methylamphotericin-b and mycosamine

methylamphotericin-b has been researched along with mycosamine* in 1 studies

Other Studies

1 other study(ies) available for methylamphotericin-b and mycosamine

ArticleYear
Synthesis and biophysical studies on 35-deoxy amphotericin B methyl ester.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2009, Jul-20, Volume: 15, Issue:29

    The use of molecular editing in the elucidation of the mechanism of action of amphotericin B is presented. A modular strategy for the synthesis of amphotericin B and its designed analogues is developed, which relies on an efficient gram-scale synthesis of various subunits of amphotericin B. A novel method for the coupling of the mycosamine to the aglycone was identified. The implementation of the approach has enabled the preparation of 35-deoxy amphotericin B methyl ester. Investigation of the antifungal activity and efflux-inducing ability of this amphotericin B congener provided new clues to the role of the 35-hydroxy group and is consistent with the involvement of double barrel ion channels in causing electrolyte efflux.

    Topics: Amphotericin B; Biophysical Phenomena; Glycosides; Hexosamines; Molecular Structure

2009