methylcellulose and 1-2-distearoyllecithin

This paper presents and demonstrates a method for using magnetic resonance imaging to measure local pressure of a fluid saturating a porous medium. The method is tested both in a static system of packed silica gel and in saturated sintered glass cylinders experiencing fluid flow. The fluid used contains 3% gas in the form of 3-mum average diameter gas filled 1,2-distearoyl-sn-glycero-3-phosphocholine (C18:0, MW: 790.16) liposomes suspended in 5% glycerol and 0.5% Methyl cellulose with water. Preliminary studies at 2.35 T demonstrate relative magnetic resonance signal changes of 20% per bar in bulk fluid for an echo time T(E)=40 ms, and 6-10% in consolidated porous media for T(E)=10 ms, over the range 0.8-1.8 bar for a spatial resolution of 0.1 mm(3) and a temporal resolution of 30 s. The stability of this solution with relation to applied pressure and methods for improving sensitivity are discussed.

Topics: Contrast Media; Gases; Glass; Glycerol; Imaging, Three-Dimensional; Liposomes; Magnetic Resonance Imaging; Methylcellulose; Microbubbles; Permeability; Phosphatidylcholines; Porosity; Pressure; Sensitivity and Specificity; Silica Gel; Silicon Dioxide; Time Factors; Water