Page last updated: 2024-08-23

methyldopa and phenytoin

methyldopa has been researched along with phenytoin in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (50.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (14.29)	29.6817
2010's	10 (35.71)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Anisimov, VN	1
Kumar, KL; Reuler, JB	1
Tabor, PA	1
Eldredge, NT; Jiller, JJ; van Robertson, WB	1
Pisciotta, AV	1
Tovi, D	1
Koe, BK; Weissman, A	1
Little, JM; Oliver, JH; Pirch, JH	1
Amdisen, A	1
DeSwarte, RD	1
Maas, D; Schubothe, H; Weber, S	1
Maddrey, WC	1
Parker, SW; Surman, OS	1
Mace, DL; Sather, MR; Weber, CE	1

Reviews

6 review(s) available for methyldopa and phenytoin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug-induced fever. Drug intelligence & clinical pharmacy, 1986, Volume: 20, Issue:6 Topics: Anti-Bacterial Agents; Antitubercular Agents; Body Temperature Regulation; Drug Hypersensitivity; Fever; Humans; Methyldopa; Phenytoin; Procainamide; Quinidine	1986
Idiosyncratic hematologic reactions to drugs. Postgraduate medicine, 1974, Volume: 55, Issue:5 Topics: Agranulocytosis; Anemia, Aplastic; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Macrocytic; Aspirin; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Cell Differentiation; Cell Division; Cephalothin; Chloramphenicol; Coombs Test; Drug Hypersensitivity; Erythrocytes; Humans; Methyldopa; Penicillins; Phenytoin; Purpura, Thrombocytopenic; Quinidine	1974
Lithium and drug interactions. Drugs, 1982, Volume: 24, Issue:2 Topics: Anti-Inflammatory Agents; Antipsychotic Agents; Carbamazepine; Diuretics; Drug Interactions; Humans; Iodides; Lithium; Methyldopa; Neuromuscular Blocking Agents; Phenytoin; Tetracyclines	1982
[Clinical significance and pathogenesis of drug- or microbe-induced autoimmune hemolytic anemias]. Immunitat und Infektion, 1983, Volume: 11, Issue:1 Topics: Adult; Anemia, Hemolytic, Autoimmune; Bacterial Infections; Female; Humans; Ibuprofen; Infections; Long-Term Care; Male; Mephenytoin; Methyldopa; Methysergide; Middle Aged; Phenytoin; Pneumonia, Mycoplasma; Virus Diseases	1983
Drug-related acute and chronic hepatitis. Clinics in gastroenterology, 1980, Volume: 9, Issue:1 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Fever; Halothane; Humans; Isoniazid; Liver; Male; Methyldopa; Middle Aged; Necrosis; Oxyphenisatin Acetate; Phenytoin	1980

Other Studies

22 other study(ies) available for methyldopa and phenytoin

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
[Pharmacologic study of adrenergic mechanisms of compensatory hypertrophy of the ovary]. Biulleten' eksperimental'noi biologii i meditsiny, 1975, Volume: 80, Issue:12 Topics: Animals; Castration; Chlorpromazine; Diethylstilbestrol; Disulfiram; Female; Follicle Stimulating Hormone; Levodopa; Methyldopa; Ovary; Phenytoin; Rats; Sympathetic Nervous System	1975
Drug fever. The Western journal of medicine, 1986, Volume: 144, Issue:6 Topics: Allopurinol; Anti-Bacterial Agents; Body Temperature Regulation; Drug Hypersensitivity; Fever; Humans; Interleukin-1; Isoniazid; Methyldopa; Phenytoin; Procainamide; Quinidine	1986
The interaction of lupus-inducing drugs with deoxyribonucleic acid. Clinical immunology and immunopathology, 1974, Volume: 3, Issue:2 Topics: Adult; Animals; Cattle; Child; DNA; DNA, Single-Stranded; Hot Temperature; Humans; Hydralazine; Immunodiffusion; Isoniazid; Lupus Erythematosus, Systemic; Methyldopa; Nucleic Acid Conformation; Nucleic Acid Denaturation; Optical Rotation; Oxazoles; Phenytoin; Procainamide; Propylthiouracil; Thymus Gland; Trimethadione; Viscosity	1974
The use of antifibrinolytic drugs to prevent early recurrent aneurysmal subarachnoid haemorrhage. Acta neurologica Scandinavica, 1973, Volume: 49, Issue:2 Topics: Adult; Aged; Antifibrinolytic Agents; Blood Cell Count; Cerebral Angiography; Cyclohexanecarboxylic Acids; Factor IX; Factor V; Factor VII; Factor X; Female; Fibrin; Fibrinogen; Fibrinolytic Agents; Humans; Hydralazine; Intracranial Aneurysm; Male; Methyldopa; Middle Aged; Phenytoin; Prothrombin; Recurrence; Subarachnoid Hemorrhage	1973
m-Fluorotyrosine convulsions and mortality: relationship to catecholamine and citrate metabolism. The Journal of pharmacology and experimental therapeutics, 1967, Volume: 155, Issue:1 Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anticonvulsants; Atropine; Azoles; Brain; Chlordiazepoxide; Chlorpromazine; Citrates; Dihydroxyphenylalanine; Disulfiram; Drug Antagonism; Drug Synergism; Kidney; Lysergic Acid Diethylamide; Male; Methyldopa; Mice; Morphine; Nialamide; Norepinephrine; Pargyline; Phenobarbital; Phenytoin; Reserpine; Seizures; Serotonin; Strychnine; Tetrabenazine; Trimethadione; Tyrosine; Urea	1967
Effect of reserpine and other drugs on the CNS and lethal effects of hyperbaric oxygen in mice. Archives internationales de pharmacodynamie et de therapie, 1970, Volume: 183, Issue:2 Topics: Animals; Central Nervous System; Electroshock; Hyperbaric Oxygenation; Methods; Methyldopa; Methyltyrosines; Mice; Phenoxybenzamine; Phenylalanine; Phenytoin; Reserpine; Seizures; Tranylcypromine	1970
Drug allergy--problems and strategies. The Journal of allergy and clinical immunology, 1984, Volume: 74, Issue:3 Pt 1 Topics: Anaphylaxis; Anemia, Hemolytic; Antigen-Antibody Complex; Desensitization, Immunologic; Dose-Response Relationship, Immunologic; Drug Hypersensitivity; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Encephalomyelitis, Acute Disseminated; Exanthema; Humans; Hydralazine; Immunity, Cellular; Isoniazid; Kidney Diseases; Liver Diseases; Lupus Erythematosus, Systemic; Lymphoid Tissue; Methyldopa; Nephritis, Interstitial; Penicillins; Phenytoin; Procainamide; Respiratory Hypersensitivity; Vasculitis, Leukocytoclastic, Cutaneous	1984
Complex partial seizures and psychiatric disturbance in end-stage renal disease. Psychosomatics, 1981, Volume: 22, Issue:12 Topics: Acute Kidney Injury; Adult; Anticonvulsants; Electroencephalography; Female; Humans; Methyldopa; Phenytoin; Prednisone; Psychoses, Substance-Induced; Psychotic Disorders; Seizures	1981
Improving patient compliance through use of single daily dosages. Hospital pharmacy, 1977, Volume: 12, Issue:10 Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Drug Administration Schedule; Humans; Methyldopa; Patient Compliance; Phenothiazines; Phenytoin	1977