methylcellulose and laurocapram

We have successfully obtained sumatriptan transdermal systems with different polymer compositions: methyl cellulose (MC), polyvinyl pyrrolidone (PVP) and a polyvinyl pyrrolidone (PVP)-polyvinyl alcohol (PVA) mixture. The systems contained 1,2-propylenglycol (MC) or sorbitol as a plasticizer (PVP and PVP-PVA), methacrylate copolymer as an adhesive agent, and an occlusive liner. Azone (5%, w/w) was incorporated into all the systems as a percutaneous enhancer. Transdermal systems are thin, transparent and non-adhesive when in a dry state. The permeation of sumatriptan succinate across pig ear skin was studied using the systems prepared. The formulation with MC polymer produced a statistically significant increment with respect to the PVP and PVP-PVA formulations (p < 0.05). Azone incorporation into the systems produced an increment in the sumatriptan flux values of all three transdermal systems with respect to those of the controls (p < 0.05). In addition, the application of iontophoresis to the wet methyl cellulose-Azone formulation produced a much higher increase of sumatriptan transdermal flux.

Topics: Administration, Cutaneous; Animals; Azepines; Chemistry, Pharmaceutical; Diffusion Chambers, Culture; Drug Carriers; Drug Compounding; Iontophoresis; Kinetics; Methylcellulose; Migraine Disorders; Permeability; Plasticizers; Polymers; Polymethacrylic Acids; Polyvinyl Alcohol; Povidone; Propylene Glycol; Serotonin Receptor Agonists; Skin; Skin Absorption; Sorbitol; Sumatriptan; Swine; Technology, Pharmaceutical; Tissue Adhesives; Vasoconstrictor Agents