methylcellulose has been researched along with aluminum-magnesium-silicate* in 3 studies
3 other study(ies) available for methylcellulose and aluminum-magnesium-silicate
Article | Year |
---|---|
Influence of pH modifiers and HPMC viscosity grades on nicotine-magnesium aluminum silicate complex-loaded buccal matrix tablets.
Hydroxypropyl methylcellulose (HPMC) tablets containing nicotine-magnesium aluminum silicate (NCT-MAS) complex particles and pH modifiers, namely, sodium chloride, citric acid, and magnesium hydroxide, were prepared using the direct compression method. The effects of HPMC viscosity grades and pH modifiers on NCT release and permeation of the matrix tablets were examined. The results showed that the higher the viscosity grade of HPMC that was used in the tablets, the lower was the unidirectional NCT release rate found. The unidirectional NCT permeation was not affected by the viscosity grade of HPMC because the NCT diffusion through the mucosal membrane was the rate-limiting step of the permeation. Incorporation of magnesium hydroxide could retard NCT release, whereas the enhancement of unidirectional NCT release was found in the tablets containing citric acid. Citric acid could inhibit NCT permeation due to the formation of protonated NCT in the swollen tablets at an acidic pH. Conversely, the NCT permeation rate increased with the use of magnesium hydroxide as a result of the neutral NCT that formed at a basic microenvironmental pH. The swollen HPMC tablets, with or without pH modifiers, gave sufficient adhesion to the mucosal membrane. Furthermore, the addition of magnesium hydroxide to the matrix tablets was the major factor in controlling buccal delivery of NCT. This study suggests that the NCT-MAS complex-loaded HPMC tablets, which contained magnesium hydroxide, are potential buccal delivery systems of NCT. Topics: Adhesiveness; Administration, Buccal; Aluminum Compounds; Aluminum Silicates; Animals; Chemistry, Pharmaceutical; Citric Acid; Delayed-Action Preparations; Drug Carriers; Esophagus; Hydrogen-Ion Concentration; Hypromellose Derivatives; Kinetics; Magnesium; Magnesium Compounds; Magnesium Hydroxide; Membranes, Artificial; Methylcellulose; Mucous Membrane; Nicotine; Nicotinic Agonists; Permeability; Silicates; Sodium Chloride; Solubility; Swine; Tablets; Technology, Pharmaceutical; Viscosity | 2012 |
Polymer-magnesium aluminum silicate composite dispersions for improved physical stability of acetaminophen suspensions.
The aims of this study were to characterize the morphology and size of flocculates and the zeta potential and rheological properties of polymer-magnesium aluminum silicate (MAS) composite dispersions and to investigate the physical properties of acetaminophen (ACT) suspensions prepared using the composite dispersions as a flocculating/suspending agent. The polymers used were sodium alginate (SA), sodium carboxymethylcellulose (SCMC), and methylcellulose (MC). The results showed that SA, SCMC, and MC could induce flocculation of MAS by a polymer-bridging mechanism, leading to the changes in the zeta potential of MAS and the flow properties of the polymer dispersions. The microscopic morphology and size of the flocculates was dependent on the molecular structure of the polymer, especially ether groups on the polymer side chain. The residual MAS from the flocculation could create a three-dimensional structure in the SA-MAS and SCMC-MAS dispersions, which brought about not only an enhancement of viscosity and thixotropic properties but also an improvement in the ACT flocculating efficiency of polymers. The use of polymer-MAS dispersions provided a higher degree of flocculation and a lower redispersibility value of ACT suspensions compared with the pure polymer dispersions. This led to a low tendency for caking of the suspensions. The SCMC-MAS dispersions provided the highest ACT flocculating efficiency, whereas the lowest ACT flocculating efficiency was found in the MC-MAS dispersions. Moreover, the added MAS did not affect ACT dissolution from the suspensions in an acidic medium. These findings suggest that the polymer-MAS dispersions show good potential for use as a flocculating/suspending agent for improving the rheological properties and physical stability of the suspensions. Topics: Acetaminophen; Alginates; Aluminum Compounds; Carboxymethylcellulose Sodium; Drug Stability; Flocculation; Glucuronic Acid; Hexuronic Acids; Magnesium Compounds; Methylcellulose; Particle Size; Polymers; Silicates; Solubility; Suspensions | 2009 |
Influence of magnesium aluminium silicate on rheological, release and permeation characteristics of diclofenac sodium aqueous gels in-vitro.
The effect of magnesium aluminium silicate (MAS) on rheological, release and permeation characteristics of diclofenac sodium (DS) aqueous gels was investigated. DS aqueous gels were prepared using various gelling agents, such as 15% w/w poloxamer 407 (PM407), 1% w/w hydroxypropylmethylcellulose (HPMC), and 1% w/w high and low viscosity grades of sodium alginate (HV-SA and LV-SA, respectively). Different amounts of MAS (0.5, 1.0 and 1.5% w/w) were incorporated into the DS gels. Incorporation of MAS into the DS gels prepared using SA or PM407 caused a statistical increase in viscosity (P<0.05) and a shift from Newtonian flow to pseudoplastic flow with thixotropic property. The DS release rates of these composite gels were significantly decreased (P<0.05) when compared with the control gels. This was due to an interaction between MAS and PM407 or SA, and adsorption of DS onto MAS particles. Moreover, a longer lag time and no change in DS permeation flux were found when MAS was added to the gels. The findings suggest that the rheological characteristics of gels prepared using PM407 or SA could be improved by incorporating MAS. However, the use of MAS could retard the DS release and extend the lag time of DS permeation. Topics: Alginates; Aluminum Compounds; Animals; Chemistry, Pharmaceutical; Diclofenac; Elapidae; Gels; Glucuronic Acid; Hexuronic Acids; Hypromellose Derivatives; In Vitro Techniques; Magnesium Compounds; Methylcellulose; Poloxamer; Rheology; Silicates; Skin Absorption; Time Factors; Viscosity | 2005 |