; Coloring Agents; Cyclic GMP; Dose-Response Relationship, Drug; Epithelium; Guinea Pigs; Histamine; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Nitric Oxide; Purinones; Trachea | 1996 |
Nitric oxide (NO)-dependent but not NO-independent guanylate cyclase activation attenuates hypoxic vasoconstriction in rabbit lungs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aminoquinolines; Animals; Aspirin; Blood Pressure; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; Guanylate Cyclase; Hypoxia; In Vitro Techniques; Lung; Male; Methylene Blue; Nitric Oxide; omega-N-Methylarginine; Pulmonary Artery; Purinones; Rabbits; Vasoconstriction; Vasoconstrictor Agents | 2000 |
Nitric oxide decreases lung liquid production via guanosine 3',5'-cyclic monophosphate.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blood Gas Analysis; Blood Pressure; Cyclic GMP; Drug Administration Routes; Enzyme Inhibitors; Fetus; Guanylate Cyclase; Lung; Methylene Blue; Nitric Oxide; Pulmonary Circulation; Purinones; Sheep; Vascular Resistance | 2001 |
Mechanisms mediating the antiproliferative effects of nitric oxide in cultured human airway smooth muscle cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Asthma; Bronchi; Cell Cycle; Cells, Cultured; Culture Media, Serum-Free; Deoxyadenosines; Deoxyguanosine; Hemoglobins; Humans; Methylene Blue; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Phosphodiesterase Inhibitors; Purinones; S-Nitroso-N-Acetylpenicillamine; Thymidine | 2001 |
Transplacental exposure to methylene blue initiates teratogenesis in the mouse: preliminary evidence for a mechanistic implication of cyclic GMP pathway disruption.
Topics: Animals; Bone and Bones; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Maternal Exposure; Methylene Blue; Mice; Mice, Inbred ICR; Neural Tube Defects; Phosphodiesterase Inhibitors; Placenta; Purinones; Teratogens; Time Factors | 2001 |
The kappa-opioid agonist (+/-)-bremazocine elicits peripheral antinociception by activation of the L-arginine/nitric oxide/cyclic GMP pathway.
Topics: Analgesics; Animals; Arginine; Benzomorphans; Cyclic GMP; Guanylate Cyclase; Hyperalgesia; Male; Methylene Blue; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pain; Phosphodiesterase Inhibitors; Purinones; Rats; Rats, Wistar; Receptors, Opioid, kappa | 2002 |
Mechanism of nicotine-evoked release of 3H-noradrenaline in human cerebral cortex slices.
Topics: Adolescent; Adult; Arginine; Calcium; Calcium Channel Blockers; Cerebral Cortex; Dihydro-beta-Erythroidine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoxetine; Ganglionic Stimulants; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Male; Mecamylamine; Methylene Blue; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nicotine; Nicotinic Antagonists; Nitrendipine; Nitric Oxide Synthase; Norepinephrine; omega-Conotoxin GVIA; Oxadiazoles; Purinones; Quinoxalines; Tetrodotoxin; Tritium; Tubocurarine | 2002 |
Mechanisms underlying the hydrogen peroxide-induced, endothelium-independent relaxation of the norepinephrine-contraction in guinea-pig aorta.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Guinea Pigs; Hydrogen Peroxide; In Vitro Techniques; Male; Methylene Blue; Myosin Light Chains; Nitroglycerin; Norepinephrine; Oxadiazoles; Phosphorylation; Purinones; Quinoxalines; Rats; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2003 |