methyldopa has been researched along with nicotine in 19 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (52.63) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Kuhn, P; Tauberger, G | 1 |
| Dzoljić, M | 1 |
| Miele, E | 1 |
| Kadzielawa, K | 2 |
| Araki, H | 1 |
| Giardina, WJ; Sabelli, HC | 1 |
| Moyer, JH | 1 |
| SCHNIEDEN, H | 1 |
| FUJIWARA, M; SHIMAMOTO, K; YAMAWAKI, T | 1 |
19 other study(ies) available for methyldopa and nicotine
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
[Central nervous sympathetic depressant effects of alpha-methyldopa].
Topics: Action Potentials; Animals; Asphyxia; Blood Pressure; Cats; Central Nervous System; Depression, Chemical; Methyldopa; Nicotine; Nikethamide; Rats; Sympathetic Nervous System | 1971 |
Peristaltic reflex and hypotensive drugs.
Topics: Acetylcholine; Angiotensin II; Animals; Bis-Trimethylammonium Compounds; Gastrointestinal Motility; Guanethidine; Guinea Pigs; Ileum; In Vitro Techniques; Isoproterenol; Methyldopa; Nicotine; Phentolamine; Reflex; Reserpine; Serotonin | 1965 |
[Changes in vascular reactivity of the cat evoked by reserpine, guanethidine and alpha-methyldopa].
Topics: Angiotensin II; Animals; Blood Pressure; Cats; Drug Synergism; Guanethidine; Methyldopa; Nicotine; Norepinephrine; Reserpine; Tyramine | 1966 |
Studies on the pharmacology of alpha-methyl-3,4-dihydroxyphenylalanine (alpha-methyl-dopa) and alpha-methyl-norepinephrine. I.
Topics: Angiotensin II; Animals; Blood Pressure; Cats; Electric Stimulation; Guinea Pigs; Heart Atria; Male; Methyldopa; Monoamine Oxidase; Nerve Endings; Neuromuscular Junction; Nicotine; Nictitating Membrane; Normetanephrine; Phentolamine; Rabbits; Rats; Reserpine; Spleen; Sympathetic Nervous System; Synaptic Transmission; Tyramine; Vas Deferens | 1967 |
[The mechanism of relaxation produced by periarterial nerve stimulation, nicotine and tyramine in the isolated rabbit ileum, particularly in relation to acetylcholine and calcium].
Topics: Acetylcholine; Animals; Bretylium Compounds; Calcium; Cocaine; Depression, Chemical; Dibenzylchlorethamine; Electric Stimulation; Epinephrine; Female; Guanethidine; Hemicholinium 3; Hexamethonium Compounds; Ileum; In Vitro Techniques; Intestine, Small; Male; Methyldopa; Muscle Contraction; Muscle, Smooth; Nicotine; Norepinephrine; Propranolol; Rabbits; Tachyphylaxis; Tyramine | 1972 |
Tranquilizing and electrophysiological effects of nicotine.
Topics: Animals; Arousal; Cerebral Cortex; Depression, Chemical; Disulfiram; Drug Synergism; Electric Stimulation; Electrodes, Implanted; Electroencephalography; Evoked Potentials; Exploratory Behavior; Injections, Intravenous; Male; Methyldopa; Methyltyrosines; Mice; Motor Cortex; Nicotine; Pargyline; Photic Stimulation; Rabbits; Sleep | 1972 |
Optimum therapy for essential hypertension.
Topics: Antihypertensive Agents; Arteriosclerosis; Autonomic Nervous System; Blood Pressure; Chlorothiazide; Diet Therapy; Diuretics; Guanethidine; Humans; Hypertension; Hypnotics and Sedatives; Kidney Function Tests; Methyldopa; Nicotine; Norepinephrine; Obesity; Smoking; Sodium; Stress, Psychological; Tranquilizing Agents | 1972 |
Pharmacology of alpha-methyl DOPA and alpha-methylnoradrenaline.
Topics: Animals; Electroencephalography; Methyldopa; Nicotine; Normetanephrine; Rabbits; Reserpine; Tyramine | 1965 |
EFFECT OF ALPHA METHYL DOPA ON EXPERIMENTAL TREMOR.
Topics: 5-Hydroxytryptophan; Atropine; Electrophysiological Phenomena; Electrophysiology; Equipment and Supplies; Heterocyclic Compounds; Hypnotics and Sedatives; Indoles; Methamphetamine; Methyldopa; Mice; Nicotine; Parasympatholytics; Research; Toxicology; Tremor | 1963 |
EFFECTS OF MONOAMINE RELEASERS ON THE TREMOR CONVULSIONS AND LETHAL EFFECTS OF NICOTINE IN MICE.
Topics: Alkaloids; Amines; Dopamine; Hypnotics and Sedatives; Methyldopa; Mice; Nicotine; Pharmacology; Rauwolfia; Research; Reserpine; Seizures; Tetrabenazine; Toxicology; Tremor | 1964 |