methylcellulose and carbitol

methylcellulose has been researched along with carbitol* in 1 studies

Other Studies

1 other study(ies) available for methylcellulose and carbitol

ArticleYear
Effects of spray-drying and choice of solid carriers on concentrations of Labrasol® and Transcutol® in solid self-microemulsifying drug delivery systems (SMEDDS).
    Molecules (Basel, Switzerland), 2013, Jan-02, Volume: 18, Issue:1

    Solid self-microemulsifying drug delivery systems (SMEDDS) have been used increasingly for improving the bioavailability of hydrophobic drugs. Labrasol® and Transcutol® are used widely as surfactant and solubilizer in the formulation of solid SMEDDS. We investigated the effects of spray-drying and the use of different solid carriers on concentrations of Labrasol® and Transcutol® in solid SMEDDS with scutellarin as the formulated drug. Liquid and gas chromatography tandem mass spectrometry (LC-MS and GC-MS) methods were developed for measuring low concentrations of Labrasol® and Transcutol®. In the preparation of solid SMEDDS, lactose, hydroxypropylmethyl cellulose (HPMC) and microcrystalline cellulose (MCC) were used as solid carriers. Judging from the retention ratios of Labrasol® and Transcutol®, the droplet size of solid SMEDDS increased after spray-drying of liquid SMEDDS, and concentrations of these excipients decreased after the solidifying procedure. In such reduction, Lactose and HPMC were found to preserve Labrasol® and Transcutol® better than MCC during spray-drying, and the resultant droplet sizes were smaller than that of MCC. Labrasol® and Transcutol® showed good thermal stability at 60 °C degree for 10 days. It can be concluded that spray-drying could increase the droplet size of solid SMEDDS and decreased the concentration of Labrasol® and Transcutol® therein, while water-soluble solid carriers could preserve Labrasol® and Transcutol® better than insoluble carriers in the solid SMEDDS.

    Topics: Apigenin; Cellulose; Chemistry, Pharmaceutical; Desiccation; Drug Carriers; Drug Compounding; Drug Stability; Emulsifying Agents; Emulsions; Ethylene Glycols; Excipients; Gas Chromatography-Mass Spectrometry; Glucuronates; Glycerides; Hypromellose Derivatives; Lactose; Methylcellulose; Organic Chemicals; Particle Size; Reference Standards; Solubility; Spectrometry, Mass, Electrospray Ionization

2013