methylcellulose has been researched along with mosapride* in 2 studies
2 other study(ies) available for methylcellulose and mosapride
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Formulation optimization of solid dispersion of mosapride hydrochloride.
Mosapride citrate (MSP) is a gastroprokinetic agent that acts as a selective 5-HT(4) agonist and accelerates the gastric emptying, and is used for the treatment of acid reflux, irritable bowel syndrome, and functional dyspepsia. The purpose of this study is to investigate the solid dispersion formulations of MSP with controlled release characteristic using various polymers, elucidate the release mechanism, and characterize the interaction patterns between MSP and polymers. Solid dispersions of MSP with different drug-to-polymer ratios were prepared by a solvent evaporation method and characterized in comparison with the simple physical mixtures. Eudragit RSPO, Eudragit RLPO, hydroxypropylmethylcellulose (HPMC) or Kollidon SR was used as a controlled-release polymer along with polyvinylpyrrolidone (PVP) as a carrier. Characterization of MSP solid dispersion was performed using thermal analysis (DSC), powder X-ray diffraction (XRD), Fourier transform-infrared (FT-IR) spectroscopy, where the drug was converted from the crystalline state to amorphous state in all polymeric carriers used. In vitro dissolution studies showed that the drug release has been extended up to 24 h by using Eudragit RSPO or HPMC. Moreover, the formulations containing higher polymer content ratio showed better slow-release profile. These results indicate that the solid dispersion formulation containing PVP/Eudragit RSPO or HPMC mixture could serve as a good controlled-release system for MSP. Topics: Benzamides; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Drug Carriers; Drug Compounding; Gastrointestinal Agents; Hypromellose Derivatives; Methylcellulose; Molecular Structure; Morpholines; Polymethacrylic Acids; Polyvinyls; Pyrrolidines; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2011 |
Characterization and optimization of orodispersible mosapride film formulations.
Orodispersible film (ODF) technology offers new possibilities for drug delivery by providing the advantages of oral delivery coupled with the enhanced onset of action and convenience to special patient categories such as pediatrics and geriatrics. In this study, mosapride (MOS) was formulated in an ODF preparation that can be used for treatment of patients who suffer from gastrointestinal disorders, especially difficulty in swallowing due to gastroesophageal reflux disease. Poloxamer 188 was used to solubilize MOS to allow its incorporation into the film matrix. The films were prepared by solvent-casting method using different polymer ratios of maltodextrin and hydroxypropyl methylcellulose and plasticizer levels of glycerol and propylene glycol. A D-optimal design was utilized to study the effect of polymer ratio, plasticizer type, and level on film mechanical properties, disintegration time, and dissolution rate. Statistical analysis of the experimental design showed that the increase of maltodextrin fraction and plasticizer level conferred optimum attributes to the prepared films in terms of film elasticity, film disintegration time, and MOS release rate. The ODF formulations were further tested for moisture sorption capacity, with formulations containing a higher ratio of maltodextrin and percent plasticizer showing more moisture uptake. The optimum film composition was also tested in vivo for film palatability and disintegration time. An optimized mosapride orodispersible film formulation was achieved that could be of benefit to patients suffering from gastrointestinal disorders. Topics: Administration, Oral; Adult; Benzamides; Chemistry, Pharmaceutical; Dosage Forms; Drug Carriers; Drug Compounding; Elasticity; Female; Gastrointestinal Agents; Glycerol; Humans; Hypromellose Derivatives; Kinetics; Male; Methylcellulose; Models, Statistical; Morpholines; Patient Satisfaction; Plasticizers; Poloxamer; Polysaccharides; Propylene Glycol; Sensation; Solubility; Technology, Pharmaceutical; Water | 2011 |