methylcellulose and sodium-carbonate

methylcellulose has been researched along with sodium-carbonate* in 5 studies

Other Studies

5 other study(ies) available for methylcellulose and sodium-carbonate

ArticleYear
Enhancing and sustaining AMG 009 dissolution from a matrix tablet via microenvironmental pH modulation and supersaturation.
    AAPS PharmSciTech, 2011, Volume: 12, Issue:4

    The objective of this study was to investigate the combined effect of pH modifiers and nucleation inhibitors on enhancing and sustaining the dissolution of AMG 009 tablet via supersaturation. Several bases and polymers were added as pH modifiers and nucleation inhibitors, respectively, to evaluate their impact on the dissolution of AMG 009 tablets. The results indicate that sodium carbonate, among the bases investigated, enhanced AMG 009 dissolution the most. HPMC E5 LV, among the nucleation inhibitors tested, was the most effective in sustaining AMG 009 supersaturation. The release of AMG 009 went from 4% for tablets which did not contain both sodium carbonate and HPMC E5 LV to 70% for the ones that did, resulting in a 17.5-fold increase in the extent of dissolution. The effect of compression force and disintegrant on the dissolution of tablets were also evaluated. The results indicate that compression force had no effect on AMG 009 release. The addition of disintegrating agents, on the other hand, decreased the dissolution of AMG 009.

    Topics: Anti-Inflammatory Agents; Carbonates; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Gastric Juice; Hydrogen-Ion Concentration; Hypromellose Derivatives; Kinetics; Methylcellulose; Phenylacetates; Solubility; Sulfonamides; Tablets; Technology, Pharmaceutical

2011
Enhancing and sustaining AMG 009 dissolution from a bilayer oral solid dosage form via microenvironmental pH modulation and supersaturation.
    AAPS PharmSciTech, 2011, Volume: 12, Issue:4

    Enhancing and sustaining AMG 009 dissolution from a matrix tablet via microenvironmental pH modulation and supersaturation, where poorly soluble acidic AMG 009 molecule was intimately mixed and compressed together with a basic pH modifier (e.g., sodium carbonate) and nucleation inhibitor hydroxypropyl methylcellulose K100 LV (HPMC K100 LV), was demonstrated previously. However, not all acidic or basic drugs are compatible with basic or acidic pH modifiers either chemically or physically. The objective of this study is to investigate whether similar dissolution enhancement of AMG 009 can be achieved from a bilayer dosage form, where AMG 009 and sodium carbonate are placed in a separate layer with or without the addition of HPMC K100 LV in each layer. Study results indicate that HPMC K100 LV-containing bilayer dosage forms gained similar dissolution enhancement as matrix dosage forms did. Bilayer dosage forms without HPMC K100 LV benefitted the least from dissolution enhancement.

    Topics: Administration, Oral; Anti-Inflammatory Agents; Capsules; Carbonates; Chemistry, Pharmaceutical; Drug Compounding; Hydrogen-Ion Concentration; Hypromellose Derivatives; Kinetics; Methylcellulose; Phenylacetates; Solubility; Sulfonamides; Tablets; Technology, Pharmaceutical

2011
Salting-out taste-masking system generates lag time with subsequent immediate release.
    International journal of pharmaceutics, 2009, Jan-05, Volume: 365, Issue:1-2

    Salting-out effects were utilized for developing a multiparticulate system balancing numbness masking and high bioavailability. A "salting-out taste-masking system" consisting of a drug core containing acetaminophen as a model drug, a salting-out layer containing sodium carbonate (Na(2)CO(3)) and hydroxypropylmethylcellulose (HPMC), and a water-penetration-control layer consisting of cetanol was designed and prepared. The system successfully generated a long lag time while achieving immediate drug release. In the system, the Na(2)CO(3) release rate was slower and the lag time was longer than when the water-penetration-control layer was not present. During the release of Na(2)CO(3) from the system, the release of HPMC and drug was suppressed. These results indicated that the water-penetration-control layer maintained a high concentration of Na(2)CO(3), prevented HPMC's dissolution, and generated a long lag time of drug release. The system generated longer lag time and released drug more immediately than formulation containing the water-penetration-control layer of same thickness without the salting-out layers. These results indicated the salting-out layers were necessary for obtain a long lag time and subsequent immediate drug release. This novel taste-masking system has the potential to be a useful multiparticulate dosage form for effective, safe, and user-friendly drug therapy.

    Topics: Acetaminophen; Biological Availability; Carbonates; Chemistry, Pharmaceutical; Fatty Alcohols; Hypromellose Derivatives; Methylcellulose; Pharmaceutical Preparations; Salts; Solubility; Taste; Time Factors

2009
Mechanism of controlled drug release from a salting-out taste-masking system.
    Journal of controlled release : official journal of the Controlled Release Society, 2008, Oct-06, Volume: 131, Issue:1

    A "salting-out taste-masking system" is a multiparticulate system consisting of a drug core, a salting-out layer containing salts and water-soluble polymers, and a water-penetration control layer containing water-insoluble materials. The system generates a long lag time for numbness masking, with subsequent immediate drug release for high bioavailability. In this study, sodium carbonate (Na2CO3) and hydroxypropylmethylcellulose (HPMC) were used as the salt and water-soluble polymer in the salting-out layer, respectively. The drug release rate from the formulation containing the HPMC layer was affected by the Na2CO3 concentrations in the media used in the drug dissolution tests. The HPMC layer suppressed drug release in a medium with a high Na2CO3 concentration, and subsequently increased the drug release rate in a medium with a low Na2CO3 concentration. Drug release from the system was suppressed while Na2CO3 remained in the formulations. Microscopic changes in HPMC in the salting-out layers correlated well with changes in the drug release rate. These results indicate that, in the salting-out taste-masking system, the drug release suppression and the immediate release are caused by insolubilization and dissolution of the water-soluble polymer respectively. These findings will allow for smarter formulation design.

    Topics: Acetaminophen; Biological Availability; Carbonates; Drug Delivery Systems; Hypromellose Derivatives; Methylcellulose; Pharmaceutical Preparations; Salts; Solubility; Taste; Time Factors; Water

2008
Optimization of salting-out taste-masking system for micro-beads containing drugs with high solubility.
    Chemical & pharmaceutical bulletin, 2008, Volume: 56, Issue:11

    The salting-out taste-masking system is a multiparticulate system consisting of a drug core, a salting-out layer containing salts and water-soluble polymers, and a water-penetration control layer containing water-insoluble materials. The system generates a long lag time (time when released drug is less than 1%) for numbness masking, and a subsequent immediate drug release for high bioavailability. Aiming to contain the system and drugs that cause numbness in oral disintegrating tablets, the system was optimized to reduce the particle size and contain drugs with high water solubility in this study. The amount of coating on the layers, the coating solvent, and the positioning of the components were also optimized. The findings in this study will lead to the provision of numbness-masked oral disintegrating tablets to patients.

    Topics: Acetaminophen; Carbonates; Chemistry, Pharmaceutical; Drug Delivery Systems; Hypromellose Derivatives; Imipramine; Methylcellulose; Microspheres; Particle Size; Pharmaceutical Preparations; Povidone; Solubility; Spectrophotometry, Ultraviolet; Tablets; Taste

2008