methylcellulose and halofantrine

methylcellulose has been researched along with halofantrine* in 2 studies

Other Studies

2 other study(ies) available for methylcellulose and halofantrine

ArticleYear
Effect of polymer molecular weight on the production of drug nanoparticles.
    Journal of pharmaceutical sciences, 2007, Volume: 96, Issue:10

    Stable, polymer-coated nanoparticles of two hydrophobic drugs, namely nabumetone and halofantrine, have been prepared by a wet-bead milling process performed in the presence of a stabilizing homopolymer, either hydroxypropylmethylcellulose (HPMC) or polyvinylpyrrolidone (PVP), of differing molecular weights and concentrations. Although nabumetone nanoparticles could only be produced when HPMC was used as stabilizing polymer, halofantrine nanoparticles could be prepared using either HPMC or PVP. Stable nanoparticles of nabumetone could be produced using a HPMC solution of viscosity average molecular weight, M(v), of 5 kg/mol over an approximate four fold polymer concentration range (0.63-2.5% w/w) when a drug loading of 20% w/w was used. Increasing the molecular weight of HPMC up to a limiting M(v) of 89 kg/mol did not result in the formation of nanoparticles at any of the polymer concentrations examined. The amount of polymer absorbed onto the nanoparticles was determined by measuring the depletion of polymer from solution based on either an ultra-violet (PVP) or optical rotatory dispersion (ORD) (HPMC) assay. The slightly lower concentration of HMPC found to be present on the surface of the halofantrine nanoparticles compared with the nabumetone nanoparticles suggested a differing affinity of the polymer for the surface of the two drugs.

    Topics: Adsorption; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Butanones; Chemistry, Pharmaceutical; Colloids; Drug Carriers; Drug Compounding; Excipients; Hypromellose Derivatives; Methylcellulose; Molecular Weight; Nabumetone; Nanoparticles; Particle Size; Phenanthrenes; Povidone; Solubility; Surface Properties; Technology, Pharmaceutical; Viscosity; Water

2007
Enhanced oral absorption of halofantrine enantiomers after encapsulation in a proliposomal formulation.
    The Journal of pharmacy and pharmacology, 2002, Volume: 54, Issue:8

    In this study, we evaluated the ability of a coated, encapsulated formulation to increase the oral bioavailability of (+/-)-halofantrine (HF) enantiomers, a drug with low and erratic oral bioavailability. After encapsulation of HF in distearoylphosphatidylcholine, the dried particles were coated with cellulose acetate phthalate. A suspension of the product was made using methylcellulose as a dispersion agent, and the product was administered to Sprague-Dawley rats to provide a HF dose of 7 mg kg-1 as the HCl salt. HF HCl powder in 1% methylcellulose with or without liposomal product excipients was also administered to separate groups of rats, which served as control groups. Serial blood samples were obtained from the rats and plasma was assayed by stereospecific high-performance liquid chromatography. There were no significant differences in the area under the concentration-time curve (AUC) or maximum concentration (Cmax) between the two control groups. Plasma concentrations of both HF enantiomers were significantly higher in the rats given HF as an encapsulated proliposomal formulation compared with the control groups. Compared with methylcellulose control, the encapsulation product resulted in increases of 41 to 47% in the AUC of HF enantiomers, and 90 to 100% in Cmax. The ability of an encapsulated proliposomal product to significantly increase the oral absorption of HF was clearly demonstrated.

    Topics: Animals; Antimalarials; Area Under Curve; Biological Availability; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Isomerism; Liposomes; Male; Methylcellulose; Phenanthrenes; Rats; Rats, Sprague-Dawley

2002