methylcellulose and racecadotril

methylcellulose has been researched along with racecadotril* in 1 studies

Other Studies

1 other study(ies) available for methylcellulose and racecadotril

ArticleYear
Preparation and evaluation of agglomerated crystals by crystallo-co-agglomeration: an integrated approach of principal component analysis and Box-Behnken experimental design.
    International journal of pharmaceutics, 2013, Aug-16, Volume: 452, Issue:1-2

    Poor mechanical properties of crystalline drug particles require wet granulation technique for tablet production which is uneconomical, laborious, and tedious. The present investigation was aimed to improve flow and mechanical properties of racecadotril (RCD), a poorly water soluble antidiarrheal agent, by a crystallo-co-agglomeration (CCA) technique. The influence of various excipients and processing conditions on formation of directly compressible agglomerates of RCD was evaluated. Principal component analysis and Box-Behnken experimental design was implemented to optimize the agglomerates with good micromeritics and mechanical properties. The overall yield of the process was 88-98% with size of agglomerates between 351 and 1214 μm. Further, higher rotational speed reduced the size of agglomerates and disturbed sphericity. The optimized batch of agglomerates exhibited excellent flowability and crushing strength. The optimized batch of RCD agglomerates was characterized by fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry and gas chromatography which illustrated absence of drug-excipient interaction with minimal entrapment of residual solvent. Hence, it may be concluded that both excipients and processing conditions played a vital role to prepare spherical crystal agglomerates of RCD by CCA and it can be adopted as an excellent alternative to wet granulation.

    Topics: Antidiarrheals; Cluster Analysis; Crystallization; Drug Compounding; Excipients; Hypromellose Derivatives; Methylcellulose; Polyethylene Glycols; Polyvinyl Alcohol; Principal Component Analysis; Research Design; Solubility; Solvents; Talc; Tensile Strength; Thiorphan

2013