methylazoxymethanol acetate has been researched along with methylazoxymethanol in 244 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 56 (22.95) | 18.7374 |
| 1990's | 89 (36.48) | 18.2507 |
| 2000's | 58 (23.77) | 29.6817 |
| 2010's | 33 (13.52) | 24.3611 |
| 2020's | 8 (3.28) | 2.80 |
| Authors | Studies |
|---|---|
| Balduini, W; Cattabeni, F; Lombardelli, G; Peruzzi, G | 2 |
| Bacon, E; de Barry, J; Girard, C; Gombos, G | 2 |
| Kinuya, M; Mamiya, G; Ohtakeno, S; Watanabe, H; Watanabe, M | 1 |
| Asano, Y; Nishida, A; Okaniwa, A | 1 |
| Conney, AH; Deschner, EE; Ferraro, TA; Huang, MT; Newmark, HL; Wang, ZY | 1 |
| Cha, JJ; Makowiec, RL; Penney, JB; Young, AB | 1 |
| de Barry, J; Garcia-Ladona, FJ; Girard, C; Gombos, G | 1 |
| Fujii, T | 1 |
| Balduini, W; Cattabeni, F; Elsner, J; Lombardelli, G; Peruzzi, G | 1 |
| Hashimoto, Y; Mizutani, M | 1 |
| Eriksdotter-Nilsson, M; Jonsson, G; Luthman, J | 1 |
| Fibiger, HC; Jakubovic, A; Radke, JM; Semba, K; Vincent, SR | 1 |
| Fiala, ES; Ishizaki, H; Sohn, OS; Yang, CS | 1 |
| el-Bayoumy, K; Fiala, ES; Joseph, C; Reddy, BS; Sohn, OS | 1 |
| Deschner, EE; Newmark, HL; Ruperto, J; Wong, G | 1 |
| Kinuya, M; Mamiya, G; Matsutani, T; Nagayoshi, M; Tatsunuma, T; Tsukada, Y; Watanabe, M | 1 |
| Centra, MM; McMahon, TF; Peggins, JO; Weiner, M | 1 |
| Deschner, EE; Lytle, JS; Newmark, HL; Ruperto, JF; Wong, G | 1 |
| Johansson, P | 1 |
| Albertini, P; Amenta, F; Bossoni, G; Cavallotti, C; Felici, L; Ferrante, F; Gaviraghi, G | 1 |
| Albertini, P; Amenta, F; Bossoni, G; Bronzetti, E; Cavallotti, C; Gaviraghi, G | 1 |
| de Barry, J; Gombos, G | 1 |
| Bacon, E; de Barry, J; Gombos, G; Matsokis, N; Roujansky, P | 1 |
| Cecchini, T; Ciaroni, S; Del Grande, P; Gazzanelli, G | 1 |
| Abbracchio, MP; Cattabeni, F; Cimino, M; Cocchi, D; Di Luca, M; Mennuni, L; Rosi, F; Zaratin, P | 1 |
| Deschner, EE; Hakissian, M; Long, FC | 1 |
| Barks, J; Greenamyre, T; Johnston, MV; Silverstein, F | 1 |
| Iwata, H; Mori, H; Niwa, K; Shinoda, T; Tanaka, T; Yoshimi, N | 1 |
| Caswell, N; Fiala, ES; Puz, C; Sohn, OS | 1 |
| Ide, G; Iwasaki, I; Yumoto, N | 1 |
| D'Incalci, M; Damia, G; Manzotti, C; Pratesi, G | 1 |
| Archer, T; Fredriksson, A; Jonsson, G; Lewander, T; Luthman, J; Söderberg, U; Sundström, E | 1 |
| de Barry, J; Gombos, G; Hamori, J; Klupp, T | 1 |
| Hirata, Y; Matsutani, T; Nagayoshi, M; Tamaru, M | 1 |
| Björklund, H; Dahl, D; Eriksdotter-Nilsson, M; Jonsson, G | 1 |
| Fournie, JW; Hawkins, WE; Overstreet, RM; Walker, WW | 2 |
| Antuono, PG; Coyle, JT; Moran, TH; Sanberg, PR | 1 |
| Czerniak, R; Fiala, ES; Puz, C; Sohn, OS | 1 |
| Fiala, ES; Hamilton, SR; Puz, C; Sohn, OS; Williams, GM | 1 |
| Davies, RJ; DeCosse, JJ; Deschner, EE; Palmer, L; Sandle, GI; Weidema, WF | 1 |
| Archer, T; Jonsson, G; Minor, BG; Mohammed, AK; Söderberg, U; Sundström, E | 1 |
| Fiala, ES; Hamilton, SR; Sohn, OS | 1 |
| Antuono, PG; Coyle, JT; Henault, MA; Moran, TH; Sanberg, PR | 1 |
| Hirabayashi, K; Hirata, Y; Matsutani, T; Nagayoshi, M; Shimizu, J; Sugimoto, S; Tamaru, M | 1 |
| Chen, S; Hillman, DE | 1 |
| Amenta, F; Bossoni, G; Carpi, C; Cavallotti, C; De Rossi, M | 1 |
| Birkenfeld, S; Kohen, F; Krispin, M; Zakut, H; Zaltsman, YA; Zor, U | 1 |
| Ashwell, K | 1 |
| Deschner, EE; Zedeck, MS | 1 |
| Luckert, PH; Pollard, M | 1 |
| Craven, PA; DeRubertis, FR; Neidig, M | 1 |
| Bejar, A; de Barry, J; Gombos, G; Roujansky, P | 1 |
| Matsutani, T | 1 |
| Hallman, H; Jonsson, G | 2 |
| U'Prichard, DC | 1 |
| Hoffmann, GR; Morgan, RW | 2 |
| Johnston, JB; Kari, FW; Truex, CR; Visek, WJ | 1 |
| Fiala, ES; Stathopoulos, C | 1 |
| Haddad, R; Kozlowski, PB; Lee, MH; Majkowski, J | 1 |
| Cupo, SH; Deschner, EE; Hakissian, M; Long, FC | 1 |
| Bennink, MR; Glauert, HP | 1 |
| Cannon-Spoor, HE; Freed, WJ | 1 |
| Hirono, I | 1 |
| Fujii, T; Hanada, S; Hayasaka, I; Nakatsuka, T | 1 |
| Kurland, LT; Molgaard, CA | 1 |
| Hopfinger, AJ; Kikuchi, O | 1 |
| Ishizaki, H; Matsumoto, H; Takata, RH | 1 |
| Guidry, C; Jacob, C; Mendeloff, AI; Nair, PP; Turjman, N | 1 |
| Barone, S; Freeman, JH; Stanton, ME | 1 |
| Bauer, KD; Hurwitz, A; Kimler, BF; Looney, GA; Pinson, DM; Sztern, MI | 1 |
| Emmett, MR; Wood, JA; Wood, PL | 1 |
| Bunton, TE | 1 |
| Caputi, A; Cattabeni, F; Cattaneo, E; Di Luca, M; Reinach, B | 1 |
| Wood, KA; Youle, RJ | 1 |
| Eizirik, DL; Kisby, GE | 1 |
| Loupe, PS; Schroeder, SR; Tessel, RE | 2 |
| Aoki, K; Ishikawa, T; Masahito, P; Nakatsuru, Y; Sakurai, J; Sato, A | 1 |
| Havu, N; Hurwitz, A; Kimler, BF; Looney, GA; Mattsson, H; Pinson, DM; Sztern, MI | 1 |
| Ichinowatari, N; Kodama, Y; Mamiya, G; Shimizu, K; Takishima, K; Watanabe, M | 1 |
| Barone, S; Crofton, KM; Goldey, ES; O'Callaghan, JP; Stanton, ME | 1 |
| Archer, T | 1 |
| Gavin, CE; Gerken, LA; Kates, B; Rodier, PM | 1 |
| Ferguson, SA; Holson, RR; Paule, MG | 1 |
| Barnabei, O; Ciani, E; Contestabile, A; Facchinetti, F; Sparapani, M | 1 |
| Ferguson, SA; Holson, RR; Paule, MG; Racey, FD | 1 |
| Gavin, CE; Hoffman, GE; Kates, B; Rodier, PM | 1 |
| Kawamori, T; Kojima, T; Mori, H; Morishita, Y; Sugie, S; Suzui, M; Tanaka, T | 1 |
| Hugon, J; Kisby, GE; Ludolph, AC; Nunn, PB; Ross, SM; Roy, DN; Spencer, PS | 1 |
| Begg, AC; Los, G; Oldenburg, J; Pinedo, HM; Ruevekamp, M; Schornagel, JH; van Vugt, MJ | 1 |
| Drago, F; Genazzani, AA; Grassi, M; Mauceri, F; Nardo, L; Valerio, C | 1 |
| Albin, RL; Turgeon, SM | 1 |
| Inagake, M; Iwashima, A; Kikuoka, N; Kitao, Y; Matsumoto, H; Nakatani, H; Nishimura, H; Oya, K; Takahashi, T; Yamane, T | 1 |
| Snyder-Keller, AM | 1 |
| Abcarian, H; Kako, H; Misumi, A; Nelson, RL; Nelson, TM; Rizk, S; Sky-Peck, H | 1 |
| Baraban, SC; Schwartzkroin, PA | 1 |
| Caputi, A; Cattabeni, FN; Cimino, M; Di Luca, M; Pastorino, L; Rurale, S | 1 |
| Becker, T; de Barry, J; Gombos, G | 1 |
| Hawkes, R; Ji, Z | 1 |
| Boyne, LJ; Fischer, I; Hoffman, JR; Levitt, P | 1 |
| Fukuda, T; Hayashi, Y; Hioki, K; Kodama, Y; Manabe, S; Matsunuma, N; Mitsumori, K; Nomura, G; Nomura, T; Okamiya, H; Sakamaki, Y; Sunaga, M; Suzuki, H; Wakana, S; Yamamoto, S | 1 |
| Ferguson, SA | 1 |
| Ambrogini, P; Buffi, O; Cecchini, T; Ciaroni, S; Del Grande, P | 1 |
| Cattabeni, F; Di Luca, M | 1 |
| Alabaster, O; Nikula, KJ; Shivapurkar, N; Tanaka, T; Tang, ZC | 1 |
| Ferguson, SA; Holson, RR | 1 |
| Ferrer, I; Planas, AM; Pozas, E | 1 |
| Barindelli, S; Buxbaum, JD; Caputi, A; Cattabeni, F; Cimino, M; Di Luca, M; Pastorino, L | 1 |
| Andres, MA; Berciano, MT; Calle, E; Lafarga, M; Lerga, A; Polanco, JI | 1 |
| Ichinowatari, N; Kodama, Y; Matsutani, T; Shimizu, K; Watanabe, M | 1 |
| Cassand, P; Maziere, S; Narbonne, JF; Tavan, E | 1 |
| Becker, T; de Barry, J; Gombos, G; Görcs, T; Hámori, J; Takács, J | 1 |
| Fujimiya, M; Funahashi, A; Kimura, H; Maeda, T | 1 |
| Germano, IM; Sperber, EF | 1 |
| Hagino, Y; Kaichi, Y; Kodama, Y; Nonaka, R; Watanabe, M | 1 |
| Ben-Ari, Y; Chevassus-au-Louis, N; Khrestchatisky, M; Rafiki, A; Represa, A | 1 |
| Hagino, Y; Kodama, Y; Nonaka, R; Watanabe, M | 2 |
| Ben-Ari, Y; Chevassus-Au-Louis, N; Jorquera, I; Rafiki, A; Represa, A | 1 |
| Ben-Ari, Y; Chevassus-Au-Louis, N; Congar, P; Gaïarsa, JL; Represa, A | 1 |
| Andres, MA; Berciano, MT; Calle, E; Lafarga, M | 1 |
| Delhaye-Bouchaud, N; Doughty, ML; Mariani, J | 1 |
| Avanzini, G; Battaglia, G; Cattabeni, F; Colacitti, C; Di Luca, M; Franceschetti, S; Sancini, G; Spreafico, R | 1 |
| Avanzini, G; Battaglia, G; Colacitti, C; Di Luca, M; Franceschetti, S; Sancini, G; Spreafico, R | 1 |
| Ben-Ari, Y; Chevassus-au-Louis, N; Vergnes, M | 1 |
| Delker, DA; McKnight, SJ; Rosenberg, DW | 1 |
| Ahuja, S; Germano, IM; Moshé, SL; Sperber, EF | 1 |
| Esclaire, F; Hugon, J; Kisby, G; Lesort, M; Milne, J; Spencer, P | 1 |
| Caputi, A; Cattabeni, F; Cimino, M; Di Luca, M; Gardoni, F; Pastorino, L | 1 |
| Avanzini, G; Battaglia, G; Caputi, A; Cattabeni, F; Colacitti, C; DeBiasi, S; Di Luca, M; Franceschetti, S; Frassoni, C; Sancini, G; Spreafico, R | 1 |
| Kusuki, T; Nishimura, A; Takeuchi, Y; Ueda, S; Yoshimoto, K | 1 |
| Baraban, SC; Ben-Ari, Y; Chevassus-au-Louis, N; Gaïarsa, JL | 1 |
| Cattabeni, F; Di Luca, M; Gardoni, F | 1 |
| Hugon, J; Kabel, H; Kisby, GE; Spencer, P | 1 |
| Esclaire, F; Hugon, J; Kisby, G; Lesort, M; Spencer, P | 1 |
| Ben-Ari, Y; Chevassus-Au-Louis, N; Jorquera, I; Represa, A | 1 |
| Baraban, SC; Hochman, DW; Schwartzkroin, PA; Wenzel, HJ | 1 |
| Aksoy, N; Arslan, SO; Bozer, M; Vural, H | 1 |
| Ali, SF; Lu, MH; Tang, N | 1 |
| Juliano, SL; McLaughlin, DF; Noctor, SC; Palmer, SL | 1 |
| Aloe, L; Amendola, T; Antonelli, A; Fiore, M; Korf, J; Westenbroek, C | 1 |
| Baraban, SC; Castro, PA; Cooper, EC; Lowenstein, DH | 1 |
| Fiala, ES; Gonzalez, FJ; Requeijo, SP; Sohn, OS; Weisburger, JH | 1 |
| Mori, H; Moriwaki, H; Okuno, M; Sugie, S; Suzui, M; Tanaka, T | 1 |
| Ambrogini, P; Cecchini, T; Ciaroni, S; Cuppini, R; Del Grande, P; Ferri, P; Lombardelli, G; Peruzzi, G | 1 |
| Baraban, SC; Calcagnotto, ME; Paredes, MF | 1 |
| Crowley, DJ; Hoffmann, GR; Theophiles, PJ | 1 |
| Ambrogini, P; Cecchini, T; Ciaroni, S; Cuppini, R; Del Grande, P; Ferri, P; Lombardelli, G; Papa, S; Riccio, M | 1 |
| Gierdalski, M; Juliano, SL | 2 |
| Baraban, SC; Colmers, WF; Pentney, AR | 1 |
| Loupe, PS; Schloss, J; Schroeder, SR; Tessel, RE | 1 |
| Darmanto, W; Funahashi, A; Inouye, M | 1 |
| Gierdalski, M; Hasling, TA; Jablonska, B; Juliano, SL | 1 |
| Baraban, SC; Calcagnotto, ME | 2 |
| Bigl, V; Rossner, S | 1 |
| Ciani, E; Contestabile, A; Frenquelli, M | 1 |
| Bassanini, S; Battaglia, G; Cattabeni, F; Di Luca, M; Pagliardini, S; Saglietti, L; Setola, V | 1 |
| Bassanini, S; Battaglia, G; Cattabeni, F; Di Luca, M; Gardoni, F; Pagliardini, S; Setola, V | 1 |
| LARSON, HO; MATSUMOTO, H; NAGAHAMA, T | 1 |
| KOBAYASHI, A; MATSUMOTO, H | 1 |
| Fonnum, F; Lock, EA | 1 |
| Obata, K; Yamanaka, H | 1 |
| Jablonska, B; Juliano, SL; Noctor, SC; Palmer, SL; Smith, AL | 1 |
| Bae, YC; Cho, JH; Choi, BJ; Choi, IS; Jung, SC; Kim, JH; Lee, MG | 1 |
| Gourevitch, R; Jay, TM; Krebs, MO; Le Pen, G; Rocher, C | 1 |
| Didriksen, M; Flagstad, P; Glenthøj, BY | 1 |
| Arnfred, S; Cumming, P; Gjedde, A; Hansen, AK; Hemmingsen, R; Jelsing, J; Olsen, AK; Pakkenberg, B | 1 |
| Dyson, JG; Teas, HJ | 1 |
| Cho, JH; Choi, BJ; Choi, IS; Lee, MG | 1 |
| Corfas, G; Gierdalski, M; Juliano, SL; Sardi, SP | 1 |
| Didriksen, M; Flagstad, P; Leist, M; Michael-Titus, AT; Penschuck, S | 1 |
| Baraban, SC; Paredes, M; Pleasure, SJ | 1 |
| Hazane, F; Hoareau, C; Krebs, MO; Le Pen, G | 1 |
| Baraban, SC; Berger, O; Li, G; Paredes, MF; Pleasure, SJ | 1 |
| Gourevitch, R; Hazane, F; Hoareau, C; Jay, TM; Krebs, MO; Le Pen, G | 1 |
| Fei, S; Jacob, T; Kisby, GE; Lu, X; Nagalla, SR; Olivas, A; Park, T; Pattee, P; Reddy, A; Standley, M | 1 |
| Featherstone, RE; Fletcher, PJ; Kapur, S; Nobrega, JN; Rizos, Z | 1 |
| Kisby, GE; Li, X; Lu, X; Muniz, J; Nagalla, SR; O'Malley, J; Olivas, A; Pattee, P; Standley, M | 1 |
| Fonnum, F; Mehl, A; Schanke, TM; Torvik, A | 1 |
| Baraban, SC; Harrington, EP; Möddel, G; Najm, IM | 1 |
| Chessel, A; Garcia, R; Krebs, MO; Le Pen, G; Léna, I | 1 |
| Juliano, SL; Poluch, S | 1 |
| Bassanini, S; Battaglia, G; Cipolla, M; Finardi, A; Hallene, K; Janigro, D; Santaguida, S | 1 |
| Grace, AA; Lodge, DJ | 1 |
| Juliano, SL; Schaefer, AW | 1 |
| Juliano, S; Poluch, S; Schaefer, A | 1 |
| Laqueur, GL; Matsumoto, H; McDaniel, EG | 1 |
| Aloe, L; Di Fausto, V; Fiore, M; Iannitelli, A | 1 |
| Fan, QY; Fazio, V; Hallene, K; Janigro, D; Marchi, N; Ramakrishna, S | 1 |
| Almeida, OF; Bessa, JM; Cerqueira, JJ; Ferreira, D; Marques, F; Melo, I; Palha, JA; Sousa, N | 1 |
| Churchwell, M; Doerge, D; Gerson, SL; Kisby, GE; Olivas, A; Park, T; Samson, LD; Turker, MS | 1 |
| Kisby, G; Palmer, V; Spencer, PS | 1 |
| Hazane, F; Jay, TM; Krebs, MO; Le Pen, G | 1 |
| Burton, CL; Coppa-Hopman, R; Featherstone, RE; Fletcher, PJ; Kapur, S; Rizos, Z; Sinyard, J | 1 |
| Chen, J; Huang, XF | 1 |
| Hirata, K; Kadowaki, T; Nakamura, A; Sakakibara, S; Ueda, S; Yoshimoto, K | 1 |
| Henningsen, K; Jayatissa, MN; West, MJ; Wiborg, O | 1 |
| Bellon, A; Beuvon, F; Daumas-Duport, C; Frieling, H; Jay, TM; Kebir, O; Krebs, MO; Le Pen, G; Matricon, J | 1 |
| Chu, K; Jung, KH; Kang, KM; Kim, JH; Kim, M; Lee, SK; Lee, ST; Park, HK; Park, KI; Roh, JK | 1 |
| Jay, TM; Krebs, MO; Le Pen, G | 1 |
| Bammler, TK; Beyer, RP; Churchwell, M; Doerge, DR; Fry, RC; Kavanagh, TJ; Kisby, GE; Lasarev, MR; Meira, LB; Palmer, VS; Ramos-Crawford, AL; Ren, X; Samson, LD; Spencer, PS; Sullivan, RC; Zarbl, H | 1 |
| Doisy, ET; Jürgen Wenzel, H; Schwartzkroin, PA; Tschuluun, N | 1 |
| Kisby, GE; Spencer, PS | 1 |
| de Groot, D; Fox, DA; Grandjean, P; Paule, MG | 1 |
| Schwartzkroin, PA; Wenzel, HJ | 1 |
| Beekhuijzen, M; Emmen, H; Lensen, J; Zmarowski, A | 1 |
| Lodge, DJ; Perez, SM | 1 |
| Adelman, AE; Gao, WJ; Snyder, MA | 1 |
| Bicker, G; Gierse, A; Stern, M; Tan, S | 1 |
| Bator, E; Latusz, J; Maćkowiak, M; Mordalska, P; Wędzony, K | 1 |
| Abbah, J; Braga, MF; Juliano, SL | 1 |
| Delaney, S; Hall, ZJ; Sherry, DF | 1 |
| Gomes, FV; Grace, AA; Guimarães, FS | 1 |
| Gean, PW; Hsiao, YH; Hung, HC | 1 |
| Bellinger, SA; Kleven, GA | 1 |
| Howe, WM; Kozak, R; Oomen, C; Tierney, PL; Young, DA | 1 |
| Bator, E; Latusz, J; Maćkowiak, M; Radaszkiewicz, A; Wędzony, K | 1 |
| Amchova, P; Babinska, Z; Drago, F; Micale, V; Ruda-Kucerova, J; Stark, T; Sulcova, A | 1 |
| Akbari, M; Beyer, C; Eqlimi, E; Mortezaee, K; Omidi, A; Ragerdi Kashani, I; Zendedel, A | 1 |
| Babinska, Z; Micale, V; Ruda-Kucerova, J; Stark, T | 1 |
| Elefant, F; Gao, WJ; Gulchina, Y; Snyder, MA; Xu, SJ | 1 |
| Gill, KM; Grace, AA; Miller, SA | 1 |
| Bator, E; Latusz, J; Maćkowiak, M; Wędzony, K | 1 |
| Bator, E; Głowacka, U; Latusz, J; Maćkowiak, M; Mudlaff, K; Radaszkiewicz, A | 1 |
| Azizi, M; Kashani, IR; Mokhtari, T; Nadji, SA; Omidi, N; Pasbakhsh, P; Pourabdollah, M; Sadr, M; Zendehdel, A | 1 |
| Edelson, JR; Gomes, FV; Grace, AA; Volk, DW | 1 |
| Huang, H; Huo, C; Liu, X; Ye, H; Zhao, J; Zhao, T | 1 |
| Kisby, GE; Palmer, VS; Spencer, PS | 1 |
| Battaglia, GS; Cagnoli, C; Cipelletti, B; Colciaghi, F; de Curtis, M; Locatelli, D; Nobili, P; Zambon, S | 1 |
| Babinska, Z; Hammer, T; Horska, K; Karpisek, M; Kotolova, H; Micale, V; Prochazka, J; Ruda-Kucerova, J; Stark, T | 1 |
| Chlebowski, AC; Eriksen, JL; Kisby, GE; Spencer, PS | 1 |
| Minami, S; Ueda, S; Yamaguchi, T | 1 |
| Bilecki, W; Chmelova, M; Gawlińska, K; Latusz, J; Maćkowiak, M | 1 |
| Kim, EJ; Kim, MJ; Lee, M; Yum, MS | 1 |
| Bilecki, W; Chmelova, M; Maćkowiak, M; Majcher-Maślanka, I; Wawrzczak-Bargieła, A | 1 |
| Grace, AA; Sved, AF; Weeks, JJ | 1 |
| An, Y; Lan, Y; Li, GY; Li, ML; Peng, Y | 1 |
20 review(s) available for methylazoxymethanol acetate and methylazoxymethanol
| Article | Year |
|---|---|
[Integrative assessment of the developmental pharmacology and developmental toxicology, with special reference to the brain].
Topics: Animals; Brain; Cell Division; Cisplatin; Female; Humans; Methylazoxymethanol Acetate; Neuropharmacology; Nimustine; Pregnancy; Prenatal Exposure Delayed Effects; Toxicology | 1991 |
Use of toxins to disrupt neurotransmitter circuitry in the developing brain.
Topics: Adult; Animals; Brain; Embryonic and Fetal Development; Humans; Mental Disorders; Methylazoxymethanol Acetate; Neurotoxins; Neurotransmitter Agents; Rats | 1988 |
Biochemical characteristics and regulation of brain alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Clonidine; Epinephrine; Humans; Hydroxydopamines; Hypertension; Methylazoxymethanol Acetate; Oxidopamine; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Species Specificity; Synapses; Tissue Distribution; Yohimbine | 1984 |
Response of central monoamine neurons following an early neurotoxic lesion.
Topics: Animals; Benzylamines; Brain; Brain Chemistry; Central Nervous System; Hydroxydopamines; Methylazoxymethanol Acetate; Neurons; Neurotoxins; Norepinephrine; Oxidopamine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1982 |
Cycasin and its mutagenic metabolites.
Topics: Animals; Azo Compounds; Carcinogens; Cell Line; Cycasin; DNA Repair; Humans; Methylazoxymethanol Acetate; Mitosis; Mutagenicity Tests; Mutagens; Mutation; Saccharomyces cerevisiae; Salmonella typhimurium | 1983 |
Review: putative mutagens and carcinogens in foods. V. Cycad azoxyglycosides.
Topics: Animals; Azo Compounds; Chromosome Aberrations; Cycasin; DNA; Escherichia coli; Food Analysis; Humans; Methylazoxymethanol Acetate; Mutagens; Saccharomyces cerevisiae; Salmonella | 1984 |
Natural carcinogenic products of plant origin.
Topics: Aflatoxins; Alkaloids; Animals; Areca; Basidiomycota; Carcinogens; Carcinogens, Environmental; Cricetinae; Cycasin; Food Contamination; Humans; Hydrolyzable Tannins; Liver Neoplasms; Methylazoxymethanol Acetate; Mice; Neoplasms, Experimental; Plants, Medicinal; Plants, Toxic; Pyrrolidines; Rats; Safrole | 1981 |
Neuroanatomical and functional alterations resulting from early postnatal cerebellar insults in rodents.
Topics: Animals; Animals, Newborn; Borna Disease; Cerebellar Diseases; Cerebellum; Methylazoxymethanol Acetate; Mice; Rats; Teratogens | 1996 |
Developmental models of brain dysfunctions induced by targeted cellular ablations with methylazoxymethanol.
Topics: Animals; Brain Diseases; Carcinogens; Methylazoxymethanol Acetate; Models, Neurological | 1997 |
Cortical malformations and epilepsy: new insights from animal models.
Topics: Abnormalities, Drug-Induced; Animals; Cerebral Cortex; Disease Models, Animal; Epilepsy; Hippocampus; Humans; Methylazoxymethanol Acetate; Mice; Mice, Knockout; Mitosis; Mutation; Nervous System Malformations; Neural Conduction; Neural Pathways; Rats; Rats, Mutant Strains; Teratogens | 1999 |
Pathophysiological implications of the structural organization of the excitatory synapse.
Topics: Alkylating Agents; Animals; Central Nervous System; Diabetes Mellitus; Methylazoxymethanol Acetate; Protein Kinases; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1999 |
Damage and repair of nerve cell DNA in toxic stress.
Topics: Animals; Carcinogens; Cycadopsida; DNA Damage; DNA Repair; Gene Expression; Humans; Methylazoxymethanol Acetate; Neurodegenerative Diseases; Stress, Physiological | 1999 |
Toxic neuronal apoptosis and modifications of tau and APP gene and protein expressions.
Topics: Amyloid beta-Protein Precursor; Apoptosis; Carcinogens; Gene Expression; Glutamic Acid; Humans; Methylazoxymethanol Acetate; Neurodegenerative Diseases; Phosphorylation; tau Proteins | 1999 |
Influence of radial glia and Cajal-Retzius cells in neuronal migration.
Topics: Animals; Astrocytes; Cell Adhesion Molecules, Neuronal; Cell Differentiation; Cell Division; Cell Movement; Cerebral Cortex; Coculture Techniques; Extracellular Matrix Proteins; Ferrets; Methylazoxymethanol Acetate; Mice; Mice, Knockout; Nerve Tissue Proteins; Neuroglia; Organ Culture Techniques; Protein Synthesis Inhibitors; Reelin Protein; Serine Endopeptidases | 2002 |
Amyloid precursor protein processing in vivo--insights from a chemically-induced constitutive overactivation of protein kinase C in Guinea pig brain.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Brain Diseases; Disease Models, Animal; Endopeptidases; Enzyme Activation; Female; Guinea Pigs; Isoenzymes; Methylazoxymethanol Acetate; Microcephaly; Mutation; Peptide Hydrolases; Pregnancy; Protein Kinase C; Protein Processing, Post-Translational | 2003 |
The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: exemplified with toxic effects on cerebellar granule cells.
Topics: Animals; Cerebellum; DNA Repair; Glutathione; Humans; Hydrocarbons, Halogenated; Methylazoxymethanol Acetate; Methylmercury Compounds; Neurons; Propionates; Thiophenes; Trichlorfon; Xenobiotics | 2004 |
The signal pathways in azoxymethane-induced colon cancer and preventive implications.
Topics: Adenocarcinoma; Adenoma; Adiponectin; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Carcinogens; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Diet; DNA Damage; Genes, ras; Humans; MAP Kinase Signaling System; Methylazoxymethanol Acetate; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta2 | 2009 |
Is neurodegenerative disease a long-latency response to early-life genotoxin exposure?
Topics: Amyotrophic Lateral Sclerosis; Brain; Cycas; Cycasin; DNA Damage; Glycosides; Guam; Humans; Methylazoxymethanol Acetate; Mutagens; Neurotoxins; Pacific Islands; Tauopathies | 2011 |
Are developmental dysplastic lesions epileptogenic?
Topics: Animals; Carcinogens; Disease Models, Animal; Epilepsy; Female; Humans; Malformations of Cortical Development; Methylazoxymethanol Acetate; Mice; Mice, Knockout; Phosphotransferases; Pregnancy; Rats; Tuberous Sclerosis | 2012 |
Developmental pathways of motor dysfunction.
Topics: Animals; Brain; Disease Models, Animal; Female; Guinea Pigs; Methylazoxymethanol Acetate; Mice; Motor Skills Disorders; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 2015 |
224 other study(ies) available for methylazoxymethanol acetate and methylazoxymethanol
| Article | Year |
|---|---|
Cholinergic hyperinnervation in the cerebral cortex of microencephalic rats does not result in muscarinic receptor down-regulation or in alteration of receptor-stimulated phosphoinositide metabolism.
Topics: Abnormalities, Drug-Induced; Acetylcholinesterase; Animals; Atropine; Brain; Cerebral Cortex; Down-Regulation; Female; Isoflurophate; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Organ Size; Phosphatidylinositols; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Muscarinic | 1992 |
[3H]muscimol and [3H]flunitrazepam binding sites in the developing cerebellum of mice treated with methylazoxymethanol at different postnatal ages.
Topics: Animals; Binding Sites; Cerebellum; Flunitrazepam; Glutamate Decarboxylase; Methylazoxymethanol Acetate; Mice; Mitosis; Muscimol; Receptors, GABA-A; Synapses | 1992 |
Effects of foetal treatment with methylazoxymethanol on noradrenergic synapses in rat cerebral cortex.
Topics: Alkylating Agents; Animals; Binding, Competitive; Cerebral Cortex; Dihydroalprenolol; Female; Fetus; Isoproterenol; Ligands; Methylazoxymethanol Acetate; Mitosis; Norepinephrine; Pregnancy; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Synapses | 1992 |
Postnatal behavioral development in methylazoxymethanol-induced microcephalic rats--a behavioral teratology study.
Topics: Abnormalities, Drug-Induced; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Female; Male; Memory; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 1992 |
Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol-induced colonic epithelial cell proliferation and focal areas of dysplasia.
Topics: Animals; Antioxidants; Ascorbic Acid; Body Weight; Colon; Curcumin; Diet; Epithelium; Female; Methylazoxymethanol Acetate; Mice; Tetradecanoylphorbol Acetate | 1992 |
Effects of methylazoxymethanol treatment on the GABAergic synaptosomes in the P2 fraction from developing mouse cerebellum.
Topics: Animals; Cerebellum; Flunitrazepam; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Methylazoxymethanol Acetate; Mice; Muscimol; Receptors, GABA-A; Synaptosomes | 1991 |
Cerebellar excitatory amino acid binding sites in normal, granuloprival, and Purkinje cell-deficient mice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellar Cortex; Dendrites; Denervation; Ibotenic Acid; Methylazoxymethanol Acetate; Mice; Mice, Neurologic Mutants; Purkinje Cells; Quinoxalines; Receptors, AMPA; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Up-Regulation | 1991 |
Ectopic granule cell layer in mouse cerebellum after methyl-azoxy-methanol (MAM) treatment.
Topics: Animals; Carbonic Anhydrases; Cerebellum; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Immunohistochemistry; Methylazoxymethanol Acetate; Mice; Mice, Inbred Strains; Microscopy, Electron; Mitosis; Phosphopyruvate Hydratase; S100 Proteins | 1991 |
Treatment with methylazoxymethanol at different gestational days: two-way shuttle box avoidance and residential maze activity in rat offspring.
Topics: Alkylating Agents; Analysis of Variance; Animals; Avoidance Learning; Brain; Exploratory Behavior; Female; Gestational Age; Methylazoxymethanol Acetate; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Rats | 1991 |
Early neurobehavioral disorders in the micrencephalic offspring induced by prenatal treatment with N-methyl-N-nitrosourea or methylazoxymethanol in the rat.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Female; Locomotion; Male; Methylazoxymethanol Acetate; Methylnitrosourea; Microcephaly; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Rodent Diseases; Swimming | 1991 |
Structural and neurochemical effects in mouse cerebellum following neonatal methylazoxymethanol and 6-hydroxydopamine treatment.
Topics: Animals; Antineoplastic Agents; Azo Compounds; Biogenic Monoamines; Cerebellum; Glial Fibrillary Acidic Protein; Hydroxydopamines; Immunohistochemistry; Methylazoxymethanol Acetate; Mice; Organ Size; Oxidopamine; Tyrosine 3-Monooxygenase | 1990 |
Loss of striatal somatostatin neurons following prenatal methylazoxymethanol.
Topics: Animals; Body Weight; Catecholamines; Corpus Striatum; Female; Fetus; Methylazoxymethanol Acetate; Mitosis; Neurons; Rats; Rats, Inbred Strains; Somatostatin | 1990 |
Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1.
Topics: Acetone; Animals; Azoxymethane; Carcinogens; Cytochrome P-450 Enzyme System; Dimethylnitrosamine; Isoenzymes; Male; Methylazoxymethanol Acetate; Microsomes, Liver; Rats; Rats, Inbred Strains | 1991 |
Mechanism of benzylselenocyanate inhibition of azoxymethane-induced colon carcinogenesis in F344 rats.
Topics: Animals; Azoxymethane; Body Weight; Colonic Neoplasms; Cyanates; Cytochrome P-450 Enzyme System; DNA; Drug Screening Assays, Antitumor; Guanine; Male; Methylation; Methylazoxymethanol Acetate; Microsomes, Liver; Organoselenium Compounds; Rats; Rats, Inbred F344; Selenium | 1991 |
Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia.
Topics: Animals; Body Weight; Carcinogens; Cell Division; Colonic Neoplasms; Female; Methylazoxymethanol Acetate; Mice; Quercetin; Rutin | 1991 |
Increased uptake sites for serotonin and dopamine with decreased S2 serotonin receptors in microencephalic rat brain.
Topics: Abnormalities, Drug-Induced; Animals; Biological Transport; Brain; Cerebral Cortex; Corpus Striatum; Dopamine; Female; Kinetics; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reference Values; Serotonin; Teratogens | 1990 |
Age-related changes in biotransformation of azoxymethane and methylazoxymethanol in vitro.
Topics: Aging; Alcohol Dehydrogenase; Animals; Azo Compounds; Azoxymethane; Biotransformation; Carcinogens; Colon; Cytochrome P-450 Enzyme System; Glucuronates; Glucuronosyltransferase; Hydroxylation; Hymecromone; Male; Methylazoxymethanol Acetate; Microsomes; Microsomes, Liver; Rats; Rats, Inbred F344 | 1990 |
The effect of dietary omega-3 fatty acids (fish oil) on azoxymethanol-induced focal areas of dysplasia and colon tumor incidence.
Topics: Animals; Colonic Neoplasms; DNA Replication; Fatty Acids, Omega-3; Female; Fish Oils; Incidence; Methylazoxymethanol Acetate; Mice; Neoplasms, Experimental; S Phase | 1990 |
Methylazoxymethanol (MAM)-induced brain lesion and oral dyskinesia in rats.
Topics: Animals; Azo Compounds; Behavior, Animal; Brain Diseases; Corpus Striatum; Dyskinesia, Drug-Induced; Female; Globus Pallidus; Glutamate Decarboxylase; Haloperidol; Methylazoxymethanol Acetate; Pregnancy; Rats; Substantia Nigra | 1990 |
Effect of acetyl-L-carnitine treatment on the density of muscarinic receptors in the brain of methylazoxymethanol-microencephalic rats.
Topics: Acetylcarnitine; Animals; Autoradiography; Azo Compounds; Brain Chemistry; Carnitine; Cerebral Cortex; Male; Methylazoxymethanol Acetate; Microcephaly; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Staining and Labeling; Sympathetic Nervous System; Synaptic Transmission | 1989 |
Effect of acetyl-L-carnitine treatment on brain ribonucleic acid levels in methylazoxymethanol-microencephalic rats.
Topics: Acetylcarnitine; Animals; Behavior, Animal; Brain Chemistry; Carnitine; Cerebral Cortex; Corpus Striatum; DNA; Hippocampus; Histocytochemistry; Male; Methylazoxymethanol Acetate; Microcephaly; Rats; Rats, Inbred Strains; RNA; RNA, Ribosomal; Staining and Labeling | 1989 |
Immunohistochemistry with anti-calbindin and anti-neurofilament antibodies in the cerebellum of methylazoxymethanol-treated mice.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Antineoplastic Agents; Azo Compounds; Calbindins; Cerebellum; Immunohistochemistry; Intermediate Filament Proteins; Methylazoxymethanol Acetate; Mice; Neurofilament Proteins; S100 Calcium Binding Protein G | 1989 |
Alteration of benzodiazepine receptors in mouse cerebellum following methylazoxymethanol treatment during development.
Topics: Aging; Alkylating Agents; Animals; Azo Compounds; Cerebellum; Flunitrazepam; Methylazoxymethanol Acetate; Mice; Receptors, GABA-A | 1989 |
Methylazoxymethanol acetate (MAM ac) effects on the ontogenesis of the mouse neocortex.
Topics: Alkylating Agents; Animals; Azo Compounds; Cell Count; Cerebral Cortex; Embryonic and Fetal Development; Methylazoxymethanol Acetate; Mice; Mitosis | 1989 |
Methylazoxymethanol-induced microencephaly: persistent increase of cortical somatostatin-like immunoreactivity.
Topics: Animals; Azo Compounds; Brain; Dose-Response Relationship, Drug; Female; Gestational Age; Immunohistochemistry; Male; Methylazoxymethanol Acetate; Organ Size; Peptides; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Sex Factors | 1989 |
Genetic factors controlling inheritance of susceptibility to 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Animals; Carcinogens; Cell Division; Colonic Neoplasms; Dimethylhydrazines; Female; Genetic Predisposition to Disease; Male; Methylazoxymethanol Acetate; Methylhydrazines; Mice; Mice, Inbred Strains; Sex Factors | 1989 |
Inhibitory effect of magnesium hydroxide on methylazoxymethanol acetate-induced large bowel carcinogenesis in male F344 rats.
Topics: Animals; Azo Compounds; Calcium; Colonic Neoplasms; Hydrogen-Ion Concentration; Magnesium; Magnesium Hydroxide; Male; Methylazoxymethanol Acetate; Rats; Rats, Inbred F344 | 1989 |
Differential susceptibility of rat and guinea pig colon mucosa DNA to methylation by methylazoxymethyl acetate in vivo.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Animals; Azo Compounds; Colon; DNA; Guinea Pigs; Intestinal Mucosa; Liver; Male; Methylation; Methylazoxymethanol Acetate; Rats; Rats, Inbred F344; Species Specificity | 1985 |
Influence of Lactobacillus arabinosus on metabolic enzyme activity of methylazoxymethanol (MAM) acetate in gnotobiotic mice.
Topics: Administration, Oral; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Animals; Azo Compounds; Esterases; Germ-Free Life; Glucuronidase; Intestinal Neoplasms; Intestine, Large; Intestine, Small; Lactobacillus; Liver; Male; Methylazoxymethanol Acetate; Mice; Mice, Inbred ICR; Microscopy, Electron; Neoplasms, Experimental | 1986 |
Response of chemically induced primary colon tumours of the mouse to flavone acetic acid (NSC 347 512).
Topics: Animals; Antineoplastic Agents; Carcinogens; Colonic Neoplasms; Female; Flavonoids; Fluorouracil; Kidney; Liver; Methylazoxymethanol Acetate; Mice; Spleen | 1988 |
Prenatal methylazoxymethanol treatment potentiates d-amphetamine- and methylphenidate-induced motor activity in male and female rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Azo Compounds; Dextroamphetamine; Disease Models, Animal; Drug Synergism; Female; Fetus; Male; Methylazoxymethanol Acetate; Methylphenidate; Motor Activity; Rats; Receptors, Dopamine | 1988 |
Alteration of mouse cerebellar circuits following methylazoxymethanol treatment during development: immunohistochemistry of GABAergic elements and electron microscopic study.
Topics: Animals; Azo Compounds; Cerebellum; gamma-Aminobutyric Acid; Immunoenzyme Techniques; Methylazoxymethanol Acetate; Mice; Microscopy, Electron; Synapses | 1987 |
Brain changes in rats induced by prenatal injection of methylazoxymethanol.
Topics: Alkylating Agents; Animals; Azo Compounds; Body Weight; Brain; DNA; Dopamine; Dose-Response Relationship, Drug; Female; Methylazoxymethanol Acetate; Norepinephrine; Organ Size; Pregnancy; Rats; Serotonin | 1988 |
Astroglial development in microencephalic rat brain after fetal methylazoxymethanol treatment.
Topics: Animals; Astrocytes; Azo Compounds; Brain; Cerebral Cortex; Female; Gestational Age; Glial Fibrillary Acidic Protein; Hippocampus; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains | 1986 |
Exocrine pancreatic neoplasms induced by methylazoxymethanol acetate in the guppy Poecilia reticulata.
Topics: Adenocarcinoma; Adenoma; Animals; Azo Compounds; Methylazoxymethanol Acetate; Pancreas; Pancreatic Neoplasms; Poecilia | 1987 |
Methylazoxymethanol acetate cortical hypoplasia alters the pattern of stimulation-induced behavior in neonatal rats.
Topics: Animals; Animals, Newborn; Azo Compounds; Behavior, Animal; Brain Mapping; Cerebral Cortex; Choline O-Acetyltransferase; Electric Stimulation; Glutamate Decarboxylase; Hypothalamic Area, Lateral; Medial Forebrain Bundle; Methylazoxymethanol Acetate; Neural Pathways; Rats | 1986 |
Differential effects of 4-iodopyrazole and 3-methylpyrazole on the metabolic activation of methylazoxymethanol to a DNA methylating species by rat liver and rat colon mucosa in vivo.
Topics: Alcohol Dehydrogenase; Alkylating Agents; Animals; Azo Compounds; Colon; DNA Damage; Intestinal Mucosa; Liver; Methylation; Methylazoxymethanol Acetate; Microsomes; Pyrazoles; Rats | 1987 |
Enhancement of rat liver microsomal metabolism of azoxymethane to methylazoxymethanol by chronic ethanol administration: similarity to the microsomal metabolism of N-nitrosodimethylamine.
Topics: Animals; Azo Compounds; Azoxymethane; Chromatography, High Pressure Liquid; Dimethylnitrosamine; Enzyme Activation; Ethanol; Kinetics; Male; Methylazoxymethanol Acetate; Microsomes, Liver; Rats; Rats, Inbred F344 | 1987 |
Sodium transport in a mouse model of colonic carcinogenesis.
Topics: 1,2-Dimethylhydrazine; Amiloride; Animals; Biological Transport; Chlorides; Colon; Colonic Neoplasms; Dimethylhydrazines; Female; Methylazoxymethanol Acetate; Mice; Mice, Inbred Strains; Sodium | 1987 |
Selective attention and place navigation in rats treated prenatally with methylazoxymethanol.
Topics: Abnormalities, Drug-Induced; Animals; Attention; Azo Compounds; Brain; Cognition Disorders; Female; Inhibition, Psychological; Learning Disabilities; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred Strains; Reaction Time; Space Perception | 1986 |
Effects of chronic dietary ethanol on in vivo and in vitro metabolism of methylazoxymethanol and on methylazoxymethanol-induced DNA methylation in rat colon and liver.
Topics: Alcoholism; Animals; Azo Compounds; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Colon; Diet; DNA; Ethanol; Kinetics; Liver; Male; Methylation; Methylazoxymethanol Acetate; Rats; Rats, Inbred F344 | 1987 |
The development of daytime rearing behavior in methylazoxymethanol-treated rats: methodological considerations.
Topics: Animals; Animals, Newborn; Azo Compounds; Behavior, Animal; Female; Male; Methylazoxymethanol Acetate; Rats; Rats, Inbred Strains | 1987 |
[A neurochemical study of rat brain maldevelopment induced by MAM treatment at different stages of gestation].
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Azo Compounds; Brain; Brain Chemistry; Conditioning, Operant; Discrimination Learning; Female; Gestational Age; Locomotion; Methylazoxymethanol Acetate; Microcephaly; Organ Size; Phosphopyruvate Hydratase; Pregnancy; Rats; Rats, Inbred Strains; S100 Proteins | 1986 |
Selective ablation of neurons by methylazoxymethanol during pre- and postnatal brain development.
Topics: Aging; Animals; Azo Compounds; Brain; Embryonic and Fetal Development; Female; Methylazoxymethanol Acetate; Neurons; Pregnancy; Rats; Rats, Inbred Strains | 1986 |
Effect of acetyl-L-carnitine treatment on some behavioural, histochemical and histological parameters of methylazoxymethanol microencephalic rats.
Topics: Acetylcarnitine; Acetylcholinesterase; Animals; Behavior, Animal; Brain; Carnitine; Female; Histocytochemistry; Male; Methylazoxymethanol Acetate; Microcephaly; NADH Tetrazolium Reductase; Nissl Bodies; Pregnancy; Rats; Rats, Inbred Strains | 1986 |
Antitumor effects of inhibitors of arachidonic acid cascade on experimentally induced intestinal tumors.
Topics: Animals; Arachidonic Acids; Catechols; Indomethacin; Intestinal Neoplasms; Male; Masoprocol; Methylazoxymethanol Acetate; Prostaglandin Antagonists; Rats; Rats, Inbred Strains | 1987 |
An abnormal retinal projection to the lateral posterior nucleus in micrencephalic rats.
Topics: Abnormalities, Drug-Induced; Animals; Female; Geniculate Bodies; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Rats; Rats, Inbred Strains; Retina; Superior Colliculi; Thalamic Nuclei; Visual Pathways | 1986 |
Lipid peroxidation in liver and colon of methylazoxymethanol treated rats.
Topics: Animals; Azo Compounds; Colon; Intestinal Mucosa; Intracellular Membranes; Lipid Peroxides; Liver; Male; Methylazoxymethanol Acetate; Microsomes, Liver; Mitochondria, Liver; Rats | 1986 |
Tumorigenic effects of direct- and indirect-acting chemical carcinogens in rats on a restricted diet.
Topics: Animals; Body Weight; Colonic Neoplasms; Diet; Intestinal Neoplasms; Intestine, Large; Intestine, Small; Male; Methylazoxymethanol Acetate; Methylnitrosourea; Rats; Rats, Inbred Strains | 1985 |
Fatty acid-stimulated oxidation of methylazoxymethanol by rat colonic mucosa.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Azo Compounds; Carcinogens; Colon; Fatty Acids; Female; Formaldehyde; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Methylazoxymethanol Acetate; NAD; Oxidation-Reduction; Pyrazoles; Rats; Rats, Inbred Strains | 1985 |
Different effect of methylazoxymethanol on mouse cerebellar development depending on the age of injection.
Topics: Age Factors; Animals; Azo Compounds; Cell Movement; Cerebellum; DNA; Methylazoxymethanol Acetate; Mice; Microscopy, Electron; Models, Neurological; Neuronal Plasticity | 1985 |
Development of aquarium fish models for environmental carcinogenesis: tumor induction in seven species.
Topics: Animals; Cyprinidae; Eye Neoplasms; Fishes; Liver Neoplasms; Methylazoxymethanol Acetate; Neoplasms, Experimental; Species Specificity; Water Pollutants; Water Pollutants, Chemical | 1985 |
A neurochemical study of experimental microencephalic rat.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Biogenic Amines; Brain; Brain Chemistry; Cytarabine; DNA; Female; Learning; Methylazoxymethanol Acetate; Myelin Proteins; Nerve Tissue Proteins; Organ Size; Phosphoric Diester Hydrolases; Pregnancy; Rats; Rats, Inbred Strains; Time Factors; Tryptophan; Tryptophan Hydroxylase | 1984 |
Effects of prenatal methylazoxymethanol treatment on the development of central monoamine neurons.
Topics: Animals; Azo Compounds; Brain; Cell Differentiation; Dopamine; Female; Methylazoxymethanol Acetate; Neurons; Neurotransmitter Agents; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Serotonin | 1981 |
Effect of dietary protein concentration on yield of mutagenic metabolites from 1,2-dimethylhydrazine in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Azo Compounds; Azoxymethane; Biotransformation; Dietary Proteins; Dimethylhydrazines; Methylazoxymethanol Acetate; Methylhydrazines; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mutagenicity Tests; Salmonella typhimurium | 1983 |
Metabolism of methylazoxymethanol acetate in the F344 rat and strain-2 guinea pig and its inhibition by pyrazole and disulfiram.
Topics: Alcohol Dehydrogenase; Alcohol Oxidoreductases; Animals; Azo Compounds; Carbon Dioxide; Carbon Radioisotopes; Carcinogens; Disulfiram; Female; Guinea Pigs; Male; Methylazoxymethanol Acetate; Pyrazoles; Rats; Rats, Inbred F344; Species Specificity | 1984 |
EEG and seizure threshold in normal and lissencephalic ferrets.
Topics: Animals; Cerebral Cortex; Electric Stimulation; Electroencephalography; Epilepsy; Female; Ferrets; Male; Methylazoxymethanol Acetate; Sleep; Syndrome | 1984 |
Differential susceptibility of inbred mouse strains forecast by acute colonic proliferative response to methylazoxymethanol.
Topics: 1,2-Dimethylhydrazine; Animals; Azo Compounds; Carcinogens; Cell Division; Colon; Dimethylhydrazines; Female; Methylazoxymethanol Acetate; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Species Specificity | 1984 |
Metabolism of 1,2-dimethylhydrazine by cultured rat colon epithelial cells.
Topics: Animals; Azoxymethane; Cells, Cultured; Colon; Culture Media; Dimethylhydrazines; Epithelial Cells; Germ-Free Life; In Vitro Techniques; Male; Methylazoxymethanol Acetate; Methylhydrazines; Rats; Rats, Inbred Strains | 1983 |
Hyperactivity induced by prenatal administration of methylazoxymethanol: association with altered performance on conditioning tasks in rats.
Topics: Alkylating Agents; Animals; Avoidance Learning; Azo Compounds; Body Weight; Conditioning, Operant; Female; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Rats, Inbred Strains | 1984 |
Effects of prenatal treatment with methylazoxymethanol acetate on growth, development, reproductive performance, learning ability and behavior in the rat offspring.
Topics: Abnormalities, Drug-Induced; Analysis of Variance; Animals; Azo Compounds; Behavior, Animal; Body Weight; Brain; Carcinogens; Female; Fetus; Learning; Male; Methylazoxymethanol Acetate; Motor Activity; Organ Size; Pregnancy; Rats; Rats, Inbred Strains; Reproduction | 1982 |
Guamanian ALS: hereditary or acquired?
Topics: Amyotrophic Lateral Sclerosis; Ethnicity; Guam; Humans; Methylazoxymethanol Acetate | 1982 |
Modeling the metabolic pathways of methylazoxymethanol: a semiempirical molecular orbital study.
Topics: Animals; Azo Compounds; Biotransformation; Chemical Phenomena; Chemistry; Methylazoxymethanol Acetate; Molecular Conformation | 1981 |
Determination of the carcinogen methylazoxymethyl-beta-D-glucosiduronic acid in rat bile and urine.
Topics: Animals; Azo Compounds; Bile; Carcinogens; Chromatography, Gas; Cycasin; Glucuronates; Male; Methylazoxymethanol Acetate; Rats; Reference Values | 1981 |
Isolation of tissue-bound lithocholic acid from livers of rats treated with methylazoxymethanol.
Topics: Amidohydrolases; Animals; Azo Compounds; Carcinogens; Lithocholic Acid; Liver; Male; Methylazoxymethanol Acetate; Rats; Trypsin | 1981 |
Disruption of cerebellar maturation by an antimitotic agent impairs the ontogeny of eyeblink conditioning in rats.
Topics: Animals; Antineoplastic Agents; Blinking; Cerebellum; Conditioning, Psychological; Maze Learning; Methylazoxymethanol Acetate; Rats; Rats, Inbred Strains; Reaction Time | 1995 |
Effects of omeprazole on cell kinetics of carcinogen-induced colon tumours in rats.
Topics: Animals; Anti-Ulcer Agents; Carcinogens; Cell Cycle; Colonic Neoplasms; DNA Replication; Gastric Mucosa; Gastrins; Male; Methylazoxymethanol Acetate; Omeprazole; Rats; Rats, Sprague-Dawley | 1995 |
Involvement of granule, basket and stellate neurons but not Purkinje or Golgi cells in cerebellar cGMP increases in vivo.
Topics: Amino Acid Oxidoreductases; Amino Acids; Animals; Cerebellum; Cyclic GMP; Cytoplasmic Granules; Female; Golgi Apparatus; Harmaline; Immunohistochemistry; Methylazoxymethanol Acetate; Mice; Mice, Neurologic Mutants; N-Methylaspartate; Neurons; Nitric Oxide Synthase; Pregnancy; Purkinje Cells | 1994 |
Intermediate filament reactivity in hyperplastic and neoplastic lesions from medaka (Oryzias latipes).
Topics: Adenoma, Liver Cell; Animals; Antibodies; Carcinogens; Carcinoma, Acinar Cell; Carcinoma, Hepatocellular; Cell Division; Cholangiocarcinoma; Hemangioma; Hemangiopericytoma; Hyperplasia; Immunohistochemistry; Intermediate Filaments; Keratins; Liver; Liver Neoplasms; Methylazoxymethanol Acetate; Neurofilament Proteins; Oryzias; Pancreas; Pancreatic Neoplasms; Vimentin | 1994 |
Selective in vitro blockade of neuroepithelial cells proliferation by methylazoxymethanol, a molecule capable of inducing long lasting functional impairments.
Topics: Animals; Astrocytes; Cell Division; Cells, Cultured; Cellular Senescence; Epithelial Cells; Methylazoxymethanol Acetate; Muscle, Smooth; Nervous System; Rats; Time Factors | 1995 |
The role of free radicals and p53 in neuron apoptosis in vivo.
Topics: Animals; Apoptosis; Cerebellum; DNA Damage; Free Radicals; Heterozygote; Immunohistochemistry; Methylazoxymethanol Acetate; Mice; Mice, Transgenic; Neurons; Tumor Suppressor Protein p53; X-Rays | 1995 |
Cycad toxin-induced damage of rodent and human pancreatic beta-cells.
Topics: Alkylating Agents; Amino Acids, Diamino; Animals; Cyanobacteria Toxins; Cycasin; Diabetes Mellitus; DNA; Environmental Exposure; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Methylazoxymethanol Acetate; Mice | 1995 |
FR discrimination training effects in SHR and microencephalic rats.
Topics: Animals; Brain; Discrimination Learning; Female; Food; Hippocampus; Hypertension; Male; Methylazoxymethanol Acetate; Microcephaly; Organ Size; Pregnancy; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Reinforcement Schedule; Teratogens | 1995 |
Age dependence of O6-methylguanine-DNA methyltransferase activity and its depletion after carcinogen treatment in the teleost medaka (Oryzias latipes).
Topics: Aging; Alkylating Agents; Animals; Carcinogens; Electrophoresis, Polyacrylamide Gel; Liver; Methylazoxymethanol Acetate; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Oryzias | 1993 |
Drug-induced hypergastrinemia: absence of trophic effects on colonic carcinoma in rats.
Topics: Analysis of Variance; Animals; Colonic Neoplasms; Gastrins; Intestinal Mucosa; Male; Methylazoxymethanol Acetate; Neoplasm Invasiveness; Omeprazole; Random Allocation; Ranitidine; Rats; Rats, Sprague-Dawley | 1995 |
Potentiating effects of methamphetamine on the hyperactivity of microencephalic rats treated prenatally with methylazoxymethanol: possible implication of hyperdopaminergia.
Topics: Alkylating Agents; Animals; Behavior, Animal; Brain Diseases; Methamphetamine; Methylazoxymethanol Acetate; Motor Activity; Neurons; Rats; Rats, Wistar; Receptors, Dopamine | 1995 |
Developmental neurotoxicity: evaluation of testing procedures with methylazoxymethanol and methylmercury.
Topics: Alkylating Agents; Animals; Brain; Cognition; Dose-Response Relationship, Drug; Female; Fetus; Glial Fibrillary Acidic Protein; Hearing; Male; Methylazoxymethanol Acetate; Methylmercury Compounds; Motor Activity; Organ Size; Pregnancy; Rats; Reflex, Startle | 1994 |
Behavioural retardation in the neuropathology of mental retardation.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Dihydroxyphenylalanine; Dopamine Agents; Female; Haloperidol; Intellectual Disability; Learning; Male; Mercury Poisoning; Methylazoxymethanol Acetate; Metoclopramide; Mice; Motor Activity; Organotin Compounds; Pregnancy; Rats; Rats, Sprague-Dawley | 1993 |
Patterns of growth deficiency in rats exposed in utero to undernutrition, ethanol, or the neuroteratogen methylazoxymethanol (MAM).
Topics: Age Factors; Animals; Birth Weight; Brain; DNA Damage; Dwarfism; Ethanol; Female; Fetal Growth Retardation; Growth Disorders; Hypothalamo-Hypophyseal System; Male; Methylazoxymethanol Acetate; Nerve Tissue Proteins; Neurons; Nutrition Disorders; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Rats; Receptors, Corticotropin-Releasing Hormone; Sexual Maturation; Somatostatin; Weight Loss | 1994 |
Effects of methylazoxymethanol-induced micrencephaly on temporal response differentiation and progressive ratio responding in rats.
Topics: Animals; Behavior, Animal; Brain; Conditioning, Operant; Frontal Lobe; Methylazoxymethanol Acetate; Microcephaly; Rats; Rats, Sprague-Dawley; Task Performance and Analysis | 1994 |
Impaired neurogenesis by methylazoxymethanol in newborn rats results in transient reduction of ornithine decarboxylase and polyamines in the cerebellum, but not in the olfactory bulbs.
Topics: Aging; Animals; Animals, Newborn; Cerebellum; Methylazoxymethanol Acetate; Olfactory Bulb; Ornithine Decarboxylase; Polyamines; Rats; Rats, Wistar; Time Factors | 1994 |
Behavioral effects of methylazoxymethanol-induced micrencephaly.
Topics: Alkylating Agents; Animals; Arousal; Association Learning; Behavior, Animal; Brain; Cerebral Cortex; Conditioning, Classical; Discrimination Learning; Dose-Response Relationship, Drug; Female; Male; Methamphetamine; Methylazoxymethanol Acetate; Motor Activity; Organ Size; Orientation; Pregnancy; Prenatal Exposure Delayed Effects; Problem Solving; Rats; Rats, Sprague-Dawley | 1993 |
Changes in the reproductive system following acute prenatal exposure to ethanol or methylazoxymethanol in the rat: I. Effects on immunoreactive LHRH cell number.
Topics: Animals; Body Weight; Brain; Cell Count; Cell Division; Ethanol; Female; Gonadotropin-Releasing Hormone; Methylazoxymethanol Acetate; Neurons; Organ Size; Pilot Projects; Pituitary Gland; Pregnancy; Rats; Teratogens | 1994 |
Synergistic effect of radiation on colon carcinogenesis induced by methylazoxymethanol acetate in ACI/N rats.
Topics: Animals; Body Weight; Cocarcinogenesis; Colonic Neoplasms; Female; Liver; Liver Neoplasms, Experimental; Male; Methylazoxymethanol Acetate; Neoplasms, Radiation-Induced; Organ Size; Rats; Rats, Inbred ACI | 1993 |
Guam ALS-PDC: possible causes.
Topics: Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Cyanobacteria Toxins; Cycasin; Dementia; Guam; Humans; Macaca; Methylazoxymethanol Acetate; Neurotoxins; Parkinson Disease; Plants, Toxic; Syndrome | 1993 |
Characterization of resistance mechanisms to cis-diamminedichloroplatinum(II) in three sublines of the CC531 colon adenocarcinoma cell line in vitro.
Topics: Adenocarcinoma; Animals; Buthionine Sulfoximine; Cisplatin; Colonic Neoplasms; DNA, Neoplasm; Drug Resistance; Glutathione; Methionine Sulfoximine; Methylazoxymethanol Acetate; Rats; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1994 |
Effects of cytidine-diphosphocholine on acetylcholine-mediated behaviors in the rat.
Topics: Acetylcholine; Alkylating Agents; Amnesia; Animals; Avoidance Learning; Basal Ganglia; Behavior, Animal; Cognition; Cytidine Diphosphate Choline; Female; Injections; Injections, Intraperitoneal; Kainic Acid; Male; Methylazoxymethanol Acetate; Motor Activity; Parasympathetic Nervous System; Postural Balance; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Scopolamine; Stereotaxic Techniques; Synaptic Transmission | 1993 |
Pharmacology, distribution, cellular localization, and development of GABAB binding in rodent cerebellum.
Topics: Adenosine Triphosphate; Alkylating Agents; Animals; Autoradiography; Binding, Competitive; Cerebellum; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Monophosphate; Kinetics; Male; Methylazoxymethanol Acetate; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thionucleotides; Tritium | 1993 |
Inhibition of 1,2-dimethylhydrazine-induced oxidative DNA damage by green tea extract in rat.
Topics: 1,2-Dimethylhydrazine; 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Animals; Anticarcinogenic Agents; Azoxymethane; Biotransformation; Catechin; Colon; Deoxyguanosine; Diazonium Compounds; Dimethylhydrazines; DNA; DNA Damage; Free Radical Scavengers; Injections, Subcutaneous; Intestinal Mucosa; Kidney; Liver; Male; Methylation; Methylazoxymethanol Acetate; Oxidation-Reduction; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Tea | 1995 |
The development of striatal patch/matrix organization after prenatal methylazoxymethanol: a combined immunocytochemical and bromo-deoxy-uridine birthdating study.
Topics: Acetylcholinesterase; Animals; Antineoplastic Agents; Bromodeoxyuridine; Choline O-Acetyltransferase; Female; Fluorescent Dyes; Immunohistochemistry; Methylazoxymethanol Acetate; Mitosis; NADP; Neostriatum; Parasympathetic Nervous System; Rats; Rats, Sprague-Dawley; Stilbamidines; Substance P | 1995 |
The effect of dietary selenium deficiency on acute colorectal mucosal nucleotoxicity induced by several carcinogens in the rodent.
Topics: Animals; Carcinogenicity Tests; Carcinogens; Colorectal Neoplasms; Deficiency Diseases; Disease Models, Animal; Intestinal Mucosa; Male; Methylazoxymethanol Acetate; Mitosis; Monomethylhydrazine; Rats; Rats, Sprague-Dawley; Selenium; Tumor Stem Cell Assay | 1996 |
Flurothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatment.
Topics: Animals; Convulsants; Epilepsy, Tonic-Clonic; Female; Flurothyl; Hippocampus; Male; Methylazoxymethanol Acetate; Mice; Myoclonus; Pregnancy; Prenatal Exposure Delayed Effects; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Seizures; Teratogens | 1996 |
Effect of prenatal treatment with methylazoxymethanol on carbachol-, norepinephrine- and glutamate-stimulated phosphoinositide metabolism in the neonatal, young, and adult offspring.
Topics: Animals; Animals, Newborn; Carbachol; Cerebral Cortex; Drug Interactions; Female; Gestational Age; Glutamic Acid; In Vitro Techniques; Male; Methylazoxymethanol Acetate; Mitosis; Norepinephrine; Phosphatidylinositols; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1995 |
Differential translocation of protein kinase C isozymes in rats characterized by a chronic lack of LTP induction and cognitive impairment.
Topics: Animals; Cognition Disorders; Enzyme Induction; Female; Isoenzymes; Long-Term Potentiation; Methylazoxymethanol Acetate; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Synapses | 1996 |
Differential ontogenic pattern of metabotropic [3H]-L-glutamate receptors in normal and granule cell-deficient mouse cerebellum.
Topics: Amino Acids, Dicarboxylic; Animals; Autoradiography; Cerebellar Nuclei; Cerebellum; Cytoplasmic Granules; Excitatory Amino Acid Agonists; Methylazoxymethanol Acetate; Mice; Mitosis; Quisqualic Acid; Receptors, Metabotropic Glutamate | 1996 |
Partial ablation of the neonatal external granular layer disrupts mossy fiber topography in the adult rat cerebellum.
Topics: Animals; Animals, Newborn; Brain Mapping; Cell Compartmentation; Cell Division; Cerebellar Cortex; Methylazoxymethanol Acetate; Mitosis; Nerve Endings; Nerve Fibers; Nerve Tissue Proteins; Purkinje Cells; Rats; Rats, Sprague-Dawley; Spinal Cord | 1996 |
Short exposure to methylazoxymethanol causes a long-term inhibition of axonal outgrowth from cultured embryonic rat hippocampal neurons.
Topics: Alkylating Agents; Animals; Axons; Cell Differentiation; Cell Survival; Cells, Cultured; Coculture Techniques; Growth Inhibitors; Hippocampus; Methylazoxymethanol Acetate; Mitosis; Neuroglia; Protein Denaturation; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Rapid induction of more malignant tumors by various genotoxic carcinogens in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenicity Tests; Carcinogens; Cocarcinogenesis; Cyclophosphamide; Diethylnitrosamine; Female; Genes, ras; Humans; Male; Methylazoxymethanol Acetate; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Neoplasms, Experimental | 1996 |
Quantitative changes in neuron and glial cells of neocortex following prenatal exposure to methylazoxymethanol.
Topics: Alkylating Agents; Animals; Cell Size; Cerebral Cortex; Methylazoxymethanol Acetate; Mice; Mice, Inbred Strains; Microscopy, Electron; Neuroglia | 1996 |
Absence of p53 gene mutations in rat colon carcinomas induced through the synergistic interaction between methylazoxymethanol and X-irradiation.
Topics: Adenocarcinoma; Animals; Carcinogens; Colonic Neoplasms; Disease Models, Animal; Immunohistochemistry; Male; Methylazoxymethanol Acetate; Neoplasms, Radiation-Induced; Point Mutation; Rats; Tumor Suppressor Protein p53; Whole-Body Irradiation | 1997 |
Methylazoxymethanol-induced micrencephaly in the brown Norway strain: behavior and brain weight.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Female; Male; Maze Learning; Methamphetamine; Methylazoxymethanol Acetate; Microcephaly; Organ Size; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Species Specificity; Teratogens | 1997 |
Ubiquitination of apoptotic cells in the developing cerebellum of the rat following ionizing radiation or methylazoxymethanol injection.
Topics: Alkylating Agents; Animals; Animals, Newborn; Apoptosis; Cerebellum; Gamma Rays; Injections, Intraperitoneal; Methylazoxymethanol Acetate; Rats; Rats, Sprague-Dawley; Teratogens; Ubiquitins | 1997 |
Increased secretion of the amino-terminal fragment of amyloid precursor protein in brains of rats with a constitutive up-regulation of protein kinase C.
Topics: Alkylating Agents; Amyloid beta-Protein Precursor; Animals; Cerebral Cortex; Female; Hippocampus; Membrane Proteins; Methylazoxymethanol Acetate; Organ Culture Techniques; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Synaptosomes | 1997 |
Apoptosis induced by methylazoxymethanol in developing rat cerebellum: organization of the cell nucleus and its relationship to DNA and rRNA degradation.
Topics: Animals; Apoptosis; Carcinogens; Cell Nucleus; Cerebellum; DNA; DNA Fragmentation; Female; Methylazoxymethanol Acetate; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; RNA, Ribosomal; RNA, Ribosomal, 18S; RNA, Ribosomal, 28S | 1997 |
5-Hydroxytryptamine1B and alpha 2 adrenaline receptors in the brain of rats prenatally treated with methylazoxymethanol.
Topics: Alkylating Agents; Animals; Autoreceptors; Biogenic Monoamines; Brain; Female; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Adrenergic, alpha-2; Receptors, Serotonin | 1997 |
Effects of vitamins A and E on methylazoxymethanol-induced mutagenesis in Salmonella typhimurium strain TA100.
Topics: Antimutagenic Agents; Dose-Response Relationship, Drug; Genome, Bacterial; Methylazoxymethanol Acetate; Mutagenesis; Mutagenicity Tests; Salmonella typhimurium; Teratogens; Vitamin A; Vitamin E | 1997 |
Distribution of metabotropic glutamate receptor type 1a in Purkinje cell dendritic spines is independent of the presence of presynaptic parallel fibers.
Topics: Aging; Animals; Animals, Newborn; Axons; Cerebellar Cortex; Dendrites; Methylazoxymethanol Acetate; Mice; Microscopy, Electron; Nerve Fibers; Purkinje Cells; Receptors, Metabotropic Glutamate; Synapses; Teratogens | 1997 |
Effects of neuroleptic and anticonvulsant drugs on repeated acquisition learning in microencephalic and normal rats.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Brain; Clozapine; Conditioning, Operant; Female; Learning; Methylazoxymethanol Acetate; Microcephaly; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens; Thioridazine | 1997 |
Abnormal development of serotonin nerve fibers in the visual cortex in rats with methylazoxymethanol-induced microcephaly.
Topics: Animals; Female; Immunohistochemistry; Male; Methylazoxymethanol Acetate; Microcephaly; Nerve Fibers; Neuronal Plasticity; Pregnancy; Rats; Rats, Wistar; Serotonin; Teratogens; Visual Cortex | 1998 |
Transplacentally induced neuronal migration disorders: an animal model for the study of the epilepsies.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Brain Mapping; Cell Movement; Disease Models, Animal; Electroencephalography; Epilepsy; Female; Gestational Age; Hippocampus; Litter Size; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Neurons; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures | 1998 |
Effect of chronic amitriptyline administration on serotonergic receptors in rats with methylazoxymethanol-induced microencephaly.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Alkylating Agents; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Cerebral Cortex; Female; Ketanserin; Kinetics; Male; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1998 |
Glutamate receptors in dysplasic cortex: an in situ hybridization and immunohistochemistry study in rats with prenatal treatment with methylazoxymethanol.
Topics: Animals; Brain Diseases; Cerebral Cortex; Choristoma; Female; Hippocampus; Immunohistochemistry; In Situ Hybridization; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, Glutamate; RNA, Messenger | 1998 |
Effects of prenatal methylazoxymethanol treatment on striatal dopaminergic systems in rat brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Autoradiography; Brain; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Homovanillic Acid; Kinetics; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Methylazoxymethanol Acetate; Microdialysis; Nerve Tissue Proteins; Piperazines; Potassium Chloride; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reference Values; Synapses; Teratogens; Tritium | 1998 |
Neocortex in the hippocampus: an anatomical and functional study of CA1 heterotopias after prenatal treatment with methylazoxymethanol in rats.
Topics: Animals; Animals, Newborn; Brain Mapping; Bromodeoxyuridine; Cell Movement; Choristoma; Female; Hippocampus; In Situ Hybridization; Methylazoxymethanol Acetate; Mitosis; Neocortex; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 1998 |
Neuronal migration disorders: heterotopic neocortical neurons in CA1 provide a bridge between the hippocampus and the neocortex.
Topics: Action Potentials; Animals; Cell Movement; Electric Stimulation; Electrophysiology; Female; Hippocampus; Methylazoxymethanol Acetate; Neocortex; Nerve Net; Patch-Clamp Techniques; Pregnancy; Pyramidal Cells; Rats; Rats, Wistar; Teratogens | 1998 |
Reactive gliosis of immature Bergmann glia and microglial cell activation in response to cell death of granule cell precursors induced by methylazoxymethanol treatment in developing rat cerebellum.
Topics: Animals; Apoptosis; Cerebellar Cortex; Fluorescent Antibody Technique, Direct; Glial Fibrillary Acidic Protein; Gliosis; In Situ Nick-End Labeling; Lectins; Male; Methylazoxymethanol Acetate; Microglia; Mitosis; Neurons; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Stem Cells; Vimentin | 1998 |
Quantitative analysis of cerebellar lobulation in normal and agranular rats.
Topics: Abnormalities, Drug-Induced; Alkylating Agents; Animals; Cerebellar Diseases; Cerebellum; Female; Male; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Radiation Injuries, Experimental; Rats; Rats, Wistar | 1998 |
Altered connections between neocortical and heterotopic areas in methylazoxymethanol-treated rat.
Topics: Animals; Axonal Transport; Brain; Brain Diseases; Choristoma; Disease Models, Animal; Female; Functional Laterality; Gestational Age; Humans; Methylazoxymethanol Acetate; Neocortex; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Teratogens | 1998 |
Dysplastic neocortex and subcortical heterotopias in methylazoxymethanol-treated rats: an intracellular study of identified pyramidal neurones.
Topics: Animals; Cell Movement; Cerebral Ventricles; Choristoma; Culture Techniques; Drug Administration Schedule; Electric Stimulation; Embryo, Mammalian; Evoked Potentials; Female; Hippocampus; Injections, Intraperitoneal; Intracellular Fluid; Maternal Exposure; Maternal-Fetal Exchange; Membrane Potentials; Methylazoxymethanol Acetate; Microelectrodes; Neocortex; Neurons; Pregnancy; Pyramidal Cells; Rats; Synaptic Transmission; Time Factors | 1998 |
Decreased seizure threshold and more rapid rate of kindling in rats with cortical malformation induced by prenatal treatment with methylazoxymethanol.
Topics: Abnormalities, Drug-Induced; Animals; Cerebral Cortex; Electroencephalography; Female; Hippocampus; Kindling, Neurologic; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Reaction Time; Seizures | 1998 |
The role of alcohol dehydrogenase in the metabolism of the colon carcinogen methylazoxymethanol.
Topics: Alcohol Dehydrogenase; Alcohols; Animals; Carcinogens; Colon; Fomepizole; Liver; Male; Methylazoxymethanol Acetate; Mice; Mice, Inbred AKR; Pyrazoles; Rats | 1998 |
Evidence of enhanced kindling and hippocampal neuronal injury in immature rats with neuronal migration disorders.
Topics: Animals; Animals, Newborn; Cell Count; Cerebral Cortex; Electric Stimulation; Epilepsy; Female; Hippocampus; Kindling, Neurologic; Methylazoxymethanol Acetate; Mitosis; Neurons; Pregnancy; Rats | 1998 |
The Guam cycad toxin methylazoxymethanol damages neuronal DNA and modulates tau mRNA expression and excitotoxicity.
Topics: Animals; Cells, Cultured; DNA Damage; DNA Repair; Guam; Methylazoxymethanol Acetate; Neurons; Neurotoxins; Plants, Toxic; Rats; RNA, Messenger; tau Proteins | 1999 |
CaMKII-dependent phosphorylation of NR2A and NR2B is decreased in animals characterized by hippocampal damage and impaired LTP.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Enzyme Activation; Female; Gene Expression; Hippocampus; In Situ Hybridization; Long-Term Potentiation; Methylazoxymethanol Acetate; Nerve Degeneration; Neurons; Organ Culture Techniques; Phosphorylation; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Serine; Synapses; Threonine; Tyrosine | 1999 |
Prenatal methylazoxymethanol treatment in rats produces brain abnormalities with morphological similarities to human developmental brain dysgeneses.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cerebral Ventricles; Choristoma; Embryonic and Fetal Development; Female; Hippocampus; Humans; Immunohistochemistry; Injections, Intraperitoneal; Methylazoxymethanol Acetate; Microscopy, Electron; Neurons; Neurotoxins; Pregnancy; Rats; Rats, Sprague-Dawley | 1999 |
Delayed 5-HT release in the developing cortex of microencephalic rats.
Topics: Abnormalities, Drug-Induced; Aging; Animals; Female; Immunohistochemistry; Male; Methylazoxymethanol Acetate; Microcephaly; Microdialysis; Rats; Rats, Sprague-Dawley; Serotonin; Somatosensory Cortex; Teratogens | 1999 |
Abnormal connections in the malformed cortex of rats with prenatal treatment with methylazoxymethanol may support hyperexcitability.
Topics: Abnormalities, Drug-Induced; Animals; Cerebral Cortex; Embryo, Mammalian; Female; Hippocampus; Methylazoxymethanol Acetate; Neocortex; Neural Pathways; Pregnancy; Rats; Rats, Wistar; Teratogens | 1999 |
Characterization of heterotopic cell clusters in the hippocampus of rats exposed to methylazoxymethanol in utero.
Topics: 4-Aminopyridine; Animals; Bicuculline; Brain Diseases; Choristoma; Convulsants; Electrophysiology; Epilepsy; Female; Hippocampus; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Synapses | 2000 |
The distribution of serotonergic nerves in microencephalic rats treated prenatally with methylazoxymethanol.
Topics: Animals; Autoradiography; Binding Sites; Brain; Carrier Proteins; Cerebellum; Cerebral Cortex; Female; Hippocampus; Membrane Glycoproteins; Membrane Transport Proteins; Methylazoxymethanol Acetate; Microcephaly; Nerve Tissue Proteins; Neurons; Nucleus Accumbens; Paroxetine; Pregnancy; Prenatal Exposure Delayed Effects; Raphe Nuclei; Rats; Rats, Wistar; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Thalamus | 2000 |
Effects of vitamin E and selenium on lipid peroxidation and antioxidant enzymes in colon of methylazoxymethanol treated rats.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Colon; Lipid Peroxidation; Methylazoxymethanol Acetate; Rats; Rats, Wistar; Selenium; Superoxide Dismutase; Vitamin E | 2000 |
Effects of single injection of methylazoxymethanol at postnatal day one on cell proliferation in different brain regions of male rats.
Topics: Aging; Animals; Animals, Newborn; Brain; Carcinogens; Cell Cycle; Cell Division; Flow Cytometry; Male; Methylazoxymethanol Acetate; Microcephaly; Rats; Rats, Sprague-Dawley | 2000 |
Disruption of layers 3 and 4 during development results in altered thalamocortical projections in ferret somatosensory cortex.
Topics: Animals; Behavior, Animal; Bromodeoxyuridine; Cell Count; Cell Differentiation; Cell Movement; Electrodes, Implanted; Female; Ferrets; Fluorescent Dyes; Methylazoxymethanol Acetate; Mitosis; Morphogenesis; Neural Pathways; Physical Stimulation; Pregnancy; Prenatal Exposure Delayed Effects; Somatosensory Cortex; Teratogens; Thalamus | 2001 |
Bromodeoxyuridine and methylazoxymethanol exposure during brain development affects behavior in rats: consideration for a role of nerve growth factor and brain derived neurotrophic factor.
Topics: Animals; Antimetabolites; Behavior, Animal; Brain; Brain Chemistry; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Choline O-Acetyltransferase; Female; Male; Maze Learning; Mental Disorders; Methylazoxymethanol Acetate; Nerve Growth Factor; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptor, Nerve Growth Factor; Teratogens | 2001 |
Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy.
Topics: 4-Aminopyridine; Action Potentials; Animals; Cerebral Cortex; Choristoma; Delayed Rectifier Potassium Channels; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Female; Hippocampus; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Methylazoxymethanol Acetate; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Pregnancy; Prenatal Exposure Delayed Effects; Pyramidal Cells; Rats; RNA, Messenger; Shab Potassium Channels; Shal Potassium Channels; Somatosensory Cortex; Tetraethylammonium | 2001 |
Differential effects of CYP2E1 status on the metabolic activation of the colon carcinogens azoxymethane and methylazoxymethanol.
Topics: Animals; Azoxymethane; Biotransformation; Carcinogens; Colon; Cytochrome P-450 CYP2E1; DNA; DNA Methylation; Female; Guanine; Liver; Male; Methylazoxymethanol Acetate; Mice; Precancerous Conditions | 2001 |
Different mutation status of the beta-catenin gene in carcinogen-induced colon, brain, and oral tumors in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anthraquinones; beta Catenin; Brain Neoplasms; Carcinogens; Colonic Neoplasms; Cytoskeletal Proteins; Genetic Markers; Male; Methylazoxymethanol Acetate; Mouth Neoplasms; Mutation; Nitrosourea Compounds; Organ Specificity; Polymerase Chain Reaction; Quinolones; Rats; Rats, Inbred F344; Trans-Activators | 2001 |
Postnatal development of rat dentate gyrus: effects of methylazoxymethanol administration.
Topics: Alkylating Agents; Animals; Benzoxazines; Coloring Agents; Dentate Gyrus; Fluorescent Antibody Technique, Indirect; Glial Fibrillary Acidic Protein; Male; Maze Learning; Methylazoxymethanol Acetate; Neural Cell Adhesion Molecule L1; Neural Cell Adhesion Molecules; Neuroglia; Oxazines; Rats; Rats, Sprague-Dawley; Sialic Acids; Staining and Labeling | 2002 |
Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy.
Topics: Animals; Carrier Proteins; Choristoma; Disease Models, Animal; Epilepsy; Female; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Membrane Proteins; Membrane Transport Proteins; Methylazoxymethanol Acetate; Nervous System Malformations; Neural Inhibition; Neurons; Organic Anion Transporters; Patch-Clamp Techniques; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Synapses | 2002 |
Comparative potencies of induction of point mutations and genetic duplications by the methylating agents methylazoxymethanol and dimethyl sulfate in bacteria.
Topics: Alleles; Base Pairing; Carcinogens; DNA Methylation; DNA Repair; DNA, Bacterial; Gene Duplication; Histidine; Lac Operon; Methylazoxymethanol Acetate; Mutagenicity Tests; Mutagens; Phosphorus-Oxygen Lyases; Point Mutation; Recombination, Genetic; Salmonella typhimurium; Sulfuric Acid Esters; Tryptophan | 2002 |
Impairment of neural precursor proliferation increases survival of cell progeny in the adult rat dentate gyrus.
Topics: Animals; Cell Death; Cell Division; Cell Survival; Dentate Gyrus; Male; Methylazoxymethanol Acetate; Neurons; Rats; Rats, Sprague-Dawley; Stem Cells | 2002 |
NPY sensitivity and postsynaptic properties of heterotopic neurons in the MAM model of malformation-associated epilepsy.
Topics: Abnormalities, Drug-Induced; Animals; Electrophysiology; Epilepsy; Excitatory Postsynaptic Potentials; Female; Hippocampus; Histocytochemistry; Membrane Potentials; Methylazoxymethanol Acetate; Neocortex; Neuropeptide Y; Potassium Channel Blockers; Potassium Channels; Pregnancy; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Teratogens | 2002 |
Kinetic assessment of the effects of task difficulty, microencephaly, and a response manipulandum alteration on the rate of fixed-ratio discrimination acquisition.
Topics: Animals; Behavior, Animal; Discrimination Learning; Female; Kinetics; Methylazoxymethanol Acetate; Microcephaly; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Task Performance and Analysis; Teratogens | 2002 |
Cortical fiber distribution in the somatosensory cortex of rats following prenatal exposure to X-irradiation.
Topics: Abnormalities, Radiation-Induced; Animals; Cerebral Cortex; Female; Male; Maternal Exposure; Methylamines; Methylazoxymethanol Acetate; Microcephaly; Nerve Fibers; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Somatosensory Cortex; Teratogens | 1997 |
A radialization factor in normal cortical plate restores disorganized radial glia and disrupted migration in a model of cortical dysplasia.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Brain; Bromodeoxyuridine; Cell Count; Cell Movement; Cerebral Cortex; Ciliary Neurotrophic Factor; Coculture Techniques; Female; Ferrets; Fluorescent Dyes; Image Processing, Computer-Assisted; Methylazoxymethanol Acetate; Models, Neurological; Neuroglia; Organ Culture Techniques; Pregnancy; Teratogens | 2003 |
An examination of calcium current function on heterotopic neurons in hippocampal slices from rats exposed to methylazoxymethanol.
Topics: Animals; Calcium; Calcium Channels; Choristoma; Disease Models, Animal; Electrophysiology; Epilepsy; Female; Hippocampus; Humans; In Vitro Techniques; Methylazoxymethanol Acetate; Nervous System Malformations; Neurons; Patch-Clamp Techniques; Potassium Channels; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Teratogens | 2003 |
Developmental expression of the cell cycle and apoptosis controlling gene, Lot1, in the rat cerebellum and in cultures of cerebellar granule cells.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cells, Cultured; Cerebellum; Gene Expression Regulation, Developmental; Genes, Tumor Suppressor; Methylazoxymethanol Acetate; Nervous System Malformations; Neurons; Neurotoxins; Purkinje Cells; Rats; Rats, Wistar; RNA, Messenger; Stem Cells; Transcription Factors | 2003 |
Factors affecting the morphology of radial glia.
Topics: Animals; Animals, Newborn; Biological Factors; Cell Movement; Cerebral Cortex; Coculture Techniques; Embryonic and Fetal Development; Ferrets; Methylazoxymethanol Acetate; Molecular Weight; Neuroglia; Neurons; Organ Culture Techniques; Proteins; Reference Values | 2003 |
Neurogenesis in cerebral heterotopia induced in rats by prenatal methylazoxymethanol treatment.
Topics: Animals; Brain Diseases; Bromodeoxyuridine; Cerebral Cortex; Choristoma; Disease Models, Animal; Female; Methylazoxymethanol Acetate; Microscopy, Confocal; Morphogenesis; Neurons; Phenotype; Pregnancy; Rats; Rats, Sprague-Dawley | 2003 |
The NMDA receptor complex is altered in an animal model of human cerebral heterotopia.
Topics: Animals; Animals, Newborn; Autoradiography; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cell Membrane; Cerebral Cortex; Choristoma; Cloning, Molecular; Disease Models, Animal; Disks Large Homolog 4 Protein; Female; Hippocampus; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Matched-Pair Analysis; Membrane Proteins; Methylazoxymethanol Acetate; Microscopy, Confocal; Nerve Tissue Proteins; Peptide Fragments; Phosphorylation; Pregnancy; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Subcellular Fractions | 2003 |
STUDIES ON METHYLAZOXYMETHANOL, THE AGLYCONE OF CYCASIN: A SYNTHESIS OF METHYLAZOXYMETHYL ACETATE.
Topics: Acetates; Azo Compounds; Carcinogens; Chemical Phenomena; Chemistry; Cycasin; Methylazoxymethanol Acetate; Nuts; Pyrrolidinones; Research | 1965 |
STUDIES ON METHYLAZOXYMETHANOL, THE AGLYCONE OF CYCASIN. ISOLATION, BIOLOGICAL, AND CHEMICAL PROPERTIES.
Topics: Azo Compounds; Chemical Phenomena; Chemistry; Cycasin; Glucosidases; Glycosides; Metabolism; Methylazoxymethanol Acetate; Rats; Research; Spectrophotometry; Toxicology | 1965 |
Displaced granule cells in the molecular layer of the cerebellar cortex in mice treated with methylazoxymethanol.
Topics: Animals; Cell Movement; Cerebellar Cortex; Female; Glutamate Decarboxylase; Isoenzymes; Male; Methylazoxymethanol Acetate; Mice; Mice, Inbred ICR; Mice, Transgenic; Neurons | 2004 |
GABAA receptors reorganize when layer 4 in ferret somatosensory cortex is disrupted by methylazoxymethanol (MAM).
Topics: Animals; Autoradiography; Female; Ferrets; Immunohistochemistry; Methylazoxymethanol Acetate; Nerve Fibers; Neurons, Afferent; Pregnancy; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Somatosensory Cortex; Thalamus | 2004 |
Excitability of CA1 neurons in the model of malformation-associated epilepsy.
Topics: Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Epilepsy; Evoked Potentials; Female; GABA Antagonists; Hippocampus; Male; Methylazoxymethanol Acetate; Neurons; Potassium Acetate; Pregnancy; Rats; Rats, Sprague-Dawley | 2004 |
Working memory deficits in adult rats after prenatal disruption of neurogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Drug Administration Schedule; Female; Hippocampus; Male; Maze Learning; Memory Disorders; Methylazoxymethanol Acetate; Organ Size; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Time Factors | 2004 |
Cognitive deficits caused by late gestational disruption of neurogenesis in rats: a preclinical model of schizophrenia.
Topics: Animals; Association Learning; Cognition Disorders; Conditioning, Operant; Disease Models, Animal; Exploratory Behavior; Female; Maze Learning; Methylazoxymethanol Acetate; Nervous System; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Rats, Wistar; Recognition, Psychology; Reversal Learning; Schizophrenia; Swimming; Teratogens | 2005 |
A volumetric screening procedure for the Göttingen minipig brain.
Topics: Algorithms; Anatomy, Cross-Sectional; Animals; Brain; Cell Count; Disease Models, Animal; Female; Methylazoxymethanol Acetate; Nervous System Malformations; Pilot Projects; Pregnancy; Prenatal Exposure Delayed Effects; Swine; Swine, Miniature; Teratogens | 2005 |
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Methylazoxymethanol Acetate; N-Methylaspartate; Patch-Clamp Techniques; Piperidines; Rats | 2005 |
Mutation in Drosophila by methylazoxymethanol, the aglycone of cycasin.
Topics: Animals; Chromosome Mapping; Chromosomes; Cycasin; Drosophila melanogaster; Male; Methylazoxymethanol Acetate; Mutagens | 1967 |
Pilocarpine-induced seizure susceptibility in rats following prenatal methylazoxymethanol treatment.
Topics: Animals; Disease Susceptibility; Female; Immunohistochemistry; Maternal Exposure; Methylazoxymethanol Acetate; Pilocarpine; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures; Teratogens | 2005 |
Endogenous neuregulin restores radial glia in a (ferret) model of cortical dysplasia.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Female; Ferrets; In Vitro Techniques; Methylazoxymethanol Acetate; Neuregulins; Neuroglia; Pregnancy; Prenatal Exposure Delayed Effects; Teratogens | 2005 |
Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cell Count; Disease Models, Animal; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Female; Gene Expression; Hippocampus; Immunohistochemistry; Methylazoxymethanol Acetate; Motor Activity; Neurons; Parvalbumins; Phencyclidine; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Schizophrenia; Time Factors | 2006 |
Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia.
Topics: Animals; Animals, Newborn; Cell Differentiation; Cell Movement; Cell Proliferation; Cerebral Cortex; Choristoma; Disease Models, Animal; Epilepsy; Female; Hippocampus; Methylazoxymethanol Acetate; Nervous System Malformations; Neuroglia; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Stem Cells; Teratogens | 2006 |
Postnatal effect of embryonic neurogenesis disturbance on reelin level in organotypic cultures of rat hippocampus.
Topics: Animals; Animals, Newborn; Cell Adhesion Molecules, Neuronal; Extracellular Matrix Proteins; Female; Hippocampus; Male; Methylazoxymethanol Acetate; Mitosis; Nerve Tissue Proteins; Neurons; Organ Culture Techniques; Pregnancy; Rats; Rats, Sprague-Dawley; Reelin Protein; Serine Endopeptidases | 2006 |
Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains.
Topics: Animals; Cell Differentiation; Cell Movement; Cerebral Cortex; Chemokine CXCL12; Chemokines, CXC; Disease Models, Animal; Methylazoxymethanol Acetate; Nervous System Malformations; Neurons; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Stem Cells; Teratogens | 2006 |
Peri-pubertal maturation after developmental disturbance: a model for psychosis onset in the rat.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Brain; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Inhibition, Psychological; Interpersonal Relations; Maze Learning; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Psychotic Disorders; Rats; Recognition, Psychology; Reflex, Startle; Time Factors | 2006 |
Proteomic analysis of the genotoxicant methylazoxymethanol (MAM)-induced changes in the developing cerebellum.
Topics: Animals; Animals, Newborn; Cerebellum; Methylazoxymethanol Acetate; Mice; Mice, Inbred C57BL; Mutagens; Neurodegenerative Diseases; Proteins; Proteomics | 2006 |
Gestational methylazoxymethanol acetate treatment impairs select cognitive functions: parallels to schizophrenia.
Topics: Animals; Atrophy; Brain; Brain Damage, Chronic; Cognition Disorders; Discrimination Learning; Disease Models, Animal; Female; Learning Disabilities; Male; Methylazoxymethanol Acetate; Neuropsychological Tests; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Reinforcement, Psychology; Schizophrenia; Teratogens | 2007 |
Genotoxicants target distinct molecular networks in neonatal neurons.
Topics: Alkylating Agents; Animals; Animals, Newborn; Astrocytes; Cell Survival; Cells, Cultured; Cerebellum; DNA Damage; Gene Expression Profiling; Mechlorethamine; Methylazoxymethanol Acetate; Mice; Mice, Inbred C57BL; Neurons; Oligonucleotide Array Sequence Analysis | 2006 |
The effect of trichlorfon and methylazoxymethanol on the development of guinea pig cerebellum.
Topics: Acetylcholinesterase; Acetyltransferases; Animals; Animals, Newborn; Carboxy-Lyases; Cerebellum; Female; Gestational Age; Guinea Pigs; Injections, Subcutaneous; Methylazoxymethanol Acetate; Microscopy, Electron; Pregnancy; Trichlorfon | 2007 |
Altered glutamate receptor - transporter expression and spontaneous seizures in rats exposed to methylazoxymethanol in utero.
Topics: Amino Acid Transport System X-AG; Amygdala; Animals; Cerebral Cortex; Choristoma; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Female; Hippocampus; Immunohistochemistry; Maternal-Fetal Exchange; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Seizures; Teratogens; Vesicular Glutamate Transport Protein 2 | 2007 |
Alterations in prefrontal glutamatergic and noradrenergic systems following MK-801 administration in rats prenatally exposed to methylazoxymethanol at gestational day 17.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Male; Methylazoxymethanol Acetate; Microdialysis; Motor Activity; Norepinephrine; Nucleus Accumbens; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2007 |
A normal radial glial scaffold is necessary for migration of interneurons during neocortical development.
Topics: Animals; Cell Communication; Cell Movement; Female; Ferrets; gamma-Aminobutyric Acid; Immunophenotyping; Interneurons; Methylazoxymethanol Acetate; Neocortex; Neuroglia; Organ Culture Techniques; Pregnancy; Teratogens | 2007 |
Early cerebrovascular and parenchymal events following prenatal exposure to the putative neurotoxin methylazoxymethanol.
Topics: Abnormalities, Drug-Induced; Animals; Aquaporin 1; Brain; Cerebral Arteries; Cerebral Cortex; Disease Models, Animal; Female; Methylazoxymethanol Acetate; Neovascularization, Physiologic; Nervous System Malformations; Neurotoxins; Pokeweed Mitogens; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Teratogens; Vascular Endothelial Growth Factor A | 2007 |
Aberrant hippocampal activity underlies the dopamine dysregulation in an animal model of schizophrenia.
Topics: Action Potentials; Animals; Disease Models, Animal; Dopamine; Hippocampus; Male; Methylazoxymethanol Acetate; Rats; Rats, Sprague-Dawley; Schizophrenia | 2007 |
Migration of transplanted neural progenitor cells in a ferret model of cortical dysplasia.
Topics: Amino Acids; Analysis of Variance; Animals; Animals, Newborn; Cell Culture Techniques; Cell Movement; Cell Proliferation; Disease Models, Animal; Embryo, Mammalian; Female; Ferrets; Malformations of Cortical Development; Methylazoxymethanol Acetate; Mice; Nerve Tissue Proteins; Neurons; Organ Culture Techniques; Pregnancy; Prenatal Exposure Delayed Effects; Stem Cell Transplantation; Stem Cells | 2008 |
Reelin is essential for neuronal migration but not for radial glial elongation in neonatal ferret cortex.
Topics: Animals; Animals, Newborn; Antimetabolites; Antimitotic Agents; Bromodeoxyuridine; Cell Adhesion Molecules, Neuronal; Cell Line; Cell Movement; Cell Size; Cerebral Cortex; Coculture Techniques; Extracellular Matrix Proteins; Female; Ferrets; Fluorescent Dyes; Genotype; Humans; Methylazoxymethanol Acetate; Nerve Tissue Proteins; Neuroglia; Neurons; Organ Culture Techniques; Pregnancy; Reelin Protein; Reverse Transcriptase Polymerase Chain Reaction; Serine Endopeptidases | 2008 |
Tumor induction in germfree rats with methylazoxymethanol (MAM) and synthetic MAM acetate.
Topics: Animals; Carcinogens; Cycasin; Female; Germ-Free Life; Hydrolysis; Injections, Intraperitoneal; Male; Methylazoxymethanol Acetate; Mitosis; Neoplasms, Experimental; Protein Synthesis Inhibitors; Rats | 1967 |
Clozapine or Haloperidol in rats prenatally exposed to methylazoxymethanol, a compound inducing entorhinal-hippocampal deficits, alter brain and blood neurotrophins' concentrations.
Topics: Alkylating Agents; Animals; Antipsychotic Agents; Body Weight; Brain Chemistry; Clozapine; Entorhinal Cortex; Female; Granulocytes; Haloperidol; Hippocampus; Methylazoxymethanol Acetate; Nerve Growth Factors; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 2008 |
Combined effects of prenatal inhibition of vasculogenesis and neurogenesis on rat brain development.
Topics: Aging; Animals; Animals, Newborn; Blood Vessels; Blood-Brain Barrier; Brain; Brain Chemistry; Brain Edema; Disease Models, Animal; Gliosis; Hippocampus; Malformations of Cortical Development; Methylazoxymethanol Acetate; Mossy Fibers, Hippocampal; Neovascularization, Physiologic; Nervous System; Neurogenesis; Rats; Rats, Sprague-Dawley; Thalidomide | 2008 |
The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling.
Topics: Affect; Analysis of Variance; Animals; Antidepressive Agents; Antidiuretic Hormone Receptor Antagonists; Behavior, Animal; Cytostatic Agents; Depression; Drug Combinations; Fluoxetine; Hippocampus; Imipramine; Indoles; Male; Methylazoxymethanol Acetate; Mitosis; Neurogenesis; Neuronal Plasticity; Prefrontal Cortex; Pyrrolidines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Stress, Psychological | 2009 |
DNA repair modulates the vulnerability of the developing brain to alkylating agents.
Topics: Alkylating Agents; Animals; Cattle; Cell Survival; Cerebellum; Chickens; DNA; DNA Fragmentation; DNA Glycosylases; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Ethylamines; Humans; Mechlorethamine; Methylazoxymethanol Acetate; Mice; Motor Activity; Neurons; Sulfuric Acid Esters; Tumor Suppressor Proteins | 2009 |
The ALS/PDC syndrome of Guam and the cycad hypothesis.
Topics: alpha-Synuclein; Amino Acids, Diamino; Amyotrophic Lateral Sclerosis; Animals; Bacterial Toxins; Causality; Cyanobacteria Toxins; Cycas; Dementia; Disease Models, Animal; Epidemiologic Research Design; Epidemiologic Studies; Flour; Guam; Hazardous Substances; Humans; Incidence; Indonesia; Japan; Marine Toxins; Methylazoxymethanol Acetate; Microcystins; Nerve Degeneration; Parkinsonian Disorders; Plant Extracts; Syndrome; Tauopathies | 2009 |
Behavioral perturbations after prenatal neurogenesis disturbance in female rat.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavioral Symptoms; Female; Inhibition, Psychological; Interpersonal Relations; Male; Maze Learning; Methylazoxymethanol Acetate; Motor Activity; Neurogenesis; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Recognition, Psychology; Reflex, Startle; Teratogens | 2009 |
Gestational treatment with methylazoxymethanol (MAM) that disrupts hippocampal-dependent memory does not alter behavioural response to cocaine.
Topics: Alkylating Agents; Animals; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Hippocampus; Learning; Maze Learning; Memory; Methylazoxymethanol Acetate; Motor Activity; Organ Size; Pregnancy; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 2009 |
Regeneration of 5-HT fibers in hippocampal heterotopia of methylazoxymethanol-induced micrencephalic rats after neonatal 5,7-DHT injection.
Topics: 5,6-Dihydroxytryptamine; Age Factors; Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Creatinine; Female; Hippocampus; Immunohistochemistry; Male; Methylazoxymethanol Acetate; Microcephaly; Nerve Fibers, Unmyelinated; Nerve Regeneration; Neurons; Periventricular Nodular Heterotopia; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Serotonin | 2010 |
Decreased cell proliferation in the dentate gyrus does not associate with development of anhedonic-like symptoms in rats.
Topics: Alkylating Agents; Analysis of Variance; Animals; Behavior, Animal; Cell Count; Cell Proliferation; Dentate Gyrus; Fluorescent Antibody Technique; Male; Methylazoxymethanol Acetate; Neurogenesis; Neurons; Organ Size; Rats; Rats, Wistar; Stress, Physiological; Stress, Psychological | 2009 |
Neuropathological and Reelin deficiencies in the hippocampal formation of rats exposed to MAM; differences and similarities with schizophrenia.
Topics: Animals; Brain Mapping; Cell Adhesion Molecules, Neuronal; Embryonic Development; Extracellular Matrix Proteins; Hippocampus; Humans; Mental Disorders; Methylation; Methylazoxymethanol Acetate; Nerve Tissue Proteins; Neurons; Rats; Reelin Protein; Schizophrenia; Serine Endopeptidases; Teratogens; Thalamus | 2010 |
Role of cortical dysplasia in epileptogenesis following prolonged febrile seizure.
Topics: Animals; Disease Models, Animal; Electroencephalography; Epilepsy, Temporal Lobe; Hippocampus; Humans; Malformations of Cortical Development; Methylazoxymethanol Acetate; Mossy Fibers, Hippocampal; Rats; Rats, Sprague-Dawley; Sclerosis; Seizures, Febrile; Synapses | 2010 |
Effect of antipsychotics on spontaneous hyperactivity and hypersensitivity to MK-801-induced hyperactivity in rats prenatally exposed to methylazoxymethanol.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Female; Hyperkinesis; Methylazoxymethanol Acetate; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Schizophrenia | 2011 |
The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked manner.
Topics: Animals; Binding Sites; Brain; Brain Neoplasms; Cycadopsida; DNA Damage; DNA Modification Methylases; DNA Repair Enzymes; Gene Expression Profiling; Gene Regulatory Networks; Guanosine; Humans; Liver; Male; Methylazoxymethanol Acetate; Mice; Mice, Inbred C57BL; Models, Biological; Mutagens; Neurodegenerative Diseases; Organ Specificity; Signal Transduction; Transcription Factors; Transcription, Genetic; Tumor Suppressor Proteins | 2011 |
Initiation of epileptiform activity in a rat model of periventricular nodular heterotopia.
Topics: Action Potentials; Animals; Disease Models, Animal; Epilepsy; Female; Hippocampus; In Vitro Techniques; Lysine; Male; Methylazoxymethanol Acetate; Neocortex; Neurons; Periventricular Nodular Heterotopia; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Teratogens | 2011 |
Developmental origins of adult diseases and neurotoxicity: epidemiological and experimental studies.
Topics: Adolescent; Adult; Age Factors; Animals; Child; Child Behavior; Child Development; Dose-Response Relationship, Drug; Environmental Pollutants; Female; Humans; Lead; Lead Poisoning, Nervous System, Adult; Lead Poisoning, Nervous System, Childhood; Male; Maternal Exposure; Mercury Poisoning, Nervous System; Methylazoxymethanol Acetate; Methylmercury Compounds; Mice; Nervous System; Neurotoxicity Syndromes; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Risk Assessment; Risk Factors; Toxicity Tests | 2012 |
Differential performance of Wistar Han and Sprague Dawley rats in behavioral tests: differences in baseline behavior and reactivity to positive control agents.
Topics: Animals; Behavior, Animal; Brain; Chlorpromazine; Control Groups; Dizocilpine Maleate; Female; Learning; Male; Memory; Methylazoxymethanol Acetate; Motor Activity; Neurotoxicity Syndromes; Neurotoxins; Nitriles; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reflex, Startle; Species Specificity | 2012 |
Aberrant dopamine D2-like receptor function in a rodent model of schizophrenia.
Topics: Alkylating Agents; Animals; Behavior, Animal; Dopamine; Dopamine Agonists; Dopamine D2 Receptor Antagonists; Dopaminergic Neurons; Dose-Response Relationship, Drug; Female; Methylazoxymethanol Acetate; Motor Activity; Nucleus Accumbens; Quinpirole; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptors, Dopamine D2; Receptors, Dopamine D4; Schizophrenia; Ventral Tegmental Area | 2012 |
Gestational methylazoxymethanol exposure leads to NMDAR dysfunction in hippocampus during early development and lasting deficits in learning.
Topics: Age Factors; Animals; Female; Hippocampus; Learning; Memory Disorders; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2013 |
Human Ntera2 cells as a predictive in vitro test system for developmental neurotoxicity.
Topics: Arsenites; Brain; Cell Differentiation; Cell Line; Cell Movement; High-Throughput Screening Assays; Humans; Methylazoxymethanol Acetate; Methylmercury Compounds; Neurons; Neurotoxicity Syndromes; Sodium Compounds; Toxicity Tests; Tubulin; Valproic Acid | 2014 |
Prenatal MAM administration affects histone H3 methylation in postnatal life in the rat medial prefrontal cortex.
Topics: Animals; Astrocytes; Body Weight; Brain; Enzyme Inhibitors; Glutamate Decarboxylase; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Male; Methylation; Methylazoxymethanol Acetate; Methyltransferases; Neurons; Oxidoreductases, N-Demethylating; Prefrontal Cortex; Rats; Rats, Wistar; RNA, Messenger; Sensory Gating; Teratogens; Valproic Acid | 2014 |
Targeted disruption of layer 4 during development increases GABAA receptor neurotransmission in the neocortex.
Topics: Animals; Disease Models, Animal; Female; Ferrets; Inhibitory Postsynaptic Potentials; Malformations of Cortical Development; Methylazoxymethanol Acetate; Miniature Postsynaptic Potentials; Neocortex; Pregnancy; Protein Subunits; Pyramidal Cells; Receptors, GABA-A; Teratogens | 2014 |
Inhibition of cell proliferation in black-capped chickadees suggests a role for neurogenesis in spatial learning.
Topics: Animals; Bromodeoxyuridine; Central Nervous System Agents; Female; Hippocampus; Lateral Ventricles; Male; Methylazoxymethanol Acetate; Neurogenesis; Neuropsychological Tests; Random Allocation; Songbirds; Spatial Learning | 2014 |
Effects of pubertal cannabinoid administration on attentional set-shifting and dopaminergic hyper-responsivity in a developmental disruption model of schizophrenia.
Topics: Amphetamine; Animals; Attention; Benzoxazines; Cannabinoids; Central Nervous System Stimulants; Disease Models, Animal; Dopaminergic Neurons; Executive Function; Female; Male; Methylazoxymethanol Acetate; Morpholines; Motor Activity; Naphthalenes; Neuropsychological Tests; Pregnancy; Prenatal Exposure Delayed Effects; Rats, Sprague-Dawley; Schizophrenia; Schizophrenic Psychology; Ventral Tegmental Area | 2014 |
Learning induces sonic hedgehog signaling in the amygdala which promotes neurogenesis and long-term memory formation.
Topics: Amygdala; Animals; Bromodeoxyuridine; Conditioning, Classical; Cytarabine; Electroshock; Exploratory Behavior; Fear; Hedgehog Proteins; Immunosuppressive Agents; Long-Term Potentiation; Male; Memory, Long-Term; Methylazoxymethanol Acetate; Mice; Mice, Inbred C57BL; Neurogenesis; RNA, Small Interfering; Signal Transduction | 2014 |
MAM (E17) rodent developmental model of neuropsychiatric disease: disruptions in learning and dysregulation of nucleus accumbens dopamine release, but spared executive function.
Topics: Amphetamine; Animals; Conditioning, Classical; Disease Models, Animal; Dopamine; Executive Function; Learning; Male; Methylazoxymethanol Acetate; Motivation; Nucleus Accumbens; Rats, Sprague-Dawley; Reward; Schizophrenia; Schizophrenic Psychology | 2015 |
Valproic acid (VPA) reduces sensorimotor gating deficits and HDAC2 overexpression in the MAM animal model of schizophrenia.
Topics: Acetylation; Animals; Disease Models, Animal; Female; Gene Expression Regulation, Enzymologic; Histone Deacetylase 2; Histones; Male; Methylazoxymethanol Acetate; Prefrontal Cortex; Rats; Schizophrenia; Sensory Gating; Valproic Acid | 2015 |
Reactivity to addictive drugs in the methylazoxymethanol (MAM) model of schizophrenia in male and female rats.
Topics: Alcohol Drinking; Animals; Behavior, Animal; Disease Models, Animal; Female; Male; Methamphetamine; Methylazoxymethanol Acetate; Pregnancy; Rats; Rats, Sprague-Dawley; Schizophrenia; Sex Characteristics | 2017 |
Prenatal transplantation of epidermal neural crest stem cells in malformation of cortical development mouse model.
Topics: Animals; Calcium-Binding Proteins; Cell- and Tissue-Based Therapy; Cells, Cultured; Cerebral Cortex; Chemokine CXCL12; Chick Embryo; Corpus Callosum; Disease Models, Animal; DNA-Binding Proteins; Doublecortin Domain Proteins; Doublecortin Protein; Epithelial Cells; Female; Glial Fibrillary Acidic Protein; Hair Follicle; Homeodomain Proteins; Methylazoxymethanol Acetate; Mice; Mice, Inbred BALB C; Microfilament Proteins; Microtubule-Associated Proteins; Nerve Tissue Proteins; Nestin; Neural Crest; Neural Stem Cells; Neurogenesis; Neuropeptides; Nuclear Proteins; Pregnancy; Receptors, CXCR4; Tissue Culture Techniques | 2017 |
Suppression of Methamphetamine Self-Administration by Ketamine Pre-treatment Is Absent in the Methylazoxymethanol (MAM) Rat Model of Schizophrenia.
Topics: Analysis of Variance; Animals; Central Nervous System Stimulants; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Ketamine; Locomotion; Methamphetamine; Methylazoxymethanol Acetate; Rats; Rats, Sprague-Dawley; Schizophrenia; Self Administration | 2017 |
Epigenetic mechanisms underlying NMDA receptor hypofunction in the prefrontal cortex of juvenile animals in the MAM model for schizophrenia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cognition Disorders; Disease Models, Animal; Epigenesis, Genetic; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Female; Gene Expression Regulation, Developmental; In Vitro Techniques; Male; Methylazoxymethanol Acetate; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Prefrontal Cortex; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2017 |
Impaired contextual fear-conditioning in MAM rodent model of schizophrenia.
Topics: Action Potentials; Amphetamine; Animals; Central Nervous System Stimulants; Conditioning, Classical; Disease Models, Animal; Dopaminergic Neurons; Fear; Female; Learning Disabilities; Locomotion; Male; Methylazoxymethanol Acetate; Neurotoxins; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Schizophrenia; Time Factors; Ventral Tegmental Area | 2018 |
Adolescent environmental enrichment prevents the emergence of schizophrenia-like abnormalities in a neurodevelopmental model of schizophrenia.
Topics: Animals; Disease Models, Animal; Environment; Histones; Housing, Animal; Male; Methylazoxymethanol Acetate; Prefrontal Cortex; Random Allocation; Rats, Wistar; Schizophrenia; Schizophrenic Psychology; Sexual Maturation; Site-Specific DNA-Methyltransferase (Adenine-Specific) | 2018 |
Adolescent Social Isolation Affects Schizophrenia-Like Behavior in the MAM-E17 Model of Schizophrenia.
Topics: Age Factors; Animals; Carcinogens; Disease Models, Animal; Embryo, Mammalian; Female; Gene Expression Regulation, Developmental; Glutamate Decarboxylase; Interpersonal Relations; Locomotion; Methylazoxymethanol Acetate; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology; Sensory Gating; Social Isolation; Statistics, Nonparametric | 2018 |
Therapeutic effect of perinatal exogenous melatonin on behavioral and histopathological changes and antioxidative enzymes in neonate mouse model of cortical malformation.
Topics: Animals; Animals, Newborn; Antioxidants; Carcinogens; Catalase; Disease Models, Animal; Exploratory Behavior; Female; Gene Expression Regulation, Developmental; Glutathione Peroxidase; Intermediate Filaments; Malformations of Cortical Development; Malondialdehyde; Maze Learning; Melatonin; Methylazoxymethanol Acetate; Mice; Mice, Inbred BALB C; Nitroprusside; Pregnancy; Prenatal Exposure Delayed Effects; Superoxide Dismutase; Tryptamines | 2018 |
Altered brain cannabinoid 1 receptor mRNA expression across postnatal development in the MAM model of schizophrenia.
Topics: Animals; Brain; Disease Models, Animal; Gene Expression Regulation, Developmental; In Situ Hybridization; Male; Methylazoxymethanol Acetate; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; RNA, Messenger; Schizophrenia | 2018 |
Abnormalities in behaviour, histology and prefrontal cortical gene expression profiles relevant to schizophrenia in embryonic day 17 MAM-Exposed C57BL/6 mice.
Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hypertrophy; Lateral Ventricles; Male; Methylazoxymethanol Acetate; Mice; Mice, Inbred C57BL; Motor Activity; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Prepulse Inhibition; Schizophrenia; Schizophrenic Psychology; Sex Characteristics; Social Behavior; Transcriptome | 2018 |
Cycad β-N-methylamino-L-alanine (BMAA), methylazoxymethanol, genotoxicity, and neurodegeneration.
Topics: Amino Acids, Diamino; Brain; Cyanobacteria Toxins; Cycas; Humans; Methylazoxymethanol Acetate; Neurodegenerative Diseases; Neurotoxins | 2018 |
Targeting PSD95-nNOS interaction by Tat-N-dimer peptide during status epilepticus is neuroprotective in MAM-pilocarpine rat model.
Topics: Animals; Disease Models, Animal; Disks Large Homolog 4 Protein; Female; Methylazoxymethanol Acetate; Neuroprotective Agents; Nitric Oxide Synthase Type I; Peptides; Pilocarpine; Pregnancy; Protein Binding; Random Allocation; Rats; Rats, Sprague-Dawley; Status Epilepticus | 2019 |
Metabolic profile of methylazoxymethanol model of schizophrenia in rats and effects of three antipsychotics in long-acting formulation.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Female; Haloperidol; Lipid Metabolism; Male; Metabolome; Methylazoxymethanol Acetate; Olanzapine; Rats, Sprague-Dawley; Risperidone; Schizophrenia | 2020 |
Cycad Genotoxin Methylazoxymethanol Disrupts the Brain Ubiquitin-Proteasome Pathway, Tau and α-Synuclein, as Reported in ALS-PDC.
Topics: alpha-Synuclein; Amyotrophic Lateral Sclerosis; Animals; Brain; Cycas; Humans; Methylazoxymethanol Acetate; Mice; Mutagens; Parkinson Disease, Secondary; Proteasome Endopeptidase Complex; Signal Transduction; Ubiquitin | 2021 |
Effects of methylazoxymethanol-induced micrencephaly on parvalbumin-positive GABAergic interneurons in the rat rostral basolateral amygdala.
Topics: Animals; Basolateral Nuclear Complex; Carcinogens; Female; GABAergic Neurons; Interneurons; Male; Methylazoxymethanol Acetate; Microcephaly; Parvalbumins; Pregnancy; Rats; Rats, Sprague-Dawley | 2021 |
Prenatal MAM treatment altered fear conditioning following social isolation: Relevance to schizophrenia.
Topics: Age Factors; Animals; Behavior, Animal; Conditioning, Classical; Fear; Female; Male; Methylazoxymethanol Acetate; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Proteome; Rats, Wistar; Schizophrenia; Social Isolation; Teratogens | 2021 |
Reduced risk aversion and impaired short-term memory in juvenile rats with malformation of cortical development.
Topics: Affect; Animals; Anxiety; Behavior, Animal; Brain; Cognition; Cues; Disease Models, Animal; Female; Hippocampus; Male; Malformations of Cortical Development; Maze Learning; Memory, Short-Term; Methylazoxymethanol Acetate; Motor Activity; Neurogenesis; Rats; Rats, Sprague-Dawley; Risk Reduction Behavior; Risk-Taking; Spatial Memory | 2021 |
Inhibition of BET Proteins during Adolescence Affects Prefrontal Cortical Development: Relevance to Schizophrenia.
Topics: Adolescent; Adolescent Development; Animals; Azepines; Disease Models, Animal; Female; Gene Expression Regulation, Developmental; Humans; Long-Term Potentiation; Male; Methylazoxymethanol Acetate; Prefrontal Cortex; Proteomics; Rats; Recognition, Psychology; Schizophrenia; Sex Characteristics; Triazoles | 2021 |
Nicotine Administration Normalizes Behavioral and Neurophysiological Perturbations in the MAM Rodent Model of Schizophrenia.
Topics: Animals; Disease Models, Animal; Dopaminergic Neurons; Hippocampus; Male; Methylazoxymethanol Acetate; Nicotine; Prepulse Inhibition; Rats; Rats, Sprague-Dawley; Schizophrenia; Self Medication; Ventral Tegmental Area | 2021 |
LY395756 promotes NR2B expression via activation of AKT/CREB signaling in the juvenile methylazoxymethanol mice model of schizophrenia.
Topics: Amino Acids, Dicarboxylic; Animals; Bridged Bicyclo Compounds; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Methylazoxymethanol Acetate; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction | 2022 |