Page last updated: 2024-08-23

methyldopa and prazosin

methyldopa has been researched along with prazosin in 94 studies

Research

Studies (94)

Timeframe	Studies, this research(%)	All Research%
pre-1990	75 (79.79)	18.7374
1990's	5 (5.32)	18.2507
2000's	6 (6.38)	29.6817
2010's	7 (7.45)	24.3611
2020's	1 (1.06)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Nies, AS	1
Oparil, S; Rick, JH	1
Gifford, RW; Tarazi, RC; Wollam, GL	1
Klien, W	1
Baietti, M; Carletta, C; Liuti, G; Mancinella, A; Paolucci, M	1
Kuchel, OG; Mahon, WA; McKenzie, JK; Ogilvie, RI	1
Enenkel, W	1
Cybulska, I	1
Sternon, J	1
Avery, GS; Brogden, RN; Heel, RC; Speight, TM	1
Riddiough, MA	1
Itskovitz, HD; Kochar, MS; Zeller, JR	1
Kuzmanić, D; Marinković, M; Radonić, M; Vrhovac, B	1
Schumacher, GE	1
Bradley, WF; Hoffman, FG; Hutchison, JC; Kalams, Z; Waldron, SL	1
Kuokkanen, K; Mattila, MJ	1
Patki, SA; Phadke, AS; Raje, PC	1
Gruppillo, P; Masoni, A; Pirani, R; Tomasi, AM	1
Finnerty, FA	2
Busby, P; Fernandes, M; Gould, AB; Kim, KE; Onesti, G; Smith, IS; Swartz, C; Weder, A	1
Grenfell, RF	1
Clark, DW; Curzio, JL; Howie, CA; Reid, JL	1
Arakaki, Y; Nakamura, N; Takaesu, N	1
Cowie, RL; Dansey, RD	1
Macaulay, RM; Pearl, RM; Waters, LM	1
Gupta, PP; Srivastava, AK; Srivastava, YP	1
Batts, J; Branche, G; Brown, J; Dowdy, V; King, A; Streets, M	1
Cerný, J; Dolezel, S; Dostál, M; Guba, P; Petrzilka, J; Sotolová, O; Urbánek, P; Vasků, A; Vasků, J	1
Cerný, J; Dostál, M; Gregor, Z; Guba, P; Rebícek, J; Sotolová, O; Urbánek, P; Vasků, A; Vasků, J	1
Durando, C; Gessa, M; Leidi, L; Maina, G; Margaria, E; Medaglia, M	1
Materson, BJ	1
Smith, PJ; Talbert, RL	1
Rubin, PC	1
Lamy, PP	1
Brunelle, R; Callaghan, JT; Goldberg, MR	1
Baricevic, K; Darley, P; Guittard, G; Place, V; Pruitt, B; Ramans, A	1
Fölling, M; Haugland, H; Pedersen, OM	1
Feldstein, E; Hernández-Pieretti, O; Morillo, J; Pellicer, R; Silva, H; Urbina-Quintana, A; Velasco, M	1
Redgrave, JE; Swartz, SL	1
Barnes, J; Drew, P; Sharman, VL; Vandenburg, MJ; Wright, P	1
Petrie, JC	1
Doyle, AE	1
Mashford, ML	1
Prinsley, DM	1
Weinshilboum, RM	1
Bullen, MU	1
van Zwieten, PA	1
Scapellato, L; Stornello, M	1
Marxer, A; Schier, O	1
Koller, H; Prager, H	1
Andrews, K; Kiruluta, HG	1
Wallin, JD	1
Stevenson, JG; Umstead, GS	1
Drayer, JI; Weber, MA	1
Timmermans, PB; Van Brummelen, P; Van Zwieten, PA	1
Bartay, J; Benson, D; Peterson, LG	1
Clineschmidt, BV; Faison, EP; Flataker, LM; Haubrich, DR	1
Chernow, B; Coleman, MD; Lake, CR; Zaloga, GP; Ziegler, MG	1
Moyer, JH	1
Latham, L; Lorimer, AR; McAreavey, D; McLaren, AD; Ramsey, LE; Reid, JL; Robertson, JI; Robertson, MP; Weir, RJ	1
Goldberg, MR; Robertson, D; Tung, CS	1
Lipson, LG	1
Eide, I; Foss, OP; Helgeland, A; Kjeldsen, S; Leren, P	1
Hebnes, K; Løken, H; Storm-Mathisen, H	1
Berkowitz, RL	1
Freed, CR; Gerber, JG; Nies, AS	1
Misra, NP; Pagare, VK	1
Russell, R; Sova-Schultz, K; Walker, WG; Whelton, PK; Wyndham, R	1
Kulkarni, SS; Nanivadekar, AS	1
Houston, MC	1
Reisman, L; Selden, RV	1
Caris, TN	1
Christensen, HD; Gherezghiher, T; Koss, MC	1
Baum, T; Moran, RM; Sabin, C	1
Patel, SC; Yajnik, VH	1
Gavras, H; Gavras, I	1
Shapiro, AP; Traub, YM	1
Kadiri, S; Salako, BL	1
Hall, DR; Odendaal, HJ	1
Grové, D; Hall, DR; Odendaal, HJ; Steyn, DW	1
Grové, D; Hall, DR; Kirsten, GF; Odendaal, HJ; Smith, J	1
Adedapo, AD; Adeleke, S; Okechukwu, R; Sikuade, O	1
Aboul-Enein, HY; Ali, I; ALOthman, ZA; Alsheetan, KM	1

Reviews

22 review(s) available for methyldopa and prazosin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinical pharmacology of antihypertensive drugs. The Medical clinics of North America, 1977, Volume: 61, Issue:3 Topics: Adrenergic alpha-Antagonists; Aldosterone; Angiotensin II; Antihypertensive Agents; Bethanidine; Blood Pressure; Clonidine; Diazoxide; Diuretics; Emergencies; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Minoxidil; Monoamine Oxidase Inhibitors; Nitroprusside; Prazosin; Propranolol; Renin; Reserpine; Sympathetic Nervous System; Trimethaphan	1977
Antihypertensive drugs: clinical pharmacology and therapeutic use. Drugs, 1977, Volume: 14, Issue:6 Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Clonidine; Diazoxide; Diuretics; Ganglionic Blockers; Humans; Hydralazine; Hypertension; Labetalol; Methyldopa; Minoxidil; Monoamine Oxidase Inhibitors; Nitroprusside; Potassium; Prazosin; Secologanin Tryptamine Alkaloids; Sympatholytics	1977
[Etiology, pathogenesis and epidemiology of hypertension]. Wiener medizinische Wochenschrift (1946), 1978, Volume: 128 Suppl 1 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Animals; Benzothiadiazines; Cardiac Output; Clonidine; Diuretics; Drug Evaluation; Haplorhini; Heart Rate; Hemodynamics; Humans; Hypertension; Methyldopa; Middle Aged; Prazosin; Rats; Sodium Chloride; Sodium Chloride Symporter Inhibitors; Stress, Psychological	1978
[Cardiac therapy in the old patient]. Wiener medizinische Wochenschrift (1946), 1979, Oct-10, Volume: 129, Issue:18 Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Body Water; Calcium; Clonidine; Digitalis Glycosides; Diuretics; Dose-Response Relationship, Drug; Drug Tolerance; Glomerular Filtration Rate; Heart Diseases; Heart Failure; Humans; Hypertension; Isosorbide Dinitrate; Kidney; Methyldopa; Middle Aged; Nitroglycerin; Prazosin; Reserpine; Water-Electrolyte Balance	1979
Prazosin: a review of its pharmacological properties and therapeutic efficacy in hypertension. Drugs, 1977, Volume: 14, Issue:3 Topics: Animals; Benzothiadiazines; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug Eruptions; Drug Therapy, Combination; Heart Rate; Humans; Hydralazine; Hypertension; Kidney; Kidney Diseases; Kinetics; Methyldopa; Prazosin; Quinazolines; Renin; Sodium Chloride Symporter Inhibitors; Time Factors	1977
Preventing, detecting and managing adverse reactions of antihypertensive agents in the ambulant patient with essential hypertension. American journal of hospital pharmacy, 1977, Volume: 34, Issue:5 Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Drug Interactions; Ethacrynic Acid; Furosemide; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Minoxidil; Prazosin; Propranolol; Reserpine; Sodium Chloride Symporter Inhibitors; Spironolactone	1977
Using pharmacokinetics in drug therapy. V: Contributions to developing dosage regimens for antihypertensive drugs. American journal of hospital pharmacy, 1979, Volume: 36, Issue:9 Topics: Antihypertensive Agents; Clonidine; Drug Administration Schedule; Guanethidine; Humans; Hydralazine; Kinetics; Methyldopa; Minoxidil; Prazosin; Propranolol	1979
Adverse effects of antihypertensive treatment. Cardiology clinics, 1986, Volume: 4, Issue:1 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Diuretics; Enzyme Inhibitors; Humans; Hypertension; Labetalol; Methyldopa; Prazosin; Quality of Life; Sympatholytics; Vasodilator Agents	1986
Sexual dysfunction with antihypertensive and antipsychotic agents. Clinical pharmacy, 1986, Volume: 5, Issue:5 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Antipsychotic Agents; Benzothiadiazines; Calcium Channel Blockers; Clonidine; Diuretics; Ejaculation; Female; Guanethidine; Humans; Male; Methyldopa; Orgasm; Penile Erection; Prazosin; Reserpine; Sexual Dysfunction, Physiological; Sodium Chloride Symporter Inhibitors; Spironolactone	1986
Treatment of hypertension in pregnancy. Clinics in obstetrics and gynaecology, 1986, Volume: 13, Issue:2 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Diazoxide; Diuretics; Eclampsia; Female; Humans; Hydralazine; Hypertension; Methyldopa; Nitroprusside; Prazosin; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular	1986
Potential adverse effects of antihypertensive drugs in the elderly. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1988, Volume: 6, Issue:1 Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Diuretics; Humans; Methyldopa; Prazosin	1988
Pharmacology of centrally acting hypotensive drugs. British journal of clinical pharmacology, 1980, Volume: 10 Suppl 1 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Brain; Clonidine; Guanfacine; Guanidines; Heart Rate; Humans; Imidazoles; Methyldopa; Phenylacetates; Prazosin; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Cholinergic; Yohimbine	1980
[Bases of pharmacological therapy of essential hypertension]. Recenti progressi in medicina, 1980, Volume: 69, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Antihypertensive Agents; Captopril; Clonidine; Diuretics; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Middle Aged; Minoxidil; Monoamine Oxidase Inhibitors; Prazosin; Secologanin Tryptamine Alkaloids	1980
Antihypertensive agents 1969-1980. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 1981, Volume: 25 Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Clonidine; Ergolines; Fusaric Acid; Guanidines; Humans; Hydralazine; Indoramin; Methyldopa; Minoxidil; Nifedipine; Piperazines; Prazosin; Prostaglandins	1981
Central and peripheral blockade of the sympathetic nervous system. The American journal of medicine, 1984, Oct-05, Volume: 77, Issue:4A Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Clonidine; Diuretics; Drug Therapy, Combination; Guanabenz; Humans; Hypertension; Indoramin; Labetalol; Methyldopa; Prazosin; Quinazolines; Reserpine; Sympathetic Nervous System; Sympatholytics	1984
Role of alpha adrenoceptors in hypertension and in antihypertensive drug treatment. The American journal of medicine, 1984, Oct-05, Volume: 77, Issue:4A Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Azepines; Blood Pressure; Calcium Channel Blockers; Clonidine; Guanfacine; Guanidines; Humans; Hypertension; Ketanserin; Methyldopa; Muscle, Smooth, Vascular; Phenylacetates; Piperazines; Piperidines; Prazosin; Radioligand Assay; Receptors, Adrenergic, alpha; Vascular Resistance	1984
Drug systems approach to hypertension. Pennsylvania medicine, 1984, Volume: 87, Issue:5 Topics: Captopril; Clonidine; Drug Combinations; Drug Therapy, Combination; Guanethidine; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Hypertension, Malignant; Methyldopa; Patient Compliance; Prazosin; Proteinuria; Renin-Angiotensin System; Reserpine; Spironolactone	1984
Anti-hypertensive drugs in the pregnant patient. Obstetrical & gynecological survey, 1980, Volume: 35, Issue:4 Topics: Antihypertensive Agents; Chronic Disease; Clonidine; Diazoxide; Diuretics; Female; Fetus; Furosemide; Guanethidine; Humans; Hydralazine; Hypertension; Infant Mortality; Methyldopa; Nitroprusside; Prazosin; Pre-Eclampsia; Pregnancy; Pregnancy Complications, Cardiovascular; Propranolol; Secologanin Tryptamine Alkaloids; Sodium; Sodium Chloride Symporter Inhibitors	1980
Antihypertensive pharmacology. The Western journal of medicine, 1980, Volume: 132, Issue:5 Topics: Adolescent; Adult; Antihypertensive Agents; Clonidine; Diazoxide; Diuretics; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Metoprolol; Minoxidil; Nitroprusside; Patient Compliance; Prazosin; Propranolol; Reserpine; Sodium Chloride Symporter Inhibitors	1980
Clonidine hydrochloride. Southern medical journal, 1982, Volume: 75, Issue:6 Topics: Antihypertensive Agents; Clonidine; Diuretics; Drug Interactions; Drug Therapy, Combination; Hemodynamics; Humans; Kinetics; Methyldopa; Prazosin; Propranolol; Renin-Angiotensin System; Vasodilator Agents	1982
Management of systemic hypertension in children. Pediatric annals, 1982, Volume: 11, Issue:7 Topics: Adolescent; Antihypertensive Agents; Child; Clonidine; Diazoxide; Diet, Sodium-Restricted; Diuretics; Humans; Hydralazine; Hypertension; Methyldopa; Minoxidil; Nitroprusside; Prazosin; Propranolol	1982

Trials

17 trial(s) available for methyldopa and prazosin

Article	Year
Prazosin: a review of its pharmacological properties and therapeutic efficacy in hypertension. Drugs, 1977, Volume: 14, Issue:3 Topics: Animals; Benzothiadiazines; Blood Pressure; Clinical Trials as Topic; Diuretics; Drug Eruptions; Drug Therapy, Combination; Heart Rate; Humans; Hydralazine; Hypertension; Kidney; Kidney Diseases; Kinetics; Methyldopa; Prazosin; Quinazolines; Renin; Sodium Chloride Symporter Inhibitors; Time Factors	1977
Prazosin in hypertension with and without methyldopa. Clinical pharmacology and therapeutics, 1979, Volume: 25, Issue:2 Topics: Adult; Blood Pressure; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Prazosin; Quinazolines	1979
Comparative study with prazosin, methyldopa and polythiazide in arterial hypertension. International journal of clinical pharmacology and biopharmacy, 1979, Volume: 17, Issue:1 Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Polythiazide; Prazosin; Pulse; Quinazolines; Renin	1979
Comparison of prazosin and methyldopa in mild to moderate hypertension, a multicenter cooperative study. Current therapeutic research, clinical and experimental, 1977, Volume: 21, Issue:1 Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Female; Heart Rate; Humans; Hypertension; Male; Methyldopa; Middle Aged; Prazosin; Quinazolines; Time Factors	1977
Antihypertensive effect of prazosin in combination with methyldopa, clonidine, or propranolol. Annals of clinical research, 1979, Volume: 11, Issue:1 Topics: Adult; Blood Pressure; Clonidine; Drug Combinations; Drug Evaluation; Female; Heart Rate; Humans; Hypertension; Male; Methyldopa; Middle Aged; Placebos; Prazosin; Propranolol; Quinazolines	1979
Prazosin in the treatment of hypertension. Clinical science and molecular medicine. Supplement, 1975, Volume: 2 Topics: Animals; Blood Pressure; Cardiac Output; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Methyldopa; Posture; Prazosin; Quinazolines; Rats; Vascular Resistance	1975
Captopril in hypertensive black men in southern Africa. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1990, Oct-20, Volume: 78, Issue:8 Topics: Captopril; Drug Evaluation; Drug Therapy, Combination; Humans; Hypertension; Male; Methyldopa; Prazosin	1990
Double-blind comparator trials with pinacidil, a potassium channel opener. Drugs, 1988, Volume: 36 Suppl 7 Topics: Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Guanidines; Heart Rate; Humans; Hydralazine; Hypertension; Methyldopa; Middle Aged; Pinacidil; Potassium Channels; Prazosin; Random Allocation	1988
Human buccal assay for evaluation of the mucosal irritation potential of drugs. Clinical pharmacology and therapeutics, 1988, Volume: 43, Issue:3 Topics: Administration, Topical; Adult; Albuterol; Anti-Inflammatory Agents, Non-Steroidal; Female; Furosemide; Gels; Humans; Male; Methyldopa; Middle Aged; Mouth Mucosa; Prazosin; Prognosis; Propranolol; Time Factors	1988
Changes in ventricular septal thickness in systemic hypertension during treatment with methyldopa and prazosin. The American journal of cardiology, 1986, Sep-01, Volume: 58, Issue:6 Topics: Adult; Clinical Trials as Topic; Echocardiography; Heart Septum; Heart Ventricles; Humans; Hypertension; Male; Methyldopa; Prazosin	1986
Effects of prazosin and alphamethyldopa on blood lipids and lipoproteins in hypertensive patients. European journal of clinical pharmacology, 1985, Volume: 28, Issue:5 Topics: Adult; Blood Pressure; Clinical Trials as Topic; Fatty Acids, Nonesterified; Heart Rate; Humans; Hypertension; Insulin; Lipids; Lipoproteins; Methyldopa; Middle Aged; Prazosin; Random Allocation	1985
Quadruple therapy for resistant hypertension. The British journal of clinical practice, 1985, Volume: 39, Issue:1 Topics: Antihypertensive Agents; Drug Therapy, Combination; Female; Guanethidine; Humans; Hypertension; Male; Methyldopa; Middle Aged; Prazosin	1985
"Third drug" trial: comparative study of antihypertensive agents added to treatment when blood pressure remains uncontrolled by a beta blocker plus thiazide diuretic. British medical journal (Clinical research ed.), 1984, Jan-14, Volume: 288, Issue:6411 Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Atenolol; Bendroflumethiazide; Blood Pressure; Clinical Trials as Topic; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydralazine; Hypertension; Labetalol; Male; Methyldopa; Middle Aged; Minoxidil; Prazosin	1984
A single blind crossover study of prazosin and methyldopa in hypertension. The Journal of the Association of Physicians of India, 1980, Volume: 28, Issue:11 Topics: Clinical Trials as Topic; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Prazosin; Quinazolines	1980
[Comparative study between prazosin and methyldopa in essential arterial hypertension: results of a parallel, randomized double-blind trial]. Cardiology, 1980, Volume: 66 Suppl 2 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Prazosin; Quinazolines; Random Allocation; Renin	1980
Prazosin and methyldopa in hypertension. The Practitioner, 1981, Volume: 225, Issue:1359 Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Prazosin; Quinazolines	1981
The addition of a diuretic to anti-hypertensive therapy for early severe hypertension in pregnancy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1998, Volume: 60, Issue:1 Topics: Adult; Amiloride; Antihypertensive Agents; Diuretics; Drug Combinations; Drug Therapy, Combination; Female; Gestational Age; Humans; Hydrochlorothiazide; Hypertension; Length of Stay; Methyldopa; Nifedipine; Prazosin; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy Outcome; Treatment Outcome	1998

Other Studies

56 other study(ies) available for methyldopa and prazosin

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Drug treatment of hypertension. Comprehensive therapy, 1977, Volume: 3, Issue:5 Topics: Clonidine; Diazoxide; Diuretics; Ganglionic Blockers; Guanethidine; Humans; Hydralazine; Hypertension; Mecamylamine; Methyldopa; Mineralocorticoid Receptor Antagonists; Minoxidil; Nitroprusside; Prazosin; Propranolol; Secologanin Tryptamine Alkaloids; Sodium Chloride Symporter Inhibitors; Spironolactone; Sympatholytics; Triamterene; Trimethaphan; Vasodilator Agents	1977
[Treatment of arterial hypertension in the aged]. La Clinica terapeutica, 1978, Aug-31, Volume: 86, Issue:4 Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Antihypertensive Agents; Clonidine; Diuretics; Humans; Hydralazine; Hypertension; Hypertension, Renovascular; Methyldopa; Prazosin; Prostaglandins, Synthetic; Reserpine	1978
Approach to drug therapy for hypertension. Canadian Medical Association journal, 1979, Mar-03, Volume: 120, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Guanidines; Humans; Hydralazine; Hypertension; Methyldopa; Middle Aged; Patient Care Planning; Patient Compliance; Prazosin; Reserpine; Sodium Chloride Symporter Inhibitors; Spironolactone; Vasodilator Agents	1979
[Hypotensive drugs]. Polskie Archiwum Medycyny Wewnetrznej, 1979, Volume: 62, Issue:5 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Clonidine; Diuretics; Guanidines; Humans; Hypertension; Methyldopa; Minoxidil; Prazosin; Secologanin Tryptamine Alkaloids; Vasodilator Agents	1979
[The practitioner and drug-induced, predominantly orthostatic hypotension]. Acta clinica Belgica, 1978, Volume: 33, Issue:6 Topics: Adrenergic Agents; Adrenergic Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Antihypertensive Agents; Antipsychotic Agents; Barbiturates; Butyrophenones; Clonidine; Debrisoquin; Diazoxide; Diuretics; Ganglionic Blockers; Humans; Hydralazine; Hypotension, Orthostatic; Levodopa; Meprobamate; Methyldopa; Mineralocorticoids; Monoamine Oxidase Inhibitors; Phenothiazines; Prazosin; Psychotropic Drugs; Reserpine; Vasodilator Agents	1978
Prazosin and methyldopa in essential hypertension. The Journal of the Association of Physicians of India, 1979, Volume: 27, Issue:2 Topics: Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Prazosin; Quinazolines	1979
[Short-term and median-term effects of tienilic acid in hypertension]. Giornale italiano di cardiologia, 1979, Volume: 9, Issue:12 Topics: Adult; Aged; Drug Evaluation; Drug Therapy, Combination; Female; Glycolates; Humans; Hypertension; Male; Methyldopa; Middle Aged; Potassium; Prazosin; Propranolol; Ticrynafen; Triglycerides; Uric Acid	1979
Workup and treatment of the average hypertensive patient. Comprehensive therapy, 1978, Volume: 4, Issue:12 Topics: Benzothiadiazines; Clonidine; Diuretics; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Minoxidil; Prazosin; Propranolol; Radiography; Renin; Reserpine; Sodium Chloride Symporter Inhibitors	1978
Treatment of chronic essential hypertension. Comprehensive therapy, 1977, Volume: 3, Issue:5 Topics: Chlorothiazide; Clonidine; Diabetes Mellitus; Diet, Sodium-Restricted; Gout; Guanethidine; Humans; Hydralazine; Hypertension; Hypnotics and Sedatives; Medical History Taking; Methyldopa; Patient Compliance; Physical Examination; Phytotherapy; Plants, Medicinal; Potassium; Prazosin; Prognosis; Propranolol; Rauwolfia; Sympathectomy; Tranquilizing Agents	1977
First-choice antihypertensive drug use in the Glasgow Blood Pressure Clinic. Journal of cardiovascular pharmacology, 1990, Volume: 16 Suppl 7 Topics: Adrenergic beta-Antagonists; Ambulatory Care Facilities; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Clonidine; Costs and Cost Analysis; Humans; Hydralazine; Hypertension; Methyldopa; Prazosin; Scotland	1990
Priapism in haemodialysis patient due to prazosin? British journal of urology, 1991, Volume: 68, Issue:5 Topics: Adult; Drug Therapy, Combination; Heparin; Humans; Hypertension; Male; Methyldopa; Nifedipine; Prazosin; Priapism; Renal Dialysis	1991
A comparative analysis of the ability of five classes of pharmacological agents to augment skin flap survival in various models and species: an attempt to standardize skin flap research. Annals of plastic surgery, 1989, Volume: 23, Issue:2 Topics: Animals; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation, Preclinical; Graft Survival; Isoxsuprine; Macaca nemestrina; Male; Methyldopa; Nitroglycerin; Prazosin; Rats; Surgical Flaps	1989
Characterization of alpha-adrenoceptors involved in central thermoregulation in rabbits. Indian journal of experimental biology, 1989, Volume: 27, Issue:6 Topics: Adrenergic alpha-Antagonists; Animals; Body Temperature; Body Temperature Regulation; Female; Male; Methyldopa; Piperoxan; Prazosin; Rabbits; Receptors, Adrenergic, alpha	1989
Centrally acting alpha-2 agonists, peripherally acting adrenergic-blocking drugs, and direct vasodilators in the treatment of mild and moderate essential hypertension. Clinical cardiology, 1989, Volume: 12, Issue:12 Suppl 4 Topics: Adult; Aged; Black People; Clinical Protocols; Clonidine; Drug Therapy, Combination; Humans; Hydralazine; Hypertension; Methyldopa; Middle Aged; Prazosin	1989
Therapy of venous hypertension in calves with total artificial heart (TAH). The International journal of artificial organs, 1989, Volume: 12, Issue:4 Topics: Animals; Antihypertensive Agents; Captopril; Cardiac Pacing, Artificial; Cattle; Central Venous Pressure; Clonidine; Heart, Artificial; Hypertension; Liver Function Tests; Methyldopa; Nifedipine; Postoperative Complications; Prazosin	1989
[Therapy of venous hypertension in animals with an artificial heart and long-term survival]. Casopis lekaru ceskych, 1989, Sep-01, Volume: 128, Issue:36 Topics: Animals; Antihypertensive Agents; Captopril; Cattle; Clonidine; Diltiazem; Heart, Artificial; Methyldopa; Nifedipine; Prazosin; Venous Pressure	1989
[Hypertension in pregnancy: proposed monitoring and therapy]. Minerva ginecologica, 1985, Volume: 37, Issue:10 Topics: Adrenergic beta-Antagonists; Captopril; Diuretics; Female; Follow-Up Studies; Humans; Hydralazine; Hypertension; Labetalol; Methyldopa; Prazosin; Pregnancy; Pregnancy Complications, Cardiovascular	1985
Diagnosis and management of malignant hypertension. Comprehensive therapy, 1985, Volume: 11, Issue:3 Topics: Antihypertensive Agents; Female; Humans; Hydralazine; Hypertension, Malignant; Kidney Function Tests; Male; Methyldopa; Minoxidil; Nitroprusside; Phentolamine; Prazosin; Pregnancy; Pregnancy Complications, Cardiovascular; Propranolol; Reserpine; Retinal Hemorrhage; Retinal Vessels; Trimethaphan	1985
Current trends in the management of hypertension. Comprehensive therapy, 1980, Volume: 6, Issue:3 Topics: Adrenergic beta-Antagonists; Aged; Diazoxide; Diuretics; Female; Humans; Hydralazine; Hypertension; Male; Methyldopa; Middle Aged; Minoxidil; Nitroprusside; Prazosin; Risk; Vasodilator Agents	1980
Errors in the treatment of hypertension. Drugs, 1980, Volume: 19, Issue:3 Topics: Adrenergic beta-Antagonists; Blood Pressure; Clonidine; Diuretics; Humans; Hypertension; Methyldopa; Patient Compliance; Prazosin	1980
Adverse drug reactions to antihypertensive therapy. Australian family physician, 1980, Volume: 9, Issue:4 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Humans; Hydralazine; Hypertension; Methyldopa; Physician-Patient Relations; Prazosin; Sodium Chloride Symporter Inhibitors	1980
The older patient with hypertension. Australian family physician, 1980, Volume: 9, Issue:4 Topics: Adrenergic beta-Antagonists; Aged; Aging; Benzothiadiazines; Blood Pressure; Blood Pressure Determination; Diuretics; Drug Interactions; Female; Humans; Hypertension; Male; Methyldopa; Patient Compliance; Potassium; Prazosin; Sodium Chloride Symporter Inhibitors	1980
Antihypertensive drugs that alter adrenergic function. Mayo Clinic proceedings, 1980, Volume: 55, Issue:6 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Catecholamines; Central Nervous System; Clonidine; Guanethidine; Humans; Methyldopa; Metoprolol; Nadolol; Prazosin; Propanolamines; Propranolol; Receptors, Adrenergic; Reserpine; Sympathetic Nervous System	1980
What patients with hypertension should know about their medication. Drugs, 1980, Volume: 19, Issue:5 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Clonidine; Diuretics; Humans; Hydralazine; Hypertension; Methyldopa; Patient Education as Topic; Prazosin; Sympatholytics	1980
[The use of vasodilator agents in the therapy of chronic cardiac insufficiency]. Wiener medizinische Wochenschrift (1946), 1982, Oct-15, Volume: 132, Issue:19 Topics: Adrenergic alpha-Antagonists; Calcium Channel Blockers; Captopril; Clonidine; Diuretics; Heart Failure; Humans; Methyldopa; Nitrates; Nitroprusside; Prazosin; Vasodilator Agents	1982
Urinary incontinence secondary to drugs. Urology, 1983, Volume: 22, Issue:1 Topics: Antihypertensive Agents; Antipsychotic Agents; Humans; Methyldopa; Phenoxybenzamine; Phentolamine; Prazosin; Reserpine; Urinary Bladder, Neurogenic; Urinary Incontinence	1983
Antihypertensives and their impact on renal function. The American journal of medicine, 1983, Oct-17, Volume: 75, Issue:4A Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Captopril; Central Nervous System; Clonidine; Glomerular Filtration Rate; Humans; Kidney; Labetalol; Methyldopa; Prazosin; Renal Circulation; Vasodilator Agents	1983
Sexual dysfunction due to antihypertensive agents. Drug intelligence & clinical pharmacy, 1984, Volume: 18, Issue:2 Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Female; Guanethidine; Humans; Hydralazine; Male; Methyldopa; Prazosin; Propranolol; Reserpine; Sex; Sexual Dysfunction, Physiological; Sodium Chloride Symporter Inhibitors; Spironolactone	1984
Office management of hypertension. Comprehensive therapy, 1984, Volume: 10, Issue:2 Topics: Adrenergic beta-Antagonists; Aged; Ambulatory Care; Antihypertensive Agents; Benzothiadiazines; Captopril; Clonidine; Diuretics; Guanabenz; Humans; Hydralazine; Hypertension; Methyldopa; Middle Aged; Prazosin; Reserpine; Sodium Chloride Symporter Inhibitors	1984
Neuropsychiatric manifestations of antihypertensive medications. Psychiatric medicine, 1983, Volume: 1, Issue:2 Topics: Adrenergic beta-Antagonists; Affective Symptoms; Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Furosemide; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Prazosin; Secologanin Tryptamine Alkaloids; Sodium Chloride Symporter Inhibitors	1983
alpha-methyldopa reduces locomotor activity in rats via its metabolite, alpha-methylnorepinephrine, acting on alpha 2-adrenoceptors. Archives internationales de pharmacodynamie et de therapie, 1980, Volume: 244, Issue:2 Topics: Animals; Clonidine; Depression, Chemical; Dose-Response Relationship, Drug; Drug Antagonism; Female; Methyldopa; Motor Activity; Nordefrin; Norepinephrine; Prazosin; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Yohimbine	1980
Effect of antihypertensive therapy on sympathetic nervous system activity in patients with essential hypertension. Federation proceedings, 1984, Volume: 43, Issue:1 Topics: Antihypertensive Agents; Captopril; Clonidine; Guanethidine; Humans; Hydrochlorothiazide; Hypertension; Methyldopa; Prazosin; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Reserpine; Sympathetic Nervous System; Vasodilator Agents	1984
Influence of alpha-methyldopa treatment on adrenergic receptor binding in rat forebrain. Clinical and experimental hypertension. Part A, Theory and practice, 1983, Volume: 5, Issue:9 Topics: Animals; Brain; Clonidine; Dihydroalprenolol; Male; Methyldopa; Prazosin; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Tritium	1983
Treatment of hypertension in diabetic men: problems with sexual dysfunction. The American journal of cardiology, 1984, Jan-27, Volume: 53, Issue:3 Topics: Antihypertensive Agents; Blood Pressure; Diabetic Angiopathies; Erectile Dysfunction; Humans; Hydrochlorothiazide; Hypertension; Male; Methyldopa; Middle Aged; Prazosin	1984
Changes in the lipoprotein profile during antihypertensive therapy. Acta pharmacologica et toxicologica, 1984, Volume: 54 Suppl 1 Topics: Antihypertensive Agents; Cholesterol; Humans; Hydrochlorothiazide; Lipoproteins; Methyldopa; Prazosin; Propranolol; Triglycerides; Uric Acid	1984
Complications in long term treatment of essential hypertension. Acta medica Scandinavica. Supplementum, 1981, Volume: 646 Topics: Benzothiadiazines; Diuretics; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Myocardial Infarction; Prazosin; Sodium Chloride Symporter Inhibitors; Time Factors	1981
Hypertension in older patients: what drugs to use and when. Geriatrics, 1982, Volume: 37, Issue:3 Topics: Aged; Antihypertensive Agents; Clonidine; Diuretics; Humans; Hypertension; Hypotension, Orthostatic; Male; Methyldopa; Middle Aged; Prazosin; Propranolol; Reserpine; Systole	1982
Studies on the mechanism of methyl-dopa-induced mydriasis in the cat. Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 320, Issue:1 Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Cats; Female; Hydrazines; Injections, Intraventricular; Male; Methyldopa; Mydriatics; Prazosin; Pupil; Time Factors; Yohimbine	1982
Comparison of hypotensive, orthostatic and sympathetic inhibitory actions of antihypertensive drugs in rats. Clinical and experimental hypertension, 1981, Volume: 3, Issue:2 Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Diazepam; Guanethidine; Heart Rate; Hydralazine; Hypotension; Male; Mecamylamine; Methyldopa; Minoxidil; Phentolamine; Posture; Prazosin; Propranolol; Rats; Reserpine; Sympathetic Nervous System	1981
Prazosin in hypertension: crossover comparison with methyldopa and long-term efficacy. The Journal of the Association of Physicians of India, 1981, Volume: 29, Issue:7 Topics: Drug Evaluation; Humans; Hypertension; Methyldopa; Prazosin; Quinazolines; Random Allocation	1981
Special considerations in treating hypertension in the elderly. Geriatrics, 1980, Volume: 35, Issue:7 Topics: Aged; Clonidine; Diet, Sodium-Restricted; Diuretics; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Prazosin	1980
Complications of antihypertensive therapy. American family physician, 1981, Volume: 23, Issue:3 Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Diuretics; Female; Guanethidine; Humans; Hydralazine; Hyperglycemia; Hypertension; Hypokalemia; Male; Methyldopa; Minoxidil; Prazosin; Propranolol; Reserpine; Sodium Chloride Symporter Inhibitors; Uric Acid	1981
Parodoxical rise in urinary albumin levels after treatment of essential hypertension. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1997, Volume: 87, Issue:9 Topics: Adult; Aged; Albuminuria; Antihypertensive Agents; Creatinine; Female; Humans; Hydroflumethiazide; Hypertension; Male; Methyldopa; Middle Aged; Prazosin	1997
Expectant management of early onset, severe pre-eclampsia: maternal outcome. BJOG : an international journal of obstetrics and gynaecology, 2000, Volume: 107, Issue:10 Topics: Adolescent; Adult; Antihypertensive Agents; Calcium Channel Blockers; Dihydralazine; Female; Fetal Distress; Humans; Magnesium Sulfate; Methyldopa; Monitoring, Physiologic; Nifedipine; Prazosin; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Prospective Studies	2000
Expectant management of early onset, severe pre-eclampsia: perinatal outcome. BJOG : an international journal of obstetrics and gynaecology, 2000, Volume: 107, Issue:10 Topics: Antihypertensive Agents; Calcium Channel Blockers; Female; Fetal Monitoring; Humans; Infant Mortality; Infant, Newborn; Intensive Care, Neonatal; Length of Stay; Male; Methyldopa; Multivariate Analysis; Nifedipine; Prazosin; Pre-Eclampsia; Pregnancy; Pregnancy Outcome; Prospective Studies	2000
Drug utilization and blood pressure control in a population where antihypertensives are given free: effect of policy change. African journal of medicine and medical sciences, 2012, Volume: 41, Issue:4 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cross-Sectional Studies; Diuretics; Drug Utilization Review; Female; Health Policy; Humans; Hypertension; Male; Medication Adherence; Methyldopa; Middle Aged; Nigeria; Prazosin; Sodium Chloride, Dietary; Treatment Outcome; Vasodilator Agents; Young Adult	2012
Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, Jun-01, Volume: 1146 Topics: Adsorption; Antihypertensive Agents; Chromatography, High Pressure Liquid; Diltiazem; Furosemide; Humans; Hydrochlorothiazide; Irbesartan; Iron; Labetalol; Limit of Detection; Losartan; Metal Nanoparticles; Methyldopa; Nanocomposites; Polyvinyl Alcohol; Prazosin; Propranolol; Reproducibility of Results; Solid Phase Microextraction; Spironolactone; Valsartan	2020