methylcellulose and candesartan-cilexetil

methylcellulose has been researched along with candesartan-cilexetil* in 2 studies

Other Studies

2 other study(ies) available for methylcellulose and candesartan-cilexetil

ArticleYear
New supersaturating drug delivery system as strategy to improve apparent solubility of candesartan cilexetil in biorelevant medium.
    Pharmaceutical development and technology, 2020, Volume: 25, Issue:1

    Candesartan cilexetil (CC) is a poorly soluble antihypertensive drug with

    Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biological Availability; Biphenyl Compounds; Chemistry, Pharmaceutical; Drug Carriers; Drug Delivery Systems; Male; Methylcellulose; Polymers; Rats; Rats, Wistar; Solubility; Tetrazoles

2020
HPMCAS as an effective precipitation inhibitor in amorphous solid dispersions of the poorly soluble drug candesartan cilexetil.
    Carbohydrate polymers, 2018, Mar-15, Volume: 184

    Among the strategies to improve the biopharmaceutic properties of poorly soluble drugs, Supersaturating Drug Delivery Systems like polymer-based amorphous solid dispersions (SD) have been successfully applied. The screening of appropriate polymeric carriers to compose SD is a crucial point on their development. In this study, hydroxypropylmethylcellulose (HPMC), hydroxypropylmethylcellulose acetate succinate (HPMCAS) types L, M and H and polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (SOL) were evaluated by in vitro supersaturation studies regarding their anti-precipitant ability on the poorly soluble drug candesartan cilexetil (CC) under two different media, including biorelevant conditions. According to the results, HPMCAS M was considered the best carrier to develop SD containing CC among all the polymers tested, due to its good anti-precipitant performance in both media. In addition, the medium used in the in vitro supersaturation studies played an important role on the results, and its selection should be carefully done.

    Topics: Benzimidazoles; Biphenyl Compounds; Drug Carriers; Drug Delivery Systems; Methylcellulose; Polymers; Solubility; Tetrazoles

2018