Page last updated: 2024-08-23

methyldopa and acetaminophen

methyldopa has been researched along with acetaminophen in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (44.19)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (18.60)	29.6817
2010's	16 (37.21)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Avdeef, A; Tam, KY	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Bellera, CL; Bruno-Blanch, LE; Castro, EA; Duchowicz, PR; Goodarzi, M; Ortiz, EV; Pesce, G; Talevi, A	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dybing, E	3
Thaler, H	1
Dybing, E; Mitchell, JR	1
Levine, L	1
Lauterburg, BH; Mitchell, JR	1
Dybing, E; McMurtry, RJ; Mitchell, JR; Nelson, SD; Thorgeirsson, SS	1
Dehner, EJ; Martin, ET; Schwartz, JB	1
McGirr, LG; O'Brien, PJ; Subrahmanyam, VV	1
Campbell, NR; Sundaram, RS; Van Loon, J; Weinshilboum, RM; Werness, PG	1
Hirayama, C; Yamamoto, T	1
Finlayson, NC	1
Markoff, N	1
Gault, MH; Hebert, MA; Singh, HP	1
Hodkinson, BA; Laleli, YR; McIntyre, PA; Wagner, HN	1
Kolts, BE; Langfitt, M	1
Foster, MG; Wright, LA	1
Salaspuro, M	1
Büchi, R; Burckhardt-Herold, S; Funk, F; Geisser, P; Klotz, J; Petrig-Schaffland, J	1
Chan, TY; Cheng, CA; Gomersall, CD; Woo, J	1
Asanuma, M; Kikkawa, Y; Kimoto, N; Miyazaki, I; Miyoshi, K; Murakami, S; Takeshima, M	1
Lotfi, S; Veisi, H	1

Reviews

5 review(s) available for methyldopa and acetaminophen

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Reported ocular side effects of the ten most frequently prescribed drugs. Journal of the American Optometric Association, 1979, Volume: 50, Issue:2 Topics: Acetaminophen; Ampicillin; Brompheniramine; Codeine; Diazepam; Digoxin; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Eye; Eye Diseases; Female; Furosemide; Humans; Hydrochlorothiazide; Methyldopa; Phenylephrine; Phenylpropanolamine; Pregnancy; Propranolol; Tetracyclines; Triamterene	1979
Metabolic activation: biochemical basis for many drug-induced liver injuries. Progress in liver diseases, 1976, Volume: 5 Topics: Acetaminophen; Animals; Binding Sites; Carcinogens; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Hydrazines; Isoniazid; Liver; Methyldopa; Necrosis; Pharmaceutical Preparations; Phenacetin; Thiophenes	1976
[Intermediate metabolites and liver toxicity]. Nihon rinsho. Japanese journal of clinical medicine, 1985, Volume: 43, Issue:6 Topics: Acetaminophen; Animals; Aspirin; Chlorpromazine; Halothane; Humans; Inactivation, Metabolic; Isoniazid; Liver; Methyldopa; Rats	1985
The adverse effects of drugs on the liver. The British journal of clinical practice, 1973, Volume: 27, Issue:8 Topics: Acetaminophen; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Contraceptives, Oral; Drug Interactions; Halothane; Humans; Hyperbilirubinemia; Methyldopa; Phenothiazines; Tetracycline	1973

Trials

1 trial(s) available for methyldopa and acetaminophen

Article	Year
Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity. Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:3 Topics: Absorption; Acetaminophen; Administration, Oral; Adult; Arylsulfotransferase; Carbon Radioisotopes; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Deoxyepinephrine; Drug Interactions; Female; Humans; Male; Methyldopa; Random Allocation; Sulfates; Sulfurtransferases	1985

Article

Year

Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity.

Clinical pharmacology and therapeutics, 1985, Volume: 37, Issue:3

Topics: Absorption; Acetaminophen; Administration, Oral; Adult; Arylsulfotransferase; Carbon Radioisotopes; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Deoxyepinephrine; Drug Interactions; Female; Humans; Male; Methyldopa; Random Allocation; Sulfates; Sulfurtransferases

1985

Other Studies

37 other study(ies) available for methyldopa and acetaminophen

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Prediction of drug intestinal absorption by new linear and non-linear QSPR. European journal of medicinal chemistry, 2011, Volume: 46, Issue:1 Topics: Humans; Intestinal Absorption; Linear Models; Molecular Conformation; Nonlinear Dynamics; Permeability; Pharmaceutical Preparations; Probability; Quantitative Structure-Activity Relationship; Thermodynamics	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Methyldopa binding to cells in culture. Acta pharmacologica et toxicologica, 1977, Volume: 40, Issue:1 Topics: Acetaminophen; Allopurinol; Animals; Ascorbic Acid; Carcinoma, Hepatocellular; Cells, Cultured; Deferoxamine; Dimethylnitrosamine; Edetic Acid; Furosemide; Glutathione; Liver Neoplasms; Maleates; Methyldopa; Neoplasms, Experimental; Protein Binding; Rats; Superoxide Dismutase; Time Factors; Xanthines	1977
Acute structural hepatic alteration due to poisons. Acta pharmacologica et toxicologica, 1977, Volume: 41 Suppl 2 Topics: Acetaminophen; Acute Disease; Amanita; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Halothane; Humans; Liver; Methane; Methyldopa; Mushroom Poisoning; Oxyphenisatin Acetate; Tetracycline	1977
The role of metabolic activation for drug-induced liver injuries. Acta pharmacologica et toxicologica, 1977, Volume: 41 Suppl 2 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Furosemide; Humans; Isoniazid; Liver; Methyldopa	1977
Activation of alpha-methyldopa, paracetamol and furosemide by human liver microsomes. Acta pharmacologica et toxicologica, 1977, Volume: 41, Issue:1 Topics: Acetaminophen; Biotransformation; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Furosemide; Humans; Methyldopa; Microsomes, Liver	1977
Drug-induced liver injury. Hospital practice, 1978, Volume: 13, Issue:9 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Halothane; Humans; Isoniazid; Liver; Methyldopa; Mice	1978
Intragranular starch: comparison of starch USP and modified cornstarch. Journal of pharmaceutical sciences, 1975, Volume: 64, Issue:2 Topics: Acetaminophen; Ascorbic Acid; Biopharmaceutics; Cellulose; Chlorothiazide; Dihydroxyphenylalanine; Excipients; Hardness Tests; Kinetics; Methyldopa; Pressure; Probenecid; Solubility; Starch; Tablets	1975
[Drug induced liver injury. Chemical liver necrosis caused by formation of reactive metabolites]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1976, Feb-10, Volume: 96, Issue:4 Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Furosemide; Humans; Isoniazid; Liver; Methyldopa; Necrosis	1976
Glutathione oxidation during peroxidase catalysed drug metabolism. Chemico-biological interactions, 1987, Volume: 61, Issue:1 Topics: Acetaminophen; Aminophenols; Aminopyrine; Dopamine; Glutathione; Glutathione Disulfide; Horseradish Peroxidase; Methyldopa; Oxidation-Reduction; Oxygen Consumption; Peroxidases; Pharmaceutical Preparations; Phenetidine; Phenothiazines; Sulfides; Superoxide Dismutase	1987
[New forms of toxic hepatitis. II]. Hippokrates, 1973, Volume: 44, Issue:4 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Humans; Methyldopa; Pemoline	1973
Effect of some drugs on clinical laboratory values as determined by the Technicon SMA 12-60. Clinical chemistry, 1972, Volume: 18, Issue:2 Topics: Acetaminophen; Alkaline Phosphatase; Aminosalicylic Acids; Ascorbic Acid; Aspartate Aminotransferases; Autoanalysis; Bilirubin; Blood Chemical Analysis; Blood Glucose; Chemical Phenomena; Chemistry; Cholesterol; Clinical Laboratory Techniques; Dihydroxyphenylalanine; Evaluation Studies as Topic; Humans; Isoniazid; L-Lactate Dehydrogenase; Mercaptopurine; Methyldopa; Pharmaceutical Preparations; Spectrophotometry; Sulfathiazoles; Uric Acid	1972
Evidence for anti-leukocyte antibodies as a mechanism for drug-induced agranulocytosis. Transactions of the Association of American Physicians, 1971, Volume: 84 Topics: Acetaminophen; Adult; Aged; Agranulocytosis; Animals; Blood Transfusion; Carbon Dioxide; Carbon Radioisotopes; Felty Syndrome; Female; Glucose; Humans; Immunoglobulin G; In Vitro Techniques; Isoantibodies; Leukocytes; Methyldopa; Polystyrenes; Prednisone; Primidone; Propylthiouracil; Rabbits	1971
Drugs and the liver. Comprehensive therapy, 1984, Volume: 10, Issue:12 Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Cholestasis; Cimetidine; Fatty Liver; Female; Hepatic Artery; Hepatic Veins; Humans; Ketoconazole; Liver; Liver Diseases; Liver Neoplasms; Methyldopa; Necrosis; Nitrofurantoin; Peliosis Hepatis; Portal Vein; Valproic Acid; Verapamil	1984
Effect of some commonly prescribed drugs on certain chemistry tests. Clinical biochemistry, 1980, Volume: 13, Issue:6 Topics: Acetaminophen; Ascorbic Acid; Aspartate Aminotransferases; Aspirin; Bilirubin; Blood Chemical Analysis; Blood Glucose; Calcium; Carbon Dioxide; Cholesterol; Humans; Methyldopa; Nitrofurantoin; Pharmacology; Tetracycline; Uric Acid	1980
[Drug-induced liver damage; new aspects on its mechanism]. Duodecim; laaketieteellinen aikakauskirja, 1980, Volume: 96, Issue:5 Topics: Acetaminophen; Chemical and Drug Induced Liver Injury; Chlorpromazine; Contraceptives, Oral; Drug-Related Side Effects and Adverse Reactions; Estrogens; Female; Halothane; Humans; Isoniazid; Liver; Methyldopa; Oxyphenisatin Acetate	1980
Interactions between iron(III)-hydroxide polymaltose complex and commonly used drugs / simulations and in vitro studies. Arzneimittel-Forschung, 2007, Volume: 57, Issue:6A Topics: Acetaminophen; Anaerobiosis; Ascorbic Acid; Aspartic Acid; Beverages; Calcium Phosphates; Citrus sinensis; Drug Interactions; Ferric Compounds; Food-Drug Interactions; Hydrogen-Ion Concentration; Indicators and Reagents; Methyldopa; Salicylic Acid; Spectrophotometry, Ultraviolet; Tetracycline	2007
Overdose of methyldopa, indapamide and theophylline resulting in prolonged hypotension, marked diuresis and hypokalaemia in an elderly patient. Pharmacoepidemiology and drug safety, 2009, Volume: 18, Issue:10 Topics: Acetaminophen; Aged, 80 and over; Analgesics, Non-Narcotic; Antihypertensive Agents; Combined Modality Therapy; Critical Care; Diuresis; Drug Overdose; Fluid Therapy; Hemodynamics; Humans; Hypokalemia; Hypotension; Indapamide; Infusions, Intravenous; Male; Methyldopa; Norepinephrine; Plasma Substitutes; Polygeline; Suicide, Attempted; Theophylline; Treatment Outcome; Vasoconstrictor Agents	2009
Cyclooxygenase-independent neuroprotective effects of aspirin against dopamine quinone-induced neurotoxicity. Neurochemical research, 2012, Volume: 37, Issue:9 Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Aspirin; Cell-Free System; Cells, Cultured; Cyclooxygenase Inhibitors; Dopamine Agents; Dopaminergic Neurons; Glutathione; Indomethacin; Levodopa; Meloxicam; Methyldopa; Mice; Neurons; Neuroprotective Agents; Quinones; Sympatholytics; Thiazines; Thiazoles	2012
Pd nanoparticles decorated poly-methyldopa@GO/Fe Materials science & engineering. C, Materials for biological applications, 2019, Volume: 105 Topics: Acetaminophen; Biosensing Techniques; Carbon; Electrochemical Techniques; Electrodes; Ferric Compounds; Graphite; Methyldopa; Nanocomposites; Nanoparticles; Oxidation-Reduction; Palladium; Phenylephrine; Reproducibility of Results; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction	2019