methylamphotericin-b has been researched along with mycosamine* in 1 studies
1 other study(ies) available for methylamphotericin-b and mycosamine
Article | Year |
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Synthesis and biophysical studies on 35-deoxy amphotericin B methyl ester.
The use of molecular editing in the elucidation of the mechanism of action of amphotericin B is presented. A modular strategy for the synthesis of amphotericin B and its designed analogues is developed, which relies on an efficient gram-scale synthesis of various subunits of amphotericin B. A novel method for the coupling of the mycosamine to the aglycone was identified. The implementation of the approach has enabled the preparation of 35-deoxy amphotericin B methyl ester. Investigation of the antifungal activity and efflux-inducing ability of this amphotericin B congener provided new clues to the role of the 35-hydroxy group and is consistent with the involvement of double barrel ion channels in causing electrolyte efflux. Topics: Amphotericin B; Biophysical Phenomena; Glycosides; Hexosamines; Molecular Structure | 2009 |