methyl-retinoate and retinol-acetate

The influence of all-trans- and 13-cys-methylretinoate on antibacterial and antiviral immunity was studied in experiments on noninbred C57Bl/6 and (CBA X C57Bl/6) F1 mice. All-trans-methylretinoate was shown to stimulate the production of antibodies to E. coli antigens, with the effect being dose-dependent. At the same time both compounds inhibited the production of inhibitors, interferon and antibodies to influenza virus.

Topics: Animals; Antibodies, Bacterial; Antibodies, Viral; Antibody Formation; Antiviral Agents; Diterpenes; Escherichia coli; Female; Interferons; Male; Mice; Orthomyxoviridae; Retinyl Esters; Tretinoin; Vitamin A

The influence of retinyl acetate, retinoic acid and its esterified cis- and trans-derivatives, retinoids C15 and C20 on erythrocytes, liver macrophages and white pulp of the spleen was studied in the experiments on mice of different strains. It was found that administration of these compounds leads to the damage of the blood cells, increase in the number of liver macrophages and the share of white pulp in the spleen and stimulation of the local response to tuberculin. The interdependence of changes in the blood and adjuvant is suggested.

Topics: Adjuvants, Immunologic; Animals; Diterpenes; Erythrocytes; Female; Liver; Macrophages; Male; Mice; Mice, Inbred CBA; Retinoids; Retinyl Esters; Spleen; Tretinoin; Vitamin A