methylbenzoprim has been researched along with methotrexate in 3 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (33.33) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Griffin, RJ; Meek, MA; Schwalbe, CH; Stevens, MF | 1 |
| Griffin, RJ; Grunwaldt, JD; Lambert, PA; Meek, MA; Queener, SF; Robson, C; Schmidt, D | 1 |
| Croughton, KA; Matthews, CS; Richardson, ML; Stevens, MF | 1 |
3 other study(ies) available for methylbenzoprim and methotrexate
| Article | Year |
|---|---|
Structural studies on bioactive compounds. 8. Synthesis, crystal structure, and biological properties of a new series of 2,4-diamino-5-aryl-6-ethylpyrimidine dihydrofolate reductase inhibitors with in vivo activity against a methotrexate-resistant tumor c
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Crystallization; Folic Acid Antagonists; Leukemia, Experimental; Liver; Methotrexate; Mice; Molecular Structure; Pyrimidines; Rats; Structure-Activity Relationship; Tumor Cells, Cultured | 1989 |
Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Topics: Animals; Antineoplastic Agents; Cell Survival; Folic Acid Antagonists; Indicators and Reagents; Kinetics; Liver; Lymphoma, Large B-Cell, Diffuse; Mice; Pneumocystis; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma | 1997 |
Structural studies on bioactive compounds. 39. Biological consequences of the structural modification of DHFR-inhibitory 2,4-diamino-6-(4-substituted benzylamino-3-nitrophenyl)-6-ethylpyrimidines ('benzoprims').
Topics: Antineoplastic Agents; Benzylamines; Cell Division; Cell Line, Tumor; Cyclization; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Protein Binding; Pyrimidines; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 2004 |