methylcellulose has been researched along with bambuterol* in 1 studies
1 other study(ies) available for methylcellulose and bambuterol
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Design and mechanism of on-off pulsed drug release using nonenteric polymeric systems via pH modulation.
The aim was to design a pH-sensitive pulsatile drug delivery system that allows for an on-off pulsed release of a drug using polyacrylic acid (PAA) blended with ethyl cellulose (EC) in different ratios. PAA, a polyelectrolyte polymer, exhibits a highly coiled conformation at low pH but a highly extended structure at high pH. Fumaric acid, which is an internal acidifying agent, was incorporated into the hydroxypropyl methylcellulose-based core tablets to create an acidic microenvironmental pH (pH(M)). The concentration of fumaric acid inside the core tablet and the ratio of PAA/EC in the coating layer were very crucial in modulating drug release behaviors. When the fumaric acid was retained in the core tablet, it gave a more acidic pH(M), so that the PAA was kept in a highly coiled state in the coated film, which hindered drug release ("off" release pattern). Interestingly, the release profiles of the drug and fumaric acid from coated tablets showed the on-off pulsed pattern upon dissolution. Imaging analyses using scanning electron microscopy, near-infrared imaging, confocal laser scanning microscopy, and Fourier transform infrared spectroscopy confirmed this on-off release behavior of the drug and fumaric acid from coated tablets. Topics: Acrylic Resins; Bronchodilator Agents; Cellulose; Delayed-Action Preparations; Drug Compounding; Excipients; Fumarates; Hydrogen-Ion Concentration; Hypromellose Derivatives; Methylcellulose; Microscopy, Confocal; Polymers; Solubility; Spectroscopy, Fourier Transform Infrared; Spectroscopy, Near-Infrared; Tablets; Terbutaline | 2011 |