methylcellulose and triethanolamine

methylcellulose has been researched along with triethanolamine* in 1 studies

Other Studies

1 other study(ies) available for methylcellulose and triethanolamine

ArticleYear
The physicochemical characteristics of freeze-dried scutellarin-cyclodextrin tetracomponent complexes.
    Drug development and industrial pharmacy, 2005, Volume: 31, Issue:8

    In an effort to improve the solubility of the insoluble drug scutellarin, a novel complexation of scutellarin with beta-cyclodextrin (beta-CD) was studied. Tetracomponent freeze-dried complex was prepared with scutellarin, beta-CD, Hydroxypropyl Methylcellulose (HPMC), and triethanolamine. To confirm complex formation, complex was characterized by Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction, and differential scanning calorimetry (DSC). Phase-solubility analysis suggested the soluble complexes having 1:1 stoichiometry. The beta-CD solubilization of scutellarin could be improved significantly by combining water-soluble polymer and pH adjuster. Comparing the binary, ternary solid systems with tetrary systems, tetracomponent freeze-dried complex showed the best effect of solubilization. A maximal solubility of scutellarin (23.65 mg/ml) was achieved with tetracomponent freeze-dried complex, up to 148-fold increase over scutellarin solubility in water, and the solubility of scutellarin is 15.35 microg/ml (up to 6-fold) in simulated gastric fluid.

    Topics: Apigenin; beta-Cyclodextrins; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Ethanolamines; Freeze Drying; Gastric Juice; Glucuronates; Hypromellose Derivatives; Methylcellulose; Polyvinyls; Powder Diffraction; Pyrrolidines; Solubility; Spectroscopy, Fourier Transform Infrared; Water; X-Ray Diffraction

2005