methyldopa has been researched along with verapamil in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (42.86) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 5 (17.86) | 29.6817 |
| 2010's | 10 (35.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bones, PJ; Lewis, GR; Maslowski, AH; Morley, KD | 1 |
| Denkl, P; Haas, Th | 1 |
| Babaian, AS; Dzhandzhapanian, AZ; Gurgenian, SV; Mikaelian, ES | 1 |
| Ram, CV | 1 |
| Rodrigues, R; Spritzer, N; Spritzer, TS | 1 |
| Robinson, BF | 1 |
| Barnea, ER; DeCherney, AH; Fakih, H; Naftolin, F; Oelsner, G; Walner, S | 1 |
| Nast, HP; Philipp, T | 1 |
| Hunt, D; Peter, T; Sloman, G; Vohra, J | 1 |
| Heinrich, F; Schultis, K | 1 |
| Kolts, BE; Langfitt, M | 1 |
| Eliahou, HE; Iaina, A | 1 |
| Carrasco, RM; da Rocha, MM; Luna, RL | 1 |
| Candy, G; Libhaber, E; Radevski, I; Sareli, P; Skudicky, D; Staessen, JA; Thijs, L; Tshele, E; Valtchanova, Z; Wang, JG | 1 |
4 review(s) available for methyldopa and verapamil
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Calcium antagonists in the treatment of hypertension.
Topics: Biological Transport, Active; Calcium; Calcium Channel Blockers; Captopril; Diltiazem; Diuretics; Drug Resistance; Drug Therapy, Combination; Electrophysiology; Humans; Hypertension; Hypertension, Renovascular; Ion Channels; Kinetics; Methyldopa; Muscle, Smooth, Vascular; Nifedipine; Propranolol; Sodium; Vascular Resistance; Verapamil | 1985 |
Calcium-entry blocking agents in the treatment of systemic hypertension.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Diuretics; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Methyldopa; Nifedipine; Renin; Sodium; Verapamil | 1985 |
From beta blockers to Ca2+ blockers in hypertension: a review.
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Circulation; Drug Therapy, Combination; Humans; Hypertension; Hypotension; Methyldopa; Nifedipine; Vascular Resistance; Verapamil | 1982 |
1 trial(s) available for methyldopa and verapamil
| Article | Year |
|---|---|
Relationship between treatment-induced changes in left ventricular mass and blood pressure in black african hypertensive patients: results of the Baragwanath Trial.
Topics: Angiotensin-Converting Enzyme Inhibitors; Black People; Blood Pressure; Body Mass Index; Calcium Channel Blockers; Diastole; Diuretics; Echocardiography; Enalapril; Female; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Male; Methyldopa; Middle Aged; Nifedipine; Patient Compliance; Regression Analysis; South Africa; Systole; Verapamil | 2002 |
23 other study(ies) available for methyldopa and verapamil
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Verapamil in the management of hypertensive patients.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Blood Pressure; Humans; Hypertension; Methyldopa; Middle Aged; Verapamil | 1979 |
[Therapy of hypertensive crises].
Topics: Acute Disease; Adrenal Gland Neoplasms; Antihypertensive Agents; Clonidine; Diazoxide; Dihydralazine; Guanethidine; Humans; Hypertension; Hypertension, Malignant; Hypertension, Renal; Methyldopa; Nitroprusside; Pheochromocytoma; Reserpine; Verapamil | 1977 |
Efficacy of intravenous verapamil in arterial hypertension refractory to three-step antihypertensive therapy.
Topics: Adult; Antihypertensive Agents; Clonidine; Echocardiography; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Hypertension, Renal; Infusions, Intravenous; Male; Methyldopa; Middle Aged; Nifedipine; Ventricular Function, Left; Verapamil | 1991 |
Treatment of resistant hypertension: 3 years of follow-up with the combination of verapamil and methyldopa.
Topics: Adult; Blood Pressure; Drug Resistance; Drug Therapy, Combination; Electrocardiography; Female; Heart Rate; Humans; Hypertension; Male; Methyldopa; Middle Aged; Verapamil | 1989 |
Effect of antihypertensive drugs on catechol-O-methyltransferase and monoamine oxidase activity in human term placental explants.
Topics: Antihypertensive Agents; Catechol O-Methyltransferase; Dose-Response Relationship, Drug; Female; Humans; Hydralazine; In Vitro Techniques; Magnesium Sulfate; Methyldopa; Monoamine Oxidase; Placenta; Pregnancy; Propranolol; Time Factors; Verapamil | 1986 |
[Hypertensive emergencies].
Topics: Brain Edema; Clonidine; Diazoxide; Digitalis Glycosides; Diuretics; Drug Combinations; Emergencies; Ferricyanides; Ganglionic Blockers; Guanethidine; Humans; Hydralazine; Hypertension; Hypertension, Malignant; Hypnotics and Sedatives; Intensive Care Units; Methyldopa; Minoxidil; Nitric Oxide; Pheochromocytoma; Reserpine; Verapamil | 1974 |
Verapamil induced premature ventricular beats before reversion of supraventricular tachycardia.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Bradycardia; Digoxin; Electrocardiography; Female; Heart Ventricles; Humans; Injections, Intravenous; Male; Methyldopa; Middle Aged; Syndrome; Tachycardia; Tachycardia, Paroxysmal; Verapamil; Wolff-Parkinson-White Syndrome | 1974 |
[Therapy of hypertension].
Topics: Adrenal Gland Neoplasms; Aniline Compounds; Antihypertensive Agents; Diuretics; Female; Guanethidine; Humans; Hydralazine; Hypertension; Imidazoles; Methyldopa; Pheochromocytoma; Porphyrias; Pregnancy; Reserpine; Sympatholytics; Verapamil | 1971 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cholestasis; Cimetidine; Fatty Liver; Female; Hepatic Artery; Hepatic Veins; Humans; Ketoconazole; Liver; Liver Diseases; Liver Neoplasms; Methyldopa; Necrosis; Nitrofurantoin; Peliosis Hepatis; Portal Vein; Valproic Acid; Verapamil | 1984 |
[Behavior of the blood pressure curve during the ergometric stress test, in treated and non-treated hypertensive patients].
Topics: Adult; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Methyldopa; Middle Aged; Physical Exertion; Propranolol; Verapamil | 1981 |