methylcellulose has been researched along with succinic-anhydride* in 1 studies
1 other study(ies) available for methylcellulose and succinic-anhydride
Article | Year |
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Monoglyceride-based self-assembling copolymers as carriers for poorly water-soluble drugs.
To develop self-assembling polymers forming polymeric micelles and increasing the solubility of poorly soluble drugs, amphiphilic polymers containing a hydrophilic PEG moiety and a hydrophobic moiety derived from monoglycerides and polyethers were designed. The biodegradable copolymers were obtained via a polycondensation reaction of polyethylene glycol (PEG), monooleylglyceride (MOG) and succinic anhydride (SA). Polymers with molecular weight below 10,000 g/mol containing a minimum of 40 mol% PEG and a maximum of 10 mol% MOG self-assembled spontaneously in aqueous media upon gentle mixing. They formed particles with a diameter of 10 nm although some aggregation was evident. The critical micellar concentration varied between 3x10(-4) and 4x10(-3) g/ml, depending on the polymer. The cloud point (> or = 66 degrees C) and flocculation point (> or = 0.89 M) increased with the PEG chain length. At a 1% concentration, the polymers increased the solubility of poorly water-soluble drug candidates up to 500-fold. Drug solubility increased as a function of the polymer concentration. HPMC capsules filled with these polymers disintegrated and released model drugs rapidly. Polymer with long PEG chains had a lower cytotoxicity (MTT test) on Caco-2 cells. All of these data suggest that the object polymers, in particular PEG1000/MOG/SA (45/5/50) might be potential candidates for improving the oral biopharmaceutical performance of poorly soluble drugs. Topics: Caco-2 Cells; Capsules; Cell Survival; Chemistry, Pharmaceutical; Drug Carriers; Drug Compounding; Flocculation; Humans; Hypromellose Derivatives; Inhibitory Concentration 50; Kinetics; Methylcellulose; Micelles; Molecular Weight; Monoglycerides; Particle Size; Pharmaceutical Preparations; Polyethylene Glycols; Solubility; Solvents; Succinic Anhydrides; Surface Properties; Technology, Pharmaceutical; Water | 2009 |