methylcellulose and nimesulide

methylcellulose has been researched along with nimesulide* in 2 studies

Other Studies

2 other study(ies) available for methylcellulose and nimesulide

ArticleYear
In vitro-in vivo correlation study on nimesulide loaded hydroxypropylmethylcellulose microparticles.
    Yao xue xue bao = Acta pharmaceutica Sinica, 2010, Volume: 45, Issue:6

    This study involves mathematical simulation model such as in vitro-in vivo correlation (IVIVC) development for various extended release formulations of nimesulide loaded hydroxypropylmethylcellulose (HPMC) microparticles (M1, M2 and M3 containing 1, 2, and 3 g HPMC, respectively and 1 g drug in each) having variable release characteristics. In vitro dissolution data of these formulations were correlated to their relevant in vivo absorption profiles followed by predictability worth analysis of these Level A IVIVC. Nimaran was used as control formulation to validate developed formulations and their respective models. The regression coefficients of IVIVC plots for M1, M2, M3 and Nimaran were 0.834 9, 0.831 2, 0.927 2 and 0.898 1, respectively. The internal prediction error for all formulations was within limits, i.e., < 10%. A good IVIVC was found for controlled release nimesulide loaded HPMC floating M3 microparticles. In other words, this mathematical simulation model is best fit for biowaiver studies which involves study parameters as those adopted for M3 because the value of its IVIVC regression coefficient is the closest to 1 as compared to M1 and M2.

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Delayed-Action Preparations; Humans; Hypromellose Derivatives; Methylcellulose; Microspheres; Models, Chemical; Sulfonamides

2010
Preparation and evaluation of nimesulide-loaded ethylcellulose and methylcellulose nanoparticles and microparticles for oral delivery.
    Journal of biomaterials applications, 2009, Volume: 24, Issue:1

    The present study was designed to assess and compare with a range of surfactant-coated, nimesulide-free, and nimesulide-loaded ethylcellulose/methylcellulose (EC/MC) nanoparticles that were prepared by varying drug concentration (ED/MD), polymer concentration (EP/MP), and surfactant concentration (ES/MS). EC/MC nanoparticles prepared by desolvation method produced discrete particles and they were characterized by SEM, AFM, and FTIR studies. The particles mean size diameter (nm) ranged from 244 to 1056 nm and 1065 to 1710 nm for EC and MC nanoparticles, respectively. Studies on drug: polymer ratio showed a linear relationship between drug concentration and percentage of loading in nanoparticles. The encapsulation efficiency decreased with the increase of nimesulide concentration with respect to polymer concentration. Encapsulation efficiency of drug-loaded nanoparticles was varied between 32.8% and 64.9%. The in vitro release of drug-loaded nanoparticles was found to be a first order. This was significantly increased in EC nanoparticles (95.50%) in comparison with MC nanoparticles (95.12%) after 12 h in 24 h long study. Nimesulide release from EC nanoparticles was much slower at slightly alkaline pH 7.4. The in vitro hemolysis tests of nanoparticles were carried out to ascertain the hemocompatibility and shown to be insignificant for EC nanoparticles. In comparison, ES4 from EC formulations with nimesulide was found to be promising with slow and sustained drug release.

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Drug Carriers; Hemolysis; Humans; Methylcellulose; Microscopy, Atomic Force; Nanoparticles; Particle Size; Spectroscopy, Fourier Transform Infrared; Sulfonamides

2009