methylcellulose and cannabigerolic-acid

methylcellulose has been researched along with cannabigerolic-acid* in 1 studies

Other Studies

1 other study(ies) available for methylcellulose and cannabigerolic-acid

ArticleYear
A stimulus-responsive, in situ-forming, nanoparticle-laden hydrogel for ocular drug delivery.
    Drug delivery and translational research, 2018, Volume: 8, Issue:3

    Most medications targeting optic neuropathies are administered as eye drops. However, their corneal penetration efficiencies are typically < 5%. There is a clear, unmet need for novel transcorneal drug delivery vehicles. To this end, we have developed a stimulus-responsive, in situ-forming, nanoparticle-laden hydrogel for controlled release of poorly bioavailable drugs into the aqueous humor of the eye. The hydrogel is formulated as a composite of hyaluronic acid (HA) and methylcellulose (MC). The amphiphilic nanoparticles are composed of poly(ethylene oxide) (PEO) and poly(lactic acid) (PLA). Experimental design aided the identification of hydrogel composition and nanoparticle content in the formulation, and the formulation reliably switched between thixotropy and temperature-dependent rheopexy when it was tested in a rheometer under conditions that simulate the ocular surface, including blinking. These properties should ensure that the formulation coats the cornea through blinking of the eyelid and facilitate application of the medication as an eye drop immediately prior to the patient's bedtime. We subsequently tested the efficacy of our formulation in whole-eye experiments by loading the nanoparticles with cannabigerolic acid (CBGA). Our formulation exhibits over a 300% increase in transcorneal penetration over control formulations. This work paves the way for the introduction of novel products targeting ocular diseases to the market.

    Topics: Administration, Ophthalmic; Animals; Benzoates; Cornea; Delayed-Action Preparations; Drug Compounding; Escherichia coli; Hyaluronic Acid; Hydrogels; Methylcellulose; Nanoparticles; Polyesters; Polyethylene Glycols; Rheology; Swine

2018