Page last updated: 2024-08-17

methylene blue and chloroquine

methylene blue has been researched along with chloroquine in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (24.24)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (30.30)	29.6817
2010's	14 (42.42)	24.3611
2020's	1 (3.03)	2.80

Authors

Authors	Studies
Ihara, M; Inoue, H; Kim, HS; Shishido, T; Suzuki, M; Takasu, K; Wataya, Y	1
Becker, K; Davioud-Charvet, E; Friebolin, W; Furrer, J; Jannack, B; Lanzer, M; Oeser, T; Sanchez, CP; Wenzel, N; Yardley, V	1
Avery, VM; Baell, JB; Duffy, S; Hutton, CA; Klonis, N; Lucantoni, L; Teguh, SC; Tilley, L	1
Alfano, G; Brindisi, M; Brogi, S; Butini, S; Caldelari, R; Campiani, G; Chemi, G; D'Alessandro, S; Dechering, KJ; Fusi, F; Gemma, S; Gorelli, B; Jez, JM; Koolen, KJM; Lamponi, S; Lee, SG; Parapini, S; Saponara, S; Taramelli, D; Vallone, A	1
Andrews, KT; Antonova-Koch, Y; Avery, VM; Diedrich, D; Duffy, S; Fisher, G; Gebru, T; Hansen, FK; Held, J; Hesping, E; Kurz, T; Meister, S; Schöler, A; Stenzel, K; Winzeler, EA	1
Bezuidenhout, B; Birkholtz, LM; Chibale, K; Churchyard, A; Coetzer, TL; Egan, TJ; Fontinha, D; Gibhard, L; Lauterbach, S; Mayoka, G; Njoroge, M; Okombo, J; Prudêncio, M; Reader, J; Sanches-Vaz, M; van der Watt, M; Wittlin, S; Yeates, C	1
Arshadi, AK; Banks, R; Boonhok, R; Chakrabarti, D; Collins, J; Huang, G; Melendez, J; Miao, J; Min, H; Murillo Solano, C; Shaw, J; Yuan, Y	1
Garfinkel, E; Hirschman, SZ	1
Allison, RG; Hahn, FE	1
Allison, RG; Hahn, FE; Wolfe, AD	1
Ciak, J; Hahn, FE	1
Barnes, MG; Polet, H	1
Buchnícek, J; Turek, B	1
Ozawa, K; Shichijo, K; Takemura, Y; Yamada, T	1
Arnold, W; Gahl, GM; Hess, G; Meyer zum Büschenfelde, KH; Möller, B	1
Burhenne, J; Fröhlich, M; Haefeli, WE; Hoppe-Tichy, T; Mikus, G; Müller, O; Rengelshausen, J; Riedel, KD; Singh, SK; Tayrouz, Y; Walter-Sack, I	1
Burhenne, J; Coulibaly, B; Jahn, A; Kouyaté, B; Mandi, G; Mansmann, U; Meissner, P; Mikus, G; Müller, O; Rengelshausen, J; Riedel, KD; Sanon, M; Schiek, W; Schirmer, H; Walter-Sack, I; Witte, S; Wüst, K	1
Burhenne, J; Coulibaly, B; Jahn, A; Kouyaté, B; Mandi, G; Mansmann, U; Meissner, PE; Mikus, G; Müller, O; Rengelshausen, J; Riedel, KD; Sanon, M; Schiek, W; Schirmer, H; Tapsoba, T; Walter-Sack, I; Witte, S	1
Akoachere, M; Becker, K; Buchholz, K; Burhenne, J; Fischer, E; Haefeli, WE; Schirmer, RH	1
Burhenne, J; Coulibaly, B; Jahn, A; Kouyaté, B; Mandi, G; Mansmann, U; Meissner, PE; Mikus, G; Müller, O; Rengelshausen, J; Riedel, KD; Schiek, W; Schirmer, RH; Tapsoba, T; Walter-Sack, I; Witte, S	1
Deharo, E; Garavito, G; Maurel, S; Monje, MC; Nepveu, F; Valentin, A	1
Adedapo, AD; Ademowo, OG; Nneji, CM	1
Burhenne, J; Meissner, P; Mikus, G; Mueller, O; Oberwittler, H; Rengelshausen, J; Walter-Sack, I	1
Amalvict, R; Baret, E; Briolant, S; Charras, S; Feraud, M; Henry, M; Huyghues des Etages, E; Pascual, A; Pradines, B; Rogier, C	1
Chen, MJ; Cheu, KW; Coghi, P; Guo, ZF; Guo, ZH; Haynes, RK; Li, KY; Monti, D; Tang, MM; Wong, HN	1
Hempelmann, E; Krafts, K; Skórska-Stania, A	1
Abdali, N; Asif, MS; Rizvi, I; Zaidi, N; Zaman, S	1
Aldana, I; Bertani, S; Deharo, E; Garavito, G; Quiliano, M; Valentin, A	1
Chan, HW; Chen, MJ; Cheu, KW; Coghi, P; Guo, ZF; Guo, ZH; Haynes, RK; Li, KY; Monti, D; Sinniah, K; Tang, MM; Witte, AB; Wong, HN	1
Davioud-Charvet, E; Deponte, M; Ehrhardt, K; Ke, H; Lanzer, M; Vaidya, AB	1
Adaramoye, OA; Ademowo, OG; Falade, CO; Nneji, CM	1
Chu, CS; Malleret, B; Nosten, F; Ong, A; PyaePhyo, A; Renia, L; Russell, B; Sriprawat, K; Suwanarusk, R	1
Chua, HH; Cobbold, SA; Creek, DJ; McConville, MJ; Nijagal, B; Ralph, SA	1

Reviews

1 review(s) available for methylene blue and chloroquine

Article	Year
From methylene blue to chloroquine: a brief review of the development of an antimalarial therapy. Parasitology research, 2012, Volume: 111, Issue:1 Topics: Antimalarials; Chloroquine; Drug Therapy; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Malaria; Methylene Blue	2012

Trials

5 trial(s) available for methylene blue and chloroquine

Article	Year
Pharmacokinetic interaction of chloroquine and methylene blue combination against malaria. European journal of clinical pharmacology, 2004, Volume: 60, Issue:10 Topics: Administration, Oral; Adult; Anti-Infective Agents, Urinary; Antimalarials; Area Under Curve; Chloroquine; Drug Interactions; Female; Half-Life; Humans; Malaria, Falciparum; Male; Methylene Blue	2004
Safety of the combination of chloroquine and methylene blue in healthy adult men with G6PD deficiency from rural Burkina Faso. Tropical medicine & international health : TM & IH, 2005, Volume: 10, Issue:1 Topics: Adolescent; Adult; Antimalarials; Chloroquine; Drug Therapy, Combination; Glucosephosphate Dehydrogenase Deficiency; Hematocrit; Hemoglobins; Hemolysis; Humans; Malaria, Falciparum; Male; Methylene Blue; Middle Aged; Rural Health	2005
Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841]. Malaria journal, 2005, Sep-22, Volume: 4 Topics: Burkina Faso; Child, Preschool; Chloroquine; Drug Therapy, Combination; Glycogen Storage Disease Type I; Humans; Infant; Malaria, Falciparum; Methylene Blue	2005
Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine. Malaria journal, 2006, Oct-08, Volume: 5 Topics: Burkina Faso; Child, Preschool; Chloroquine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Infant; Malaria, Falciparum; Male; Methylene Blue; Random Allocation; Treatment Failure	2006
High absolute bioavailability of methylene blue given as an aqueous oral formulation. European journal of clinical pharmacology, 2009, Volume: 65, Issue:2 Topics: Administration, Oral; Adult; Antimalarials; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Chloroquine; Cross-Over Studies; Drug Therapy, Combination; Female; Half-Life; Humans; Injections, Intravenous; Male; Methylene Blue; Plasma; Tablets; Time Factors; Water; Young Adult	2009

Other Studies

27 other study(ies) available for methylene blue and chloroquine

Article	Year
Rhodacyanine dyes as antimalarials. 1. Preliminary evaluation of their activity and toxicity. Journal of medicinal chemistry, 2002, Feb-28, Volume: 45, Issue:5 Topics: Animals; Antimalarials; Coloring Agents; Plasmodium falciparum; Pyridines; Structure-Activity Relationship; Thiazoles	2002
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum. Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5 Topics: Animals; Antimalarials; Biological Transport; Cell Line, Tumor; Chloroquine; Drug Resistance; Drug Therapy, Combination; Glutathione Reductase; Humans; In Vitro Techniques; Malaria; Mice; Mice, Inbred BALB C; Naphthalenes; Parasitic Sensitivity Tests; Plasmodium berghei; Plasmodium falciparum; Structure-Activity Relationship	2008
Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity. Journal of medicinal chemistry, 2013, Aug-08, Volume: 56, Issue:15 Topics: Aminoquinolines; Antimalarials; Chloroquine; Drug Resistance; HEK293 Cells; Hemeproteins; Hemoglobins; Humans; Indoles; Inhibitory Concentration 50; Membrane Potential, Mitochondrial; Mitochondria; Plasmodium falciparum; Structure-Activity Relationship	2013
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]-N-[(piperidin-4-yl)methyl]methanamine (MMV019918) and analog European journal of medicinal chemistry, 2018, Apr-25, Volume: 150 Topics: Antimalarials; Dose-Response Relationship, Drug; Enzyme Inhibitors; Furans; Life Cycle Stages; Malaria, Falciparum; Methyltransferases; Molecular Structure; Parasitic Sensitivity Tests; Piperidines; Plasmodium falciparum; Structure-Activity Relationship	2018
One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites. European journal of medicinal chemistry, 2018, Oct-05, Volume: 158 Topics: Acetylation; Antimalarials; Hep G2 Cells; Histone Deacetylase Inhibitors; Histones; Humans; Malaria, Falciparum; Peptoids; Plasmodium falciparum; Protozoan Proteins	2018
Structure-Activity Relationship Studies and Plasmodium Life Cycle Profiling Identifies Pan-Active N-Aryl-3-trifluoromethyl Pyrido[1,2- a]benzimidazoles Which Are Efficacious in an in Vivo Mouse Model of Malaria. Journal of medicinal chemistry, 2019, 01-24, Volume: 62, Issue:2 Topics: Animals; Antimalarials; Benzimidazoles; Disease Models, Animal; Drug Design; ERG1 Potassium Channel; Half-Life; Hemeproteins; Life Cycle Stages; Malaria; Mice; Mice, Inbred C57BL; Plasmodium; Structure-Activity Relationship; Survival Rate	2019
Synthesis, Structure-Activity Relationship, and Antimalarial Efficacy of 6-Chloro-2-arylvinylquinolines. Journal of medicinal chemistry, 2020, 10-22, Volume: 63, Issue:20 Topics: Antimalarials; Dose-Response Relationship, Drug; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum; Structure-Activity Relationship	2020
Inhibition of hepatitis B DNA polymerase by intercalating agents. Nature, 1978, Feb-16, Volume: 271, Issue:5646 Topics: Chloroquine; Chlorpromazine; Drug Synergism; Ethidium; Hepatitis B; Hepatitis B virus; Humans; Indicators and Reagents; Methylene Blue; Nucleic Acid Synthesis Inhibitors; Primaquine; Quinacrine	1978
Changes in superhelical density of closed circular deoxyribonucleic acid by intercalation of anti-R-plasmid drugs and primaquine. Antimicrobial agents and chemotherapy, 1977, Volume: 11, Issue:2 Topics: Acridines; Chemical Phenomena; Chemistry; Chloroquine; Chlorpromazine; DNA, Circular; Ethidium; Extrachromosomal Inheritance; Methylene Blue; Plasmids; Primaquine; Pseudomonas; Quinine	1977
Labilizing action of intercalating drugs and dyes on bacterial ribosomes. Biochemistry, 1972, Apr-25, Volume: 11, Issue:9 Topics: Acridines; Bacterial Proteins; Berberine Alkaloids; Carbon Isotopes; Centrifugation, Density Gradient; Chloroquine; Coloring Agents; Daunorubicin; Dioxoles; Escherichia coli; Ethidium; Hot Temperature; Lucanthone; Methylene Blue; Nucleoproteins; Phenanthridines; Phenylalanine; Quinacrine; Quinolines; Ribosomes; RNA, Ribosomal; Spectrometry, Fluorescence; Spermine; Tritium; Uridine	1972
The problems of drug-resistant pathogenic bacteria. Elimination of bacterial episomes by DNA-complexing compounds. Annals of the New York Academy of Sciences, 1971, Jun-11, Volume: 182 Topics: Acridines; Carbon Isotopes; Centrifugation, Density Gradient; Cesium; Chloramphenicol; Chlorides; Chloroquine; DNA, Bacterial; Drug Resistance, Microbial; Escherichia coli; Genetics, Microbial; Kanamycin; Lactose; Methylene Blue; Phenanthridines; Quinacrine; Quinine; Rosaniline Dyes; Spermine; Thymidine	1971
The influence of methylene blue on the pentose phosphate pathway in erythrocytes of monkeys infected with Plasmodium knowlesi. The Journal of laboratory and clinical medicine, 1969, Volume: 74, Issue:1 Topics: Animals; Carbon Isotopes; Chloroquine; DNA; Erythrocytes; Glucose; Haplorhini; Isoleucine; Malaria; Methylene Blue; Orotic Acid; Pentosephosphates; Plasmodium; Protein Biosynthesis; Quinacrine; Quinine; RNA; Tritium	1969
The inhibitory effect of mepacrine and chloroquine on the photodynamic action. Arzneimittel-Forschung, 1967, Volume: 17, Issue:6 Topics: Animals; Chloroquine; Depression, Chemical; Light; Methylene Blue; Quinacrine; Tetrahymena	1967
Comparison of the effects of several drugs on tissue uptake of labeled thyroxine and triiodothyronine in the presence of rat plasma in vitro. Metabolism: clinical and experimental, 1966, Volume: 15, Issue:8 Topics: Animals; Chloroquine; Coloring Agents; Dinitrophenols; In Vitro Techniques; Isoniazid; Liver; Methylene Blue; Muscles; Novobiocin; Pituitary Gland; Quinine; Rats; Rose Bengal; Salicylates; Surface-Active Agents; Thyroxine; Triiodothyronine; Trypan Blue	1966
Inhibition of hepatitis B virus specific DNA polymerase by intercalating agents. Medical microbiology and immunology, 1980, Volume: 168, Issue:1 Topics: Carrier State; Chloroquine; DNA-Directed DNA Polymerase; Ethidium; Hepatitis B; Hepatitis B Antigens; Hepatitis B virus; Humans; Intercalating Agents; Magnesium; Methylene Blue; Nucleic Acid Synthesis Inhibitors; Primaquine; Quinacrine; Quinine	1980
In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:11 Topics: Animals; Artemisinins; Chloroquine; Drug Resistance; Drug Synergism; Erythrocytes; Methylene Blue; Parasitic Sensitivity Tests; Plasmodium falciparum; Sesquiterpenes	2005
A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds. Experimental parasitology, 2007, Volume: 116, Issue:3 Topics: Amodiaquine; Animals; Antimalarials; Artemether; Artemisinins; Atovaquone; Chloroquine; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Glutathione; Heme; Indicators and Reagents; Mefloquine; Methylene Blue; o-Phthalaldehyde; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinine; Spectrometry, Fluorescence	2007
In vitro antimalarial activity of methylene blue against field isolates of Plasmodium falciparum from children in Southwest Nigeria. The Indian journal of medical research, 2007, Volume: 126, Issue:1 Topics: Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Female; Humans; Male; Methylene Blue; Plasmodium falciparum; Quinine	2007
In vitro activity of Proveblue (methylene blue) on Plasmodium falciparum strains resistant to standard antimalarial drugs. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:5 Topics: Amodiaquine; Antimalarials; Chloroquine; Ethanolamines; Fluorenes; Inhibitory Concentration 50; Lumefantrine; Mefloquine; Methylene Blue; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine	2011
A partial convergence in action of methylene blue and artemisinins: antagonism with chloroquine, a reversal with verapamil, and an insight into the antimalarial activity of chloroquine. ChemMedChem, 2011, Sep-05, Volume: 6, Issue:9 Topics: Animals; Antimalarials; Artemisinins; Chloroquine; Drug Resistance; Drug Synergism; Flavin-Adenine Dinucleotide; Homeostasis; Humans; Malaria; Methylene Blue; Oxidation-Reduction; Verapamil	2011
Acute life-threatening methaemoglobinaemia following ingestion of chloroquine. BMJ case reports, 2012, Mar-20, Volume: 2012 Topics: Acute Disease; Adult; Antimalarials; Chloroquine; Diagnosis, Differential; Enzyme Inhibitors; Fever; Humans; Male; Methemoglobinemia; Methylene Blue	2012
The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine. Memorias do Instituto Oswaldo Cruz, 2012, Volume: 107, Issue:6 Topics: Animals; Antimalarials; Chloroquine; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Malaria; Male; Methylene Blue; Mice; Plasmodium berghei; Pyrimethamine; Quinine	2012
Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action. ChemMedChem, 2012, Volume: 7, Issue:12 Topics: Antimalarials; Artemisinins; Chloroquine; Drug Interactions; Ferric Compounds; Flavin-Adenine Dinucleotide; Humans; Malaria; Methylene Blue; NAD; NADP; Oxidative Stress; Quinolines; Riboflavin	2012
The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:5 Topics: Antimalarials; Atovaquone; Chloroquine; Electron Transport; Erythrocytes; Humans; Inhibitory Concentration 50; Methylene Blue; Mitochondria; Oxidation-Reduction; Plasmodium falciparum; Structure-Activity Relationship; Vitamin K 3	2013
Effect of chloroquine, methylene blue and artemether on red cell and hepatic antioxidant defence system in mice infected with Plasmodium yoelii nigeriensis. Parasitology research, 2013, Volume: 112, Issue:7 Topics: Animals; Antimalarials; Antioxidants; Artemether; Artemisinins; Chloroquine; Erythrocytes; Liver; Malaria; Methylene Blue; Mice; Oxidative Stress; Plasmodium yoelii	2013
Methylene blue inhibits the asexual development of vivax malaria parasites from a region of increasing chloroquine resistance. The Journal of antimicrobial chemotherapy, 2015, Volume: 70, Issue:1 Topics: Antimalarials; Cell Survival; Chloroquine; Drug Resistance; Flow Cytometry; Humans; Inhibitory Concentration 50; Laser Scanning Cytometry; Malaria, Vivax; Methylene Blue; Myanmar; Parasitic Sensitivity Tests; Plasmodium vivax; Thailand	2015
Metabolic Dysregulation Induced in Plasmodium falciparum by Dihydroartemisinin and Other Front-Line Antimalarial Drugs. The Journal of infectious diseases, 2016, Jan-15, Volume: 213, Issue:2 Topics: Antimalarials; Artemisinins; Atovaquone; Chloroquine; Fosfomycin; Gas Chromatography-Mass Spectrometry; Hemoglobins; Inhibitory Concentration 50; Methylene Blue; Naphthyridines; Plasmodium falciparum; Proguanil; Triazines	2016