methylcellulose and scutellarin

methylcellulose has been researched along with scutellarin* in 2 studies

Other Studies

2 other study(ies) available for methylcellulose and scutellarin

ArticleYear
Effects of spray-drying and choice of solid carriers on concentrations of Labrasol® and Transcutol® in solid self-microemulsifying drug delivery systems (SMEDDS).
    Molecules (Basel, Switzerland), 2013, Jan-02, Volume: 18, Issue:1

    Solid self-microemulsifying drug delivery systems (SMEDDS) have been used increasingly for improving the bioavailability of hydrophobic drugs. Labrasol® and Transcutol® are used widely as surfactant and solubilizer in the formulation of solid SMEDDS. We investigated the effects of spray-drying and the use of different solid carriers on concentrations of Labrasol® and Transcutol® in solid SMEDDS with scutellarin as the formulated drug. Liquid and gas chromatography tandem mass spectrometry (LC-MS and GC-MS) methods were developed for measuring low concentrations of Labrasol® and Transcutol®. In the preparation of solid SMEDDS, lactose, hydroxypropylmethyl cellulose (HPMC) and microcrystalline cellulose (MCC) were used as solid carriers. Judging from the retention ratios of Labrasol® and Transcutol®, the droplet size of solid SMEDDS increased after spray-drying of liquid SMEDDS, and concentrations of these excipients decreased after the solidifying procedure. In such reduction, Lactose and HPMC were found to preserve Labrasol® and Transcutol® better than MCC during spray-drying, and the resultant droplet sizes were smaller than that of MCC. Labrasol® and Transcutol® showed good thermal stability at 60 °C degree for 10 days. It can be concluded that spray-drying could increase the droplet size of solid SMEDDS and decreased the concentration of Labrasol® and Transcutol® therein, while water-soluble solid carriers could preserve Labrasol® and Transcutol® better than insoluble carriers in the solid SMEDDS.

    Topics: Apigenin; Cellulose; Chemistry, Pharmaceutical; Desiccation; Drug Carriers; Drug Compounding; Drug Stability; Emulsifying Agents; Emulsions; Ethylene Glycols; Excipients; Gas Chromatography-Mass Spectrometry; Glucuronates; Glycerides; Hypromellose Derivatives; Lactose; Methylcellulose; Organic Chemicals; Particle Size; Reference Standards; Solubility; Spectrometry, Mass, Electrospray Ionization

2013
The physicochemical characteristics of freeze-dried scutellarin-cyclodextrin tetracomponent complexes.
    Drug development and industrial pharmacy, 2005, Volume: 31, Issue:8

    In an effort to improve the solubility of the insoluble drug scutellarin, a novel complexation of scutellarin with beta-cyclodextrin (beta-CD) was studied. Tetracomponent freeze-dried complex was prepared with scutellarin, beta-CD, Hydroxypropyl Methylcellulose (HPMC), and triethanolamine. To confirm complex formation, complex was characterized by Fourier transform infrared spectroscopy (FT-IR), powder X-ray diffraction, and differential scanning calorimetry (DSC). Phase-solubility analysis suggested the soluble complexes having 1:1 stoichiometry. The beta-CD solubilization of scutellarin could be improved significantly by combining water-soluble polymer and pH adjuster. Comparing the binary, ternary solid systems with tetrary systems, tetracomponent freeze-dried complex showed the best effect of solubilization. A maximal solubility of scutellarin (23.65 mg/ml) was achieved with tetracomponent freeze-dried complex, up to 148-fold increase over scutellarin solubility in water, and the solubility of scutellarin is 15.35 microg/ml (up to 6-fold) in simulated gastric fluid.

    Topics: Apigenin; beta-Cyclodextrins; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Ethanolamines; Freeze Drying; Gastric Juice; Glucuronates; Hypromellose Derivatives; Methylcellulose; Polyvinyls; Powder Diffraction; Pyrrolidines; Solubility; Spectroscopy, Fourier Transform Infrared; Water; X-Ray Diffraction

2005